Rib72 protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rib72 protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HQF8_LEIBR

TriTrypDb:

LbrM.35.6710 , LBRM2903_350079900

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	586	590	PF00656	0.494
CLV_C14_Caspase3-7	60	64	PF00656	0.350
CLV_NRD_NRD_1	107	109	PF00675	0.212
CLV_NRD_NRD_1	216	218	PF00675	0.467
CLV_NRD_NRD_1	261	263	PF00675	0.315
CLV_NRD_NRD_1	297	299	PF00675	0.218
CLV_NRD_NRD_1	31	33	PF00675	0.519
CLV_NRD_NRD_1	380	382	PF00675	0.640
CLV_NRD_NRD_1	442	444	PF00675	0.176
CLV_NRD_NRD_1	475	477	PF00675	0.316
CLV_NRD_NRD_1	667	669	PF00675	0.399
CLV_NRD_NRD_1	728	730	PF00675	0.312
CLV_PCSK_FUR_1	295	299	PF00082	0.267
CLV_PCSK_FUR_1	508	512	PF00082	0.314
CLV_PCSK_KEX2_1	216	218	PF00082	0.389
CLV_PCSK_KEX2_1	261	263	PF00082	0.279
CLV_PCSK_KEX2_1	295	297	PF00082	0.212
CLV_PCSK_KEX2_1	31	33	PF00082	0.538
CLV_PCSK_KEX2_1	379	381	PF00082	0.562
CLV_PCSK_KEX2_1	397	399	PF00082	0.687
CLV_PCSK_KEX2_1	442	444	PF00082	0.196
CLV_PCSK_KEX2_1	475	477	PF00082	0.315
CLV_PCSK_KEX2_1	510	512	PF00082	0.407
CLV_PCSK_KEX2_1	667	669	PF00082	0.373
CLV_PCSK_KEX2_1	728	730	PF00082	0.340
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.279
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.599
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.641
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.427
CLV_PCSK_SKI1_1	108	112	PF00082	0.237
CLV_PCSK_SKI1_1	176	180	PF00082	0.462
CLV_PCSK_SKI1_1	250	254	PF00082	0.239
CLV_PCSK_SKI1_1	304	308	PF00082	0.255
CLV_PCSK_SKI1_1	340	344	PF00082	0.364
CLV_PCSK_SKI1_1	383	387	PF00082	0.553
CLV_PCSK_SKI1_1	43	47	PF00082	0.484
CLV_PCSK_SKI1_1	659	663	PF00082	0.378
CLV_PCSK_SKI1_1	70	74	PF00082	0.439
CLV_PCSK_SKI1_1	737	741	PF00082	0.513
DEG_SPOP_SBC_1	553	557	PF00917	0.508
DOC_ANK_TNKS_1	141	148	PF00023	0.479
DOC_CDC14_PxL_1	9	17	PF14671	0.435
DOC_CKS1_1	124	129	PF01111	0.455
DOC_CKS1_1	233	238	PF01111	0.448
DOC_CKS1_1	700	705	PF01111	0.562
DOC_CKS1_1	717	722	PF01111	0.341
DOC_CYCLIN_RxL_1	656	665	PF00134	0.401
DOC_CYCLIN_yClb1_LxF_4	250	256	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.547
DOC_MAPK_gen_1	142	150	PF00069	0.437
DOC_MAPK_gen_1	261	268	PF00069	0.467
DOC_MAPK_gen_1	296	308	PF00069	0.504
DOC_PP1_RVXF_1	263	269	PF00149	0.515
DOC_PP1_RVXF_1	83	90	PF00149	0.423
DOC_PP4_FxxP_1	338	341	PF00568	0.515
DOC_SPAK_OSR1_1	443	447	PF12202	0.433
DOC_USP7_MATH_1	117	121	PF00917	0.515
DOC_USP7_MATH_1	271	275	PF00917	0.525
DOC_USP7_MATH_1	392	396	PF00917	0.654
DOC_USP7_MATH_1	433	437	PF00917	0.354
DOC_USP7_MATH_1	553	557	PF00917	0.575
DOC_USP7_MATH_1	57	61	PF00917	0.612
DOC_USP7_MATH_1	616	620	PF00917	0.648
