Putative lmgt2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lmgt2

Gene product:

glucose transporter 3, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HQD6_LEIBR

TriTrypDb:

LbrM.35.6480 , LBRM2903_330007400

Length:

565

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 39
NetGPI	no	yes: 0, no: 39

Show entries

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	3
GO:0016020	membrane	2	40
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3
GO:0110165	cellular anatomical entity	1	40

Previous1Next

Expansion

Sequence features

A4HQD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD6

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	15
GO:0008643	carbohydrate transport	5	15
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0051179	localization	1	15
GO:0051234	establishment of localization	2	15
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	15

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	40
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0015578	mannose transmembrane transporter activity	7	1
GO:0022857	transmembrane transporter activity	2	40
GO:0051119	sugar transmembrane transporter activity	4	2

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.564
CLV_C14_Caspase3-7	539	543	PF00656	0.642
CLV_NRD_NRD_1	114	116	PF00675	0.561
CLV_PCSK_KEX2_1	114	116	PF00082	0.485
CLV_PCSK_KEX2_1	246	248	PF00082	0.335
CLV_PCSK_KEX2_1	554	556	PF00082	0.521
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.348
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.521
CLV_PCSK_SKI1_1	402	406	PF00082	0.264
CLV_PCSK_SKI1_1	45	49	PF00082	0.338

Previous1 2 3 4 5…16Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
A0A0N0P2E1	Leptomonas seymouri	54%	100%
A0A0N0P3Z7	Leptomonas seymouri	48%	74%
A0A0N0P4D8	Leptomonas seymouri	49%	77%
A0A0N0P5V6	Leptomonas seymouri	21%	98%
A0A0N1IG16	Leptomonas seymouri	71%	100%
A0A0N1P9H5	Leptomonas seymouri	47%	100%
A0A0S4JDF9	Bodo saltans	39%	100%
A0A0S4JEY7	Bodo saltans	39%	100%
A0A0S4JH90	Bodo saltans	34%	100%

Previous1 2 3 4 5…12Next