Glucose transporter, lmgt2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter 2

Species:

Leishmania braziliensis

UniProt:

A4HQD7_LEIBR

TriTrypDb:

LbrM.35.6490 , LBRM2903_330007400

Length:

531

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	41
GO:0110165	cellular anatomical entity	1	41
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

A4HQD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0022857	transmembrane transporter activity	2	41
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.567
CLV_C14_Caspase3-7	511	515	PF00656	0.651
CLV_NRD_NRD_1	86	88	PF00675	0.561
CLV_PCSK_KEX2_1	218	220	PF00082	0.334
CLV_PCSK_KEX2_1	526	528	PF00082	0.520
CLV_PCSK_KEX2_1	86	88	PF00082	0.483
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.347
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.520
CLV_PCSK_SKI1_1	17	21	PF00082	0.337
CLV_PCSK_SKI1_1	374	378	PF00082	0.262
CLV_PCSK_SKI1_1	67	71	PF00082	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.531
DEG_ODPH_VHL_1	344	355	PF01847	0.347
DOC_CDC14_PxL_1	307	315	PF14671	0.351
DOC_CYCLIN_RxL_1	371	381	PF00134	0.534
DOC_MAPK_gen_1	216	225	PF00069	0.481
DOC_MAPK_gen_1	443	452	PF00069	0.376
DOC_MAPK_HePTP_8	188	200	PF00069	0.434
DOC_MAPK_MEF2A_6	158	166	PF00069	0.478
DOC_MAPK_MEF2A_6	191	200	PF00069	0.316
DOC_MAPK_MEF2A_6	216	225	PF00069	0.491
DOC_MAPK_NFAT4_5	191	199	PF00069	0.386
DOC_PP1_RVXF_1	156	162	PF00149	0.473
DOC_PP4_FxxP_1	147	150	PF00568	0.455
DOC_PP4_FxxP_1	505	508	PF00568	0.346
DOC_SPAK_OSR1_1	191	195	PF12202	0.416
DOC_USP7_MATH_1	150	154	PF00917	0.365
DOC_USP7_MATH_1	398	402	PF00917	0.345
DOC_USP7_UBL2_3	403	407	PF12436	0.302
DOC_WW_Pin1_4	72	77	PF00397	0.243
LIG_14-3-3_CanoR_1	109	115	PF00244	0.313
LIG_14-3-3_CanoR_1	158	162	PF00244	0.498
LIG_14-3-3_CanoR_1	445	450	PF00244	0.474
LIG_14-3-3_CanoR_1	86	92	PF00244	0.353
LIG_BIR_III_2	6	10	PF00653	0.550
LIG_BRCT_BRCA1_1	129	133	PF00533	0.281
LIG_BRCT_BRCA1_1	245	249	PF00533	0.303
LIG_BRCT_BRCA1_1	267	271	PF00533	0.455
LIG_BRCT_BRCA1_1	31	35	PF00533	0.355
LIG_BRCT_BRCA1_1	367	371	PF00533	0.418
LIG_BRCT_BRCA1_1	73	77	PF00533	0.136
LIG_deltaCOP1_diTrp_1	183	192	PF00928	0.325
LIG_FHA_1	218	224	PF00498	0.492
LIG_FHA_1	228	234	PF00498	0.253
LIG_FHA_1	273	279	PF00498	0.423
LIG_FHA_1	320	326	PF00498	0.349
LIG_FHA_1	411	417	PF00498	0.367
LIG_FHA_1	467	473	PF00498	0.275
LIG_GBD_Chelix_1	138	146	PF00786	0.361
LIG_GBD_Chelix_1	151	159	PF00786	0.445
LIG_GBD_Chelix_1	20	28	PF00786	0.431
LIG_LIR_Apic_2	145	150	PF02991	0.455
LIG_LIR_Gen_1	160	169	PF02991	0.343
LIG_LIR_Gen_1	183	193	PF02991	0.312
LIG_LIR_Gen_1	268	278	PF02991	0.380
LIG_LIR_Gen_1	303	314	PF02991	0.538
LIG_LIR_Gen_1	88	99	PF02991	0.346
LIG_LIR_Nem_3	160	164	PF02991	0.345
LIG_LIR_Nem_3	181	187	PF02991	0.257
LIG_LIR_Nem_3	268	274	PF02991	0.363
LIG_LIR_Nem_3	303	307	PF02991	0.564
LIG_LIR_Nem_3	32	38	PF02991	0.332
LIG_LIR_Nem_3	88	94	PF02991	0.257
LIG_LYPXL_S_1	396	400	PF13949	0.333
LIG_LYPXL_yS_3	397	400	PF13949	0.270
LIG_NRBOX	158	164	PF00104	0.562
LIG_NRBOX	269	275	PF00104	0.423
LIG_Pex14_2	267	271	PF04695	0.445
LIG_Pex14_2	379	383	PF04695	0.434
LIG_Pex14_2	418	422	PF04695	0.286
LIG_Pex14_2	438	442	PF04695	0.478
LIG_Pex14_2	505	509	PF04695	0.368
LIG_PTB_Apo_2	459	466	PF02174	0.315
LIG_PTB_Phospho_1	459	465	PF10480	0.355
LIG_SH2_CRK	39	43	PF00017	0.359
LIG_SH2_CRK	91	95	PF00017	0.367
LIG_SH2_GRB2like	91	94	PF00017	0.180
LIG_SH2_STAP1	39	43	PF00017	0.382
LIG_SH2_STAT3	114	117	PF00017	0.266
LIG_SH2_STAT3	208	211	PF00017	0.495
LIG_SH2_STAT5	208	211	PF00017	0.448
LIG_SH2_STAT5	306	309	PF00017	0.602
LIG_SH2_STAT5	369	372	PF00017	0.530
LIG_SH2_STAT5	431	434	PF00017	0.378
LIG_SH2_STAT5	89	92	PF00017	0.324
LIG_SH3_3	200	206	PF00018	0.316
LIG_SH3_3	392	398	PF00018	0.305
LIG_SH3_3	460	466	PF00018	0.316
LIG_SH3_3	56	62	PF00018	0.136
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.310
LIG_TRAF2_1	115	118	PF00917	0.328
LIG_TRFH_1	504	508	PF08558	0.346
MOD_CK1_1	127	133	PF00069	0.291
MOD_CK1_1	272	278	PF00069	0.395
MOD_CK1_1	381	387	PF00069	0.393
MOD_CK1_1	51	57	PF00069	0.223
MOD_CK2_1	112	118	PF00069	0.321
MOD_CK2_1	123	129	PF00069	0.282
MOD_CK2_1	175	181	PF00069	0.435
MOD_Cter_Amidation	514	517	PF01082	0.470
MOD_Cter_Amidation	524	527	PF01082	0.551
MOD_GlcNHglycan	11	14	PF01048	0.421
MOD_GlcNHglycan	129	132	PF01048	0.427
MOD_GlcNHglycan	472	475	PF01048	0.448
MOD_GlcNHglycan	476	479	PF01048	0.448
MOD_GSK3_1	123	130	PF00069	0.265
MOD_GSK3_1	265	272	PF00069	0.345
MOD_GSK3_1	319	326	PF00069	0.326
MOD_GSK3_1	334	341	PF00069	0.278
MOD_GSK3_1	357	364	PF00069	0.339
MOD_GSK3_1	365	372	PF00069	0.316
MOD_GSK3_1	378	385	PF00069	0.243
MOD_GSK3_1	44	51	PF00069	0.181
MOD_GSK3_1	466	473	PF00069	0.316
MOD_GSK3_1	67	74	PF00069	0.237
MOD_GSK3_1	81	88	PF00069	0.298
MOD_N-GLC_1	72	77	PF02516	0.511
MOD_N-GLC_1	92	97	PF02516	0.454
MOD_N-GLC_2	462	464	PF02516	0.372
MOD_NEK2_1	11	16	PF00069	0.635
MOD_NEK2_1	133	138	PF00069	0.328
MOD_NEK2_1	142	147	PF00069	0.262
MOD_NEK2_1	151	156	PF00069	0.191
MOD_NEK2_1	243	248	PF00069	0.268
MOD_NEK2_1	282	287	PF00069	0.460
MOD_NEK2_1	319	324	PF00069	0.318
MOD_NEK2_1	358	363	PF00069	0.349
MOD_NEK2_1	378	383	PF00069	0.129
MOD_NEK2_1	43	48	PF00069	0.286
MOD_NEK2_1	69	74	PF00069	0.376
MOD_NEK2_2	266	271	PF00069	0.416
MOD_NEK2_2	369	374	PF00069	0.498
MOD_OFUCOSY	78	85	PF10250	0.483
MOD_PIKK_1	431	437	PF00454	0.350
MOD_PK_1	445	451	PF00069	0.421
MOD_PKA_2	110	116	PF00069	0.339
MOD_PKA_2	157	163	PF00069	0.505
MOD_PKA_2	85	91	PF00069	0.366
MOD_PKB_1	443	451	PF00069	0.474
MOD_Plk_4	133	139	PF00069	0.343
MOD_Plk_4	142	148	PF00069	0.289
MOD_Plk_4	157	163	PF00069	0.453
MOD_Plk_4	169	175	PF00069	0.278
MOD_Plk_4	266	272	PF00069	0.322
MOD_Plk_4	334	340	PF00069	0.284
MOD_Plk_4	365	371	PF00069	0.335
MOD_Plk_4	378	384	PF00069	0.284
MOD_Plk_4	38	44	PF00069	0.335
MOD_Plk_4	445	451	PF00069	0.356
MOD_ProDKin_1	72	78	PF00069	0.243
TRG_AP2beta_CARGO_1	181	191	PF09066	0.335
TRG_DiLeu_BaEn_1	183	188	PF01217	0.334
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.512
TRG_ENDOCYTIC_2	304	307	PF00928	0.546
TRG_ENDOCYTIC_2	39	42	PF00928	0.321
TRG_ENDOCYTIC_2	397	400	PF00928	0.270
TRG_ENDOCYTIC_2	430	433	PF00928	0.423
TRG_ENDOCYTIC_2	91	94	PF00928	0.365
TRG_ER_diArg_1	109	112	PF00400	0.292
TRG_ER_diArg_1	442	445	PF00400	0.480
TRG_NLS_MonoExtN_4	513	520	PF00514	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	23%	100%
A0A0N0P2E1	Leptomonas seymouri	54%	100%
A0A0N0P3Z7	Leptomonas seymouri	47%	69%
A0A0N0P4D8	Leptomonas seymouri	50%	72%
A0A0N0P5V6	Leptomonas seymouri	21%	92%
A0A0N1IG16	Leptomonas seymouri	73%	94%
A0A0N1P9H5	Leptomonas seymouri	46%	100%
A0A0S4JDF9	Bodo saltans	38%	100%
A0A0S4JEY7	Bodo saltans	39%	100%
A0A0S4JH90	Bodo saltans	34%	100%
A0A0S4JS00	Bodo saltans	32%	97%
A0A1X0NIR0	Trypanosomatidae	21%	100%
A0A1X0NLE0	Trypanosomatidae	58%	97%
A0A1X0NM05	Trypanosomatidae	59%	97%
A0A1X0NN62	Trypanosomatidae	53%	97%
A0A1X0P9L7	Trypanosomatidae	37%	96%
A0A381N054	Leishmania infantum	88%	94%
A0A3Q8IDK1	Leishmania donovani	46%	89%
A0A3Q8IK60	Leishmania donovani	87%	94%
A0A3Q8IWJ4	Leishmania donovani	86%	81%
A0A3R7KPU3	Trypanosoma rangeli	36%	96%
A0A3R7MGQ7	Trypanosoma rangeli	21%	100%
A0A3S7WY58	Leishmania donovani	24%	97%
A0A3S7XC27	Leishmania donovani	88%	94%
A0A422MNQ4	Trypanosoma rangeli	57%	97%
A0A422MRN5	Trypanosoma rangeli	63%	100%
A4HDC6	Leishmania braziliensis	22%	100%
A4HL65	Leishmania braziliensis	45%	100%
A4HQD6	Leishmania braziliensis	97%	100%
A4HQE7	Leishmania braziliensis	97%	100%
A4I0Q6	Leishmania infantum	24%	97%
A4I8N6	Leishmania infantum	46%	89%
A4IC83	Leishmania infantum	86%	81%
A4ZYQ5	Rattus norvegicus	22%	100%
A6ZT02	Saccharomyces cerevisiae (strain YJM789)	21%	92%
B4HNS1	Drosophila sechellia	24%	100%
C0SPB2	Bacillus subtilis (strain 168)	24%	100%
C7GWV6	Saccharomyces cerevisiae (strain JAY291)	21%	92%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AHY8	Leishmania infantum	91%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	94%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	94%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	87%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	99%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	85%
K0E3U9	Aspergillus rugulosus	22%	98%
O52733	Levilactobacillus brevis	23%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	95%
O62786	Sus scrofa	22%	100%
O62787	Sus scrofa	22%	100%
O65413	Arabidopsis thaliana	25%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P11166	Homo sapiens	24%	100%
P11167	Rattus norvegicus	24%	100%
P11168	Homo sapiens	22%	100%
P12336	Rattus norvegicus	23%	100%
P13355	Oryctolagus cuniculus	24%	100%
P13865	Leishmania enriettii	85%	94%
P14246	Mus musculus	21%	100%
P15686	Parachlorella kessleri	24%	99%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P17809	Mus musculus	23%	100%
P18631	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	94%
P20303	Sus scrofa	23%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	98%
P23586	Arabidopsis thaliana	25%	100%
P27674	Bos taurus	24%	100%
P28568	Gallus gallus	23%	100%
P32037	Mus musculus	23%	100%
P32465	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P32466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P32467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	92%
P38695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	90%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	94%
P40886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P43427	Rattus norvegicus	22%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	97%
P46333	Bacillus subtilis (strain 168)	23%	100%
P46896	Gallus gallus	23%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	96%
P53387	Kluyveromyces lactis	22%	94%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P54723	Bacillus subtilis (strain 168)	21%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	94%
P58351	Bos taurus	23%	100%
P58353	Bos taurus	22%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	97%
P79365	Ovis aries	24%	100%
Q01440	Leishmania donovani	24%	97%
Q01441	Leishmania donovani	46%	95%
Q06221	Trypanosoma brucei brucei	45%	100%
Q06222	Trypanosoma brucei brucei	48%	100%
Q07423	Ricinus communis	21%	100%
Q07647	Rattus norvegicus	23%	100%
Q09037	Trypanosoma brucei brucei	45%	100%
Q0JCR9	Oryza sativa subsp. japonica	22%	100%
Q0WVE9	Arabidopsis thaliana	25%	100%
Q27115	Trypanosoma vivax	47%	98%
Q39525	Parachlorella kessleri	24%	99%
Q41144	Ricinus communis	23%	100%
Q4Q0D0	Leishmania major	86%	100%
Q4Q0D1	Leishmania major	87%	100%
Q4Q0D2	Leishmania major	86%	100%
Q4Q4J1	Leishmania major	45%	100%
Q4QAR5	Leishmania major	23%	100%
Q6PXP3	Homo sapiens	22%	100%
Q6Z401	Oryza sativa subsp. japonica	24%	100%
Q7EZD7	Oryza sativa subsp. japonica	26%	100%
Q851G4	Oryza sativa subsp. japonica	23%	100%
Q8GW61	Arabidopsis thaliana	24%	100%
Q8L6Z8	Arabidopsis thaliana	22%	100%
Q8MKK4	Drosophila melanogaster	24%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q8WMN1	Ovis aries	23%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	89%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	96%
Q93Y91	Arabidopsis thaliana	24%	100%
Q94EC3	Oryza sativa subsp. japonica	25%	100%
Q94EC4	Oryza sativa subsp. japonica	23%	100%
Q9FYG3	Arabidopsis thaliana	22%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	95%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	97%
Q9WV38	Mus musculus	22%	100%
Q9XIH6	Arabidopsis thaliana	22%	100%
Q9XSC2	Oryctolagus cuniculus	24%	100%