Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQF2_LEIBR

TriTrypDb:

LbrM.35.6650

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.600
CLV_PCSK_KEX2_1	141	143	PF00082	0.394
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.394
CLV_PCSK_PC7_1	137	143	PF00082	0.394
CLV_PCSK_SKI1_1	214	218	PF00082	0.473
DEG_APCC_DBOX_1	136	144	PF00400	0.443
DOC_CKS1_1	205	210	PF01111	0.404
DOC_CYCLIN_RxL_1	141	155	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.427
DOC_MAPK_RevD_3	127	142	PF00069	0.419
DOC_PP4_FxxP_1	11	14	PF00568	0.414
DOC_PP4_FxxP_1	124	127	PF00568	0.451
DOC_PP4_FxxP_1	205	208	PF00568	0.411
DOC_WW_Pin1_4	204	209	PF00397	0.475
DOC_WW_Pin1_4	9	14	PF00397	0.439
LIG_14-3-3_CanoR_1	94	102	PF00244	0.485
LIG_FHA_1	110	116	PF00498	0.488
LIG_FHA_1	20	26	PF00498	0.464
LIG_FHA_1	205	211	PF00498	0.459
LIG_FHA_1	69	75	PF00498	0.316
LIG_FHA_2	198	204	PF00498	0.437
LIG_GBD_Chelix_1	160	168	PF00786	0.446
LIG_IRF3_LxIS_1	86	93	PF10401	0.403
LIG_LIR_Apic_2	123	127	PF02991	0.515
LIG_LIR_Apic_2	203	208	PF02991	0.426
LIG_LYPXL_yS_3	7	10	PF13949	0.448
LIG_MYND_1	14	18	PF01753	0.422
LIG_PDZ_Class_1	215	220	PF00595	0.338
LIG_SH2_SRC	169	172	PF00017	0.306
LIG_SH2_STAP1	169	173	PF00017	0.433
LIG_SH2_STAP1	88	92	PF00017	0.488
LIG_SH2_STAT5	173	176	PF00017	0.413
LIG_SH2_STAT5	3	6	PF00017	0.434
LIG_SH3_3	142	148	PF00018	0.268
LIG_SH3_3	7	13	PF00018	0.430
LIG_SUMO_SIM_par_1	111	118	PF11976	0.530
LIG_SUMO_SIM_par_1	128	133	PF11976	0.297
LIG_TRFH_1	173	177	PF08558	0.407
LIG_TYR_ITIM	4	9	PF00017	0.454
LIG_WW_2	14	17	PF00397	0.418
MOD_CK1_1	109	115	PF00069	0.262
MOD_CK1_1	93	99	PF00069	0.515
MOD_CK2_1	36	42	PF00069	0.613
MOD_GlcNHglycan	197	200	PF01048	0.533
MOD_GlcNHglycan	25	28	PF01048	0.669
MOD_GlcNHglycan	82	85	PF01048	0.455
MOD_GlcNHglycan	95	98	PF01048	0.413
MOD_GSK3_1	19	26	PF00069	0.517
MOD_GSK3_1	80	87	PF00069	0.400
MOD_N-GLC_1	109	114	PF02516	0.412
MOD_N-GLC_2	187	189	PF02516	0.344
MOD_NEK2_1	164	169	PF00069	0.408
MOD_NEK2_1	19	24	PF00069	0.489
MOD_NEK2_1	51	56	PF00069	0.560
MOD_NEK2_1	82	87	PF00069	0.435
MOD_NEK2_1	90	95	PF00069	0.489
MOD_NEK2_2	53	58	PF00069	0.576
MOD_PKA_2	93	99	PF00069	0.490
MOD_Plk_2-3	197	203	PF00069	0.390
MOD_Plk_4	164	170	PF00069	0.476
MOD_ProDKin_1	204	210	PF00069	0.466
MOD_ProDKin_1	9	15	PF00069	0.440
MOD_SUMO_rev_2	133	143	PF00179	0.396
TRG_DiLeu_BaEn_1	139	144	PF01217	0.472
TRG_ENDOCYTIC_2	173	176	PF00928	0.413
TRG_ENDOCYTIC_2	6	9	PF00928	0.596
TRG_ER_diArg_1	57	60	PF00400	0.427
TRG_NES_CRM1_1	113	123	PF08389	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK6	Leptomonas seymouri	50%	100%
A0A1X0NLE1	Trypanosomatidae	29%	100%
A0A3S5IQS5	Trypanosoma rangeli	33%	100%
A0A3S7XC31	Leishmania donovani	91%	100%
A4IC89	Leishmania infantum	91%	100%
D0A3T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AU69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0C5	Leishmania major	85%	100%