Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQE4_LEIBR

TriTrypDb:

LbrM.35.6560 , LBRM2903_350077100

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQE4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.595
CLV_C14_Caspase3-7	393	397	PF00656	0.534
CLV_C14_Caspase3-7	669	673	PF00656	0.655
CLV_C14_Caspase3-7	690	694	PF00656	0.535
CLV_C14_Caspase3-7	729	733	PF00656	0.652
CLV_NRD_NRD_1	226	228	PF00675	0.372
CLV_NRD_NRD_1	615	617	PF00675	0.558
CLV_NRD_NRD_1	708	710	PF00675	0.633
CLV_PCSK_FUR_1	224	228	PF00082	0.377
CLV_PCSK_KEX2_1	226	228	PF00082	0.372
CLV_PCSK_KEX2_1	49	51	PF00082	0.535
CLV_PCSK_KEX2_1	615	617	PF00082	0.558
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.503
CLV_PCSK_PC7_1	45	51	PF00082	0.497
CLV_PCSK_SKI1_1	149	153	PF00082	0.403
CLV_PCSK_SKI1_1	226	230	PF00082	0.553
CLV_PCSK_SKI1_1	249	253	PF00082	0.357
CLV_PCSK_SKI1_1	445	449	PF00082	0.633
CLV_PCSK_SKI1_1	57	61	PF00082	0.371
CLV_PCSK_SKI1_1	606	610	PF00082	0.535
CLV_PCSK_SKI1_1	682	686	PF00082	0.548
CLV_PCSK_SKI1_1	718	722	PF00082	0.558
CLV_Separin_Metazoa	146	150	PF03568	0.417
DEG_SCF_FBW7_2	82	89	PF00400	0.371
DEG_SPOP_SBC_1	461	465	PF00917	0.686
DOC_CKS1_1	307	312	PF01111	0.487
DOC_CKS1_1	380	385	PF01111	0.534
DOC_CKS1_1	536	541	PF01111	0.558
DOC_CKS1_1	587	592	PF01111	0.690
DOC_MAPK_gen_1	49	60	PF00069	0.420
DOC_MAPK_gen_1	612	621	PF00069	0.552
DOC_MAPK_MEF2A_6	162	169	PF00069	0.393
DOC_MAPK_MEF2A_6	53	60	PF00069	0.440
DOC_PP2B_LxvP_1	101	104	PF13499	0.512
DOC_PP2B_LxvP_1	186	189	PF13499	0.380
DOC_PP2B_LxvP_1	523	526	PF13499	0.680
DOC_USP7_MATH_1	137	141	PF00917	0.531
DOC_USP7_MATH_1	363	367	PF00917	0.629
DOC_USP7_MATH_1	375	379	PF00917	0.524
DOC_USP7_MATH_1	450	454	PF00917	0.590
DOC_USP7_MATH_1	461	465	PF00917	0.662
DOC_USP7_MATH_1	494	498	PF00917	0.613
DOC_USP7_MATH_1	507	511	PF00917	0.610
DOC_USP7_MATH_1	649	653	PF00917	0.548
DOC_USP7_MATH_1	692	696	PF00917	0.582
DOC_USP7_UBL2_3	682	686	PF12436	0.538
DOC_WW_Pin1_4	11	16	PF00397	0.508
DOC_WW_Pin1_4	18	23	PF00397	0.528
DOC_WW_Pin1_4	306	311	PF00397	0.571
DOC_WW_Pin1_4	322	327	PF00397	0.515
DOC_WW_Pin1_4	379	384	PF00397	0.594
DOC_WW_Pin1_4	387	392	PF00397	0.689
DOC_WW_Pin1_4	457	462	PF00397	0.684
DOC_WW_Pin1_4	521	526	PF00397	0.651
DOC_WW_Pin1_4	531	536	PF00397	0.630
DOC_WW_Pin1_4	586	591	PF00397	0.665
DOC_WW_Pin1_4	596	601	PF00397	0.630
DOC_WW_Pin1_4	724	729	PF00397	0.545
DOC_WW_Pin1_4	82	87	PF00397	0.449
