N-acetyltransferase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQF0_LEIBR

TriTrypDb:

LbrM.35.6630 , LBRM2903_350078000

Length:

278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HQF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016559	peroxisome fission	6	1
GO:0048285	organelle fission	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.676
CLV_MEL_PAP_1	178	184	PF00089	0.528
CLV_PCSK_KEX2_1	255	257	PF00082	0.522
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.391
CLV_PCSK_SKI1_1	123	127	PF00082	0.593
CLV_PCSK_SKI1_1	131	135	PF00082	0.576
CLV_PCSK_SKI1_1	139	143	PF00082	0.576
CLV_PCSK_SKI1_1	157	161	PF00082	0.529
CLV_PCSK_SKI1_1	251	255	PF00082	0.491
CLV_PCSK_SKI1_1	36	40	PF00082	0.276
DOC_CYCLIN_RxL_1	139	149	PF00134	0.283
DOC_MAPK_DCC_7	231	241	PF00069	0.535
DOC_MAPK_HePTP_8	186	198	PF00069	0.362
DOC_MAPK_MEF2A_6	189	198	PF00069	0.360
DOC_MAPK_MEF2A_6	26	33	PF00069	0.495
DOC_PP1_RVXF_1	121	127	PF00149	0.384
DOC_PP4_FxxP_1	108	111	PF00568	0.189
DOC_PP4_FxxP_1	74	77	PF00568	0.553
DOC_USP7_UBL2_3	247	251	PF12436	0.629
DOC_WW_Pin1_4	166	171	PF00397	0.406
DOC_WW_Pin1_4	232	237	PF00397	0.614
LIG_14-3-3_CanoR_1	139	145	PF00244	0.377
LIG_14-3-3_CanoR_1	173	179	PF00244	0.379
LIG_14-3-3_CanoR_1	76	82	PF00244	0.503
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	104	108	PF00533	0.215
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.331
LIG_FHA_1	228	234	PF00498	0.659
LIG_FHA_2	4	10	PF00498	0.708
LIG_LIR_Apic_2	105	111	PF02991	0.210
LIG_LIR_Gen_1	132	141	PF02991	0.297
LIG_LIR_Gen_1	193	202	PF02991	0.361
LIG_LIR_Gen_1	95	104	PF02991	0.393
LIG_LIR_Nem_3	105	110	PF02991	0.212
LIG_LIR_Nem_3	132	137	PF02991	0.304
LIG_LIR_Nem_3	193	198	PF02991	0.365
LIG_LIR_Nem_3	203	207	PF02991	0.388
LIG_LIR_Nem_3	95	100	PF02991	0.383
LIG_MLH1_MIPbox_1	104	108	PF16413	0.215
LIG_Pex14_1	200	204	PF04695	0.296
LIG_Pex14_1	97	101	PF04695	0.364
LIG_Pex14_2	136	140	PF04695	0.378
LIG_REV1ctd_RIR_1	104	110	PF16727	0.325
LIG_REV1ctd_RIR_1	134	143	PF16727	0.279
LIG_SH2_CRK	204	208	PF00017	0.337
LIG_SH2_STAT5	120	123	PF00017	0.382
LIG_SH2_STAT5	195	198	PF00017	0.322
LIG_SH2_STAT5	212	215	PF00017	0.227
LIG_SH2_STAT5	232	235	PF00017	0.603
LIG_SH2_STAT5	58	61	PF00017	0.582
LIG_SH3_3	230	236	PF00018	0.639
LIG_SH3_3	238	244	PF00018	0.709
LIG_SUMO_SIM_anti_2	9	16	PF11976	0.525
LIG_SUMO_SIM_par_1	17	23	PF11976	0.545
LIG_SUMO_SIM_par_1	237	243	PF11976	0.552
LIG_UBA3_1	87	91	PF00899	0.473
LIG_WRC_WIRS_1	133	138	PF05994	0.219
MOD_CDK_SPxxK_3	166	173	PF00069	0.435
MOD_CK1_1	10	16	PF00069	0.540
MOD_CK2_1	270	276	PF00069	0.761
MOD_CMANNOS	224	227	PF00535	0.411
MOD_GlcNHglycan	1	4	PF01048	0.444
MOD_GlcNHglycan	114	117	PF01048	0.567
MOD_GlcNHglycan	157	160	PF01048	0.574
MOD_GlcNHglycan	217	220	PF01048	0.288
MOD_GSK3_1	140	147	PF00069	0.254
MOD_GSK3_1	239	246	PF00069	0.665
MOD_GSK3_1	3	10	PF00069	0.551
MOD_N-GLC_1	127	132	PF02516	0.497
MOD_N-GLC_1	7	12	PF02516	0.409
MOD_NEK2_1	140	145	PF00069	0.254
MOD_NEK2_1	146	151	PF00069	0.259
MOD_NEK2_1	152	157	PF00069	0.351
MOD_NEK2_1	174	179	PF00069	0.388
MOD_NEK2_1	180	185	PF00069	0.333
MOD_NEK2_1	34	39	PF00069	0.503
MOD_NEK2_2	77	82	PF00069	0.464
MOD_PKA_2	180	186	PF00069	0.357
MOD_Plk_1	7	13	PF00069	0.612
MOD_Plk_4	10	16	PF00069	0.623
MOD_Plk_4	102	108	PF00069	0.294
MOD_Plk_4	146	152	PF00069	0.202
MOD_ProDKin_1	166	172	PF00069	0.407
MOD_ProDKin_1	232	238	PF00069	0.619
TRG_ENDOCYTIC_2	138	141	PF00928	0.277
TRG_ENDOCYTIC_2	195	198	PF00928	0.283
TRG_ENDOCYTIC_2	204	207	PF00928	0.312
TRG_ENDOCYTIC_2	58	61	PF00928	0.490
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG3	Leptomonas seymouri	62%	100%
A0A0S4JRR1	Bodo saltans	29%	100%
A0A1X0NLN6	Trypanosomatidae	35%	100%
A0A3Q8ILX5	Leishmania donovani	77%	100%
A0A422N9F2	Trypanosoma rangeli	34%	100%
A4IC87	Leishmania infantum	77%	100%
D0A3T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AU67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q0C7	Leishmania major	77%	100%
V5D8S7	Trypanosoma cruzi	35%	100%