Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQF7_LEIBR

TriTrypDb:

LbrM.35.6700 , LBRM2903_350079800

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	481	485	PF00656	0.480
CLV_C14_Caspase3-7	551	555	PF00656	0.493
CLV_NRD_NRD_1	335	337	PF00675	0.494
CLV_NRD_NRD_1	369	371	PF00675	0.411
CLV_NRD_NRD_1	69	71	PF00675	0.551
CLV_PCSK_KEX2_1	369	371	PF00082	0.480
CLV_PCSK_KEX2_1	566	568	PF00082	0.518
CLV_PCSK_KEX2_1	590	592	PF00082	0.498
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.548
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.498
CLV_PCSK_SKI1_1	118	122	PF00082	0.646
CLV_PCSK_SKI1_1	177	181	PF00082	0.532
CLV_PCSK_SKI1_1	213	217	PF00082	0.720
CLV_PCSK_SKI1_1	275	279	PF00082	0.530
CLV_PCSK_SKI1_1	331	335	PF00082	0.486
CLV_PCSK_SKI1_1	361	365	PF00082	0.335
CLV_PCSK_SKI1_1	464	468	PF00082	0.368
CLV_PCSK_SKI1_1	52	56	PF00082	0.421
CLV_PCSK_SKI1_1	66	70	PF00082	0.472
CLV_PCSK_SKI1_1	73	77	PF00082	0.486
CLV_Separin_Metazoa	523	527	PF03568	0.394
DEG_APCC_DBOX_1	302	310	PF00400	0.426
DEG_APCC_DBOX_1	495	503	PF00400	0.392
DEG_APCC_DBOX_1	505	513	PF00400	0.306
DEG_SPOP_SBC_1	221	225	PF00917	0.699
DOC_MAPK_gen_1	336	344	PF00069	0.525
DOC_MAPK_gen_1	369	375	PF00069	0.378
DOC_MAPK_MEF2A_6	464	473	PF00069	0.335
DOC_MAPK_MEF2A_6	60	69	PF00069	0.336
DOC_MAPK_MEF2A_6	607	615	PF00069	0.610
DOC_PP1_RVXF_1	369	376	PF00149	0.355
DOC_PP1_RVXF_1	451	457	PF00149	0.447
DOC_PP1_RVXF_1	64	70	PF00149	0.343
DOC_PP4_FxxP_1	121	124	PF00568	0.522
DOC_PP4_FxxP_1	180	183	PF00568	0.529
DOC_PP4_FxxP_1	285	288	PF00568	0.410
DOC_PP4_FxxP_1	290	293	PF00568	0.404
DOC_PP4_FxxP_1	363	366	PF00568	0.378
DOC_SPAK_OSR1_1	492	496	PF12202	0.480
DOC_USP7_MATH_1	137	141	PF00917	0.732
DOC_USP7_MATH_1	146	150	PF00917	0.476
DOC_USP7_MATH_1	191	195	PF00917	0.675
DOC_USP7_MATH_1	200	204	PF00917	0.577
DOC_USP7_MATH_1	208	212	PF00917	0.537
DOC_USP7_MATH_1	244	248	PF00917	0.754
DOC_USP7_MATH_1	25	29	PF00917	0.472
DOC_USP7_MATH_1	254	258	PF00917	0.739
DOC_USP7_MATH_1	32	36	PF00917	0.350
DOC_USP7_UBL2_3	274	278	PF12436	0.620
DOC_USP7_UBL2_3	327	331	PF12436	0.480
DOC_USP7_UBL2_3	449	453	PF12436	0.480
DOC_USP7_UBL2_3	589	593	PF12436	0.482
DOC_WW_Pin1_4	120	125	PF00397	0.603
DOC_WW_Pin1_4	158	163	PF00397	0.535
DOC_WW_Pin1_4	179	184	PF00397	0.778
DOC_WW_Pin1_4	204	209	PF00397	0.621
DOC_WW_Pin1_4	222	227	PF00397	0.754
DOC_WW_Pin1_4	99	104	PF00397	0.622
LIG_14-3-3_CanoR_1	574	583	PF00244	0.519
LIG_AP2alpha_1	482	486	PF02296	0.353
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	134	138	PF00533	0.683
LIG_BRCT_BRCA1_1	236	240	PF00533	0.679
LIG_BRCT_BRCA1_2	236	242	PF00533	0.751
LIG_Clathr_ClatBox_1	524	528	PF01394	0.504
