Putative homocysteine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homocysteine S-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQE8_LEIBR

TriTrypDb:

LbrM.35.6610 , LBRM2903_350077700

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQE8

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	6
GO:0000097	sulfur amino acid biosynthetic process	5	6
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006555	methionine metabolic process	5	6
GO:0006790	sulfur compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008652	amino acid biosynthetic process	4	6
GO:0009058	biosynthetic process	2	6
GO:0009066	aspartate family amino acid metabolic process	5	6
GO:0009067	aspartate family amino acid biosynthetic process	6	6
GO:0009086	methionine biosynthetic process	6	6
GO:0009987	cellular process	1	6
GO:0016053	organic acid biosynthetic process	4	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0032259	methylation	2	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044272	sulfur compound biosynthetic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0044283	small molecule biosynthetic process	3	6
GO:0046394	carboxylic acid biosynthetic process	5	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6
GO:1901605	alpha-amino acid metabolic process	4	6
GO:1901607	alpha-amino acid biosynthetic process	5	6
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0033477	S-methylmethionine metabolic process	4	1
GO:0033528	S-methylmethionine cycle	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008270	zinc ion binding	6	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0008172	S-methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	101	105	PF00082	0.312
CLV_PCSK_SKI1_1	77	81	PF00082	0.385
DEG_APCC_KENBOX_2	103	107	PF00400	0.409
DEG_Nend_UBRbox_2	1	3	PF02207	0.426
DOC_CKS1_1	67	72	PF01111	0.513
DOC_CYCLIN_yClb5_NLxxxL_5	25	33	PF00134	0.409
DOC_USP7_MATH_1	126	130	PF00917	0.556
DOC_USP7_MATH_1	188	192	PF00917	0.565
DOC_USP7_MATH_1	233	237	PF00917	0.505
DOC_USP7_MATH_1	312	316	PF00917	0.538
DOC_USP7_UBL2_3	41	45	PF12436	0.409
DOC_WW_Pin1_4	195	200	PF00397	0.513
DOC_WW_Pin1_4	216	221	PF00397	0.409
DOC_WW_Pin1_4	39	44	PF00397	0.585
DOC_WW_Pin1_4	66	71	PF00397	0.513
LIG_14-3-3_CanoR_1	187	193	PF00244	0.565
LIG_14-3-3_CanoR_1	59	68	PF00244	0.513
LIG_14-3-3_CanoR_1	77	85	PF00244	0.585
LIG_APCC_ABBA_1	212	217	PF00400	0.409
LIG_BRCT_BRCA1_1	314	318	PF00533	0.553
LIG_CSL_BTD_1	266	269	PF09270	0.585
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.409
LIG_EH1_1	172	180	PF00400	0.409
LIG_FHA_1	195	201	PF00498	0.515
LIG_FHA_1	245	251	PF00498	0.585
LIG_FHA_1	275	281	PF00498	0.585
LIG_FHA_2	18	24	PF00498	0.513
LIG_FHA_2	206	212	PF00498	0.409
LIG_Integrin_RGD_1	132	134	PF01839	0.313
LIG_LIR_Gen_1	206	216	PF02991	0.514
LIG_LIR_LC3C_4	247	252	PF02991	0.585
LIG_LIR_Nem_3	140	145	PF02991	0.473
LIG_LIR_Nem_3	206	212	PF02991	0.576
LIG_LIR_Nem_3	264	270	PF02991	0.498
