RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQD2_LEIBR

TriTrypDb:

LbrM.35.6440 , LBRM2903_350076000

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.867
CLV_NRD_NRD_1	115	117	PF00675	0.857
CLV_NRD_NRD_1	128	130	PF00675	0.603
CLV_NRD_NRD_1	257	259	PF00675	0.878
CLV_NRD_NRD_1	353	355	PF00675	0.846
CLV_NRD_NRD_1	431	433	PF00675	0.680
CLV_NRD_NRD_1	585	587	PF00675	0.833
CLV_PCSK_KEX2_1	115	117	PF00082	0.857
CLV_PCSK_KEX2_1	130	132	PF00082	0.570
CLV_PCSK_KEX2_1	257	259	PF00082	0.878
CLV_PCSK_KEX2_1	353	355	PF00082	0.846
CLV_PCSK_KEX2_1	431	433	PF00082	0.680
CLV_PCSK_KEX2_1	539	541	PF00082	0.860
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.833
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.860
CLV_PCSK_PC7_1	349	355	PF00082	0.851
CLV_PCSK_SKI1_1	116	120	PF00082	0.862
CLV_PCSK_SKI1_1	165	169	PF00082	0.853
CLV_PCSK_SKI1_1	224	228	PF00082	0.860
CLV_PCSK_SKI1_1	385	389	PF00082	0.669
CLV_Separin_Metazoa	428	432	PF03568	0.681
DEG_APCC_DBOX_1	348	356	PF00400	0.851
DEG_SCF_FBW7_1	319	324	PF00400	0.837
DEG_SCF_FBW7_1	527	534	PF00400	0.853
DOC_ANK_TNKS_1	257	264	PF00023	0.871
DOC_CKS1_1	341	346	PF01111	0.867
DOC_CKS1_1	506	511	PF01111	0.819
DOC_CKS1_1	528	533	PF01111	0.854
DOC_MAPK_gen_1	586	592	PF00069	0.842
DOC_PP2B_PxIxI_1	157	163	PF00149	0.877
DOC_PP4_FxxP_1	568	571	PF00568	0.792
DOC_USP7_MATH_1	137	141	PF00917	0.836
DOC_USP7_MATH_1	171	175	PF00917	0.848
DOC_USP7_MATH_1	178	182	PF00917	0.721
DOC_USP7_MATH_1	210	214	PF00917	0.840
DOC_USP7_MATH_1	218	222	PF00917	0.721
DOC_USP7_MATH_1	245	249	PF00917	0.869
DOC_USP7_MATH_1	272	276	PF00917	0.836
DOC_USP7_MATH_1	283	287	PF00917	0.655
DOC_USP7_MATH_1	33	37	PF00917	0.841
DOC_USP7_MATH_1	467	471	PF00917	0.653
DOC_USP7_MATH_1	497	501	PF00917	0.846
DOC_USP7_MATH_1	531	535	PF00917	0.858
DOC_USP7_MATH_1	541	545	PF00917	0.688
DOC_USP7_MATH_1	575	579	PF00917	0.829
DOC_USP7_MATH_1	71	75	PF00917	0.866
DOC_USP7_MATH_1	8	12	PF00917	0.660
DOC_WW_Pin1_4	153	158	PF00397	0.869
DOC_WW_Pin1_4	165	170	PF00397	0.643
DOC_WW_Pin1_4	27	32	PF00397	0.788
DOC_WW_Pin1_4	296	301	PF00397	0.831
DOC_WW_Pin1_4	317	322	PF00397	0.839
DOC_WW_Pin1_4	336	341	PF00397	0.527
DOC_WW_Pin1_4	36	41	PF00397	0.689
DOC_WW_Pin1_4	505	510	PF00397	0.812
DOC_WW_Pin1_4	527	532	PF00397	0.847
DOC_WW_Pin1_4	625	630	PF00397	0.837
DOC_WW_Pin1_4	661	666	PF00397	0.795
DOC_WW_Pin1_4	98	103	PF00397	0.830
LIG_14-3-3_CanoR_1	115	119	PF00244	0.859