LIG_14-3-3_CanoR_1	120	127	PF00244	0.498
LIG_14-3-3_CanoR_1	149	157	PF00244	0.394
LIG_14-3-3_CanoR_1	173	179	PF00244	0.382
LIG_14-3-3_CanoR_1	226	233	PF00244	0.520
LIG_14-3-3_CanoR_1	278	286	PF00244	0.452
LIG_14-3-3_CanoR_1	405	410	PF00244	0.610
LIG_14-3-3_CanoR_1	436	444	PF00244	0.562
LIG_14-3-3_CanoR_1	603	609	PF00244	0.657
LIG_14-3-3_CanoR_1	718	728	PF00244	0.552
LIG_Actin_WH2_2	135	151	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_eIF4E_1	160	166	PF01652	0.417
LIG_EVH1_1	307	311	PF00568	0.483
LIG_FHA_1	139	145	PF00498	0.535
LIG_FHA_1	183	189	PF00498	0.382
LIG_FHA_1	210	216	PF00498	0.356
LIG_FHA_1	228	234	PF00498	0.385
LIG_FHA_1	250	256	PF00498	0.365
LIG_FHA_1	307	313	PF00498	0.547
LIG_FHA_1	433	439	PF00498	0.548
LIG_FHA_1	483	489	PF00498	0.601
LIG_FHA_1	536	542	PF00498	0.671
LIG_FHA_1	553	559	PF00498	0.400
LIG_FHA_1	608	614	PF00498	0.676
LIG_FHA_1	642	648	PF00498	0.649
LIG_FHA_1	719	725	PF00498	0.577
LIG_FHA_1	86	92	PF00498	0.428
LIG_FHA_2	106	112	PF00498	0.371
LIG_FHA_2	278	284	PF00498	0.446
LIG_FHA_2	318	324	PF00498	0.551
LIG_FHA_2	667	673	PF00498	0.782
LIG_GBD_Chelix_1	549	557	PF00786	0.531
LIG_IBAR_NPY_1	428	430	PF08397	0.547
LIG_LIR_Gen_1	111	118	PF02991	0.410
LIG_LIR_Gen_1	735	741	PF02991	0.593
LIG_LIR_LC3C_4	547	551	PF02991	0.468
LIG_LIR_Nem_3	111	116	PF02991	0.389
LIG_LIR_Nem_3	2	6	PF02991	0.487
LIG_LIR_Nem_3	735	739	PF02991	0.598
LIG_MAD2	235	243	PF02301	0.470
LIG_NRBOX	288	294	PF00104	0.478
LIG_PDZ_Class_2	736	741	PF00595	0.649
LIG_PTB_Apo_2	730	737	PF02174	0.657
LIG_RPA_C_Fungi	290	302	PF08784	0.359
LIG_SH2_NCK_1	689	693	PF00017	0.533
LIG_SH2_STAP1	196	200	PF00017	0.326
LIG_SH2_STAT3	180	183	PF00017	0.389
LIG_SH2_STAT5	20	23	PF00017	0.648
LIG_SH2_STAT5	482	485	PF00017	0.516
LIG_SH2_STAT5	84	87	PF00017	0.437
LIG_SH3_3	305	311	PF00018	0.478
LIG_SH3_3	423	429	PF00018	0.555
LIG_SH3_3	486	492	PF00018	0.515
LIG_SH3_3	529	535	PF00018	0.635
LIG_SH3_3	538	544	PF00018	0.649
LIG_SH3_3	558	564	PF00018	0.441
LIG_SH3_3	584	590	PF00018	0.648
LIG_SH3_3	648	654	PF00018	0.510
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.336
LIG_SUMO_SIM_par_1	155	161	PF11976	0.338
LIG_SUMO_SIM_par_1	209	217	PF11976	0.341
LIG_SUMO_SIM_par_1	547	555	PF11976	0.457
LIG_SUMO_SIM_par_1	677	683	PF11976	0.526
LIG_TRAF2_1	181	184	PF00917	0.386
LIG_TRAF2_1	280	283	PF00917	0.446
LIG_TRAF2_1	545	548	PF00917	0.482
LIG_TRAF2_1	674	677	PF00917	0.655
