Ribosome biogenesis protein NSA2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S8, putative

Species:

Leishmania braziliensis

UniProt:

A4HQG0_LEIBR

TriTrypDb:

LbrM.35.6730 , LBRM2903_350080100

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1

Expansion

Sequence features

A4HQG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.176
CLV_NRD_NRD_1	16	18	PF00675	0.395
CLV_NRD_NRD_1	162	164	PF00675	0.176
CLV_NRD_NRD_1	24	26	PF00675	0.360
CLV_NRD_NRD_1	29	31	PF00675	0.364
CLV_NRD_NRD_1	61	63	PF00675	0.180
CLV_PCSK_KEX2_1	109	111	PF00082	0.176
CLV_PCSK_KEX2_1	12	14	PF00082	0.390
CLV_PCSK_KEX2_1	140	142	PF00082	0.176
CLV_PCSK_KEX2_1	147	149	PF00082	0.176
CLV_PCSK_KEX2_1	16	18	PF00082	0.395
CLV_PCSK_KEX2_1	162	164	PF00082	0.176
CLV_PCSK_KEX2_1	26	28	PF00082	0.360
CLV_PCSK_KEX2_1	40	42	PF00082	0.176
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.176
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.390
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.176
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.176
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.360
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.176
CLV_PCSK_SKI1_1	134	138	PF00082	0.176
CLV_PCSK_SKI1_1	43	47	PF00082	0.179
CLV_PCSK_SKI1_1	83	87	PF00082	0.176
DOC_CKS1_1	229	234	PF01111	0.376
DOC_MAPK_DCC_7	189	199	PF00069	0.376
DOC_MAPK_gen_1	113	121	PF00069	0.376
DOC_MAPK_gen_1	147	155	PF00069	0.376
DOC_MAPK_gen_1	166	176	PF00069	0.376
DOC_MAPK_JIP1_4	172	178	PF00069	0.376
DOC_MAPK_MEF2A_6	169	178	PF00069	0.376
DOC_MAPK_MEF2A_6	216	224	PF00069	0.388
DOC_PP1_RVXF_1	150	156	PF00149	0.376
DOC_PP1_RVXF_1	233	239	PF00149	0.376
DOC_PP2B_PxIxI_1	194	200	PF00149	0.376
DOC_PP4_FxxP_1	170	173	PF00568	0.376
DOC_PP4_FxxP_1	192	195	PF00568	0.376
DOC_USP7_MATH_1	135	139	PF00917	0.387
DOC_USP7_MATH_1	85	89	PF00917	0.322
DOC_USP7_UBL2_3	107	111	PF12436	0.376
DOC_USP7_UBL2_3	140	144	PF12436	0.376
DOC_USP7_UBL2_3	48	52	PF12436	0.382
DOC_WW_Pin1_4	228	233	PF00397	0.376
LIG_14-3-3_CanoR_1	141	147	PF00244	0.397
LIG_14-3-3_CanoR_1	30	39	PF00244	0.380
LIG_Actin_WH2_2	120	136	PF00022	0.480
LIG_FHA_1	189	195	PF00498	0.376
LIG_FHA_1	72	78	PF00498	0.400
LIG_FHA_2	124	130	PF00498	0.496
LIG_FHA_2	182	188	PF00498	0.376
LIG_LIR_Apic_2	168	173	PF02991	0.376
LIG_LIR_Apic_2	191	195	PF02991	0.376
LIG_LIR_Nem_3	145	149	PF02991	0.453
LIG_PDZ_Class_2	255	260	PF00595	0.376
LIG_SH2_CRK	208	212	PF00017	0.376
LIG_SH2_CRK	241	245	PF00017	0.376
LIG_SH2_NCK_1	241	245	PF00017	0.376
LIG_SH2_STAP1	55	59	PF00017	0.387
LIG_SH2_STAT3	6	9	PF00017	0.426
LIG_SH2_STAT5	208	211	PF00017	0.402
LIG_SH2_STAT5	38	41	PF00017	0.443
LIG_SH2_STAT5	6	9	PF00017	0.382
LIG_SH3_3	180	186	PF00018	0.376
LIG_WRC_WIRS_1	86	91	PF05994	0.322
MOD_CDK_SPxxK_3	228	235	PF00069	0.376
MOD_CK2_1	123	129	PF00069	0.405
MOD_CK2_1	181	187	PF00069	0.383
MOD_CK2_1	215	221	PF00069	0.387
MOD_Cter_Amidation	138	141	PF01082	0.176
MOD_Cter_Amidation	14	17	PF01082	0.391
