Putative small G-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small G-protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQE5_LEIBR

TriTrypDb:

LbrM.35.6570 , LBRM2903_350077200

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0035869	ciliary transition zone	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQE5

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.500
CLV_NRD_NRD_1	282	284	PF00675	0.498
CLV_NRD_NRD_1	36	38	PF00675	0.296
CLV_PCSK_SKI1_1	26	30	PF00082	0.201
CLV_PCSK_SKI1_1	292	296	PF00082	0.644
CLV_PCSK_SKI1_1	59	63	PF00082	0.254
DOC_MAPK_gen_1	273	280	PF00069	0.507
DOC_MAPK_MEF2A_6	138	147	PF00069	0.290
DOC_PP2B_LxvP_1	143	146	PF13499	0.274
DOC_PP4_FxxP_1	233	236	PF00568	0.487
DOC_USP7_MATH_1	200	204	PF00917	0.625
DOC_USP7_MATH_1	205	209	PF00917	0.633
DOC_USP7_MATH_1	239	243	PF00917	0.733
DOC_USP7_MATH_1	257	261	PF00917	0.530
DOC_USP7_MATH_1	88	92	PF00917	0.193
DOC_USP7_MATH_2	2	8	PF00917	0.345
DOC_USP7_UBL2_3	265	269	PF12436	0.547
DOC_USP7_UBL2_3	286	290	PF12436	0.597
DOC_USP7_UBL2_3	291	295	PF12436	0.617
DOC_WW_Pin1_4	232	237	PF00397	0.670
LIG_14-3-3_CanoR_1	149	156	PF00244	0.314
LIG_14-3-3_CanoR_1	273	279	PF00244	0.641
LIG_14-3-3_CanoR_1	52	62	PF00244	0.334
LIG_EVH1_1	233	237	PF00568	0.487
LIG_FHA_1	113	119	PF00498	0.366
LIG_FHA_1	19	25	PF00498	0.277
LIG_FHA_1	197	203	PF00498	0.553
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	55	61	PF00498	0.250
LIG_FHA_2	119	125	PF00498	0.274
LIG_FHA_2	130	136	PF00498	0.274
LIG_FHA_2	150	156	PF00498	0.294
LIG_FHA_2	172	178	PF00498	0.450
LIG_LIR_Gen_1	43	51	PF02991	0.205
LIG_LIR_Gen_1	69	79	PF02991	0.300
LIG_LIR_Gen_1	95	102	PF02991	0.254
LIG_LIR_Nem_3	69	74	PF02991	0.300
LIG_LIR_Nem_3	95	100	PF02991	0.254
LIG_NRBOX	293	299	PF00104	0.455
LIG_SH2_STAT5	31	34	PF00017	0.284
LIG_SH3_3	107	113	PF00018	0.303
LIG_SH3_3	231	237	PF00018	0.617
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.506
LIG_SUMO_SIM_par_1	276	282	PF11976	0.506
LIG_SUMO_SIM_par_1	9	15	PF11976	0.334
LIG_TRAF2_1	178	181	PF00917	0.496
LIG_TRAF2_1	2	5	PF00917	0.429
LIG_TRAF2_1	249	252	PF00917	0.474
LIG_TRAF2_1	66	69	PF00917	0.274
MOD_CAAXbox	296	299	PF01239	0.527
MOD_CK1_1	171	177	PF00069	0.483
MOD_CK1_1	53	59	PF00069	0.276
MOD_CK1_1	96	102	PF00069	0.254
MOD_CK2_1	129	135	PF00069	0.274
MOD_CK2_1	171	177	PF00069	0.430
MOD_GlcNHglycan	100	103	PF01048	0.259
MOD_GlcNHglycan	171	174	PF01048	0.494
MOD_GlcNHglycan	202	205	PF01048	0.643
MOD_GSK3_1	171	178	PF00069	0.500
MOD_GSK3_1	192	199	PF00069	0.639
MOD_GSK3_1	253	260	PF00069	0.631