LIG_14-3-3_CanoR_1	129	135	PF00244	0.592
LIG_14-3-3_CanoR_1	183	188	PF00244	0.855
LIG_14-3-3_CanoR_1	257	262	PF00244	0.874
LIG_14-3-3_CanoR_1	431	435	PF00244	0.681
LIG_14-3-3_CanoR_1	475	483	PF00244	0.734
LIG_14-3-3_CanoR_1	648	652	PF00244	0.752
LIG_14-3-3_CanoR_1	82	89	PF00244	0.848
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_CaM_IQ_9	391	406	PF13499	0.665
LIG_EVH1_1	43	47	PF00568	0.831
LIG_EVH1_2	506	510	PF00568	0.813
LIG_FHA_1	1	7	PF00498	0.671
LIG_FHA_1	104	110	PF00498	0.846
LIG_FHA_1	236	242	PF00498	0.862
LIG_FHA_1	244	250	PF00498	0.733
LIG_FHA_1	318	324	PF00498	0.839
LIG_FHA_1	506	512	PF00498	0.821
LIG_FHA_1	574	580	PF00498	0.827
LIG_FHA_1	656	662	PF00498	0.789
LIG_FHA_1	83	89	PF00498	0.845
LIG_FHA_2	232	238	PF00498	0.862
LIG_FHA_2	274	280	PF00498	0.846
LIG_GBD_Chelix_1	468	476	PF00786	0.664
LIG_LIR_Apic_2	41	46	PF02991	0.840
LIG_LIR_Apic_2	567	571	PF02991	0.788
LIG_LIR_Gen_1	13	23	PF02991	0.663
LIG_LIR_Gen_1	464	472	PF02991	0.656
LIG_LIR_Gen_1	559	569	PF02991	0.791
LIG_LIR_Gen_1	57	65	PF02991	0.730
LIG_LIR_Nem_3	464	469	PF02991	0.657
LIG_LIR_Nem_3	559	565	PF02991	0.792
LIG_LIR_Nem_3	57	62	PF02991	0.718
LIG_NRBOX	578	584	PF00104	0.839
LIG_PCNA_PIPBox_1	459	468	PF02747	0.664
LIG_PCNA_yPIPBox_3	453	466	PF02747	0.680
LIG_SH2_CRK	59	63	PF00017	0.726
LIG_SH2_NCK_1	562	566	PF00017	0.792
LIG_SH2_STAP1	372	376	PF00017	0.766
LIG_SH2_STAP1	405	409	PF00017	0.674
LIG_SH2_STAP1	523	527	PF00017	0.836
LIG_SH2_STAP1	562	566	PF00017	0.792
LIG_SH2_STAT3	523	526	PF00017	0.835
LIG_SH2_STAT5	630	633	PF00017	0.835
LIG_SH2_STAT5	9	12	PF00017	0.656
LIG_SH3_1	209	215	PF00018	0.841
LIG_SH3_3	147	153	PF00018	0.872
LIG_SH3_3	209	215	PF00018	0.841
LIG_SH3_3	41	47	PF00018	0.837
LIG_SH3_3	500	506	PF00018	0.826
LIG_SH3_3	525	531	PF00018	0.842
LIG_SH3_3	535	541	PF00018	0.683
LIG_SH3_3	547	553	PF00018	0.645
LIG_SH3_3	587	593	PF00018	0.836
LIG_SH3_3	605	611	PF00018	0.503
LIG_SUMO_SIM_anti_2	646	653	PF11976	0.759
LIG_SUMO_SIM_par_1	103	112	PF11976	0.845
LIG_TRAF2_1	443	446	PF00917	0.716
LIG_TRAF2_1	457	460	PF00917	0.438
LIG_TRAF2_1	48	51	PF00917	0.801
LIG_TRAF2_1	555	558	PF00917	0.806
LIG_TRAF2_2	593	598	PF00917	0.832
LIG_TYR_ITSM	558	565	PF00017	0.795
LIG_WRC_WIRS_1	323	328	PF05994	0.839
LIG_WRC_WIRS_1	565	570	PF05994	0.789
MOD_CDC14_SPxK_1	339	342	PF00782	0.861
MOD_CDC14_SPxK_1	39	42	PF00782	0.849
MOD_CDC14_SPxK_1	664	667	PF00782	0.798
MOD_CDK_SPxK_1	336	342	PF00069	0.860
MOD_CDK_SPxK_1	36	42	PF00069	0.848