MOD_GlcNHglycan	137	140	PF01048	0.186
MOD_GlcNHglycan	232	235	PF01048	0.176
MOD_N-GLC_1	222	227	PF02516	0.176
MOD_NEK2_1	102	107	PF00069	0.376
MOD_NEK2_1	188	193	PF00069	0.405
MOD_Plk_4	151	157	PF00069	0.376
MOD_Plk_4	215	221	PF00069	0.413
MOD_Plk_4	85	91	PF00069	0.322
MOD_ProDKin_1	228	234	PF00069	0.376
MOD_SUMO_for_1	165	168	PF00179	0.376
MOD_SUMO_rev_2	67	73	PF00179	0.387
TRG_ENDOCYTIC_2	208	211	PF00928	0.382
TRG_ENDOCYTIC_2	241	244	PF00928	0.376
TRG_ER_diArg_1	16	18	PF00400	0.395
TRG_ER_diArg_1	162	164	PF00400	0.376
TRG_NLS_Bipartite_1	25	44	PF00514	0.493
TRG_NLS_MonoExtC_3	139	144	PF00514	0.376
TRG_NLS_MonoExtC_3	61	66	PF00514	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXC2	Leptomonas seymouri	97%	100%
A0A0S4IXU2	Bodo saltans	91%	100%
A0A1X0NLB8	Trypanosomatidae	90%	100%
A0A3R7NFI2	Trypanosoma rangeli	91%	100%
A0A3S7XC47	Leishmania donovani	98%	100%
A1CJS8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	60%	98%
A1D7P0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	61%	96%
A3LQ06	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	59%	100%
A4IC96	Leishmania infantum	98%	100%
A5DCN7	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	59%	100%
A5DZE1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	60%	100%
A6R3Q6	Ajellomyces capsulatus (strain NAm1 / WU24)	61%	100%
A6S4J2	Botryotinia fuckeliana (strain B05.10)	56%	100%
A6ZR80	Saccharomyces cerevisiae (strain YJM789)	59%	100%
A7TIZ1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	60%	100%
D0A3L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	100%
E9AU76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O95478	Homo sapiens	66%	100%
P0CQ60	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	56%	100%
P0CQ61	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	56%	100%
P0CU36	Candida albicans (strain SC5314 / ATCC MYA-2876)	60%	100%
P40078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
Q0UV95	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	59%	100%
Q1DQ27	Coccidioides immitis (strain RS)	60%	100%
Q3SX11	Bos taurus	66%	100%
Q4P3S7	Ustilago maydis (strain 521 / FGSC 9021)	58%	99%
Q4Q0B8	Leishmania major	99%	100%
Q4WX36	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	60%	92%
Q54GN8	Dictyostelium discoideum	66%	100%
Q5A2Y7	Candida albicans (strain SC5314 / ATCC MYA-2876)	60%	100%
Q5B954	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	61%	100%
Q6BU14	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	58%	100%
Q6C6D1	Yarrowia lipolytica (strain CLIB 122 / E 150)	61%	99%
Q6CNC5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	60%	100%
Q6FN72	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	59%	100%
Q75CG9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	61%	100%
Q7SGE1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	100%
Q9CR47	Mus musculus	66%	100%
Q9QYU7	Rattus norvegicus	65%	100%
Q9UU79	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	100%
V5BCT6	Trypanosoma cruzi	91%	100%