DOC_USP7_MATH_1	636	640	PF00917	0.363
DOC_USP7_MATH_1	671	675	PF00917	0.466
DOC_USP7_MATH_1	678	682	PF00917	0.466
DOC_USP7_UBL2_3	413	417	PF12436	0.438
DOC_USP7_UBL2_3	646	650	PF12436	0.368
DOC_USP7_UBL2_3	697	701	PF12436	0.525
DOC_WW_Pin1_4	123	128	PF00397	0.412
DOC_WW_Pin1_4	232	237	PF00397	0.419
DOC_WW_Pin1_4	699	704	PF00397	0.578
DOC_WW_Pin1_4	716	721	PF00397	0.257
LIG_14-3-3_CanoR_1	330	336	PF00244	0.479
LIG_14-3-3_CanoR_1	398	406	PF00244	0.574
LIG_14-3-3_CanoR_1	544	552	PF00244	0.384
LIG_14-3-3_CanoR_1	627	633	PF00244	0.499
LIG_14-3-3_CanoR_1	659	664	PF00244	0.472
LIG_14-3-3_CanoR_1	667	671	PF00244	0.331
LIG_14-3-3_CanoR_1	673	683	PF00244	0.249
LIG_14-3-3_CanoR_1	728	733	PF00244	0.359
LIG_Actin_RPEL_3	722	741	PF02755	0.290
LIG_Actin_WH2_2	317	332	PF00022	0.374
LIG_Actin_WH2_2	474	490	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_deltaCOP1_diTrp_1	593	601	PF00928	0.505
LIG_FHA_1	102	108	PF00498	0.459
LIG_FHA_1	124	130	PF00498	0.430
LIG_FHA_1	40	46	PF00498	0.494
LIG_FHA_1	452	458	PF00498	0.423
LIG_FHA_1	490	496	PF00498	0.432
LIG_FHA_1	525	531	PF00498	0.364
LIG_FHA_1	555	561	PF00498	0.563
LIG_FHA_1	600	606	PF00498	0.307
LIG_FHA_1	667	673	PF00498	0.445
LIG_FHA_1	717	723	PF00498	0.377
LIG_FHA_1	92	98	PF00498	0.479
LIG_FHA_2	233	239	PF00498	0.443
LIG_FHA_2	331	337	PF00498	0.485
LIG_FHA_2	34	40	PF00498	0.630
LIG_FHA_2	575	581	PF00498	0.455
LIG_FHA_2	660	666	PF00498	0.442
LIG_FHA_2	703	709	PF00498	0.393
LIG_FHA_2	79	85	PF00498	0.515
LIG_LIR_Apic_2	336	341	PF02991	0.515
LIG_LIR_Apic_2	456	461	PF02991	0.393
LIG_LIR_Gen_1	177	187	PF02991	0.433
LIG_LIR_Gen_1	19	27	PF02991	0.455
LIG_LIR_Gen_1	509	520	PF02991	0.461
LIG_LIR_Gen_1	593	601	PF02991	0.488
LIG_LIR_Gen_1	7	16	PF02991	0.446
LIG_LIR_Nem_3	175	181	PF02991	0.402
LIG_LIR_Nem_3	19	23	PF02991	0.414
LIG_LIR_Nem_3	244	248	PF02991	0.524
LIG_LIR_Nem_3	288	293	PF02991	0.515
LIG_LIR_Nem_3	339	345	PF02991	0.412
LIG_LIR_Nem_3	546	552	PF02991	0.386
LIG_LIR_Nem_3	593	598	PF02991	0.496
LIG_LIR_Nem_3	622	626	PF02991	0.578
LIG_LIR_Nem_3	7	12	PF02991	0.460
LIG_LIR_Nem_3	78	82	PF02991	0.443
LIG_PDZ_Class_2	736	741	PF00595	0.369
LIG_Pex14_2	174	178	PF04695	0.533
LIG_Pex14_2	255	259	PF04695	0.412
LIG_Pex14_2	264	268	PF04695	0.412
LIG_Pex14_2	338	342	PF04695	0.423
LIG_Pex14_2	610	614	PF04695	0.507
LIG_Rb_pABgroove_1	273	281	PF01858	0.515
LIG_SH2_CRK	9	13	PF00017	0.444
LIG_SH2_STAP1	248	252	PF00017	0.515
LIG_SH2_STAP1	421	425	PF00017	0.455
LIG_SH2_STAP1	93	97	PF00017	0.515
LIG_SH2_STAT3	537	540	PF00017	0.480
LIG_SH2_STAT5	114	117	PF00017	0.426
LIG_SH2_STAT5	267	270	PF00017	0.419
LIG_SH2_STAT5	34	37	PF00017	0.504
LIG_SH2_STAT5	449	452	PF00017	0.433
