LeishMANIAdb
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N-acetyltransferase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
N-acetyltransferase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQF0_LEIBR
TriTrypDb:
LbrM.35.6630 , LBRM2903_350078000
Length:
278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HQF0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQF0

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016559 peroxisome fission 6 1
GO:0048285 organelle fission 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 6 10 PF00656 0.676
CLV_MEL_PAP_1 178 184 PF00089 0.528
CLV_PCSK_KEX2_1 255 257 PF00082 0.522
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.391
CLV_PCSK_SKI1_1 123 127 PF00082 0.593
CLV_PCSK_SKI1_1 131 135 PF00082 0.576
CLV_PCSK_SKI1_1 139 143 PF00082 0.576
CLV_PCSK_SKI1_1 157 161 PF00082 0.529
CLV_PCSK_SKI1_1 251 255 PF00082 0.491
CLV_PCSK_SKI1_1 36 40 PF00082 0.276
DOC_CYCLIN_RxL_1 139 149 PF00134 0.283
DOC_MAPK_DCC_7 231 241 PF00069 0.535
DOC_MAPK_HePTP_8 186 198 PF00069 0.362
DOC_MAPK_MEF2A_6 189 198 PF00069 0.360
DOC_MAPK_MEF2A_6 26 33 PF00069 0.495
DOC_PP1_RVXF_1 121 127 PF00149 0.384
DOC_PP4_FxxP_1 108 111 PF00568 0.189
DOC_PP4_FxxP_1 74 77 PF00568 0.553
DOC_USP7_UBL2_3 247 251 PF12436 0.629
DOC_WW_Pin1_4 166 171 PF00397 0.406
DOC_WW_Pin1_4 232 237 PF00397 0.614
LIG_14-3-3_CanoR_1 139 145 PF00244 0.377
LIG_14-3-3_CanoR_1 173 179 PF00244 0.379
LIG_14-3-3_CanoR_1 76 82 PF00244 0.503
LIG_BIR_II_1 1 5 PF00653 0.725
LIG_BRCT_BRCA1_1 104 108 PF00533 0.215
LIG_deltaCOP1_diTrp_1 95 101 PF00928 0.331
LIG_FHA_1 228 234 PF00498 0.659
LIG_FHA_2 4 10 PF00498 0.708
LIG_LIR_Apic_2 105 111 PF02991 0.210
LIG_LIR_Gen_1 132 141 PF02991 0.297
LIG_LIR_Gen_1 193 202 PF02991 0.361
LIG_LIR_Gen_1 95 104 PF02991 0.393
LIG_LIR_Nem_3 105 110 PF02991 0.212
LIG_LIR_Nem_3 132 137 PF02991 0.304
LIG_LIR_Nem_3 193 198 PF02991 0.365
LIG_LIR_Nem_3 203 207 PF02991 0.388
LIG_LIR_Nem_3 95 100 PF02991 0.383
LIG_MLH1_MIPbox_1 104 108 PF16413 0.215
LIG_Pex14_1 200 204 PF04695 0.296
LIG_Pex14_1 97 101 PF04695 0.364
LIG_Pex14_2 136 140 PF04695 0.378
LIG_REV1ctd_RIR_1 104 110 PF16727 0.325
LIG_REV1ctd_RIR_1 134 143 PF16727 0.279
LIG_SH2_CRK 204 208 PF00017 0.337
LIG_SH2_STAT5 120 123 PF00017 0.382
LIG_SH2_STAT5 195 198 PF00017 0.322
LIG_SH2_STAT5 212 215 PF00017 0.227
LIG_SH2_STAT5 232 235 PF00017 0.603
LIG_SH2_STAT5 58 61 PF00017 0.582
LIG_SH3_3 230 236 PF00018 0.639
LIG_SH3_3 238 244 PF00018 0.709
LIG_SUMO_SIM_anti_2 9 16 PF11976 0.525
LIG_SUMO_SIM_par_1 17 23 PF11976 0.545
LIG_SUMO_SIM_par_1 237 243 PF11976 0.552
LIG_UBA3_1 87 91 PF00899 0.473
LIG_WRC_WIRS_1 133 138 PF05994 0.219
MOD_CDK_SPxxK_3 166 173 PF00069 0.435
MOD_CK1_1 10 16 PF00069 0.540
MOD_CK2_1 270 276 PF00069 0.761
MOD_CMANNOS 224 227 PF00535 0.411
MOD_GlcNHglycan 1 4 PF01048 0.444
MOD_GlcNHglycan 114 117 PF01048 0.567
MOD_GlcNHglycan 157 160 PF01048 0.574
MOD_GlcNHglycan 217 220 PF01048 0.288
MOD_GSK3_1 140 147 PF00069 0.254
MOD_GSK3_1 239 246 PF00069 0.665
MOD_GSK3_1 3 10 PF00069 0.551
MOD_N-GLC_1 127 132 PF02516 0.497
MOD_N-GLC_1 7 12 PF02516 0.409
MOD_NEK2_1 140 145 PF00069 0.254
MOD_NEK2_1 146 151 PF00069 0.259
MOD_NEK2_1 152 157 PF00069 0.351
MOD_NEK2_1 174 179 PF00069 0.388
MOD_NEK2_1 180 185 PF00069 0.333
MOD_NEK2_1 34 39 PF00069 0.503
MOD_NEK2_2 77 82 PF00069 0.464
MOD_PKA_2 180 186 PF00069 0.357
MOD_Plk_1 7 13 PF00069 0.612
MOD_Plk_4 10 16 PF00069 0.623
MOD_Plk_4 102 108 PF00069 0.294
MOD_Plk_4 146 152 PF00069 0.202
MOD_ProDKin_1 166 172 PF00069 0.407
MOD_ProDKin_1 232 238 PF00069 0.619
TRG_ENDOCYTIC_2 138 141 PF00928 0.277
TRG_ENDOCYTIC_2 195 198 PF00928 0.283
TRG_ENDOCYTIC_2 204 207 PF00928 0.312
TRG_ENDOCYTIC_2 58 61 PF00928 0.490
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.466

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDG3 Leptomonas seymouri 62% 100%
A0A0S4JRR1 Bodo saltans 29% 100%
A0A1X0NLN6 Trypanosomatidae 35% 100%
A0A3Q8ILX5 Leishmania donovani 77% 100%
A0A422N9F2 Trypanosoma rangeli 34% 100%
A4IC87 Leishmania infantum 77% 100%
D0A3T7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AU67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4Q0C7 Leishmania major 77% 100%
V5D8S7 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS