Chalcone_isomerase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQG5_LEIBR

TriTrypDb:

LbrM.35.6780 , LBRM2903_350080700

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.691
CLV_NRD_NRD_1	148	150	PF00675	0.669
CLV_NRD_NRD_1	169	171	PF00675	0.584
CLV_PCSK_KEX2_1	148	150	PF00082	0.669
CLV_PCSK_SKI1_1	175	179	PF00082	0.609
CLV_PCSK_SKI1_1	184	188	PF00082	0.525
CLV_PCSK_SKI1_1	191	195	PF00082	0.449
DOC_MAPK_gen_1	148	154	PF00069	0.642
DOC_MAPK_gen_1	90	98	PF00069	0.626
DOC_PP4_FxxP_1	154	157	PF00568	0.572
DOC_PP4_FxxP_1	76	79	PF00568	0.677
DOC_USP7_MATH_1	22	26	PF00917	0.704
DOC_USP7_MATH_1	79	83	PF00917	0.680
LIG_14-3-3_CanoR_1	103	109	PF00244	0.660
LIG_14-3-3_CanoR_1	122	126	PF00244	0.626
LIG_14-3-3_CanoR_1	184	192	PF00244	0.608
LIG_14-3-3_CanoR_1	23	27	PF00244	0.597
LIG_14-3-3_CanoR_1	71	77	PF00244	0.566
LIG_Actin_WH2_2	55	73	PF00022	0.638
LIG_APCC_ABBA_1	56	61	PF00400	0.594
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.574
LIG_BH_BH3_1	35	51	PF00452	0.631
LIG_BRCT_BRCA1_1	182	186	PF00533	0.630
LIG_deltaCOP1_diTrp_1	172	178	PF00928	0.571
LIG_FHA_1	112	118	PF00498	0.610
LIG_FHA_1	140	146	PF00498	0.599
LIG_LIR_Apic_2	151	157	PF02991	0.579
LIG_LIR_Apic_2	75	79	PF02991	0.678
LIG_LIR_Gen_1	94	99	PF02991	0.565
LIG_LIR_Nem_3	94	98	PF02991	0.582
LIG_OCRL_FandH_1	88	100	PF00620	0.622
LIG_SH2_STAP1	74	78	PF00017	0.679
LIG_SH2_STAT3	106	109	PF00017	0.587
LIG_SH2_STAT5	106	109	PF00017	0.587
LIG_SH2_STAT5	74	77	PF00017	0.621
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.425
LIG_SUMO_SIM_par_1	28	35	PF11976	0.425
LIG_UBA3_1	165	171	PF00899	0.607
LIG_WRC_WIRS_1	73	78	PF05994	0.564
MOD_Cter_Amidation	101	104	PF01082	0.694
MOD_GlcNHglycan	5	8	PF01048	0.625
MOD_GSK3_1	176	183	PF00069	0.638
MOD_NEK2_1	121	126	PF00069	0.697
MOD_NEK2_1	31	36	PF00069	0.623
MOD_NMyristoyl	1	7	PF02799	0.570
MOD_PKA_2	121	127	PF00069	0.599
MOD_PKA_2	137	143	PF00069	0.677
MOD_PKA_2	22	28	PF00069	0.579
MOD_Plk_4	72	78	PF00069	0.582
MOD_SUMO_rev_2	47	57	PF00179	0.662
TRG_ER_diArg_1	189	192	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ7	Leptomonas seymouri	86%	100%
A0A0S4IQL1	Bodo saltans	62%	100%
A0A1X0NLH3	Trypanosomatidae	69%	100%
A0A3R7MH65	Trypanosoma rangeli	68%	100%
A0A3S7XC64	Leishmania donovani	93%	100%
A4ICA1	Leishmania infantum	93%	100%
D0A3L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AU81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0B3	Leishmania major	92%	100%