HU-CCDC81_euk_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania braziliensis

UniProt:

A4HQG1_LEIBR

TriTrypDb:

LbrM.35.6740 , LBRM2903_350080300

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.652
CLV_NRD_NRD_1	187	189	PF00675	0.422
CLV_NRD_NRD_1	272	274	PF00675	0.495
CLV_NRD_NRD_1	287	289	PF00675	0.528
CLV_NRD_NRD_1	344	346	PF00675	0.714
CLV_NRD_NRD_1	46	48	PF00675	0.351
CLV_NRD_NRD_1	475	477	PF00675	0.539
CLV_NRD_NRD_1	523	525	PF00675	0.703
CLV_NRD_NRD_1	81	83	PF00675	0.410
CLV_PCSK_KEX2_1	247	249	PF00082	0.580
CLV_PCSK_KEX2_1	271	273	PF00082	0.496
CLV_PCSK_KEX2_1	286	288	PF00082	0.525
CLV_PCSK_KEX2_1	344	346	PF00082	0.714
CLV_PCSK_KEX2_1	426	428	PF00082	0.531
CLV_PCSK_KEX2_1	46	48	PF00082	0.351
CLV_PCSK_KEX2_1	475	477	PF00082	0.643
CLV_PCSK_KEX2_1	525	527	PF00082	0.588
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.502
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.531
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.588
CLV_PCSK_PC7_1	283	289	PF00082	0.408
CLV_PCSK_PC7_1	521	527	PF00082	0.591
CLV_PCSK_SKI1_1	137	141	PF00082	0.313
CLV_PCSK_SKI1_1	169	173	PF00082	0.272
CLV_PCSK_SKI1_1	248	252	PF00082	0.574
CLV_PCSK_SKI1_1	26	30	PF00082	0.418
CLV_PCSK_SKI1_1	46	50	PF00082	0.220
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SPOP_SBC_1	385	389	PF00917	0.632
DOC_ANK_TNKS_1	106	113	PF00023	0.527
DOC_CYCLIN_RxL_1	43	53	PF00134	0.351
DOC_MAPK_gen_1	146	155	PF00069	0.347
DOC_MAPK_gen_1	166	172	PF00069	0.461
DOC_MAPK_gen_1	80	90	PF00069	0.418
DOC_MAPK_MEF2A_6	149	157	PF00069	0.369
DOC_MAPK_MEF2A_6	166	174	PF00069	0.304
DOC_MAPK_MEF2A_6	36	43	PF00069	0.336
DOC_MAPK_MEF2A_6	400	407	PF00069	0.526
DOC_MAPK_RevD_3	153	167	PF00069	0.369
DOC_PP1_RVXF_1	80	87	PF00149	0.354
DOC_PP2B_LxvP_1	155	158	PF13499	0.304
DOC_PP4_FxxP_1	446	449	PF00568	0.583
DOC_USP7_MATH_1	208	212	PF00917	0.538
DOC_USP7_MATH_1	213	217	PF00917	0.598
DOC_USP7_MATH_1	222	226	PF00917	0.602
DOC_USP7_MATH_1	254	258	PF00917	0.544
DOC_USP7_MATH_1	274	278	PF00917	0.374
DOC_USP7_MATH_1	351	355	PF00917	0.600
DOC_USP7_MATH_1	374	378	PF00917	0.613
DOC_USP7_MATH_1	385	389	PF00917	0.632
DOC_USP7_MATH_2	469	475	PF00917	0.660
DOC_WW_Pin1_4	252	257	PF00397	0.551
DOC_WW_Pin1_4	483	488	PF00397	0.705
LIG_14-3-3_CanoR_1	115	119	PF00244	0.304
LIG_14-3-3_CanoR_1	130	139	PF00244	0.304
LIG_14-3-3_CanoR_1	229	233	PF00244	0.650
LIG_14-3-3_CanoR_1	273	279	PF00244	0.483
