Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQE0_LEIBR

TriTrypDb:

LbrM.35.6520 , LBRM2903_350076700

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016491	oxidoreductase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.455
CLV_C14_Caspase3-7	668	672	PF00656	0.367
CLV_NRD_NRD_1	268	270	PF00675	0.621
CLV_NRD_NRD_1	327	329	PF00675	0.735
CLV_NRD_NRD_1	499	501	PF00675	0.777
CLV_NRD_NRD_1	534	536	PF00675	0.608
CLV_NRD_NRD_1	640	642	PF00675	0.560
CLV_NRD_NRD_1	725	727	PF00675	0.380
CLV_NRD_NRD_1	87	89	PF00675	0.468
CLV_PCSK_KEX2_1	267	269	PF00082	0.670
CLV_PCSK_KEX2_1	327	329	PF00082	0.735
CLV_PCSK_KEX2_1	499	501	PF00082	0.777
CLV_PCSK_KEX2_1	640	642	PF00082	0.560
CLV_PCSK_KEX2_1	725	727	PF00082	0.380
CLV_PCSK_KEX2_1	87	89	PF00082	0.468
CLV_PCSK_SKI1_1	163	167	PF00082	0.586
CLV_PCSK_SKI1_1	175	179	PF00082	0.666
CLV_PCSK_SKI1_1	535	539	PF00082	0.699
CLV_PCSK_SKI1_1	585	589	PF00082	0.406
CLV_PCSK_SKI1_1	9	13	PF00082	0.562
DEG_APCC_DBOX_1	543	551	PF00400	0.624
DEG_APCC_DBOX_1	8	16	PF00400	0.555
DEG_SPOP_SBC_1	342	346	PF00917	0.513
DEG_SPOP_SBC_1	39	43	PF00917	0.459
DEG_SPOP_SBC_1	484	488	PF00917	0.598
DOC_ANK_TNKS_1	553	560	PF00023	0.494
DOC_CDC14_PxL_1	22	30	PF14671	0.693
DOC_CDC14_PxL_1	696	704	PF14671	0.299
DOC_CKS1_1	468	473	PF01111	0.517
DOC_CKS1_1	609	614	PF01111	0.507
DOC_CKS1_1	714	719	PF01111	0.607
DOC_CYCLIN_RxL_1	3	13	PF00134	0.597
DOC_CYCLIN_yClb1_LxF_4	707	713	PF00134	0.373
DOC_MAPK_DCC_7	208	216	PF00069	0.450
DOC_MAPK_DCC_7	544	552	PF00069	0.599
DOC_MAPK_gen_1	123	132	PF00069	0.459
DOC_MAPK_gen_1	327	336	PF00069	0.745
DOC_MAPK_gen_1	388	398	PF00069	0.500
DOC_MAPK_MEF2A_6	123	132	PF00069	0.688
DOC_MAPK_MEF2A_6	208	216	PF00069	0.519
DOC_MAPK_MEF2A_6	544	553	PF00069	0.590
DOC_PP1_RVXF_1	139	145	PF00149	0.575
DOC_PP1_RVXF_1	393	399	PF00149	0.553
DOC_PP2B_LxvP_1	303	306	PF13499	0.455
DOC_PP4_FxxP_1	152	155	PF00568	0.617
DOC_PP4_FxxP_1	5	8	PF00568	0.671
DOC_PP4_FxxP_1	51	54	PF00568	0.711
DOC_USP7_MATH_1	153	157	PF00917	0.699
DOC_USP7_MATH_1	196	200	PF00917	0.681
DOC_USP7_MATH_1	239	243	PF00917	0.684
DOC_USP7_MATH_1	439	443	PF00917	0.664
DOC_USP7_MATH_1	446	450	PF00917	0.681
DOC_USP7_MATH_1	45	49	PF00917	0.670
DOC_USP7_MATH_1	485	489	PF00917	0.660
DOC_USP7_MATH_1	527	531	PF00917	0.499
DOC_USP7_MATH_1	613	617	PF00917	0.595
DOC_USP7_MATH_1	634	638	PF00917	0.568
DOC_USP7_UBL2_3	532	536	PF12436	0.446
DOC_WW_Pin1_4	192	197	PF00397	0.494
DOC_WW_Pin1_4	224	229	PF00397	0.504
DOC_WW_Pin1_4	275	280	PF00397	0.601
DOC_WW_Pin1_4	335	340	PF00397	0.731
DOC_WW_Pin1_4	356	361	PF00397	0.546
DOC_WW_Pin1_4	467	472	PF00397	0.762
DOC_WW_Pin1_4	608	613	PF00397	0.510
DOC_WW_Pin1_4	642	647	PF00397	0.541
DOC_WW_Pin1_4	713	718	PF00397	0.613
LIG_14-3-3_CanoR_1	141	145	PF00244	0.613
LIG_14-3-3_CanoR_1	365	369	PF00244	0.603
LIG_14-3-3_CanoR_1	432	439	PF00244	0.502
LIG_14-3-3_CanoR_1	500	510	PF00244	0.748
LIG_14-3-3_CanoR_1	585	590	PF00244	0.409