MOD_CDK_SPK_2	18	23	PF00069	0.532
MOD_CDK_SPxK_1	724	730	PF00069	0.542
MOD_CDK_SPxxK_3	379	386	PF00069	0.629
MOD_CDK_SPxxK_3	596	603	PF00069	0.538
MOD_CK1_1	123	129	PF00069	0.594
MOD_CK1_1	14	20	PF00069	0.539
MOD_CK1_1	2	8	PF00069	0.539
MOD_CK1_1	256	262	PF00069	0.382
MOD_CK1_1	26	32	PF00069	0.599
MOD_CK1_1	306	312	PF00069	0.626
MOD_CK1_1	325	331	PF00069	0.546
MOD_CK1_1	352	358	PF00069	0.642
MOD_CK1_1	453	459	PF00069	0.619
MOD_CK1_1	460	466	PF00069	0.655
MOD_CK1_1	469	475	PF00069	0.533
MOD_CK1_1	521	527	PF00069	0.677
MOD_CK1_1	552	558	PF00069	0.436
MOD_CK1_1	622	628	PF00069	0.534
MOD_CK1_1	652	658	PF00069	0.537
MOD_CK1_1	680	686	PF00069	0.526
MOD_CK2_1	123	129	PF00069	0.517
MOD_CK2_1	173	179	PF00069	0.446
MOD_CK2_1	277	283	PF00069	0.440
MOD_CK2_1	436	442	PF00069	0.565
MOD_CMANNOS	8	11	PF00535	0.391
MOD_GlcNHglycan	122	125	PF01048	0.609
MOD_GlcNHglycan	16	19	PF01048	0.514
MOD_GlcNHglycan	25	28	PF01048	0.676
MOD_GlcNHglycan	255	258	PF01048	0.357
MOD_GlcNHglycan	327	330	PF01048	0.563
MOD_GlcNHglycan	34	37	PF01048	0.564
MOD_GlcNHglycan	354	357	PF01048	0.637
MOD_GlcNHglycan	396	399	PF01048	0.675
MOD_GlcNHglycan	40	43	PF01048	0.370
MOD_GlcNHglycan	432	435	PF01048	0.667
MOD_GlcNHglycan	455	458	PF01048	0.640
MOD_GlcNHglycan	468	471	PF01048	0.544
MOD_GlcNHglycan	472	475	PF01048	0.509
MOD_GlcNHglycan	492	495	PF01048	0.533
MOD_GlcNHglycan	510	513	PF01048	0.758
MOD_GlcNHglycan	520	523	PF01048	0.596
MOD_GlcNHglycan	621	624	PF01048	0.685
MOD_GlcNHglycan	672	675	PF01048	0.656
MOD_GlcNHglycan	682	685	PF01048	0.633
MOD_GlcNHglycan	689	692	PF01048	0.518
MOD_GlcNHglycan	693	697	PF01048	0.557
MOD_GlcNHglycan	75	78	PF01048	0.433
MOD_GSK3_1	14	21	PF00069	0.522
MOD_GSK3_1	2	9	PF00069	0.555
MOD_GSK3_1	249	256	PF00069	0.420
MOD_GSK3_1	313	320	PF00069	0.694
MOD_GSK3_1	336	343	PF00069	0.657
MOD_GSK3_1	359	366	PF00069	0.555
MOD_GSK3_1	375	382	PF00069	0.598
MOD_GSK3_1	386	393	PF00069	0.537
MOD_GSK3_1	405	412	PF00069	0.769
MOD_GSK3_1	432	439	PF00069	0.617
MOD_GSK3_1	453	460	PF00069	0.767
MOD_GSK3_1	462	469	PF00069	0.665
MOD_GSK3_1	478	485	PF00069	0.493
MOD_GSK3_1	490	497	PF00069	0.578
MOD_GSK3_1	527	534	PF00069	0.558
MOD_GSK3_1	576	583	PF00069	0.681
MOD_GSK3_1	615	622	PF00069	0.592
MOD_GSK3_1	63	70	PF00069	0.394
MOD_GSK3_1	641	648	PF00069	0.459
MOD_GSK3_1	666	673	PF00069	0.644
MOD_GSK3_1	687	694	PF00069	0.535
MOD_GSK3_1	718	725	PF00069	0.558
MOD_N-GLC_1	198	203	PF02516	0.570