LIG_14-3-3_CanoR_1	368	374	PF00244	0.543
LIG_14-3-3_CanoR_1	475	485	PF00244	0.571
LIG_14-3-3_CanoR_1	5	15	PF00244	0.387
LIG_APCC_ABBA_1	172	177	PF00400	0.227
LIG_APCC_ABBA_1	408	413	PF00400	0.532
LIG_FHA_1	160	166	PF00498	0.288
LIG_FHA_1	222	228	PF00498	0.650
LIG_FHA_1	368	374	PF00498	0.615
LIG_FHA_1	419	425	PF00498	0.548
LIG_FHA_1	492	498	PF00498	0.680
LIG_FHA_1	499	505	PF00498	0.678
LIG_FHA_1	79	85	PF00498	0.361
LIG_FHA_1	98	104	PF00498	0.410
LIG_FHA_2	202	208	PF00498	0.366
LIG_FHA_2	237	243	PF00498	0.654
LIG_FHA_2	420	426	PF00498	0.624
LIG_FHA_2	452	458	PF00498	0.600
LIG_IBAR_NPY_1	77	79	PF08397	0.448
LIG_LIR_Apic_2	323	329	PF02991	0.532
LIG_LIR_Apic_2	443	449	PF02991	0.573
LIG_LIR_Apic_2	463	469	PF02991	0.574
LIG_LIR_Gen_1	111	121	PF02991	0.369
LIG_LIR_Gen_1	138	147	PF02991	0.304
LIG_LIR_Gen_1	197	206	PF02991	0.492
LIG_LIR_Gen_1	35	45	PF02991	0.367
LIG_LIR_Gen_1	356	367	PF02991	0.613
LIG_LIR_Gen_1	65	73	PF02991	0.412
LIG_LIR_Nem_3	111	116	PF02991	0.484
LIG_LIR_Nem_3	138	143	PF02991	0.331
LIG_LIR_Nem_3	197	202	PF02991	0.479
LIG_LIR_Nem_3	297	302	PF02991	0.526
LIG_LIR_Nem_3	35	41	PF02991	0.370
LIG_LIR_Nem_3	356	362	PF02991	0.619
LIG_LIR_Nem_3	65	71	PF02991	0.408
LIG_Pex14_1	64	68	PF04695	0.367
LIG_Pex14_2	60	64	PF04695	0.321
LIG_PTB_Apo_2	308	315	PF02174	0.510
LIG_PTB_Phospho_1	308	314	PF10480	0.507
LIG_SH2_CRK	466	470	PF00017	0.587
LIG_SH2_GRB2like	92	95	PF00017	0.425
LIG_SH2_NCK_1	326	330	PF00017	0.605
LIG_SH2_NCK_1	359	363	PF00017	0.685
LIG_SH2_NCK_1	466	470	PF00017	0.587
LIG_SH2_PTP2	113	116	PF00017	0.304
LIG_SH2_PTP2	68	71	PF00017	0.362
LIG_SH2_STAP1	315	319	PF00017	0.656
LIG_SH2_STAP1	92	96	PF00017	0.356
LIG_SH2_STAT3	302	305	PF00017	0.484
LIG_SH2_STAT5	113	116	PF00017	0.304
LIG_SH2_STAT5	142	145	PF00017	0.350
LIG_SH2_STAT5	315	318	PF00017	0.605
LIG_SH2_STAT5	326	329	PF00017	0.550
LIG_SH2_STAT5	68	71	PF00017	0.371
LIG_SH3_3	343	349	PF00018	0.695
LIG_SH3_3	414	420	PF00018	0.631
LIG_SH3_3	425	431	PF00018	0.520
LIG_SH3_3	479	485	PF00018	0.548
LIG_SUMO_SIM_anti_2	404	409	PF11976	0.608
LIG_SUMO_SIM_par_1	120	126	PF11976	0.227
LIG_SUMO_SIM_par_1	406	415	PF11976	0.672
LIG_TRAF2_1	330	333	PF00917	0.684
LIG_UBA3_1	30	36	PF00899	0.365
MOD_CDK_SPxxK_3	252	259	PF00069	0.545
MOD_CK1_1	123	129	PF00069	0.262
MOD_CK1_1	220	226	PF00069	0.692
MOD_CK1_1	228	234	PF00069	0.578
MOD_CK1_1	354	360	PF00069	0.613
MOD_CK1_1	389	395	PF00069	0.757
