Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQD3_LEIBR

TriTrypDb:

LbrM.35.6450 , LBRM2903_350076100

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.672
CLV_C14_Caspase3-7	161	165	PF00656	0.832
CLV_NRD_NRD_1	155	157	PF00675	0.608
CLV_NRD_NRD_1	324	326	PF00675	0.586
CLV_NRD_NRD_1	328	330	PF00675	0.561
CLV_NRD_NRD_1	481	483	PF00675	0.814
CLV_NRD_NRD_1	541	543	PF00675	0.594
CLV_NRD_NRD_1	567	569	PF00675	0.604
CLV_NRD_NRD_1	585	587	PF00675	0.553
CLV_NRD_NRD_1	690	692	PF00675	0.658
CLV_NRD_NRD_1	75	77	PF00675	0.781
CLV_NRD_NRD_1	751	753	PF00675	0.601
CLV_PCSK_FUR_1	153	157	PF00082	0.604
CLV_PCSK_KEX2_1	155	157	PF00082	0.608
CLV_PCSK_KEX2_1	307	309	PF00082	0.773
CLV_PCSK_KEX2_1	324	326	PF00082	0.539
CLV_PCSK_KEX2_1	328	330	PF00082	0.559
CLV_PCSK_KEX2_1	541	543	PF00082	0.623
CLV_PCSK_KEX2_1	567	569	PF00082	0.604
CLV_PCSK_KEX2_1	585	587	PF00082	0.553
CLV_PCSK_KEX2_1	690	692	PF00082	0.638
CLV_PCSK_KEX2_1	722	724	PF00082	0.605
CLV_PCSK_KEX2_1	75	77	PF00082	0.781
CLV_PCSK_KEX2_1	751	753	PF00082	0.601
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.608
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.784
CLV_PCSK_PC1ET2_1	722	724	PF00082	0.605
CLV_PCSK_PC7_1	324	330	PF00082	0.582
CLV_PCSK_SKI1_1	157	161	PF00082	0.593
CLV_PCSK_SKI1_1	440	444	PF00082	0.569
CLV_PCSK_SKI1_1	732	736	PF00082	0.599
DEG_MDM2_SWIB_1	217	225	PF02201	0.682
DEG_SCF_FBW7_1	386	391	PF00400	0.613
DOC_ANK_TNKS_1	689	696	PF00023	0.587
DOC_MAPK_HePTP_8	729	741	PF00069	0.595
DOC_MAPK_MEF2A_6	732	741	PF00069	0.591
DOC_MAPK_RevD_3	737	752	PF00069	0.589
DOC_PP2B_LxvP_1	473	476	PF13499	0.592
DOC_PP2B_LxvP_1	504	507	PF13499	0.579
DOC_USP7_MATH_1	108	112	PF00917	0.766
DOC_USP7_MATH_1	11	15	PF00917	0.716
DOC_USP7_MATH_1	121	125	PF00917	0.589
DOC_USP7_MATH_1	126	130	PF00917	0.521
DOC_USP7_MATH_1	133	137	PF00917	0.643
DOC_USP7_MATH_1	209	213	PF00917	0.518
DOC_USP7_MATH_1	250	254	PF00917	0.678
DOC_USP7_MATH_1	300	304	PF00917	0.573
DOC_USP7_MATH_1	316	320	PF00917	0.529
DOC_USP7_MATH_1	432	436	PF00917	0.770
DOC_USP7_MATH_1	457	461	PF00917	0.759
DOC_USP7_MATH_1	463	467	PF00917	0.724
DOC_USP7_MATH_1	556	560	PF00917	0.767
DOC_USP7_MATH_1	61	65	PF00917	0.699
DOC_USP7_MATH_1	71	75	PF00917	0.586
DOC_USP7_MATH_1	715	719	PF00917	0.843
DOC_USP7_MATH_1	728	732	PF00917	0.644
DOC_USP7_MATH_1	737	741	PF00917	0.548
DOC_WW_Pin1_4	142	147	PF00397	0.601
DOC_WW_Pin1_4	191	196	PF00397	0.674
DOC_WW_Pin1_4	2	7	PF00397	0.543
DOC_WW_Pin1_4	293	298	PF00397	0.812
DOC_WW_Pin1_4	360	365	PF00397	0.788
DOC_WW_Pin1_4	382	387	PF00397	0.661
DOC_WW_Pin1_4	411	416	PF00397	0.606
DOC_WW_Pin1_4	502	507	PF00397	0.836
DOC_WW_Pin1_4	618	623	PF00397	0.851