LIG_SH2_STAT5	500	503	PF00017	0.491
LIG_SH2_STAT5	512	515	PF00017	0.399
LIG_SH2_STAT5	524	527	PF00017	0.392
LIG_SH2_STAT5	537	540	PF00017	0.381
LIG_SH2_STAT5	718	721	PF00017	0.313
LIG_SH2_STAT5	93	96	PF00017	0.426
LIG_SH3_3	10	16	PF00018	0.414
LIG_SH3_3	121	127	PF00018	0.479
LIG_SH3_3	313	319	PF00018	0.542
LIG_SH3_3	360	366	PF00018	0.414
LIG_SH3_3	478	484	PF00018	0.354
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.437
LIG_SUMO_SIM_par_1	452	459	PF11976	0.424
LIG_SUMO_SIM_par_1	668	674	PF11976	0.506
LIG_TRAF2_1	369	372	PF00917	0.429
LIG_TRAF2_1	435	438	PF00917	0.515
LIG_TRAF2_1	731	734	PF00917	0.471
LIG_UBA3_1	501	510	PF00899	0.458
LIG_WRC_WIRS_1	611	616	PF05994	0.559
LIG_WRC_WIRS_1	672	677	PF05994	0.484
MOD_CDK_SPxxK_3	232	239	PF00069	0.410
MOD_CK1_1	101	107	PF00069	0.489
MOD_CK1_1	232	238	PF00069	0.465
MOD_CK1_1	309	315	PF00069	0.524
MOD_CK1_1	543	549	PF00069	0.384
MOD_CK1_1	554	560	PF00069	0.417
MOD_CK1_1	674	680	PF00069	0.397
MOD_CK1_1	78	84	PF00069	0.547
MOD_CK2_1	16	22	PF00069	0.477
MOD_CK2_1	232	238	PF00069	0.430
MOD_CK2_1	432	438	PF00069	0.354
MOD_CK2_1	453	459	PF00069	0.423
MOD_CK2_1	574	580	PF00069	0.500
MOD_CK2_1	616	622	PF00069	0.441
MOD_CK2_1	659	665	PF00069	0.329
MOD_CK2_1	702	708	PF00069	0.386
MOD_CK2_1	728	734	PF00069	0.361
MOD_CK2_1	97	103	PF00069	0.412
MOD_Cter_Amidation	29	32	PF01082	0.546
MOD_Cter_Amidation	377	380	PF01082	0.627
MOD_Cter_Amidation	395	398	PF01082	0.562
MOD_Cter_Amidation	440	443	PF01082	0.174
MOD_GlcNHglycan	131	134	PF01048	0.212
MOD_GlcNHglycan	394	397	PF01048	0.611
MOD_GlcNHglycan	407	411	PF01048	0.510
MOD_GlcNHglycan	428	431	PF01048	0.193
MOD_GlcNHglycan	464	467	PF01048	0.212
MOD_GlcNHglycan	52	56	PF01048	0.590
MOD_GlcNHglycan	59	62	PF01048	0.497
MOD_GlcNHglycan	676	679	PF01048	0.416
MOD_GlcNHglycan	680	683	PF01048	0.431
MOD_GSK3_1	222	229	PF00069	0.522
MOD_GSK3_1	51	58	PF00069	0.472
MOD_GSK3_1	554	561	PF00069	0.572
MOD_GSK3_1	674	681	PF00069	0.444
MOD_GSK3_1	97	104	PF00069	0.479
MOD_NEK2_1	399	404	PF00069	0.582
MOD_NEK2_1	406	411	PF00069	0.459
MOD_NEK2_1	51	56	PF00069	0.646
MOD_NEK2_1	610	615	PF00069	0.675
MOD_NEK2_2	41	46	PF00069	0.554
MOD_NEK2_2	671	676	PF00069	0.473
MOD_PIKK_1	524	530	PF00454	0.399
MOD_PIKK_1	554	560	PF00454	0.574
MOD_PIKK_1	616	622	PF00454	0.678
MOD_PIKK_1	676	682	PF00454	0.276
MOD_PK_1	728	734	PF00069	0.301
MOD_PKA_1	728	734	PF00069	0.361
MOD_PKA_2	426	432	PF00069	0.403
MOD_PKA_2	462	468	PF00069	0.413
MOD_PKA_2	543	549	PF00069	0.383
MOD_PKA_2	616	622	PF00069	0.627
MOD_PKA_2	666	672	PF00069	0.413
MOD_PKA_2	728	734	PF00069	0.361
MOD_Plk_1	373	379	PF00069	0.595
MOD_Plk_1	4	10	PF00069	0.493