LIG_14-3-3_CanoR_1	695	700	PF00244	0.591
LIG_14-3-3_CanoR_1	80	86	PF00244	0.636
LIG_Actin_WH2_2	144	162	PF00022	0.569
LIG_Actin_WH2_2	624	642	PF00022	0.481
LIG_Actin_WH2_2	74	92	PF00022	0.548
LIG_APCC_ABBA_1	553	558	PF00400	0.532
LIG_BRCT_BRCA1_1	337	341	PF00533	0.766
LIG_BRCT_BRCA1_1	47	51	PF00533	0.753
LIG_Clathr_ClatBox_1	628	632	PF01394	0.474
LIG_EH1_1	410	418	PF00400	0.610
LIG_FHA_1	174	180	PF00498	0.733
LIG_FHA_1	188	194	PF00498	0.652
LIG_FHA_1	279	285	PF00498	0.608
LIG_FHA_1	412	418	PF00498	0.705
LIG_FHA_1	468	474	PF00498	0.588
LIG_FHA_1	505	511	PF00498	0.689
LIG_FHA_1	95	101	PF00498	0.416
LIG_FHA_2	107	113	PF00498	0.637
LIG_FHA_2	116	122	PF00498	0.510
LIG_FHA_2	289	295	PF00498	0.704
LIG_FHA_2	403	409	PF00498	0.448
LIG_FHA_2	570	576	PF00498	0.664
LIG_HP1_1	549	553	PF01393	0.606
LIG_LIR_Apic_2	2	8	PF02991	0.701
LIG_LIR_Apic_2	48	54	PF02991	0.729
LIG_LIR_Gen_1	521	529	PF02991	0.649
LIG_LIR_Gen_1	55	64	PF02991	0.503
LIG_LIR_Nem_3	143	147	PF02991	0.623
LIG_LIR_Nem_3	293	299	PF02991	0.690
LIG_LIR_Nem_3	521	525	PF02991	0.637
LIG_LIR_Nem_3	55	60	PF02991	0.500
LIG_LIR_Nem_3	709	715	PF02991	0.386
LIG_NRBOX	298	304	PF00104	0.432
LIG_PCNA_yPIPBox_3	314	328	PF02747	0.458
LIG_Pex14_1	569	573	PF04695	0.759
LIG_Pex14_2	520	524	PF04695	0.384
LIG_SH2_STAP1	120	124	PF00017	0.414
LIG_SH2_STAP1	282	286	PF00017	0.516
LIG_SH2_STAP1	493	497	PF00017	0.557
LIG_SH2_STAT5	333	336	PF00017	0.654
LIG_SH2_STAT5	493	496	PF00017	0.664
LIG_SH2_STAT5	723	726	PF00017	0.611
LIG_SH2_STAT5	91	94	PF00017	0.511
LIG_SH3_1	450	456	PF00018	0.661
LIG_SH3_3	23	29	PF00018	0.673
LIG_SH3_3	333	339	PF00018	0.756
LIG_SH3_3	346	352	PF00018	0.541
LIG_SH3_3	412	418	PF00018	0.605
LIG_SH3_3	450	456	PF00018	0.732
LIG_SH3_3	465	471	PF00018	0.663
LIG_SH3_3	478	484	PF00018	0.475
LIG_SH3_3	604	610	PF00018	0.519
LIG_SH3_3	97	103	PF00018	0.701
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.565
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.523
LIG_SUMO_SIM_par_1	101	109	PF11976	0.682
LIG_SUMO_SIM_par_1	212	217	PF11976	0.697
LIG_SUMO_SIM_par_1	354	359	PF11976	0.593
LIG_SUMO_SIM_par_1	381	387	PF11976	0.652
LIG_SUMO_SIM_par_1	461	467	PF11976	0.648
LIG_SUMO_SIM_par_1	665	671	PF11976	0.613
LIG_TRAF2_1	263	266	PF00917	0.463
LIG_TRFH_1	713	717	PF08558	0.606
LIG_ULM_U2AF65_1	267	273	PF00076	0.507
LIG_Vh1_VBS_1	666	684	PF01044	0.350
LIG_WW_2	349	352	PF00397	0.496
MOD_CDK_SPK_2	713	718	PF00069	0.351
MOD_CDK_SPxxK_3	608	615	PF00069	0.509
MOD_CK1_1	227	233	PF00069	0.777
MOD_CK1_1	285	291	PF00069	0.635
MOD_CK2_1	106	112	PF00069	0.639
MOD_CK2_1	115	121	PF00069	0.506
MOD_CK2_1	17	23	PF00069	0.508
MOD_CK2_1	227	233	PF00069	0.772
MOD_CK2_1	260	266	PF00069	0.468
MOD_CK2_1	288	294	PF00069	0.717
MOD_CK2_1	439	445	PF00069	0.629
MOD_CK2_1	485	491	PF00069	0.781
MOD_CK2_1	569	575	PF00069	0.666
MOD_CK2_1	59	65	PF00069	0.744
MOD_GlcNHglycan	144	147	PF01048	0.628
MOD_GlcNHglycan	216	219	PF01048	0.703
