UBX domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2962), putative

Species:

Leishmania braziliensis

UniProt:

A4HQF6_LEIBR

TriTrypDb:

LbrM.35.6690 , LBRM2903_350079700

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.629
CLV_NRD_NRD_1	2	4	PF00675	0.677
CLV_NRD_NRD_1	240	242	PF00675	0.541
CLV_NRD_NRD_1	247	249	PF00675	0.593
CLV_PCSK_FUR_1	10	14	PF00082	0.748
CLV_PCSK_KEX2_1	12	14	PF00082	0.641
CLV_PCSK_KEX2_1	2	4	PF00082	0.686
CLV_PCSK_KEX2_1	234	236	PF00082	0.511
CLV_PCSK_KEX2_1	240	242	PF00082	0.540
CLV_PCSK_KEX2_1	246	248	PF00082	0.561
CLV_PCSK_KEX2_1	31	33	PF00082	0.172
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.744
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.506
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.187
CLV_PCSK_SKI1_1	168	172	PF00082	0.566
CLV_PCSK_SKI1_1	2	6	PF00082	0.680
CLV_PCSK_SKI1_1	234	238	PF00082	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DOC_MAPK_gen_1	185	192	PF00069	0.700
DOC_MAPK_gen_1	28	36	PF00069	0.444
DOC_MAPK_gen_1	42	51	PF00069	0.444
DOC_PP2B_LxvP_1	125	128	PF13499	0.444
DOC_USP7_UBL2_3	194	198	PF12436	0.680
DOC_USP7_UBL2_3	207	211	PF12436	0.669
DOC_USP7_UBL2_3	40	44	PF12436	0.375
DOC_WW_Pin1_4	161	166	PF00397	0.603
LIG_14-3-3_CanoR_1	42	51	PF00244	0.280
LIG_FAT_LD_1	171	179	PF03623	0.629
LIG_FHA_1	109	115	PF00498	0.301
LIG_FHA_1	147	153	PF00498	0.325
LIG_FHA_1	66	72	PF00498	0.284
LIG_LIR_Gen_1	252	262	PF02991	0.503
LIG_LIR_Nem_3	252	258	PF02991	0.498
LIG_NRBOX	170	176	PF00104	0.627
LIG_PCNA_PIPBox_1	48	57	PF02747	0.233
LIG_REV1ctd_RIR_1	52	62	PF16727	0.344
LIG_SH2_CRK	255	259	PF00017	0.509
LIG_SH2_NCK_1	66	70	PF00017	0.233
LIG_SH2_STAP1	66	70	PF00017	0.444
LIG_SH2_STAT5	66	69	PF00017	0.444
LIG_SH2_STAT5	83	86	PF00017	0.325
LIG_SH3_3	12	18	PF00018	0.401
LIG_SH3_3	187	193	PF00018	0.636
LIG_SH3_5	251	255	PF00018	0.490
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.349
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.359
LIG_TRAF2_1	170	173	PF00917	0.539
LIG_TRAF2_1	226	229	PF00917	0.592
MOD_CDK_SPxxK_3	161	168	PF00069	0.653
MOD_CK2_1	260	266	PF00069	0.593
MOD_CK2_1	5	11	PF00069	0.685
MOD_GlcNHglycan	120	123	PF01048	0.444
MOD_GlcNHglycan	7	10	PF01048	0.689
MOD_GlcNHglycan	89	94	PF01048	0.388
MOD_GSK3_1	206	213	PF00069	0.623
MOD_GSK3_1	38	45	PF00069	0.339
MOD_GSK3_1	60	67	PF00069	0.376
MOD_LATS_1	17	23	PF00433	0.444
MOD_N-GLC_1	128	133	PF02516	0.389
MOD_NEK2_1	108	113	PF00069	0.427
MOD_NEK2_1	5	10	PF00069	0.683
MOD_NEK2_1	64	69	PF00069	0.333
MOD_PIKK_1	143	149	PF00454	0.272
MOD_PK_1	19	25	PF00069	0.444
MOD_PKA_1	234	240	PF00069	0.662
MOD_PKA_2	234	240	PF00069	0.634
MOD_Plk_1	108	114	PF00069	0.444
MOD_Plk_1	19	25	PF00069	0.444
MOD_Plk_1	213	219	PF00069	0.579
MOD_Plk_1	72	78	PF00069	0.446
MOD_Plk_1	89	95	PF00069	0.444
MOD_Plk_4	148	154	PF00069	0.420
MOD_ProDKin_1	161	167	PF00069	0.603
MOD_SUMO_for_1	43	46	PF00179	0.444
TRG_DiLeu_BaEn_4	89	95	PF01217	0.369
TRG_ENDOCYTIC_2	255	258	PF00928	0.505
TRG_ER_diArg_1	1	3	PF00400	0.701
TRG_ER_diArg_1	177	180	PF00400	0.584
TRG_ER_diArg_1	220	223	PF00400	0.641
TRG_ER_diArg_1	246	248	PF00400	0.708
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I784	Leptomonas seymouri	71%	100%
A0A1X0NLZ7	Trypanosomatidae	44%	100%
A0A3Q8IJD2	Leishmania donovani	82%	100%
A0A422MX73	Trypanosoma rangeli	40%	100%
A4IC92	Leishmania infantum	81%	100%
D0A3K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AU72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q0C2	Leishmania major	80%	100%