MOD_CDK_SPxK_1	527	533	PF00069	0.852
MOD_CDK_SPxK_1	661	667	PF00069	0.798
MOD_CDK_SPxxK_3	27	34	PF00069	0.800
MOD_CK1_1	101	107	PF00069	0.538
MOD_CK1_1	111	117	PF00069	0.675
MOD_CK1_1	132	138	PF00069	0.838
MOD_CK1_1	140	146	PF00069	0.708
MOD_CK1_1	156	162	PF00069	0.596
MOD_CK1_1	181	187	PF00069	0.849
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	201	207	PF00069	0.505
MOD_CK1_1	248	254	PF00069	0.866
MOD_CK1_1	282	288	PF00069	0.846
MOD_CK1_1	292	298	PF00069	0.667
MOD_CK1_1	308	314	PF00069	0.571
MOD_CK1_1	336	342	PF00069	0.860
MOD_CK1_1	36	42	PF00069	0.848
MOD_CK1_1	577	583	PF00069	0.837
MOD_CK1_1	66	72	PF00069	0.832
MOD_CK1_1	84	90	PF00069	0.526
MOD_CK2_1	231	237	PF00069	0.862
MOD_CK2_1	273	279	PF00069	0.845
MOD_CK2_1	292	298	PF00069	0.510
MOD_CK2_1	552	558	PF00069	0.816
MOD_DYRK1A_RPxSP_1	165	169	PF00069	0.853
MOD_GlcNHglycan	142	145	PF01048	0.848
MOD_GlcNHglycan	165	168	PF01048	0.859
MOD_GlcNHglycan	183	186	PF01048	0.538
MOD_GlcNHglycan	195	198	PF01048	0.659
MOD_GlcNHglycan	200	203	PF01048	0.569
MOD_GlcNHglycan	216	219	PF01048	0.580
MOD_GlcNHglycan	250	253	PF01048	0.867
MOD_GlcNHglycan	254	257	PF01048	0.794
MOD_GlcNHglycan	264	267	PF01048	0.613
MOD_GlcNHglycan	269	273	PF01048	0.509
MOD_GlcNHglycan	281	284	PF01048	0.549
MOD_GlcNHglycan	285	288	PF01048	0.565
MOD_GlcNHglycan	291	294	PF01048	0.681
MOD_GlcNHglycan	405	408	PF01048	0.674
MOD_GlcNHglycan	53	56	PF01048	0.736
MOD_GlcNHglycan	579	582	PF01048	0.841
MOD_GlcNHglycan	598	601	PF01048	0.502
MOD_GlcNHglycan	614	617	PF01048	0.575
MOD_GlcNHglycan	77	80	PF01048	0.872
MOD_GSK3_1	125	132	PF00069	0.838
MOD_GSK3_1	183	190	PF00069	0.850
MOD_GSK3_1	210	217	PF00069	0.841
MOD_GSK3_1	231	238	PF00069	0.862
MOD_GSK3_1	248	255	PF00069	0.569
MOD_GSK3_1	268	275	PF00069	0.488
MOD_GSK3_1	278	285	PF00069	0.675
MOD_GSK3_1	289	296	PF00069	0.657
MOD_GSK3_1	301	308	PF00069	0.628
MOD_GSK3_1	309	316	PF00069	0.500
MOD_GSK3_1	317	324	PF00069	0.559
MOD_GSK3_1	336	343	PF00069	0.529
MOD_GSK3_1	34	41	PF00069	0.846
MOD_GSK3_1	368	375	PF00069	0.772
MOD_GSK3_1	492	499	PF00069	0.831
MOD_GSK3_1	522	529	PF00069	0.835
MOD_GSK3_1	552	559	PF00069	0.812
MOD_GSK3_1	560	567	PF00069	0.651
MOD_GSK3_1	571	578	PF00069	0.479
MOD_GSK3_1	69	76	PF00069	0.859
MOD_LATS_1	473	479	PF00433	0.688
MOD_N-GLC_1	122	127	PF02516	0.849
MOD_N-GLC_1	140	145	PF02516	0.528
MOD_N-GLC_1	368	373	PF02516	0.776
MOD_N-GLC_1	492	497	PF02516	0.824
MOD_NEK2_1	200	205	PF00069	0.864
MOD_NEK2_1	231	236	PF00069	0.864
MOD_NEK2_1	305	310	PF00069	0.842
MOD_NEK2_1	313	318	PF00069	0.709
MOD_NEK2_1	376	381	PF00069	0.726
MOD_NEK2_1	387	392	PF00069	0.473
MOD_NEK2_1	487	492	PF00069	0.814
MOD_NEK2_1	83	88	PF00069	0.847
MOD_NEK2_2	178	183	PF00069	0.846
MOD_NEK2_2	245	250	PF00069	0.870
MOD_NEK2_2	497	502	PF00069	0.848
MOD_PIKK_1	235	241	PF00454	0.859
MOD_PIKK_1	313	319	PF00454	0.847
MOD_PIKK_1	361	367	PF00454	0.814
MOD_PIKK_1	446	452	PF00454	0.706
MOD_PIKK_1	477	483	PF00454	0.748
MOD_PIKK_1	522	528	PF00454	0.833
MOD_PK_1	183	189	PF00069	0.850
MOD_PK_1	257	263	PF00069	0.871
MOD_PK_1	34	40	PF00069	0.846
MOD_PKA_1	129	135	PF00069	0.837
MOD_PKA_1	257	263	PF00069	0.871
MOD_PKA_2	114	120	PF00069	0.860
MOD_PKA_2	130	136	PF00069	0.558
MOD_PKA_2	231	237	PF00069	0.862
MOD_PKA_2	257	263	PF00069	0.871
MOD_PKA_2	345	351	PF00069	0.866
MOD_PKA_2	430	436	PF00069	0.682
MOD_PKA_2	532	538	PF00069	0.861
MOD_PKA_2	596	602	PF00069	0.832
MOD_PKA_2	647	653	PF00069	0.755
MOD_PKA_2	66	72	PF00069	0.832
MOD_PKA_2	81	87	PF00069	0.594
MOD_Plk_1	122	128	PF00069	0.846
MOD_Plk_1	171	177	PF00069	0.849
MOD_Plk_1	268	274	PF00069	0.837
MOD_Plk_1	368	374	PF00069	0.774
MOD_Plk_1	542	548	PF00069	0.872
MOD_Plk_1	556	562	PF00069	0.556
MOD_Plk_2-3	122	128	PF00069	0.846
MOD_Plk_4	183	189	PF00069	0.850
MOD_Plk_4	201	207	PF00069	0.539
MOD_Plk_4	372	378	PF00069	0.763
MOD_Plk_4	387	393	PF00069	0.404
MOD_Plk_4	461	467	PF00069	0.659
MOD_Plk_4	557	563	PF00069	0.798
MOD_Plk_4	564	570	PF00069	0.668
MOD_Plk_4	647	653	PF00069	0.755
MOD_Plk_4	655	661	PF00069	0.641
MOD_Plk_4	84	90	PF00069	0.841
MOD_ProDKin_1	153	159	PF00069	0.870
MOD_ProDKin_1	165	171	PF00069	0.641
MOD_ProDKin_1	27	33	PF00069	0.794
MOD_ProDKin_1	296	302	PF00069	0.831
MOD_ProDKin_1	317	323	PF00069	0.840
MOD_ProDKin_1	336	342	PF00069	0.528
MOD_ProDKin_1	36	42	PF00069	0.691
MOD_ProDKin_1	505	511	PF00069	0.817
MOD_ProDKin_1	527	533	PF00069	0.852
MOD_ProDKin_1	625	631	PF00069	0.837
MOD_ProDKin_1	661	667	PF00069	0.798
MOD_ProDKin_1	98	104	PF00069	0.830
TRG_ENDOCYTIC_2	405	408	PF00928	0.674
TRG_ENDOCYTIC_2	562	565	PF00928	0.791
TRG_ENDOCYTIC_2	59	62	PF00928	0.722
TRG_ENDOCYTIC_2	9	12	PF00928	0.656
TRG_ER_diArg_1	328	331	PF00400	0.834
TRG_ER_diArg_1	352	354	PF00400	0.853
TRG_ER_diArg_1	430	432	PF00400	0.683
TRG_NLS_Bipartite_1	115	133	PF00514	0.850
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.842
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.680