LeishMANIAdb
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Glucose transporter, lmgt1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter, lmgt1
Gene product:
glucose transporter 1
Species:
Leishmania braziliensis
UniProt:
A4HQE7_LEIBR
TriTrypDb:
LbrM.35.6600 , LBRM2903_330007400
Length:
436

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

A4HQE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQE7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 17
GO:0008643 carbohydrate transport 5 17
GO:0051179 localization 1 17
GO:0051234 establishment of localization 2 17
GO:0071702 organic substance transport 4 17
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0022857 transmembrane transporter activity 2 40
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 415 419 PF00656 0.648
CLV_PCSK_KEX2_1 122 124 PF00082 0.349
CLV_PCSK_PC1ET2_1 122 124 PF00082 0.349
CLV_PCSK_SKI1_1 278 282 PF00082 0.272
DEG_ODPH_VHL_1 248 259 PF01847 0.364
DOC_CDC14_PxL_1 211 219 PF14671 0.353
DOC_CYCLIN_RxL_1 275 285 PF00134 0.536
DOC_MAPK_gen_1 120 129 PF00069 0.483
DOC_MAPK_HePTP_8 92 104 PF00069 0.436
DOC_MAPK_MEF2A_6 120 129 PF00069 0.493
DOC_MAPK_MEF2A_6 62 70 PF00069 0.480
DOC_MAPK_MEF2A_6 95 104 PF00069 0.334
DOC_MAPK_NFAT4_5 95 103 PF00069 0.388
DOC_PP1_RVXF_1 60 66 PF00149 0.488
DOC_PP4_FxxP_1 409 412 PF00568 0.347
DOC_PP4_FxxP_1 51 54 PF00568 0.444
DOC_SPAK_OSR1_1 95 99 PF12202 0.457
DOC_USP7_MATH_1 302 306 PF00917 0.347
DOC_USP7_MATH_1 54 58 PF00917 0.475
DOC_USP7_UBL2_3 307 311 PF12436 0.365
LIG_14-3-3_CanoR_1 13 19 PF00244 0.337
LIG_14-3-3_CanoR_1 349 354 PF00244 0.489
LIG_14-3-3_CanoR_1 62 66 PF00244 0.508
LIG_BRCT_BRCA1_1 149 153 PF00533 0.305
LIG_BRCT_BRCA1_1 171 175 PF00533 0.457
LIG_BRCT_BRCA1_1 271 275 PF00533 0.420
LIG_BRCT_BRCA1_1 33 37 PF00533 0.283
LIG_deltaCOP1_diTrp_1 87 96 PF00928 0.352
LIG_FHA_1 122 128 PF00498 0.494
LIG_FHA_1 132 138 PF00498 0.255
LIG_FHA_1 177 183 PF00498 0.424
LIG_FHA_1 224 230 PF00498 0.358
LIG_FHA_1 315 321 PF00498 0.369
LIG_FHA_1 352 358 PF00498 0.369
LIG_FHA_1 371 377 PF00498 0.392
LIG_GBD_Chelix_1 42 50 PF00786 0.362
LIG_GBD_Chelix_1 55 63 PF00786 0.447
LIG_LIR_Apic_2 49 54 PF02991 0.454
LIG_LIR_Gen_1 172 182 PF02991 0.381
LIG_LIR_Gen_1 207 218 PF02991 0.539
LIG_LIR_Gen_1 64 73 PF02991 0.343
LIG_LIR_Gen_1 87 97 PF02991 0.324
LIG_LIR_Nem_3 172 178 PF02991 0.361
LIG_LIR_Nem_3 207 211 PF02991 0.566
LIG_LIR_Nem_3 64 68 PF02991 0.345
LIG_LIR_Nem_3 85 91 PF02991 0.260
LIG_LYPXL_S_1 300 304 PF13949 0.342
LIG_LYPXL_yS_3 301 304 PF13949 0.276
LIG_NRBOX 173 179 PF00104 0.425
LIG_NRBOX 62 68 PF00104 0.500
LIG_Pex14_2 171 175 PF04695 0.446
LIG_Pex14_2 283 287 PF04695 0.457
LIG_Pex14_2 322 326 PF04695 0.287
LIG_Pex14_2 342 346 PF04695 0.456
LIG_Pex14_2 409 413 PF04695 0.383
LIG_PTB_Apo_2 363 370 PF02174 0.328
LIG_PTB_Phospho_1 363 369 PF10480 0.374
LIG_SH2_STAT3 112 115 PF00017 0.496
LIG_SH2_STAT3 18 21 PF00017 0.290
LIG_SH2_STAT5 112 115 PF00017 0.453
LIG_SH2_STAT5 210 213 PF00017 0.604
LIG_SH2_STAT5 273 276 PF00017 0.522
LIG_SH2_STAT5 29 32 PF00017 0.164
LIG_SH2_STAT5 335 338 PF00017 0.384
LIG_SH3_3 104 110 PF00018 0.325
LIG_SH3_3 296 302 PF00018 0.317
LIG_SH3_3 364 370 PF00018 0.325
LIG_SUMO_SIM_anti_2 176 182 PF11976 0.318
LIG_TRFH_1 408 412 PF08558 0.347
MOD_CK1_1 176 182 PF00069 0.412
MOD_CK1_1 285 291 PF00069 0.391
MOD_CK1_1 31 37 PF00069 0.293
MOD_CK2_1 79 85 PF00069 0.437
MOD_Cter_Amidation 418 421 PF01082 0.465
MOD_GlcNHglycan 33 36 PF01048 0.430
MOD_GlcNHglycan 376 379 PF01048 0.453
MOD_GlcNHglycan 380 383 PF01048 0.451
MOD_GSK3_1 169 176 PF00069 0.354
MOD_GSK3_1 223 230 PF00069 0.340
MOD_GSK3_1 238 245 PF00069 0.281
MOD_GSK3_1 261 268 PF00069 0.341
MOD_GSK3_1 269 276 PF00069 0.314