DOC_WW_Pin1_4	626	631	PF00397	0.720
DOC_WW_Pin1_4	647	652	PF00397	0.826
DOC_WW_Pin1_4	662	667	PF00397	0.584
DOC_WW_Pin1_4	689	694	PF00397	0.581
LIG_14-3-3_CanoR_1	138	144	PF00244	0.827
LIG_14-3-3_CanoR_1	181	186	PF00244	0.579
LIG_14-3-3_CanoR_1	291	297	PF00244	0.726
LIG_14-3-3_CanoR_1	317	321	PF00244	0.845
LIG_14-3-3_CanoR_1	34	38	PF00244	0.731
LIG_14-3-3_CanoR_1	402	411	PF00244	0.846
LIG_14-3-3_CanoR_1	440	449	PF00244	0.818
LIG_14-3-3_CanoR_1	568	574	PF00244	0.677
LIG_14-3-3_CanoR_1	591	595	PF00244	0.784
LIG_14-3-3_CanoR_1	640	645	PF00244	0.704
LIG_14-3-3_CanoR_1	75	82	PF00244	0.792
LIG_14-3-3_CanoR_1	759	767	PF00244	0.654
LIG_14-3-3_CanoR_1	773	778	PF00244	0.542
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BRCT_BRCA1_1	35	39	PF00533	0.727
LIG_BRCT_BRCA1_1	628	632	PF00533	0.601
LIG_deltaCOP1_diTrp_1	32	39	PF00928	0.730
LIG_FHA_1	107	113	PF00498	0.768
LIG_FHA_1	403	409	PF00498	0.810
LIG_FHA_1	489	495	PF00498	0.613
LIG_FHA_1	499	505	PF00498	0.565
LIG_FHA_1	559	565	PF00498	0.599
LIG_FHA_1	736	742	PF00498	0.586
LIG_FHA_1	759	765	PF00498	0.597
LIG_FHA_2	276	282	PF00498	0.557
LIG_FHA_2	33	39	PF00498	0.729
LIG_FHA_2	389	395	PF00498	0.622
LIG_FHA_2	412	418	PF00498	0.600
LIG_FHA_2	43	49	PF00498	0.516
LIG_FHA_2	521	527	PF00498	0.569
LIG_FHA_2	60	66	PF00498	0.633
LIG_IBAR_NPY_1	80	82	PF08397	0.796
LIG_LIR_Gen_1	102	108	PF02991	0.764
LIG_LIR_Gen_1	251	259	PF02991	0.584
LIG_LIR_Nem_3	201	207	PF02991	0.759
LIG_LIR_Nem_3	234	240	PF02991	0.506
LIG_LIR_Nem_3	251	257	PF02991	0.519
LIG_LIR_Nem_3	77	82	PF02991	0.791
LIG_PCNA_yPIPBox_3	493	504	PF02747	0.574
LIG_Pex14_2	217	221	PF04695	0.688
LIG_SH2_SRC	113	116	PF00017	0.542
LIG_SH2_STAP1	238	242	PF00017	0.524
LIG_SH2_STAP1	288	292	PF00017	0.577
LIG_SH2_STAT5	113	116	PF00017	0.795
LIG_SH2_STAT5	219	222	PF00017	0.430
LIG_SH3_2	81	86	PF14604	0.801
LIG_SH3_3	140	146	PF00018	0.786
LIG_SH3_3	221	227	PF00018	0.674
LIG_SH3_3	731	737	PF00018	0.745
LIG_SH3_3	78	84	PF00018	0.797
LIG_Sin3_3	529	536	PF02671	0.553
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.570
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.596
LIG_TRAF2_1	165	168	PF00917	0.786
LIG_TRAF2_2	607	612	PF00917	0.565
LIG_UBA3_1	487	493	PF00899	0.694
LIG_WW_3	505	509	PF00397	0.721
MOD_CDC14_SPxK_1	505	508	PF00782	0.782
MOD_CDK_SPK_2	145	150	PF00069	0.592
MOD_CDK_SPxK_1	502	508	PF00069	0.787
MOD_CDK_SPxxK_3	360	367	PF00069	0.712
MOD_CDK_SPxxK_3	626	633	PF00069	0.816
MOD_CK1_1	12	18	PF00069	0.584
MOD_CK1_1	142	148	PF00069	0.709
MOD_CK1_1	184	190	PF00069	0.804
MOD_CK1_1	194	200	PF00069	0.711
MOD_CK1_1	2	8	PF00069	0.573
MOD_CK1_1	231	237	PF00069	0.477
MOD_CK1_1	245	251	PF00069	0.656
MOD_CK1_1	25	31	PF00069	0.715
MOD_CK1_1	253	259	PF00069	0.797
MOD_CK1_1	287	293	PF00069	0.727
MOD_CK1_1	295	301	PF00069	0.783
MOD_CK1_1	347	353	PF00069	0.814
MOD_CK1_1	363	369	PF00069	0.561
MOD_CK1_1	397	403	PF00069	0.646
MOD_CK1_1	551	557	PF00069	0.860
MOD_CK1_1	559	565	PF00069	0.712
MOD_CK1_1	571	577	PF00069	0.522
MOD_CK1_1	600	606	PF00069	0.772
MOD_CK1_1	643	649	PF00069	0.602
MOD_CK1_1	74	80	PF00069	0.684
MOD_CK2_1	275	281	PF00069	0.559
MOD_CK2_1	388	394	PF00069	0.616
MOD_CK2_1	411	417	PF00069	0.567
MOD_CK2_1	42	48	PF00069	0.471
MOD_CK2_1	520	526	PF00069	0.571
MOD_CK2_1	59	65	PF00069	0.627
MOD_Cter_Amidation	153	156	PF01082	0.604
MOD_Cter_Amidation	480	483	PF01082	0.574
MOD_DYRK1A_RPxSP_1	293	297	PF00069	0.770
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	121	124	PF01048	0.626
MOD_GlcNHglycan	128	131	PF01048	0.621
MOD_GlcNHglycan	175	178	PF01048	0.642
MOD_GlcNHglycan	244	247	PF01048	0.703
MOD_GlcNHglycan	268	272	PF01048	0.603
MOD_GlcNHglycan	330	333	PF01048	0.771
MOD_GlcNHglycan	369	372	PF01048	0.726
MOD_GlcNHglycan	431	435	PF01048	0.707
MOD_GlcNHglycan	455	458	PF01048	0.651
MOD_GlcNHglycan	459	462	PF01048	0.593
MOD_GlcNHglycan	465	468	PF01048	0.660
MOD_GlcNHglycan	479	482	PF01048	0.497
MOD_GlcNHglycan	581	584	PF01048	0.665
MOD_GlcNHglycan	602	605	PF01048	0.835
MOD_GlcNHglycan	637	640	PF01048	0.781
MOD_GlcNHglycan	717	720	PF01048	0.845
MOD_GlcNHglycan	726	729	PF01048	0.709
MOD_GlcNHglycan	9	12	PF01048	0.727
MOD_GSK3_1	102	109	PF00069	0.513
MOD_GSK3_1	128	135	PF00069	0.736
MOD_GSK3_1	138	145	PF00069	0.584
MOD_GSK3_1	181	188	PF00069	0.717
MOD_GSK3_1	24	31	PF00069	0.531
MOD_GSK3_1	267	274	PF00069	0.720
MOD_GSK3_1	287	294	PF00069	0.497
MOD_GSK3_1	316	323	PF00069	0.819
MOD_GSK3_1	328	335	PF00069	0.645
MOD_GSK3_1	359	366	PF00069	0.815
MOD_GSK3_1	384	391	PF00069	0.613
MOD_GSK3_1	397	404	PF00069	0.550
MOD_GSK3_1	430	437	PF00069	0.791
MOD_GSK3_1	443	450	PF00069	0.551
MOD_GSK3_1	453	460	PF00069	0.776
MOD_GSK3_1	488	495	PF00069	0.696
MOD_GSK3_1	498	505	PF00069	0.767
MOD_GSK3_1	559	566	PF00069	0.669
MOD_GSK3_1	569	576	PF00069	0.766
MOD_GSK3_1	590	597	PF00069	0.651
MOD_GSK3_1	643	650	PF00069	0.590
MOD_GSK3_1	67	74	PF00069	0.731
MOD_GSK3_1	696	703	PF00069	0.596
MOD_GSK3_1	7	14	PF00069	0.768
MOD_GSK3_1	724	731	PF00069	0.857
MOD_N-GLC_1	600	605	PF02516	0.837
MOD_N-GLC_1	744	749	PF02516	0.730
MOD_NEK2_1	137	142	PF00069	0.661
MOD_NEK2_1	185	190	PF00069	0.636
MOD_NEK2_1	199	204	PF00069	0.482
MOD_NEK2_1	292	297	PF00069	0.560
MOD_NEK2_1	320	325	PF00069	0.590
MOD_NEK2_1	488	493	PF00069	0.824
MOD_NEK2_1	584	589	PF00069	0.660
MOD_NEK2_1	653	658	PF00069	0.579
MOD_NEK2_1	7	12	PF00069	0.533
MOD_NEK2_1	743	748	PF00069	0.588
MOD_NEK2_2	108	113	PF00069	0.772
MOD_NEK2_2	133	138	PF00069	0.645
MOD_PIKK_1	245	251	PF00454	0.797
MOD_PIKK_1	397	403	PF00454	0.602
MOD_PIKK_1	434	440	PF00454	0.829
MOD_PIKK_1	74	80	PF00454	0.528
MOD_PK_1	447	453	PF00069	0.558
MOD_PK_1	569	575	PF00069	0.602
MOD_PK_1	640	646	PF00069	0.591
MOD_PK_1	744	750	PF00069	0.726
MOD_PKA_1	328	334	PF00069	0.565
MOD_PKA_1	568	574	PF00069	0.601
MOD_PKA_2	137	143	PF00069	0.762
MOD_PKA_2	149	155	PF00069	0.577
MOD_PKA_2	292	298	PF00069	0.802
MOD_PKA_2	316	322	PF00069	0.843
MOD_PKA_2	328	334	PF00069	0.619
MOD_PKA_2	33	39	PF00069	0.729
MOD_PKA_2	394	400	PF00069	0.776
MOD_PKA_2	401	407	PF00069	0.824
MOD_PKA_2	559	565	PF00069	0.845
MOD_PKA_2	574	580	PF00069	0.609
MOD_PKA_2	584	590	PF00069	0.772
MOD_PKA_2	612	618	PF00069	0.798
MOD_PKA_2	635	641	PF00069	0.593
MOD_PKA_2	724	730	PF00069	0.857
MOD_PKA_2	74	80	PF00069	0.776
MOD_PKA_2	743	749	PF00069	0.528
MOD_PKA_2	758	764	PF00069	0.689
MOD_PKA_2	772	778	PF00069	0.620
MOD_Plk_1	133	139	PF00069	0.561
MOD_Plk_1	200	206	PF00069	0.527
MOD_Plk_1	347	353	PF00069	0.814
MOD_Plk_1	589	595	PF00069	0.868
MOD_Plk_1	744	750	PF00069	0.843
MOD_Plk_2-3	344	350	PF00069	0.811
MOD_Plk_4	102	108	PF00069	0.688
MOD_Plk_4	139	145	PF00069	0.825
MOD_Plk_4	200	206	PF00069	0.682
MOD_Plk_4	250	256	PF00069	0.828
MOD_Plk_4	300	306	PF00069	0.569
MOD_Plk_4	316	322	PF00069	0.528
MOD_Plk_4	499	505	PF00069	0.584
MOD_Plk_4	640	646	PF00069	0.603
MOD_ProDKin_1	142	148	PF00069	0.602
MOD_ProDKin_1	191	197	PF00069	0.673
MOD_ProDKin_1	2	8	PF00069	0.545
MOD_ProDKin_1	293	299	PF00069	0.815
MOD_ProDKin_1	360	366	PF00069	0.788
MOD_ProDKin_1	382	388	PF00069	0.657
MOD_ProDKin_1	411	417	PF00069	0.606
MOD_ProDKin_1	502	508	PF00069	0.839
MOD_ProDKin_1	618	624	PF00069	0.849
MOD_ProDKin_1	626	632	PF00069	0.722
MOD_ProDKin_1	647	653	PF00069	0.826
MOD_ProDKin_1	662	668	PF00069	0.586
MOD_ProDKin_1	689	695	PF00069	0.582
MOD_SUMO_for_1	682	685	PF00179	0.596
MOD_SUMO_for_1	91	94	PF00179	0.764
MOD_SUMO_rev_2	161	171	PF00179	0.575
MOD_SUMO_rev_2	262	269	PF00179	0.564
MOD_SUMO_rev_2	281	287	PF00179	0.494
MOD_SUMO_rev_2	352	362	PF00179	0.788
MOD_SUMO_rev_2	370	378	PF00179	0.547
TRG_ENDOCYTIC_2	229	232	PF00928	0.709
TRG_ER_diArg_1	541	543	PF00400	0.594
TRG_ER_diArg_1	584	586	PF00400	0.627
TRG_ER_diArg_1	723	726	PF00400	0.856
TRG_ER_diArg_1	751	753	PF00400	0.601
TRG_NLS_MonoExtC_3	721	726	PF00514	0.600
TRG_NLS_MonoExtN_4	153	159	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XC30	Leishmania donovani	58%	100%
A4IE25	Leishmania infantum	57%	100%
E9AU49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q0E6	Leishmania major	59%	98%