MOD_GSK3_1	269	276	PF00069	0.679
MOD_GSK3_1	50	57	PF00069	0.303
MOD_LATS_1	288	294	PF00433	0.475
MOD_N-GLC_1	156	161	PF02516	0.247
MOD_N-GLC_1	192	197	PF02516	0.530
MOD_N-GLC_1	258	263	PF02516	0.642
MOD_N-GLC_1	54	59	PF02516	0.303
MOD_NEK2_1	118	123	PF00069	0.274
MOD_NEK2_1	148	153	PF00069	0.274
MOD_NEK2_1	156	161	PF00069	0.274
MOD_NEK2_1	50	55	PF00069	0.307
MOD_NEK2_1	62	67	PF00069	0.230
MOD_NEK2_1	87	92	PF00069	0.274
MOD_NEK2_1	98	103	PF00069	0.193
MOD_PIKK_1	156	162	PF00454	0.303
MOD_PIKK_1	171	177	PF00454	0.439
MOD_PIKK_1	72	78	PF00454	0.274
MOD_PK_1	106	112	PF00069	0.334
MOD_PKA_1	290	296	PF00069	0.471
MOD_PKA_2	148	154	PF00069	0.314
MOD_PKA_2	239	245	PF00069	0.770
MOD_PKA_2	36	42	PF00069	0.354
MOD_PKA_2	51	57	PF00069	0.334
MOD_PKA_2	93	99	PF00069	0.373
MOD_Plk_1	156	162	PF00069	0.247
MOD_Plk_1	4	10	PF00069	0.302
MOD_Plk_1	54	60	PF00069	0.247
MOD_Plk_2-3	176	182	PF00069	0.452
MOD_Plk_4	19	25	PF00069	0.317
MOD_Plk_4	274	280	PF00069	0.508
MOD_Plk_4	93	99	PF00069	0.274
MOD_ProDKin_1	232	238	PF00069	0.669
MOD_SUMO_rev_2	261	271	PF00179	0.509
TRG_DiLeu_BaEn_2	45	51	PF01217	0.334
TRG_NLS_MonoExtN_4	237	244	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC49	Leptomonas seymouri	57%	96%
A0A0N1IKL4	Leptomonas seymouri	28%	72%
A0A0S4J9T5	Bodo saltans	25%	100%
A0A1X0NQ87	Trypanosomatidae	29%	81%
A0A1X0NUW7	Trypanosomatidae	26%	100%
A0A1X0P706	Trypanosomatidae	29%	100%
A0A3Q8I8T8	Leishmania donovani	34%	100%
A0A3Q8ICX9	Leishmania donovani	32%	100%
A0A3Q8ID64	Leishmania donovani	32%	100%
A0A3Q8IE68	Leishmania donovani	35%	100%
A0A3Q8IK84	Leishmania donovani	35%	100%
A0A3Q8IRV7	Leishmania donovani	67%	100%
A0A3R7KA22	Trypanosoma rangeli	67%	100%
A0A3R7LYA6	Trypanosoma rangeli	26%	100%
A0A3S5H4Z2	Leishmania donovani	33%	100%
A0A3S5H5Y5	Leishmania donovani	33%	100%
A0A3S5H6H3	Leishmania donovani	30%	100%
A0A3S7WRA9	Leishmania donovani	31%	100%
A0A3S7WUY8	Leishmania donovani	34%	100%
A0A3S7WV84	Leishmania donovani	28%	100%
A0A3S7X3D1	Leishmania donovani	28%	100%
A0A3S7X5J2	Leishmania donovani	33%	100%
A0A422NH56	Trypanosoma rangeli	27%	100%
A1KXP5	Leishmania donovani	29%	100%
A4H506	Leishmania braziliensis	31%	100%
A4H679	Leishmania braziliensis	31%	100%
A4H6A4	Leishmania braziliensis	34%	100%
A4H6A5	Leishmania braziliensis	30%	100%
A4H9M3	Leishmania braziliensis	28%	100%
A4HEE8	Leishmania braziliensis	29%	100%
A4HFK0	Leishmania braziliensis	34%	100%
A4HHR8	Leishmania braziliensis	29%	100%
A4HIB4	Leishmania braziliensis	33%	100%
A4HK33	Leishmania braziliensis	35%	100%
A4HKH2	Leishmania braziliensis	33%	100%