LIG_deltaCOP1_diTrp_1	326	334	PF00928	0.402
LIG_deltaCOP1_diTrp_1	85	90	PF00928	0.363
LIG_eIF4E_1	289	295	PF01652	0.538
LIG_FHA_1	100	106	PF00498	0.501
LIG_FHA_1	225	231	PF00498	0.525
LIG_FHA_1	404	410	PF00498	0.335
LIG_FHA_1	413	419	PF00498	0.335
LIG_FHA_1	505	511	PF00498	0.371
LIG_FHA_1	56	62	PF00498	0.340
LIG_FHA_2	400	406	PF00498	0.447
LIG_LIR_Apic_2	119	124	PF02991	0.521
LIG_LIR_Apic_2	178	183	PF02991	0.528
LIG_LIR_Apic_2	283	288	PF02991	0.474
LIG_LIR_Apic_2	360	366	PF02991	0.378
LIG_LIR_Gen_1	21	31	PF02991	0.515
LIG_LIR_Gen_1	39	48	PF02991	0.322
LIG_LIR_Gen_1	478	487	PF02991	0.337
LIG_LIR_Gen_1	520	527	PF02991	0.396
LIG_LIR_Nem_3	21	26	PF02991	0.512
LIG_LIR_Nem_3	382	386	PF02991	0.348
LIG_LIR_Nem_3	39	43	PF02991	0.406
LIG_LIR_Nem_3	478	483	PF02991	0.346
LIG_LIR_Nem_3	614	618	PF02991	0.489
LIG_LIR_Nem_3	85	90	PF02991	0.515
LIG_LYPXL_SIV_4	385	393	PF13949	0.355
LIG_PCNA_PIPBox_1	444	453	PF02747	0.447
LIG_Pex14_1	434	438	PF04695	0.480
LIG_Pex14_1	457	461	PF04695	0.335
LIG_Pex14_2	138	142	PF04695	0.721
LIG_Pex14_2	36	40	PF04695	0.559
LIG_Pex14_2	476	480	PF04695	0.335
LIG_Pex14_2	482	486	PF04695	0.335
LIG_Pex14_2	493	497	PF04695	0.335
LIG_PTB_Apo_2	374	381	PF02174	0.408
LIG_PTB_Phospho_1	374	380	PF10480	0.447
LIG_SH2_CRK	335	339	PF00017	0.476
LIG_SH2_PTP2	341	344	PF00017	0.445
LIG_SH2_STAP1	564	568	PF00017	0.511
LIG_SH2_STAT3	438	441	PF00017	0.480
LIG_SH2_STAT5	279	282	PF00017	0.485
LIG_SH2_STAT5	289	292	PF00017	0.401
LIG_SH2_STAT5	341	344	PF00017	0.409
LIG_SH2_STAT5	392	395	PF00017	0.346
LIG_SH2_STAT5	417	420	PF00017	0.344
LIG_SH2_STAT5	438	441	PF00017	0.480
LIG_SH2_STAT5	461	464	PF00017	0.335
LIG_SUMO_SIM_anti_2	535	542	PF11976	0.508
LIG_SUMO_SIM_anti_2	554	561	PF11976	0.264
LIG_SUMO_SIM_par_1	397	403	PF11976	0.335
LIG_SUMO_SIM_par_1	507	517	PF11976	0.530
LIG_TRAF2_1	92	95	PF00917	0.511
LIG_TYR_ITIM	339	344	PF00017	0.424
LIG_UBA3_1	509	513	PF00899	0.456
LIG_ULM_U2AF65_1	589	595	PF00076	0.497
LIG_WRC_WIRS_1	256	261	PF05994	0.740
LIG_WRC_WIRS_1	33	38	PF05994	0.403
LIG_WRC_WIRS_1	479	484	PF05994	0.461
MOD_CDK_SPxxK_3	206	213	PF00069	0.523
MOD_CK1_1	116	122	PF00069	0.632
MOD_CK1_1	131	137	PF00069	0.530
MOD_CK1_1	141	147	PF00069	0.657
MOD_CK1_1	160	166	PF00069	0.493
MOD_CK1_1	178	184	PF00069	0.472
MOD_CK1_1	203	209	PF00069	0.659
MOD_CK1_1	247	253	PF00069	0.784
MOD_CK1_1	258	264	PF00069	0.700
MOD_CK1_1	39	45	PF00069	0.424
MOD_CK1_1	79	85	PF00069	0.610
MOD_CK2_1	258	264	PF00069	0.592
MOD_CK2_1	399	405	PF00069	0.408
MOD_CK2_1	79	85	PF00069	0.577
MOD_GlcNHglycan	124	127	PF01048	0.609
MOD_GlcNHglycan	133	137	PF01048	0.594
MOD_GlcNHglycan	155	158	PF01048	0.606
MOD_GlcNHglycan	183	186	PF01048	0.790
