Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania braziliensis

UniProt:

A4HQF5_LEIBR

TriTrypDb:

LbrM.35.6680 , LBRM2903_350078600

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HQF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	22
GO:0005488	binding	1	22
GO:0097159	organic cyclic compound binding	2	22
GO:1901363	heterocyclic compound binding	2	22
GO:0000175	3'-5'-RNA exonuclease activity	7	3
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0004532	RNA exonuclease activity	5	3
GO:0004535	poly(A)-specific ribonuclease activity	8	1
GO:0004540	RNA nuclease activity	4	3
GO:0008408	3'-5' exonuclease activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	3
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0003723	RNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	490	494	PF00656	0.351
CLV_NRD_NRD_1	225	227	PF00675	0.330
CLV_NRD_NRD_1	249	251	PF00675	0.348
CLV_NRD_NRD_1	321	323	PF00675	0.332
CLV_NRD_NRD_1	444	446	PF00675	0.614
CLV_NRD_NRD_1	71	73	PF00675	0.330
CLV_PCSK_KEX2_1	224	226	PF00082	0.310
CLV_PCSK_KEX2_1	320	322	PF00082	0.332
CLV_PCSK_KEX2_1	461	463	PF00082	0.395
CLV_PCSK_KEX2_1	54	56	PF00082	0.282
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.323
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.271
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.289
CLV_PCSK_SKI1_1	133	137	PF00082	0.276
CLV_PCSK_SKI1_1	244	248	PF00082	0.238
CLV_PCSK_SKI1_1	281	285	PF00082	0.337
CLV_PCSK_SKI1_1	462	466	PF00082	0.315
CLV_PCSK_SKI1_1	499	503	PF00082	0.437
CLV_PCSK_SKI1_1	96	100	PF00082	0.154
DEG_APCC_DBOX_1	498	506	PF00400	0.253
DEG_APCC_DBOX_1	95	103	PF00400	0.539
DEG_MDM2_SWIB_1	239	247	PF02201	0.447
DEG_Nend_UBRbox_2	1	3	PF02207	0.362
DOC_CYCLIN_RxL_1	240	249	PF00134	0.389
DOC_CYCLIN_RxL_1	496	506	PF00134	0.261
DOC_MAPK_DCC_7	96	104	PF00069	0.469
DOC_MAPK_gen_1	231	239	PF00069	0.539
DOC_MAPK_gen_1	469	476	PF00069	0.457
DOC_MAPK_MEF2A_6	96	104	PF00069	0.469
DOC_MIT_MIM_1	478	487	PF04212	0.403
DOC_PP1_RVXF_1	203	209	PF00149	0.560
DOC_PP1_RVXF_1	233	240	PF00149	0.455
DOC_PP1_RVXF_1	460	467	PF00149	0.246
DOC_PP2B_LxvP_1	97	100	PF13499	0.469
DOC_PP4_FxxP_1	43	46	PF00568	0.444
DOC_USP7_MATH_1	100	104	PF00917	0.354
DOC_USP7_MATH_1	160	164	PF00917	0.507
DOC_USP7_MATH_1	388	392	PF00917	0.501
DOC_USP7_UBL2_3	244	248	PF12436	0.403
DOC_USP7_UBL2_3	349	353	PF12436	0.539
DOC_WW_Pin1_4	268	273	PF00397	0.409
LIG_14-3-3_CanoR_1	445	450	PF00244	0.494
LIG_14-3-3_CanoR_1	462	467	PF00244	0.326
LIG_14-3-3_CanoR_1	469	475	PF00244	0.409
LIG_14-3-3_CanoR_1	482	487	PF00244	0.466
LIG_14-3-3_CanoR_1	72	79	PF00244	0.518
LIG_BRCT_BRCA1_1	493	497	PF00533	0.499
LIG_Clathr_ClatBox_1	394	398	PF01394	0.451
LIG_FHA_1	115	121	PF00498	0.535
LIG_FHA_1	138	144	PF00498	0.512
LIG_FHA_1	406	412	PF00498	0.408
LIG_FHA_1	417	423	PF00498	0.390
LIG_FHA_1	463	469	PF00498	0.395
LIG_FHA_2	288	294	PF00498	0.494
LIG_FHA_2	30	36	PF00498	0.471
LIG_FHA_2	308	314	PF00498	0.540
LIG_GBD_Chelix_1	166	174	PF00786	0.154
LIG_GBD_Chelix_1	176	184	PF00786	0.244
LIG_GBD_Chelix_1	202	210	PF00786	0.269
LIG_GBD_Chelix_1	366	374	PF00786	0.310
LIG_LIR_Apic_2	331	337	PF02991	0.460
LIG_LIR_Apic_2	41	46	PF02991	0.440
LIG_LIR_Gen_1	23	31	PF02991	0.430
LIG_LIR_Gen_1	276	284	PF02991	0.514
LIG_LIR_Gen_1	377	386	PF02991	0.344
LIG_LIR_Gen_1	4	13	PF02991	0.517
LIG_LIR_Gen_1	494	505	PF02991	0.272
LIG_LIR_Gen_1	59	69	PF02991	0.456
LIG_LIR_Nem_3	23	27	PF02991	0.398
LIG_LIR_Nem_3	276	280	PF02991	0.457
LIG_LIR_Nem_3	356	362	PF02991	0.456
LIG_LIR_Nem_3	377	382	PF02991	0.327
LIG_LIR_Nem_3	4	9	PF02991	0.464
LIG_LIR_Nem_3	494	500	PF02991	0.394
LIG_LIR_Nem_3	59	64	PF02991	0.452
LIG_MAD2	244	252	PF02301	0.539
LIG_Pex14_2	239	243	PF04695	0.453
LIG_SH2_CRK	334	338	PF00017	0.519
LIG_SH2_STAP1	131	135	PF00017	0.545
LIG_SH2_STAP1	188	192	PF00017	0.444
LIG_SH2_STAP1	359	363	PF00017	0.455
LIG_SH2_STAP1	418	422	PF00017	0.236
LIG_SH2_STAT3	131	134	PF00017	0.354
LIG_SH2_STAT3	201	204	PF00017	0.518
LIG_SH2_STAT5	201	204	PF00017	0.497
LIG_SH2_STAT5	277	280	PF00017	0.546
LIG_SH2_STAT5	393	396	PF00017	0.456
LIG_SH2_STAT5	418	421	PF00017	0.352
LIG_SH2_STAT5	87	90	PF00017	0.457
LIG_SH3_3	31	37	PF00018	0.476
LIG_SH3_3	7	13	PF00018	0.526
LIG_SUMO_SIM_par_1	8	14	PF11976	0.491
LIG_TRAF2_1	125	128	PF00917	0.470
LIG_TRFH_1	334	338	PF08558	0.539
LIG_UBA3_1	501	509	PF00899	0.248
MOD_CK1_1	457	463	PF00069	0.498
MOD_CK1_1	492	498	PF00069	0.563
MOD_CK2_1	211	217	PF00069	0.502
MOD_CK2_1	307	313	PF00069	0.539
MOD_GlcNHglycan	162	165	PF01048	0.275
MOD_GlcNHglycan	386	389	PF01048	0.459
MOD_GlcNHglycan	390	393	PF01048	0.481
MOD_GlcNHglycan	91	94	PF01048	0.333
MOD_GSK3_1	133	140	PF00069	0.514
MOD_GSK3_1	287	294	PF00069	0.482
MOD_GSK3_1	307	314	PF00069	0.498
MOD_GSK3_1	324	331	PF00069	0.548
MOD_GSK3_1	384	391	PF00069	0.400
MOD_GSK3_1	445	452	PF00069	0.468
MOD_GSK3_1	478	485	PF00069	0.513
MOD_N-GLC_1	405	410	PF02516	0.463
MOD_N-GLC_1	89	94	PF02516	0.312
MOD_NEK2_1	1	6	PF00069	0.424
MOD_NEK2_1	114	119	PF00069	0.492
MOD_NEK2_1	170	175	PF00069	0.458
MOD_NEK2_1	208	213	PF00069	0.495
MOD_NEK2_1	246	251	PF00069	0.456
MOD_NEK2_1	284	289	PF00069	0.526
MOD_NEK2_1	307	312	PF00069	0.415
MOD_NEK2_1	411	416	PF00069	0.309
MOD_NEK2_1	470	475	PF00069	0.407
MOD_NEK2_1	491	496	PF00069	0.444
MOD_PIKK_1	38	44	PF00454	0.472
MOD_PKA_1	445	451	PF00069	0.407
MOD_PKA_2	71	77	PF00069	0.531
MOD_Plk_1	1	7	PF00069	0.367
MOD_Plk_1	328	334	PF00069	0.376
MOD_Plk_1	405	411	PF00069	0.409
MOD_Plk_2-3	217	223	PF00069	0.444
MOD_Plk_4	100	106	PF00069	0.499
MOD_Plk_4	134	140	PF00069	0.518
MOD_Plk_4	287	293	PF00069	0.510
MOD_Plk_4	311	317	PF00069	0.537
MOD_Plk_4	405	411	PF00069	0.415
MOD_ProDKin_1	268	274	PF00069	0.409
MOD_SUMO_rev_2	276	283	PF00179	0.502
MOD_SUMO_rev_2	377	385	PF00179	0.409
TRG_DiLeu_BaEn_1	279	284	PF01217	0.354
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.559
TRG_ENDOCYTIC_2	277	280	PF00928	0.461
TRG_ENDOCYTIC_2	61	64	PF00928	0.459
TRG_ER_diArg_1	225	228	PF00400	0.502
TRG_ER_diArg_1	320	322	PF00400	0.528
TRG_NES_CRM1_1	2	14	PF08389	0.291
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	54%	99%
A0A0N1ILJ1	Leptomonas seymouri	26%	84%
A0A0S4IJ60	Bodo saltans	24%	100%
A0A0S4IMW3	Bodo saltans	24%	100%
A0A0S4J225	Bodo saltans	34%	70%
A0A1X0NLC6	Trypanosomatidae	34%	99%
A0A1X0NXI3	Trypanosomatidae	27%	84%
A0A3Q8ICI3	Leishmania donovani	26%	85%
A0A3R7K5K5	Trypanosoma rangeli	33%	98%
A0A3S7XC77	Leishmania donovani	74%	100%
A0A422N5N5	Trypanosoma rangeli	27%	86%
A4HCS6	Leishmania braziliensis	26%	100%
A4I0A0	Leishmania infantum	26%	85%
A4IC91	Leishmania infantum	75%	100%
B2RXZ1	Mus musculus	24%	96%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	86%
H9JAQ7	Bombyx mori	26%	96%
O94386	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
O95453	Homo sapiens	25%	80%
P69341	Bos taurus	25%	80%
Q21412	Caenorhabditis elegans	25%	90%
Q4Q0C3	Leishmania major	75%	100%
Q4QBB3	Leishmania major	27%	100%
Q5R6R6	Pongo abelii	25%	98%
Q5RC51	Pongo abelii	25%	80%
Q8NA58	Homo sapiens	25%	98%
Q8VDG3	Mus musculus	26%	82%
Q8W4C3	Arabidopsis thaliana	21%	83%
Q90ZA1	Xenopus laevis	25%	81%
Q9LG26	Arabidopsis thaliana	23%	74%
V5ASU9	Trypanosoma cruzi	35%	99%
V5BCG2	Trypanosoma cruzi	27%	100%