MOD_N-GLC_1	352	357	PF02516	0.666
MOD_N-GLC_1	414	419	PF02516	0.690
MOD_N-GLC_1	508	513	PF02516	0.586
MOD_N-GLC_1	718	723	PF02516	0.601
MOD_N-GLC_1	732	737	PF02516	0.626
MOD_NEK2_1	351	356	PF00069	0.661
MOD_NEK2_1	549	554	PF00069	0.565
MOD_NEK2_1	60	65	PF00069	0.381
MOD_NEK2_1	619	624	PF00069	0.548
MOD_NEK2_1	90	95	PF00069	0.301
MOD_NEK2_2	244	249	PF00069	0.466
MOD_PIKK_1	340	346	PF00454	0.540
MOD_PIKK_1	390	396	PF00454	0.536
MOD_PIKK_1	607	613	PF00454	0.616
MOD_PIKK_1	666	672	PF00454	0.549
MOD_PKA_1	226	232	PF00069	0.369
MOD_PKA_1	49	55	PF00069	0.432
MOD_PKA_1	615	621	PF00069	0.555
MOD_PKA_2	174	180	PF00069	0.381
MOD_PKA_2	226	232	PF00069	0.373
MOD_PKA_2	277	283	PF00069	0.440
MOD_PKA_2	404	410	PF00069	0.612
MOD_PKA_2	49	55	PF00069	0.531
MOD_PKA_2	60	66	PF00069	0.336
MOD_PKA_2	615	621	PF00069	0.621
MOD_PKA_2	73	79	PF00069	0.397
MOD_PKB_1	120	128	PF00069	0.564
MOD_PKB_1	224	232	PF00069	0.372
MOD_Plk_1	244	250	PF00069	0.395
MOD_Plk_1	559	565	PF00069	0.637
MOD_Plk_1	634	640	PF00069	0.529
MOD_Plk_1	649	655	PF00069	0.597
MOD_Plk_2-3	580	586	PF00069	0.570
MOD_Plk_2-3	732	738	PF00069	0.592
MOD_Plk_4	2	8	PF00069	0.483
MOD_Plk_4	272	278	PF00069	0.359
MOD_Plk_4	375	381	PF00069	0.536
MOD_Plk_4	405	411	PF00069	0.562
MOD_Plk_4	635	641	PF00069	0.523
MOD_Plk_4	67	73	PF00069	0.422
MOD_ProDKin_1	11	17	PF00069	0.514
MOD_ProDKin_1	18	24	PF00069	0.528
MOD_ProDKin_1	306	312	PF00069	0.574
MOD_ProDKin_1	322	328	PF00069	0.517
MOD_ProDKin_1	379	385	PF00069	0.594
MOD_ProDKin_1	387	393	PF00069	0.691
MOD_ProDKin_1	457	463	PF00069	0.684
MOD_ProDKin_1	521	527	PF00069	0.650
MOD_ProDKin_1	531	537	PF00069	0.630
MOD_ProDKin_1	586	592	PF00069	0.665
MOD_ProDKin_1	596	602	PF00069	0.627
MOD_ProDKin_1	724	730	PF00069	0.542
MOD_ProDKin_1	82	88	PF00069	0.454
MOD_SUMO_for_1	181	184	PF00179	0.386
MOD_SUMO_rev_2	378	387	PF00179	0.538
TRG_DiLeu_BaEn_1	288	293	PF01217	0.337
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.459
TRG_ER_diArg_1	172	175	PF00400	0.415
TRG_ER_diArg_1	224	227	PF00400	0.387
TRG_ER_diArg_1	614	616	PF00400	0.552
TRG_NLS_MonoExtC_3	708	713	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	606	611	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD4	Leptomonas seymouri	43%	99%
A0A3Q8IJC2	Leishmania donovani	68%	100%
A4IE35	Leishmania infantum	68%	100%
E9AU59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q0D6	Leishmania major	67%	100%