Putative lmgt2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lmgt2

Gene product:

glucose transporter 3, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HQD6_LEIBR

TriTrypDb:

LbrM.35.6480 , LBRM2903_330007400

Length:

565

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 39
NetGPI	no	yes: 0, no: 39

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	40
GO:0110165	cellular anatomical entity	1	40
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

A4HQD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	15
GO:0008643	carbohydrate transport	5	15
GO:0051179	localization	1	15
GO:0051234	establishment of localization	2	15
GO:0071702	organic substance transport	4	15
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	40
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	40
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.564
CLV_C14_Caspase3-7	539	543	PF00656	0.642
CLV_NRD_NRD_1	114	116	PF00675	0.561
CLV_PCSK_KEX2_1	114	116	PF00082	0.485
CLV_PCSK_KEX2_1	246	248	PF00082	0.335
CLV_PCSK_KEX2_1	554	556	PF00082	0.521
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.348
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.521
CLV_PCSK_SKI1_1	402	406	PF00082	0.264
CLV_PCSK_SKI1_1	45	49	PF00082	0.338
CLV_PCSK_SKI1_1	95	99	PF00082	0.544
DEG_ODPH_VHL_1	372	383	PF01847	0.348
DOC_CDC14_PxL_1	335	343	PF14671	0.350
DOC_CYCLIN_RxL_1	399	409	PF00134	0.535
DOC_MAPK_gen_1	244	253	PF00069	0.483
DOC_MAPK_gen_1	471	480	PF00069	0.378
DOC_MAPK_HePTP_8	216	228	PF00069	0.435
DOC_MAPK_MEF2A_6	186	194	PF00069	0.477
DOC_MAPK_MEF2A_6	219	228	PF00069	0.319
DOC_MAPK_MEF2A_6	244	253	PF00069	0.493
DOC_MAPK_NFAT4_5	219	227	PF00069	0.388
DOC_PP1_RVXF_1	184	190	PF00149	0.476
DOC_PP4_FxxP_1	175	178	PF00568	0.455
DOC_PP4_FxxP_1	533	536	PF00568	0.349
DOC_SPAK_OSR1_1	219	223	PF12202	0.417
DOC_USP7_MATH_1	11	15	PF00917	0.565
DOC_USP7_MATH_1	178	182	PF00917	0.368
DOC_USP7_MATH_1	426	430	PF00917	0.346
DOC_USP7_UBL2_3	431	435	PF12436	0.300
LIG_14-3-3_CanoR_1	114	120	PF00244	0.354
LIG_14-3-3_CanoR_1	137	143	PF00244	0.315
LIG_14-3-3_CanoR_1	186	190	PF00244	0.501
LIG_14-3-3_CanoR_1	473	478	PF00244	0.476
LIG_BIR_II_1	1	5	PF00653	0.773
LIG_BIR_III_2	34	38	PF00653	0.550
LIG_BRCT_BRCA1_1	1	5	PF00533	0.555
LIG_BRCT_BRCA1_1	157	161	PF00533	0.284
LIG_BRCT_BRCA1_1	273	277	PF00533	0.305
LIG_BRCT_BRCA1_1	295	299	PF00533	0.455
LIG_BRCT_BRCA1_1	395	399	PF00533	0.420
LIG_BRCT_BRCA1_1	59	63	PF00533	0.359
LIG_deltaCOP1_diTrp_1	211	220	PF00928	0.326
LIG_FHA_1	246	252	PF00498	0.494
LIG_FHA_1	256	262	PF00498	0.255
LIG_FHA_1	301	307	PF00498	0.423
LIG_FHA_1	348	354	PF00498	0.354
LIG_FHA_1	439	445	PF00498	0.369
LIG_FHA_1	495	501	PF00498	0.279
LIG_FHA_2	19	25	PF00498	0.744
LIG_GBD_Chelix_1	166	174	PF00786	0.365
LIG_GBD_Chelix_1	179	187	PF00786	0.447
LIG_GBD_Chelix_1	48	56	PF00786	0.433
LIG_LIR_Apic_2	118	122	PF02991	0.330
LIG_LIR_Apic_2	173	178	PF02991	0.455
LIG_LIR_Gen_1	188	197	PF02991	0.347
LIG_LIR_Gen_1	211	221	PF02991	0.316
LIG_LIR_Gen_1	296	306	PF02991	0.382
LIG_LIR_Gen_1	331	342	PF02991	0.539
LIG_LIR_Nem_3	188	192	PF02991	0.349
LIG_LIR_Nem_3	209	215	PF02991	0.257
LIG_LIR_Nem_3	296	302	PF02991	0.365
LIG_LIR_Nem_3	331	335	PF02991	0.563
LIG_LIR_Nem_3	60	66	PF02991	0.336
LIG_LYPXL_S_1	424	428	PF13949	0.336
LIG_LYPXL_yS_3	425	428	PF13949	0.272
LIG_NRBOX	186	192	PF00104	0.562
LIG_NRBOX	297	303	PF00104	0.424
LIG_Pex14_2	295	299	PF04695	0.445
LIG_Pex14_2	407	411	PF04695	0.435
LIG_Pex14_2	446	450	PF04695	0.288
LIG_Pex14_2	466	470	PF04695	0.481
LIG_Pex14_2	533	537	PF04695	0.370
LIG_PTB_Apo_2	487	494	PF02174	0.318
LIG_PTB_Phospho_1	487	493	PF10480	0.358
LIG_SH2_CRK	119	123	PF00017	0.374
LIG_SH2_CRK	67	71	PF00017	0.363
LIG_SH2_STAP1	67	71	PF00017	0.386
LIG_SH2_STAT3	142	145	PF00017	0.269
LIG_SH2_STAT3	236	239	PF00017	0.496
LIG_SH2_STAT5	105	108	PF00017	0.324
LIG_SH2_STAT5	117	120	PF00017	0.329
LIG_SH2_STAT5	153	156	PF00017	0.160
LIG_SH2_STAT5	236	239	PF00017	0.450
LIG_SH2_STAT5	334	337	PF00017	0.601
LIG_SH2_STAT5	397	400	PF00017	0.531
LIG_SH2_STAT5	459	462	PF00017	0.381
LIG_SH3_3	228	234	PF00018	0.319
LIG_SH3_3	420	426	PF00018	0.308
LIG_SH3_3	488	494	PF00018	0.319
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.312
LIG_TRFH_1	532	536	PF08558	0.349
MOD_CK1_1	155	161	PF00069	0.285
MOD_CK1_1	300	306	PF00069	0.397
MOD_CK1_1	409	415	PF00069	0.395
MOD_CK1_1	558	564	PF00069	0.756
MOD_CK1_1	79	85	PF00069	0.222
MOD_CK2_1	11	17	PF00069	0.766
MOD_CK2_1	203	209	PF00069	0.436
MOD_Cter_Amidation	542	545	PF01082	0.462
MOD_Cter_Amidation	552	555	PF01082	0.548
MOD_GlcNHglycan	157	160	PF01048	0.425
MOD_GlcNHglycan	39	42	PF01048	0.415
MOD_GlcNHglycan	500	503	PF01048	0.450
MOD_GlcNHglycan	504	507	PF01048	0.451
MOD_GlcNHglycan	559	563	PF01048	0.546
MOD_GSK3_1	293	300	PF00069	0.348
MOD_GSK3_1	347	354	PF00069	0.328
MOD_GSK3_1	362	369	PF00069	0.241
MOD_GSK3_1	385	392	PF00069	0.342
MOD_GSK3_1	393	400	PF00069	0.320
MOD_GSK3_1	406	413	PF00069	0.246
MOD_GSK3_1	494	501	PF00069	0.319
MOD_GSK3_1	558	565	PF00069	0.745
MOD_GSK3_1	72	79	PF00069	0.181
MOD_GSK3_1	9	16	PF00069	0.740
MOD_GSK3_1	95	102	PF00069	0.240
MOD_N-GLC_2	490	492	PF02516	0.375
MOD_NEK2_1	161	166	PF00069	0.332
MOD_NEK2_1	170	175	PF00069	0.267
MOD_NEK2_1	179	184	PF00069	0.193
MOD_NEK2_1	271	276	PF00069	0.270
MOD_NEK2_1	310	315	PF00069	0.462
MOD_NEK2_1	347	352	PF00069	0.330
MOD_NEK2_1	386	391	PF00069	0.352
MOD_NEK2_1	39	44	PF00069	0.640
MOD_NEK2_1	406	411	PF00069	0.128
MOD_NEK2_1	71	76	PF00069	0.286
MOD_NEK2_2	294	299	PF00069	0.417
MOD_NEK2_2	397	402	PF00069	0.500
MOD_OFUCOSY	106	113	PF10250	0.486
MOD_PIKK_1	459	465	PF00454	0.352
MOD_PK_1	473	479	PF00069	0.424
MOD_PKA_2	138	144	PF00069	0.340
MOD_PKA_2	185	191	PF00069	0.508
MOD_PKB_1	471	479	PF00069	0.476
MOD_Plk_2-3	13	19	PF00069	0.656
MOD_Plk_4	161	167	PF00069	0.348
MOD_Plk_4	170	176	PF00069	0.294
MOD_Plk_4	185	191	PF00069	0.457
MOD_Plk_4	197	203	PF00069	0.287
MOD_Plk_4	294	300	PF00069	0.325
MOD_Plk_4	362	368	PF00069	0.276
MOD_Plk_4	393	399	PF00069	0.338
MOD_Plk_4	406	412	PF00069	0.286
MOD_Plk_4	473	479	PF00069	0.357
MOD_Plk_4	66	72	PF00069	0.339
MOD_SUMO_rev_2	19	28	PF00179	0.685
MOD_SUMO_rev_2	87	97	PF00179	0.193
TRG_AP2beta_CARGO_1	209	219	PF09066	0.336
TRG_DiLeu_BaEn_1	211	216	PF01217	0.335
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.514
TRG_ENDOCYTIC_2	332	335	PF00928	0.544
TRG_ENDOCYTIC_2	425	428	PF00928	0.272
TRG_ENDOCYTIC_2	458	461	PF00928	0.424
TRG_ENDOCYTIC_2	67	70	PF00928	0.325
TRG_ER_diArg_1	137	140	PF00400	0.293
TRG_ER_diArg_1	470	473	PF00400	0.482
TRG_NLS_MonoExtN_4	541	548	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
A0A0N0P2E1	Leptomonas seymouri	54%	100%
A0A0N0P3Z7	Leptomonas seymouri	48%	74%
A0A0N0P4D8	Leptomonas seymouri	49%	77%
A0A0N0P5V6	Leptomonas seymouri	21%	98%
A0A0N1IG16	Leptomonas seymouri	71%	100%
A0A0N1P9H5	Leptomonas seymouri	47%	100%
A0A0S4JDF9	Bodo saltans	39%	100%
A0A0S4JEY7	Bodo saltans	39%	100%
A0A0S4JH90	Bodo saltans	34%	100%
A0A0S4JS00	Bodo saltans	32%	100%
A0A1X0NIR0	Trypanosomatidae	22%	100%
A0A1X0NLE0	Trypanosomatidae	57%	100%
A0A1X0NM05	Trypanosomatidae	57%	100%
A0A1X0NN62	Trypanosomatidae	52%	100%
A0A1X0P9L7	Trypanosomatidae	37%	100%
A0A381N054	Leishmania infantum	86%	100%
A0A3Q8IDK1	Leishmania donovani	45%	95%
A0A3Q8IK60	Leishmania donovani	85%	100%
A0A3Q8IWJ4	Leishmania donovani	85%	87%
A0A3R7KPU3	Trypanosoma rangeli	34%	100%
A0A3R7MGQ7	Trypanosoma rangeli	21%	100%
A0A3S7WY58	Leishmania donovani	24%	100%
A0A3S7XC27	Leishmania donovani	86%	100%
A0A422MNQ4	Trypanosoma rangeli	56%	100%
A0A422MRN5	Trypanosoma rangeli	63%	100%
A4HDC6	Leishmania braziliensis	22%	100%
A4HL65	Leishmania braziliensis	43%	100%
A4HQD7	Leishmania braziliensis	97%	100%
A4HQE7	Leishmania braziliensis	98%	100%
A4I0Q6	Leishmania infantum	24%	100%
A4I8N6	Leishmania infantum	45%	95%
A4IC83	Leishmania infantum	85%	87%
B3NSE1	Drosophila erecta	25%	66%
B4HNS1	Drosophila sechellia	23%	100%
B4QBN3	Drosophila simulans	24%	100%
C0SPB2	Bacillus subtilis (strain 168)	25%	100%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	93%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	90%
K0E3U9	Aspergillus rugulosus	22%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
O62786	Sus scrofa	22%	100%
O62787	Sus scrofa	23%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P11166	Homo sapiens	23%	100%
P11167	Rattus norvegicus	22%	100%
P11168	Homo sapiens	22%	100%
P12336	Rattus norvegicus	22%	100%
P13355	Oryctolagus cuniculus	23%	100%
P13865	Leishmania enriettii	83%	100%
P14246	Mus musculus	20%	100%
P15686	Parachlorella kessleri	24%	100%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P18631	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
P20303	Sus scrofa	22%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P23586	Arabidopsis thaliana	25%	100%
P32465	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P32466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	95%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P40886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	99%
P43427	Rattus norvegicus	22%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P46333	Bacillus subtilis (strain 168)	23%	100%
P46896	Gallus gallus	23%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
P53387	Kluyveromyces lactis	22%	100%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54723	Bacillus subtilis (strain 168)	21%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P58351	Bos taurus	22%	100%
P58353	Bos taurus	22%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q01440	Leishmania donovani	24%	100%
Q01441	Leishmania donovani	45%	100%
Q06221	Trypanosoma brucei brucei	44%	100%
Q06222	Trypanosoma brucei brucei	46%	100%
Q09037	Trypanosoma brucei brucei	44%	100%
Q27115	Trypanosoma vivax	47%	100%
Q39525	Parachlorella kessleri	24%	100%
Q41144	Ricinus communis	23%	100%
Q4Q0D0	Leishmania major	85%	100%
Q4Q0D1	Leishmania major	85%	100%
Q4Q0D2	Leishmania major	85%	100%
Q4Q4J1	Leishmania major	43%	100%
Q4QAR5	Leishmania major	24%	100%
Q8L6Z8	Arabidopsis thaliana	22%	100%
Q8MKK4	Drosophila melanogaster	24%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q8WMN1	Ovis aries	23%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	95%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q94EC4	Oryza sativa subsp. japonica	23%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q9WV38	Mus musculus	22%	100%
Q9XIH6	Arabidopsis thaliana	23%	100%