MOD_GSK3_1 282 289 PF00069 0.250
MOD_GSK3_1 370 377 PF00069 0.314
MOD_N-GLC_2 366 368 PF02516 0.394
MOD_NEK2_1 147 152 PF00069 0.269
MOD_NEK2_1 186 191 PF00069 0.460
MOD_NEK2_1 223 228 PF00069 0.328
MOD_NEK2_1 262 267 PF00069 0.344
MOD_NEK2_1 282 287 PF00069 0.131
MOD_NEK2_1 37 42 PF00069 0.336
MOD_NEK2_1 46 51 PF00069 0.267
MOD_NEK2_1 55 60 PF00069 0.193
MOD_NEK2_2 170 175 PF00069 0.418
MOD_NEK2_2 273 278 PF00069 0.508
MOD_PIKK_1 335 341 PF00454 0.352
MOD_PIKK_1 351 357 PF00454 0.316
MOD_PIKK_1 402 408 PF00454 0.141
MOD_PIKK_1 421 427 PF00454 0.522
MOD_PK_1 349 355 PF00069 0.423
MOD_PKA_1 421 427 PF00069 0.521
MOD_PKA_2 14 20 PF00069 0.367
MOD_PKA_2 61 67 PF00069 0.526
MOD_PKB_1 347 355 PF00069 0.489
MOD_Plk_4 170 176 PF00069 0.325
MOD_Plk_4 238 244 PF00069 0.289
MOD_Plk_4 269 275 PF00069 0.342
MOD_Plk_4 282 288 PF00069 0.290
MOD_Plk_4 37 43 PF00069 0.349
MOD_Plk_4 46 52 PF00069 0.295
MOD_Plk_4 61 67 PF00069 0.468
MOD_Plk_4 73 79 PF00069 0.288
TRG_AP2beta_CARGO_1 85 95 PF09066 0.337
TRG_DiLeu_BaEn_1 87 92 PF01217 0.349
TRG_DiLeu_BaLyEn_6 213 218 PF01217 0.536
TRG_ENDOCYTIC_2 208 211 PF00928 0.556
TRG_ENDOCYTIC_2 301 304 PF00928 0.276
TRG_ENDOCYTIC_2 334 337 PF00928 0.418
TRG_ER_diArg_1 13 16 PF00400 0.293
TRG_ER_diArg_1 346 349 PF00400 0.496
TRG_NLS_MonoExtN_4 417 424 PF00514 0.694

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 24% 98%
A0A0N0P2E1 Leptomonas seymouri 56% 82%
A0A0N1IG16 Leptomonas seymouri 79% 77%
A0A0N1P9H5 Leptomonas seymouri 48% 93%
A0A0S4J363 Bodo saltans 27% 77%
A0A0S4JDF9 Bodo saltans 43% 85%
A0A0S4JEY7 Bodo saltans 41% 84%
A0A0S4JH90 Bodo saltans 37% 84%
A0A0S4JS00 Bodo saltans 34% 80%
A0A1X0NIR0 Trypanosomatidae 21% 92%
A0A1X0NLE0 Trypanosomatidae 60% 79%
A0A1X0NM05 Trypanosomatidae 61% 80%
A0A1X0NN62 Trypanosomatidae 56% 80%
A0A1X0P9L7 Trypanosomatidae 40% 79%
A0A381N054 Leishmania infantum 90% 77%
A0A3Q8IDK1 Leishmania donovani 50% 73%
A0A3Q8IK60 Leishmania donovani 90% 77%
A0A3Q8IWJ4 Leishmania donovani 90% 67%
A0A3R7KPU3 Trypanosoma rangeli 39% 79%
A0A3R7MGQ7 Trypanosoma rangeli 21% 89%
A0A3S7WY58 Leishmania donovani 24% 80%
A0A3S7XC27 Leishmania donovani 91% 77%
A0A422MNQ4 Trypanosoma rangeli 62% 80%
A0A422MRN5 Trypanosoma rangeli 63% 100%
A4HDC6 Leishmania braziliensis 22% 80%
A4HL65 Leishmania braziliensis 47% 100%
A4HQD6 Leishmania braziliensis 98% 100%
A4HQD7 Leishmania braziliensis 97% 100%
A4I0Q6 Leishmania infantum 24% 80%
A4I8N6 Leishmania infantum 50% 73%
A4IC83 Leishmania infantum 90% 67%
A4ZYQ5 Rattus norvegicus 23% 85%
B0WC46 Culex quinquefasciatus 21% 84%
B4HNS1 Drosophila sechellia 23% 89%
B4QBN3 Drosophila simulans 23% 89%
C0SPB2 Bacillus subtilis (strain 168) 24% 95%
C7GWV6 Saccharomyces cerevisiae (strain JAY291) 21% 76%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 79%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 83%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 83%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 82%
E9AHY8 Leishmania infantum 91% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 77%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 77%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 71%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 81%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 70%
K0E3U9 Aspergillus rugulosus 22% 81%
O04249 Arabidopsis thaliana 24% 85%
O52733 Levilactobacillus brevis 22% 95%
O59932 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 78%
O62786 Sus scrofa 22% 83%
O62787 Sus scrofa 23% 88%
O65413 Arabidopsis thaliana 25% 86%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 81%
O74969 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 82%
P11166 Homo sapiens 24% 89%
P11167 Rattus norvegicus 23% 89%
