Dimer_Tnp_hAT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQF3_LEIBR

TriTrypDb:

LbrM.35.6660 , LBRM2903_350078300

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.453
CLV_NRD_NRD_1	150	152	PF00675	0.598
CLV_NRD_NRD_1	45	47	PF00675	0.580
CLV_PCSK_KEX2_1	150	152	PF00082	0.534
CLV_PCSK_KEX2_1	156	158	PF00082	0.469
CLV_PCSK_KEX2_1	2	4	PF00082	0.538
CLV_PCSK_KEX2_1	22	24	PF00082	0.597
CLV_PCSK_KEX2_1	45	47	PF00082	0.464
CLV_PCSK_KEX2_1	58	60	PF00082	0.517
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.569
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.456
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.597
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.517
CLV_PCSK_SKI1_1	151	155	PF00082	0.647
CLV_PCSK_SKI1_1	182	186	PF00082	0.559
CLV_PCSK_SKI1_1	22	26	PF00082	0.720
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DOC_CYCLIN_RxL_1	148	159	PF00134	0.577
DOC_MAPK_gen_1	45	52	PF00069	0.526
LIG_14-3-3_CanoR_1	173	181	PF00244	0.519
LIG_14-3-3_CanoR_1	23	29	PF00244	0.552
LIG_BIR_III_4	142	146	PF00653	0.485
LIG_BRCT_BRCA1_1	31	35	PF00533	0.558
LIG_FHA_1	13	19	PF00498	0.600
LIG_FHA_1	90	96	PF00498	0.680
LIG_FHA_2	46	52	PF00498	0.548
LIG_LIR_Gen_1	164	169	PF02991	0.553
LIG_LIR_Nem_3	159	165	PF02991	0.540
LIG_MYND_3	131	135	PF01753	0.576
LIG_NRBOX	109	115	PF00104	0.627
LIG_Pex14_1	176	180	PF04695	0.480
LIG_Pex14_1	37	41	PF04695	0.592
LIG_SH2_CRK	165	169	PF00017	0.503
LIG_SH2_NCK_1	165	169	PF00017	0.527
LIG_SH2_STAT5	180	183	PF00017	0.484
LIG_SH2_STAT5	41	44	PF00017	0.559
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.442
LIG_SUMO_SIM_par_1	9	15	PF11976	0.543
LIG_TRAF2_1	144	147	PF00917	0.536
LIG_WRC_WIRS_1	25	30	PF05994	0.592
MOD_CK1_1	164	170	PF00069	0.540
MOD_CK1_1	174	180	PF00069	0.530
MOD_CK1_1	26	32	PF00069	0.616
MOD_CK2_1	164	170	PF00069	0.593
MOD_CK2_1	45	51	PF00069	0.543
MOD_CMANNOS	176	179	PF00535	0.477
MOD_GlcNHglycan	176	179	PF01048	0.478
MOD_GlcNHglycan	74	77	PF01048	0.623
MOD_GSK3_1	12	19	PF00069	0.671
MOD_GSK3_1	2	9	PF00069	0.623
MOD_N-GLC_1	72	77	PF02516	0.572
MOD_NEK2_2	145	150	PF00069	0.539
MOD_PKA_1	156	162	PF00069	0.556
MOD_PKA_1	2	8	PF00069	0.647
MOD_PKA_1	45	51	PF00069	0.543
MOD_PKA_2	156	162	PF00069	0.556
MOD_PKA_2	172	178	PF00069	0.534
MOD_PKA_2	2	8	PF00069	0.593
MOD_PKA_2	45	51	PF00069	0.549
MOD_Plk_1	145	151	PF00069	0.565
MOD_Plk_1	171	177	PF00069	0.503
MOD_Plk_1	72	78	PF00069	0.496
MOD_Plk_2-3	101	107	PF00069	0.454
MOD_Plk_4	101	107	PF00069	0.440
MOD_SUMO_for_1	186	189	PF00179	0.424
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.604
TRG_ENDOCYTIC_2	165	168	PF00928	0.515
TRG_ER_diArg_1	149	151	PF00400	0.587
TRG_ER_diArg_1	66	69	PF00400	0.582
TRG_ER_diLys_1	185	190	PF00400	0.582
TRG_NES_CRM1_1	51	64	PF08389	0.509
TRG_NLS_Bipartite_1	45	61	PF00514	0.592
TRG_NLS_MonoExtC_3	56	61	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I8	Leptomonas seymouri	66%	69%
A0A1X0NM61	Trypanosomatidae	43%	100%
A0A3Q8II22	Leishmania donovani	86%	100%
A0A3R7LRR3	Trypanosoma rangeli	42%	100%
A4IC90	Leishmania infantum	86%	100%
D0A3T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AU70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0C4	Leishmania major	84%	96%