TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQD4_LEIBR

TriTrypDb:

LbrM.35.6460 , LBRM2903_350076200

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HQD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.440
CLV_NRD_NRD_1	310	312	PF00675	0.418
CLV_NRD_NRD_1	337	339	PF00675	0.416
CLV_PCSK_KEX2_1	112	114	PF00082	0.465
CLV_PCSK_KEX2_1	337	339	PF00082	0.323
CLV_PCSK_SKI1_1	315	319	PF00082	0.356
CLV_PCSK_SKI1_1	337	341	PF00082	0.301
CLV_TASPASE1	58	64	PF01112	0.639
DEG_SPOP_SBC_1	165	169	PF00917	0.720
DEG_SPOP_SBC_1	254	258	PF00917	0.641
DEG_SPOP_SBC_1	275	279	PF00917	0.771
DOC_CDC14_PxL_1	351	359	PF14671	0.364
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.564
DOC_PP4_FxxP_1	352	355	PF00568	0.431
DOC_USP7_MATH_1	165	169	PF00917	0.763
DOC_USP7_MATH_1	229	233	PF00917	0.623
DOC_USP7_MATH_1	254	258	PF00917	0.635
DOC_USP7_MATH_1	275	279	PF00917	0.804
DOC_USP7_MATH_1	4	8	PF00917	0.608
DOC_WW_Pin1_4	155	160	PF00397	0.717
DOC_WW_Pin1_4	268	273	PF00397	0.701
LIG_14-3-3_CanoR_1	295	303	PF00244	0.516
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BIR_III_2	288	292	PF00653	0.563
LIG_deltaCOP1_diTrp_1	101	107	PF00928	0.623
LIG_FHA_1	256	262	PF00498	0.689
LIG_FHA_1	351	357	PF00498	0.231
LIG_FHA_1	40	46	PF00498	0.626
LIG_FHA_2	115	121	PF00498	0.674
LIG_FHA_2	180	186	PF00498	0.627
LIG_FHA_2	65	71	PF00498	0.579
LIG_FHA_2	8	14	PF00498	0.564
LIG_LIR_Gen_1	104	115	PF02991	0.571
LIG_LIR_Nem_3	101	106	PF02991	0.576
LIG_LIR_Nem_3	149	155	PF02991	0.748
LIG_LIR_Nem_3	298	303	PF02991	0.497
LIG_LYPXL_SIV_4	72	80	PF13949	0.519
LIG_NRBOX	335	341	PF00104	0.499
LIG_PDZ_Class_2	359	364	PF00595	0.312
LIG_PTB_Apo_2	28	35	PF02174	0.512
LIG_PTB_Phospho_1	28	34	PF10480	0.511
LIG_SH2_CRK	307	311	PF00017	0.507
LIG_SH2_CRK	34	38	PF00017	0.528
LIG_SH2_GRB2like	319	322	PF00017	0.444
LIG_SH2_STAP1	293	297	PF00017	0.592
LIG_SH2_STAP1	73	77	PF00017	0.527
LIG_SH2_STAT5	307	310	PF00017	0.497
LIG_SH2_STAT5	319	322	PF00017	0.502
LIG_SH2_STAT5	345	348	PF00017	0.317
LIG_SH2_STAT5	97	100	PF00017	0.529
LIG_SH3_3	207	213	PF00018	0.636
LIG_SUMO_SIM_anti_2	89	96	PF11976	0.459
LIG_TRAF2_1	136	139	PF00917	0.634
LIG_TYR_ITIM	305	310	PF00017	0.486
LIG_UBA3_1	94	100	PF00899	0.576
MOD_CK1_1	127	133	PF00069	0.641
MOD_CK1_1	164	170	PF00069	0.632
MOD_CK1_1	2	8	PF00069	0.605
MOD_CK1_1	239	245	PF00069	0.695
MOD_CK1_1	246	252	PF00069	0.701
MOD_CK1_1	268	274	PF00069	0.753
MOD_CK1_1	83	89	PF00069	0.561
MOD_CK2_1	132	138	PF00069	0.638
MOD_CK2_1	16	22	PF00069	0.564