MOD_Plk_1	451	457	PF00069	0.412
MOD_Plk_2-3	453	459	PF00069	0.423
MOD_Plk_4	135	141	PF00069	0.451
MOD_Plk_4	229	235	PF00069	0.437
MOD_Plk_4	4	10	PF00069	0.512
MOD_Plk_4	400	406	PF00069	0.508
MOD_Plk_4	453	459	PF00069	0.423
MOD_Plk_4	482	488	PF00069	0.389
MOD_Plk_4	533	539	PF00069	0.432
MOD_Plk_4	636	642	PF00069	0.573
MOD_Plk_4	659	665	PF00069	0.486
MOD_ProDKin_1	123	129	PF00069	0.412
MOD_ProDKin_1	232	238	PF00069	0.414
MOD_ProDKin_1	699	705	PF00069	0.577
MOD_ProDKin_1	716	722	PF00069	0.262
MOD_SUMO_rev_2	78	87	PF00179	0.439
TRG_DiLeu_BaEn_1	708	713	PF01217	0.362
TRG_DiLeu_BaEn_2	439	445	PF01217	0.412
TRG_ENDOCYTIC_2	267	270	PF00928	0.467
TRG_ENDOCYTIC_2	290	293	PF00928	0.515
TRG_ENDOCYTIC_2	34	37	PF00928	0.510
TRG_ENDOCYTIC_2	512	515	PF00928	0.483
TRG_ENDOCYTIC_2	9	12	PF00928	0.456
TRG_ER_diArg_1	105	108	PF00400	0.414
TRG_ER_diArg_1	215	217	PF00400	0.409
TRG_ER_diArg_1	294	297	PF00400	0.412
TRG_ER_diArg_1	380	383	PF00400	0.645
TRG_ER_diArg_1	442	444	PF00400	0.396
TRG_ER_diArg_1	728	730	PF00400	0.315
TRG_NLS_MonoExtC_3	378	383	PF00514	0.568
TRG_NLS_MonoExtN_4	106	112	PF00514	0.423
TRG_NLS_MonoExtN_4	261	266	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ98	Leptomonas seymouri	26%	96%
A0A0N1I3M2	Leptomonas seymouri	26%	97%
A0A0N1PBW1	Leptomonas seymouri	74%	99%
A0A0S4IJW8	Bodo saltans	25%	90%
A0A0S4IQM0	Bodo saltans	39%	100%
A0A0S4J8J7	Bodo saltans	26%	81%
A0A1X0NEV8	Trypanosomatidae	25%	93%
A0A1X0NLI2	Trypanosomatidae	50%	100%
A0A1X0NMQ3	Trypanosomatidae	27%	95%
A0A1X0P419	Trypanosomatidae	25%	98%
A0A3Q1N1R0	Bos taurus	26%	100%
A0A3Q8IDH4	Leishmania donovani	28%	96%
A0A3Q8IPU3	Leishmania donovani	26%	98%
A0A3R7KM50	Trypanosoma rangeli	25%	93%
A0A3R7L048	Trypanosoma rangeli	26%	98%
A0A3S7XC76	Leishmania donovani	87%	100%
A0A422N0Z6	Trypanosoma rangeli	27%	95%
A0A422NK00	Trypanosoma rangeli	51%	100%
A4HE78	Leishmania braziliensis	29%	100%
A4HFK9	Leishmania braziliensis	25%	96%
A4I1J2	Leishmania infantum	28%	96%
A4IC94	Leishmania infantum	87%	100%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
D0A3K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E1BKH1	Bos taurus	29%	100%
E9AD64	Leishmania major	26%	98%
E9AHF6	Leishmania infantum	26%	98%
E9AU74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AXM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
E9AYY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
Q32TF8	Danio rerio	27%	99%
Q32TG3	Gallus gallus	27%	99%
Q4Q0C0	Leishmania major	87%	100%
Q4Q9U5	Leishmania major	28%	100%
Q5JST6	Homo sapiens	25%	99%
Q9D485	Mus musculus	25%	99%
V5ASV2	Trypanosoma cruzi	51%	100%
V5D3X9	Trypanosoma cruzi	26%	95%
V5DA42	Trypanosoma cruzi	28%	98%