MOD_GlcNHglycan	210	213	PF01048	0.646
MOD_GlcNHglycan	227	230	PF01048	0.662
MOD_GlcNHglycan	431	434	PF01048	0.378
MOD_GlcNHglycan	78	81	PF01048	0.511
MOD_GlcNHglycan	90	93	PF01048	0.446
MOD_GSK3_1	116	123	PF00069	0.589
MOD_GSK3_1	128	135	PF00069	0.525
MOD_GSK3_1	137	144	PF00069	0.581
MOD_GSK3_1	153	160	PF00069	0.485
MOD_GSK3_1	175	182	PF00069	0.732
MOD_GSK3_1	187	194	PF00069	0.711
MOD_GSK3_1	200	207	PF00069	0.598
MOD_GSK3_1	220	227	PF00069	0.713
MOD_GSK3_1	240	247	PF00069	0.758
MOD_GSK3_1	254	261	PF00069	0.547
MOD_GSK3_1	32	39	PF00069	0.403
MOD_GSK3_1	399	406	PF00069	0.378
MOD_GSK3_1	95	102	PF00069	0.653
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	153	158	PF00069	0.548
MOD_NEK2_1	36	41	PF00069	0.423
MOD_NEK2_1	429	434	PF00069	0.319
MOD_NEK2_1	55	60	PF00069	0.466
MOD_NEK2_1	558	563	PF00069	0.556
MOD_NEK2_1	97	102	PF00069	0.640
MOD_NEK2_2	146	151	PF00069	0.514
MOD_NEK2_2	359	364	PF00069	0.335
MOD_PIKK_1	113	119	PF00454	0.707
MOD_PIKK_1	161	167	PF00454	0.625
MOD_PIKK_1	172	178	PF00454	0.622
MOD_PIKK_1	558	564	PF00454	0.526
MOD_PK_1	543	549	PF00069	0.497
MOD_Plk_1	244	250	PF00069	0.527
MOD_Plk_1	359	365	PF00069	0.369
MOD_Plk_2-3	478	484	PF00069	0.480
MOD_Plk_2-3	552	558	PF00069	0.506
MOD_Plk_4	105	111	PF00069	0.766
MOD_Plk_4	116	122	PF00069	0.618
MOD_Plk_4	146	152	PF00069	0.721
MOD_Plk_4	164	170	PF00069	0.526
MOD_Plk_4	175	181	PF00069	0.700
MOD_Plk_4	388	394	PF00069	0.351
MOD_Plk_4	457	463	PF00069	0.335
MOD_ProDKin_1	120	126	PF00069	0.604
MOD_ProDKin_1	158	164	PF00069	0.536
MOD_ProDKin_1	179	185	PF00069	0.778
MOD_ProDKin_1	204	210	PF00069	0.620
MOD_ProDKin_1	222	228	PF00069	0.754
MOD_ProDKin_1	99	105	PF00069	0.627
MOD_SUMO_for_1	576	579	PF00179	0.552
MOD_SUMO_rev_2	269	277	PF00179	0.610
MOD_SUMO_rev_2	46	54	PF00179	0.501
MOD_SUMO_rev_2	582	592	PF00179	0.549
MOD_SUMO_rev_2	604	609	PF00179	0.538
TRG_DiLeu_BaEn_1	520	525	PF01217	0.507
TRG_DiLeu_BaEn_2	477	483	PF01217	0.408
TRG_DiLeu_LyEn_5	302	307	PF01217	0.473
TRG_ENDOCYTIC_2	289	292	PF00928	0.493
TRG_ENDOCYTIC_2	341	344	PF00928	0.403
TRG_ENDOCYTIC_2	380	383	PF00928	0.420
TRG_ENDOCYTIC_2	522	525	PF00928	0.393
TRG_ER_diArg_1	321	324	PF00400	0.423
TRG_NES_CRM1_1	291	302	PF08389	0.549
TRG_NLS_MonoCore_2	589	594	PF00514	0.527
TRG_NLS_MonoExtN_4	589	594	PF00514	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL31	Leptomonas seymouri	64%	100%
A0A0S4IUJ5	Bodo saltans	49%	100%
A0A1X0NLM8	Trypanosomatidae	50%	100%
A0A3Q8IRX0	Leishmania donovani	78%	100%
A4IC93	Leishmania infantum	78%	100%
D0A3K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AU73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q0C1	Leishmania major	78%	90%
V5B8C0	Trypanosoma cruzi	49%	100%