MOD_CK1_1	486	492	PF00069	0.570
MOD_CK1_1	500	506	PF00069	0.594
MOD_CK2_1	170	176	PF00069	0.222
MOD_CK2_1	201	207	PF00069	0.356
MOD_CK2_1	29	35	PF00069	0.359
MOD_CK2_1	327	333	PF00069	0.699
MOD_CK2_1	390	396	PF00069	0.547
MOD_CK2_1	412	418	PF00069	0.635
MOD_CK2_1	451	457	PF00069	0.603
MOD_Cter_Amidation	522	525	PF01082	0.592
MOD_GlcNHglycan	132	135	PF01048	0.314
MOD_GlcNHglycan	215	218	PF01048	0.578
MOD_GlcNHglycan	233	236	PF01048	0.583
MOD_GlcNHglycan	256	259	PF01048	0.689
MOD_GlcNHglycan	351	354	PF01048	0.663
MOD_GlcNHglycan	457	461	PF01048	0.625
MOD_GlcNHglycan	478	481	PF01048	0.645
MOD_GlcNHglycan	51	55	PF01048	0.428
MOD_GlcNHglycan	511	514	PF01048	0.647
MOD_GSK3_1	208	215	PF00069	0.530
MOD_GSK3_1	217	224	PF00069	0.488
MOD_GSK3_1	231	238	PF00069	0.591
MOD_GSK3_1	324	331	PF00069	0.548
MOD_GSK3_1	385	392	PF00069	0.745
MOD_GSK3_1	451	458	PF00069	0.612
MOD_GSK3_1	496	503	PF00069	0.629
MOD_N-GLC_1	21	26	PF02516	0.512
MOD_NEK2_1	1	6	PF00069	0.482
MOD_NEK2_1	153	158	PF00069	0.304
MOD_NEK2_1	324	329	PF00069	0.555
MOD_NEK2_1	411	416	PF00069	0.541
MOD_NEK2_1	464	469	PF00069	0.623
MOD_NEK2_1	50	55	PF00069	0.424
MOD_NEK2_1	506	511	PF00069	0.535
MOD_NEK2_2	161	166	PF00069	0.369
MOD_PIKK_1	201	207	PF00454	0.356
MOD_PIKK_1	464	470	PF00454	0.616
MOD_PIKK_1	498	504	PF00454	0.549
MOD_PIKK_1	62	68	PF00454	0.275
MOD_PKA_2	114	120	PF00069	0.300
MOD_PKA_2	220	226	PF00069	0.576
MOD_PKA_2	228	234	PF00069	0.604
MOD_PKA_2	367	373	PF00069	0.683
MOD_Plk_1	411	417	PF00069	0.527
MOD_Plk_2-3	412	418	PF00069	0.530
MOD_Plk_4	354	360	PF00069	0.627
MOD_Plk_4	412	418	PF00069	0.530
MOD_Plk_4	536	542	PF00069	0.579
MOD_ProDKin_1	252	258	PF00069	0.549
MOD_ProDKin_1	483	489	PF00069	0.705
MOD_SUMO_rev_2	242	249	PF00179	0.572
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.333
TRG_ENDOCYTIC_2	113	116	PF00928	0.304
TRG_ENDOCYTIC_2	199	202	PF00928	0.489
TRG_ENDOCYTIC_2	359	362	PF00928	0.623
TRG_ENDOCYTIC_2	68	71	PF00928	0.371
TRG_ER_diArg_1	271	273	PF00400	0.575
TRG_ER_diArg_1	285	288	PF00400	0.447
TRG_ER_diArg_1	343	345	PF00400	0.714
TRG_ER_diArg_1	46	48	PF00400	0.351
TRG_ER_diArg_1	475	478	PF00400	0.544
TRG_ER_diArg_1	524	527	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I476	Leptomonas seymouri	55%	97%
A0A3Q8IPX9	Leishmania donovani	76%	100%
A4IC97	Leishmania infantum	76%	100%
E9AU77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0B7	Leishmania major	76%	97%