MOD_GlcNHglycan	229	232	PF01048	0.627
MOD_GlcNHglycan	242	245	PF01048	0.540
MOD_GlcNHglycan	322	325	PF01048	0.697
MOD_GlcNHglycan	346	349	PF01048	0.601
MOD_GlcNHglycan	42	45	PF01048	0.631
MOD_GlcNHglycan	433	436	PF01048	0.492
MOD_GlcNHglycan	513	517	PF01048	0.574
MOD_GlcNHglycan	527	530	PF01048	0.519
MOD_GlcNHglycan	585	588	PF01048	0.605
MOD_GlcNHglycan	604	607	PF01048	0.677
MOD_GlcNHglycan	660	664	PF01048	0.550
MOD_GSK3_1	17	24	PF00069	0.574
MOD_GSK3_1	183	190	PF00069	0.668
MOD_GSK3_1	192	199	PF00069	0.505
MOD_GSK3_1	278	285	PF00069	0.776
MOD_GSK3_1	359	366	PF00069	0.664
MOD_GSK3_1	398	405	PF00069	0.572
MOD_GSK3_1	463	470	PF00069	0.671
MOD_GSK3_1	502	509	PF00069	0.690
MOD_GSK3_1	55	62	PF00069	0.625
MOD_GSK3_1	588	595	PF00069	0.609
MOD_N-GLC_1	132	137	PF02516	0.671
MOD_NEK2_1	142	147	PF00069	0.619
MOD_NEK2_1	21	26	PF00069	0.584
MOD_NEK2_1	214	219	PF00069	0.491
MOD_NEK2_1	320	325	PF00069	0.589
MOD_NEK2_1	341	346	PF00069	0.710
MOD_NEK2_1	363	368	PF00069	0.690
MOD_NEK2_1	398	403	PF00069	0.566
MOD_NEK2_1	512	517	PF00069	0.594
MOD_NEK2_1	525	530	PF00069	0.456
MOD_NEK2_1	542	547	PF00069	0.674
MOD_NEK2_1	576	581	PF00069	0.743
MOD_NEK2_1	592	597	PF00069	0.469
MOD_PIKK_1	310	316	PF00454	0.446
MOD_PK_1	506	512	PF00069	0.698
MOD_PKA_2	106	112	PF00069	0.530
MOD_PKA_2	140	146	PF00069	0.616
MOD_PKA_2	183	189	PF00069	0.667
MOD_PKA_2	364	370	PF00069	0.607
MOD_PKA_2	431	437	PF00069	0.485
MOD_PKA_2	79	85	PF00069	0.646
MOD_Plk_1	173	179	PF00069	0.732
MOD_Plk_1	574	580	PF00069	0.708
MOD_Plk_2-3	17	23	PF00069	0.571
MOD_Plk_4	154	160	PF00069	0.654
MOD_Plk_4	17	23	PF00069	0.627
MOD_Plk_4	411	417	PF00069	0.707
MOD_Plk_4	439	445	PF00069	0.655
MOD_Plk_4	588	594	PF00069	0.612
MOD_Plk_4	634	640	PF00069	0.577
MOD_Plk_4	677	683	PF00069	0.598
MOD_ProDKin_1	192	198	PF00069	0.489
MOD_ProDKin_1	224	230	PF00069	0.504
MOD_ProDKin_1	275	281	PF00069	0.600
MOD_ProDKin_1	335	341	PF00069	0.736
MOD_ProDKin_1	356	362	PF00069	0.544
MOD_ProDKin_1	467	473	PF00069	0.762
MOD_ProDKin_1	608	614	PF00069	0.507
MOD_ProDKin_1	642	648	PF00069	0.541
MOD_ProDKin_1	713	719	PF00069	0.609
TRG_DiLeu_BaEn_1	174	179	PF01217	0.632
TRG_DiLeu_BaEn_1	30	35	PF01217	0.423
TRG_DiLeu_BaEn_2	16	22	PF01217	0.558
TRG_DiLeu_BaEn_2	393	399	PF01217	0.390
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.445
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.564
TRG_ENDOCYTIC_2	333	336	PF00928	0.754
TRG_ENDOCYTIC_2	573	576	PF00928	0.758
TRG_ER_diArg_1	122	125	PF00400	0.420
TRG_ER_diArg_1	267	269	PF00400	0.544
TRG_ER_diArg_1	326	328	PF00400	0.740
TRG_ER_diArg_1	498	500	PF00400	0.782
TRG_ER_diArg_1	639	641	PF00400	0.530
TRG_ER_diArg_1	724	726	PF00400	0.364
TRG_ER_diArg_1	86	88	PF00400	0.439
TRG_NES_CRM1_1	394	408	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z5	Leptomonas seymouri	37%	68%
A0A3S7XC58	Leishmania donovani	71%	67%
E9AU55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	67%
Q4Q0E0	Leishmania major	71%	100%