LIG_RPA_C_Fungi	144	156	PF08784	0.262
LIG_SH2_GRB2like	253	256	PF00017	0.378
LIG_SH2_NCK_1	260	264	PF00017	0.378
LIG_SH2_STAT5	102	105	PF00017	0.224
LIG_SH2_STAT5	124	127	PF00017	0.367
LIG_SH2_STAT5	135	138	PF00017	0.245
LIG_SH2_STAT5	253	256	PF00017	0.319
LIG_SH2_STAT5	4	7	PF00017	0.485
LIG_SH2_STAT5	53	56	PF00017	0.354
LIG_SUMO_SIM_par_1	10	15	PF11976	0.418
LIG_SUMO_SIM_par_1	159	165	PF11976	0.378
LIG_SUMO_SIM_par_1	246	254	PF11976	0.386
LIG_TRAF2_1	138	141	PF00917	0.378
MOD_CAAXbox	317	320	PF01239	0.308
MOD_CDC14_SPxK_1	198	201	PF00782	0.232
MOD_CDC14_SPxK_1	42	45	PF00782	0.335
MOD_CDK_SPK_2	66	71	PF00069	0.232
MOD_CDK_SPxK_1	195	201	PF00069	0.232
MOD_CDK_SPxK_1	39	45	PF00069	0.335
MOD_CK1_1	191	197	PF00069	0.378
MOD_CK1_1	204	210	PF00069	0.378
MOD_CK1_1	256	262	PF00069	0.378
MOD_CK2_1	135	141	PF00069	0.378
MOD_CK2_1	165	171	PF00069	0.479
MOD_CK2_1	17	23	PF00069	0.378
MOD_CK2_1	205	211	PF00069	0.395
MOD_CK2_1	69	75	PF00069	0.479
MOD_GlcNHglycan	137	140	PF01048	0.479
MOD_GlcNHglycan	167	170	PF01048	0.479
MOD_GlcNHglycan	234	238	PF01048	0.378
MOD_GlcNHglycan	255	258	PF01048	0.378
MOD_GlcNHglycan	314	317	PF01048	0.562
MOD_GlcNHglycan	34	37	PF01048	0.336
MOD_GSK3_1	188	195	PF00069	0.378
MOD_GSK3_1	201	208	PF00069	0.378
MOD_GSK3_1	62	69	PF00069	0.378
MOD_NEK2_1	192	197	PF00069	0.378
MOD_PIKK_1	162	168	PF00454	0.329
MOD_PIKK_1	286	292	PF00454	0.319
MOD_PKA_2	301	307	PF00069	0.232
MOD_Plk_1	204	210	PF00069	0.232
MOD_Plk_1	233	239	PF00069	0.378
MOD_Plk_1	88	94	PF00069	0.378
MOD_Plk_2-3	205	211	PF00069	0.405
MOD_Plk_4	69	75	PF00069	0.479
MOD_ProDKin_1	195	201	PF00069	0.378
MOD_ProDKin_1	216	222	PF00069	0.232
MOD_ProDKin_1	39	45	PF00069	0.479
MOD_ProDKin_1	66	72	PF00069	0.378
MOD_SUMO_rev_2	138	145	PF00179	0.386
MOD_SUMO_rev_2	2	11	PF00179	0.323
TRG_AP2beta_CARGO_1	140	149	PF09066	0.378
TRG_DiLeu_BaEn_2	210	216	PF01217	0.232
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.232
TRG_ER_diArg_1	147	150	PF00400	0.378
TRG_ER_diArg_1	300	303	PF00400	0.232
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P604	Leptomonas seymouri	71%	100%
A0A1X0NWF3	Trypanosomatidae	24%	77%
A0A3S7XC66	Leishmania donovani	85%	94%
A0A422NJL4	Trypanosoma rangeli	25%	78%
A4ZGQ8	Brassica oleracea var. italica	37%	98%
C9ZI75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	74%
E9AU65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O31463	Bacillus subtilis (strain 168)	45%	100%
P56707	Astragalus bisulcatus	37%	95%
Q08985	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	98%
Q12525	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	99%
Q47690	Escherichia coli (strain K12)	51%	100%
Q4Q0C9	Leishmania major	83%	100%
Q4VNK0	Brassica oleracea var. italica	37%	92%
Q8LAX0	Arabidopsis thaliana	36%	92%
Q9FUM7	Zea mays	39%	94%
Q9FUM8	Zea mays	40%	95%
Q9FUM9	Zea mays	42%	94%
Q9FUN0	Zea mays	36%	99%
Q9M1W4	Arabidopsis thaliana	37%	96%
Q9SDL7	Arabidopsis thaliana	38%	98%
V5C098	Trypanosoma cruzi	25%	78%