MOD_CK2_1	179	185	PF00069	0.624
MOD_CK2_1	281	287	PF00069	0.714
MOD_CK2_1	64	70	PF00069	0.589
MOD_CK2_1	83	89	PF00069	0.486
MOD_GlcNHglycan	134	137	PF01048	0.440
MOD_GlcNHglycan	155	158	PF01048	0.484
MOD_GlcNHglycan	163	166	PF01048	0.443
MOD_GlcNHglycan	168	171	PF01048	0.541
MOD_GlcNHglycan	188	191	PF01048	0.462
MOD_GlcNHglycan	2	5	PF01048	0.481
MOD_GlcNHglycan	201	204	PF01048	0.515
MOD_GlcNHglycan	218	221	PF01048	0.437
MOD_GlcNHglycan	231	234	PF01048	0.520
MOD_GlcNHglycan	238	241	PF01048	0.477
MOD_GlcNHglycan	248	251	PF01048	0.451
MOD_GSK3_1	153	160	PF00069	0.631
MOD_GSK3_1	16	23	PF00069	0.520
MOD_GSK3_1	161	168	PF00069	0.635
MOD_GSK3_1	186	193	PF00069	0.770
MOD_GSK3_1	216	223	PF00069	0.661
MOD_GSK3_1	239	246	PF00069	0.648
MOD_GSK3_1	249	256	PF00069	0.756
MOD_GSK3_1	267	274	PF00069	0.743
MOD_GSK3_1	276	283	PF00069	0.693
MOD_GSK3_1	35	42	PF00069	0.642
MOD_GSK3_1	64	71	PF00069	0.706
MOD_NEK2_1	132	137	PF00069	0.637
MOD_NEK2_1	153	158	PF00069	0.640
MOD_NEK2_1	199	204	PF00069	0.692
MOD_NEK2_1	20	25	PF00069	0.509
MOD_NEK2_1	255	260	PF00069	0.707
MOD_NEK2_1	265	270	PF00069	0.672
MOD_NEK2_1	35	40	PF00069	0.627
MOD_NEK2_1	350	355	PF00069	0.366
MOD_PIKK_1	255	261	PF00454	0.698
MOD_PKA_2	199	205	PF00069	0.745
MOD_PKA_2	280	286	PF00069	0.645
MOD_Plk_1	68	74	PF00069	0.605
MOD_Plk_1	83	89	PF00069	0.469
MOD_Plk_2-3	16	22	PF00069	0.564
MOD_Plk_4	106	112	PF00069	0.548
MOD_Plk_4	16	22	PF00069	0.562
MOD_Plk_4	193	199	PF00069	0.630
MOD_Plk_4	220	226	PF00069	0.663
MOD_Plk_4	47	53	PF00069	0.488
MOD_Plk_4	83	89	PF00069	0.583
MOD_ProDKin_1	155	161	PF00069	0.718
MOD_ProDKin_1	268	274	PF00069	0.703
MOD_SUMO_rev_2	156	165	PF00179	0.632
TRG_DiLeu_BaEn_1	16	21	PF01217	0.502
TRG_DiLeu_BaEn_1	331	336	PF01217	0.471
TRG_DiLeu_BaEn_1	89	94	PF01217	0.571
TRG_DiLeu_BaEn_4	331	337	PF01217	0.568
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.551
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.487
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.312
TRG_ENDOCYTIC_2	293	296	PF00928	0.578
TRG_ENDOCYTIC_2	300	303	PF00928	0.466
TRG_ENDOCYTIC_2	307	310	PF00928	0.404
TRG_ENDOCYTIC_2	34	37	PF00928	0.558
TRG_ER_diArg_1	111	113	PF00400	0.662
TRG_ER_diArg_1	336	338	PF00400	0.615
TRG_NES_CRM1_1	46	60	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I247	Leptomonas seymouri	37%	100%
A0A3S7XC14	Leishmania donovani	62%	100%
A4IE26	Leishmania infantum	62%	100%
E9AU50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q0E5	Leishmania major	64%	99%