Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQD9_LEIBR

TriTrypDb:

LbrM.35.6510 , LBRM2903_350076600

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD9

PDB structure(s): 7aih_Bj , 7ane_Bj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.694
CLV_NRD_NRD_1	178	180	PF00675	0.749
CLV_PCSK_KEX2_1	127	129	PF00082	0.573
CLV_PCSK_KEX2_1	178	180	PF00082	0.659
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.609
CLV_PCSK_SKI1_1	127	131	PF00082	0.598
CLV_PCSK_SKI1_1	157	161	PF00082	0.504
CLV_PCSK_SKI1_1	172	176	PF00082	0.537
CLV_PCSK_SKI1_1	80	84	PF00082	0.489
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.438
DOC_MAPK_gen_1	74	84	PF00069	0.456
DOC_PP4_FxxP_1	97	100	PF00568	0.441
DOC_WW_Pin1_4	24	29	PF00397	0.629
LIG_14-3-3_CanoR_1	128	133	PF00244	0.585
LIG_14-3-3_CanoR_1	50	58	PF00244	0.456
LIG_14-3-3_CanoR_1	77	83	PF00244	0.438
LIG_Actin_WH2_2	19	35	PF00022	0.529
LIG_APCC_ABBA_1	103	108	PF00400	0.441
LIG_FHA_1	79	85	PF00498	0.429
LIG_HP1_1	101	105	PF01393	0.569
LIG_LIR_Apic_2	36	40	PF02991	0.442
LIG_LIR_Apic_2	94	100	PF02991	0.442
LIG_MYND_1	30	34	PF01753	0.484
LIG_SH2_CRK	153	157	PF00017	0.425
LIG_SH2_CRK	37	41	PF00017	0.441
LIG_SH2_STAT5	153	156	PF00017	0.422
LIG_SH2_STAT5	41	44	PF00017	0.443
LIG_SUMO_SIM_par_1	80	87	PF11976	0.445
LIG_WRC_WIRS_1	43	48	PF05994	0.469
MOD_CDK_SPxxK_3	24	31	PF00069	0.622
MOD_CK1_1	170	176	PF00069	0.546
MOD_CK1_1	177	183	PF00069	0.614
MOD_CK2_1	86	92	PF00069	0.440
MOD_GlcNHglycan	11	14	PF01048	0.505
MOD_GlcNHglycan	110	113	PF01048	0.408
MOD_GlcNHglycan	169	172	PF01048	0.525
MOD_GSK3_1	170	177	PF00069	0.524
MOD_GSK3_1	66	73	PF00069	0.404
MOD_GSK3_1	86	93	PF00069	0.332
MOD_N-GLC_1	90	95	PF02516	0.325
MOD_NEK2_1	22	27	PF00069	0.635
MOD_NEK2_1	78	83	PF00069	0.446
MOD_PKA_2	108	114	PF00069	0.426
MOD_PKA_2	177	183	PF00069	0.691
MOD_Plk_1	66	72	PF00069	0.481
MOD_Plk_2-3	66	72	PF00069	0.401
MOD_ProDKin_1	24	30	PF00069	0.629
TRG_ER_diArg_1	161	164	PF00400	0.476
TRG_ER_diArg_1	178	181	PF00400	0.598
TRG_ER_diArg_1	72	75	PF00400	0.468
TRG_NLS_MonoExtN_4	125	131	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGK0	Leptomonas seymouri	87%	100%
A0A0S4JRU2	Bodo saltans	62%	100%
A0A1X0NLE2	Trypanosomatidae	75%	99%
A0A3Q8ILV7	Leishmania donovani	92%	100%
A0A3S5IQU3	Trypanosoma rangeli	77%	100%
A4IE30	Leishmania infantum	92%	100%
D0A3V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	88%
E9AU54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0E1	Leishmania major	92%	100%
V5B3P3	Trypanosoma cruzi	77%	100%