A4HKJ3	Leishmania braziliensis	32%	100%
A4HLP5	Leishmania braziliensis	35%	100%
A4HRM3	Leishmania infantum	33%	100%
A4HT72	Leishmania infantum	33%	100%
A4HUK3	Leishmania infantum	31%	100%
A4HUM8	Leishmania infantum	34%	100%
A4HUM9	Leishmania infantum	30%	100%
A4HVF7	Leishmania infantum	28%	100%
A4HXY7	Leishmania infantum	28%	100%
A4I1I6	Leishmania infantum	29%	100%
A4I5J8	Leishmania infantum	28%	100%
A4I7N3	Leishmania infantum	32%	100%
A4I7Z9	Leishmania infantum	33%	100%
A4I825	Leishmania infantum	32%	100%
A4I946	Leishmania infantum	35%	100%
A4IC86	Leishmania infantum	67%	100%
B1A5Z4	Leishmania donovani	29%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0AA91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AD53	Leishmania major	35%	100%
E9AGQ4	Leishmania infantum	34%	100%
E9AHE8	Leishmania infantum	35%	100%
E9AJI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ARM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AU60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O04486	Arabidopsis thaliana	34%	100%
P01119	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	97%
P09527	Rattus norvegicus	32%	100%
P20338	Homo sapiens	28%	100%
P35288	Mus musculus	38%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P61017	Canis lupus familiaris	30%	100%
P61018	Homo sapiens	30%	100%
P61028	Mus musculus	29%	100%
P70550	Rattus norvegicus	29%	100%
P97950	Mus musculus	32%	100%
Q06AU4	Sus scrofa	35%	100%
Q06AU5	Sus scrofa	31%	100%
Q0WQN4	Arabidopsis thaliana	31%	100%
Q14088	Homo sapiens	32%	100%
Q20365	Caenorhabditis elegans	28%	97%
Q2HJI8	Bos taurus	29%	100%
Q2TBH7	Bos taurus	28%	100%
Q4Q0D5	Leishmania major	66%	100%
Q4Q404	Leishmania major	34%	100%
Q4Q573	Leishmania major	32%	100%
Q4Q595	Leishmania major	33%	100%
Q4Q5N4	Leishmania major	36%	100%
Q4Q7C3	Leishmania major	32%	100%
Q4Q9V1	Leishmania major	29%	100%
Q4QDS9	Leishmania major	28%	100%
Q4QGD2	Leishmania major	29%	100%
Q4QH97	Leishmania major	30%	100%
Q4QH98	Leishmania major	34%	100%
Q4QHC3	Leishmania major	32%	100%
Q4QIN6	Leishmania major	33%	100%
Q53S08	Homo sapiens	31%	100%
Q54QR3	Dictyostelium discoideum	32%	100%
Q5REC9	Pongo abelii	29%	100%
Q5U1Y1	Rattus norvegicus	32%	100%
Q64008	Mus musculus	32%	100%
Q6PHI9	Danio rerio	28%	100%
Q8SS11	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q92930	Homo sapiens	29%	100%
Q99260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q99P58	Mus musculus	30%	100%
Q9BZG1	Homo sapiens	34%	100%
Q9H0N0	Homo sapiens	30%	100%
Q9N2P5	Leishmania major	34%	100%
Q9ULC3	Homo sapiens	39%	100%