Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQG2_LEIBR

TriTrypDb:

LbrM.35.6750 , LBRM2903_350080400

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HQG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.520
CLV_NRD_NRD_1	167	169	PF00675	0.537
CLV_PCSK_KEX2_1	167	169	PF00082	0.534
CLV_PCSK_SKI1_1	134	138	PF00082	0.360
CLV_PCSK_SKI1_1	71	75	PF00082	0.289
DEG_APCC_DBOX_1	6	14	PF00400	0.400
DEG_COP1_1	148	157	PF00400	0.542
DEG_MDM2_SWIB_1	61	68	PF02201	0.203
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_CYCLIN_RxL_1	61	70	PF00134	0.233
DOC_MAPK_gen_1	167	177	PF00069	0.584
DOC_MAPK_MEF2A_6	7	15	PF00069	0.368
DOC_MAPK_MEF2A_6	71	78	PF00069	0.347
DOC_MAPK_NFAT4_5	71	79	PF00069	0.308
DOC_PP2B_LxvP_1	181	184	PF13499	0.613
DOC_PP4_FxxP_1	15	18	PF00568	0.344
DOC_USP7_MATH_1	126	130	PF00917	0.507
DOC_WW_Pin1_4	175	180	PF00397	0.680
LIG_14-3-3_CanoR_1	134	142	PF00244	0.539
LIG_14-3-3_CanoR_1	188	193	PF00244	0.656
LIG_14-3-3_CanoR_1	92	98	PF00244	0.616
LIG_APCC_ABBAyCdc20_2	194	200	PF00400	0.554
LIG_BRCT_BRCA1_1	57	61	PF00533	0.244
LIG_DCNL_PONY_1	1	4	PF03556	0.389
LIG_FHA_1	149	155	PF00498	0.710
LIG_FHA_1	187	193	PF00498	0.752
LIG_FHA_1	38	44	PF00498	0.344
LIG_FHA_1	68	74	PF00498	0.361
LIG_FHA_2	136	142	PF00498	0.619
LIG_FHA_2	27	33	PF00498	0.519
LIG_LIR_Apic_2	14	18	PF02991	0.400
LIG_LIR_Gen_1	42	52	PF02991	0.430
LIG_LIR_Nem_3	42	48	PF02991	0.405
LIG_LIR_Nem_3	99	105	PF02991	0.594
LIG_MYND_1	179	183	PF01753	0.562
LIG_NRBOX	1	7	PF00104	0.330
LIG_Pex14_2	61	65	PF04695	0.355
LIG_PTAP_UEV_1	154	159	PF05743	0.566
LIG_PTB_Apo_2	77	84	PF02174	0.376
LIG_SH2_CRK	90	94	PF00017	0.538
LIG_SH2_SRC	199	202	PF00017	0.665
LIG_SH2_STAT3	124	127	PF00017	0.609
LIG_SH2_STAT5	101	104	PF00017	0.634
LIG_SH2_STAT5	67	70	PF00017	0.314
LIG_SH2_STAT5	77	80	PF00017	0.426
LIG_SH2_STAT5	9	12	PF00017	0.386
LIG_SH3_3	152	158	PF00018	0.596
LIG_SH3_3	177	183	PF00018	0.744
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.324
LIG_SUMO_SIM_par_1	47	53	PF11976	0.310
LIG_WRC_WIRS_1	12	17	PF05994	0.400
MOD_CDK_SPxxK_3	175	182	PF00069	0.687
MOD_CK1_1	149	155	PF00069	0.665
MOD_CK2_1	135	141	PF00069	0.618
MOD_GlcNHglycan	118	121	PF01048	0.359
MOD_GlcNHglycan	128	131	PF01048	0.373
MOD_GSK3_1	149	156	PF00069	0.643
MOD_GSK3_1	157	164	PF00069	0.680
MOD_GSK3_1	93	100	PF00069	0.670
MOD_N-GLC_1	37	42	PF02516	0.284
MOD_NEK2_1	146	151	PF00069	0.572
MOD_NEK2_1	55	60	PF00069	0.378
MOD_NEK2_1	93	98	PF00069	0.540
MOD_PIKK_1	161	167	PF00454	0.713
MOD_PKA_2	193	199	PF00069	0.626
MOD_Plk_1	37	43	PF00069	0.308
MOD_Plk_4	104	110	PF00069	0.607
MOD_Plk_4	11	17	PF00069	0.368
MOD_Plk_4	128	134	PF00069	0.584
MOD_Plk_4	193	199	PF00069	0.698
MOD_Plk_4	39	45	PF00069	0.371
MOD_Plk_4	56	62	PF00069	0.155
MOD_Plk_4	93	99	PF00069	0.689
MOD_ProDKin_1	175	181	PF00069	0.680
TRG_ENDOCYTIC_2	101	104	PF00928	0.580
TRG_ENDOCYTIC_2	12	15	PF00928	0.427
TRG_ENDOCYTIC_2	90	93	PF00928	0.579
TRG_ER_diArg_1	167	170	PF00400	0.740
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P600	Leptomonas seymouri	60%	73%
A0A1X0NN71	Trypanosomatidae	35%	79%
A0A3Q8IK72	Leishmania donovani	74%	100%
A0A3R7KG37	Trypanosoma rangeli	33%	100%
A4IC98	Leishmania infantum	74%	100%
E9AU78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q0B6	Leishmania major	75%	100%
V5B8C5	Trypanosoma cruzi	36%	100%