P11168 Homo sapiens 22% 83%
P12336 Rattus norvegicus 22% 84%
P13355 Oryctolagus cuniculus 24% 89%
P13865 Leishmania enriettii 86% 77%
P14246 Mus musculus 20% 83%
P14672 Homo sapiens 22% 86%
P15686 Parachlorella kessleri 25% 82%
P15729 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 93%
P17809 Mus musculus 23% 89%
P18631 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 22% 77%
P20303 Sus scrofa 23% 89%
P23585 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 81%
P23586 Arabidopsis thaliana 25% 84%
P27674 Bos taurus 24% 89%
P28568 Gallus gallus 23% 88%
P32037 Mus musculus 23% 88%
P32465 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 76%
P32466 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 77%
P32467 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 76%
P38695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 74%
P39003 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 76%
P39004 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 76%
P39924 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 77%
P40885 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 77%
P40886 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 77%
P43427 Rattus norvegicus 22% 87%
P43581 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 80%
P46333 Bacillus subtilis (strain 168) 23% 95%
P46896 Gallus gallus 22% 89%
P47185 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 77%
P49374 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 24% 79%
P53387 Kluyveromyces lactis 22% 77%
P53631 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 77%
P54723 Bacillus subtilis (strain 168) 21% 90%
P54854 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 77%
P54862 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 77%
P58351 Bos taurus 22% 85%
P58353 Bos taurus 23% 87%
P78831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 80%
P79365 Ovis aries 24% 89%
P96710 Bacillus subtilis (strain 168) 23% 94%
Q01440 Leishmania donovani 24% 80%
Q01441 Leishmania donovani 50% 78%
Q06221 Trypanosoma brucei brucei 49% 83%
Q06222 Trypanosoma brucei brucei 51% 82%
Q07423 Ricinus communis 21% 85%
Q07647 Rattus norvegicus 23% 88%
Q09037 Trypanosoma brucei brucei 49% 83%
Q0JCR9 Oryza sativa subsp. japonica 22% 84%
Q0WVE9 Arabidopsis thaliana 24% 83%
Q10710 Ricinus communis 25% 84%
Q10PW9 Oryza sativa subsp. japonica 24% 85%
Q27115 Trypanosoma vivax 51% 80%
Q39524 Parachlorella kessleri 22% 81%
Q39525 Parachlorella kessleri 24% 82%
Q41144 Ricinus communis 23% 83%
Q4Q0D0 Leishmania major 90% 67%
Q4Q0D1 Leishmania major 90% 100%
Q4Q0D2 Leishmania major 88% 100%
Q4Q4J1 Leishmania major 48% 100%
Q4QAR5 Leishmania major 24% 100%
Q6PXP3 Homo sapiens 23% 85%
Q6Z401 Oryza sativa subsp. japonica 24% 82%
Q7EZD7 Oryza sativa subsp. japonica 26% 84%
Q851G4 Oryza sativa subsp. japonica 23% 84%
Q8GW61 Arabidopsis thaliana 25% 87%
Q8L6Z8 Arabidopsis thaliana 22% 87%
Q8L7R8 Arabidopsis thaliana 21% 85%
Q8MKK4 Drosophila melanogaster 24% 89%
Q8TFG1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 84%
Q8WMN1 Ovis aries 23% 87%
Q92253 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 73%
Q92339 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 79%
Q93Y91 Arabidopsis thaliana 24% 86%
Q94AZ2 Arabidopsis thaliana 24% 83%
Q94EC3 Oryza sativa subsp. japonica 26% 85%
Q94EC4 Oryza sativa subsp. japonica 24% 85%
Q9LT15 Arabidopsis thaliana 22% 85%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 78%
Q9P3U7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 80%
Q9SX48 Arabidopsis thaliana 23% 84%
Q9WV38 Mus musculus 23% 87%
Q9XIH6 Arabidopsis thaliana 21% 85%
Q9XIH7 Arabidopsis thaliana 22% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS