Putative centrin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative centrin

Gene product:

centrin-3

Species:

Leishmania braziliensis

UniProt:

A4HQD0_LEIBR

TriTrypDb:

LbrM.35.6420 , LBRM2903_350075600

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQD0

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.701
CLV_NRD_NRD_1	12	14	PF00675	0.727
CLV_NRD_NRD_1	63	65	PF00675	0.640
CLV_PCSK_KEX2_1	12	14	PF00082	0.727
CLV_PCSK_KEX2_1	121	123	PF00082	0.525
CLV_PCSK_KEX2_1	63	65	PF00082	0.527
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.525
CLV_PCSK_SKI1_1	122	126	PF00082	0.508
CLV_PCSK_SKI1_1	159	163	PF00082	0.563
CLV_PCSK_SKI1_1	16	20	PF00082	0.664
CLV_PCSK_SKI1_1	47	51	PF00082	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.711
DOC_WW_Pin1_4	39	44	PF00397	0.550
LIG_14-3-3_CanoR_1	122	131	PF00244	0.438
LIG_14-3-3_CanoR_1	71	80	PF00244	0.634
LIG_Actin_WH2_2	34	49	PF00022	0.626
LIG_APCC_ABBA_1	104	109	PF00400	0.636
LIG_FHA_1	156	162	PF00498	0.417
LIG_FHA_1	74	80	PF00498	0.522
LIG_FHA_2	40	46	PF00498	0.530
LIG_LIR_Gen_1	112	120	PF02991	0.527
LIG_LIR_Gen_1	155	163	PF02991	0.544
LIG_LIR_Gen_1	81	91	PF02991	0.524
LIG_LIR_Nem_3	101	107	PF02991	0.376
LIG_LIR_Nem_3	112	117	PF02991	0.498
LIG_LIR_Nem_3	27	33	PF02991	0.556
LIG_LIR_Nem_3	81	86	PF02991	0.511
LIG_TRAF2_1	153	156	PF00917	0.536
MOD_CK2_1	150	156	PF00069	0.524
MOD_CK2_1	78	84	PF00069	0.652
MOD_Cter_Amidation	10	13	PF01082	0.722
MOD_GSK3_1	1	8	PF00069	0.608
MOD_GSK3_1	105	112	PF00069	0.539
MOD_NEK2_1	1	6	PF00069	0.644
MOD_PKA_2	150	156	PF00069	0.560
MOD_Plk_2-3	113	119	PF00069	0.542
MOD_ProDKin_1	39	45	PF00069	0.548
MOD_SUMO_rev_2	113	123	PF00179	0.527
TRG_DiLeu_BaEn_3	155	161	PF01217	0.537
TRG_ER_diArg_1	12	14	PF00400	0.703
TRG_ER_diArg_1	62	64	PF00400	0.436
TRG_ER_diArg_1	87	90	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	33%	100%
A0A0N0P8Y6	Leptomonas seymouri	36%	91%
A0A0N1I2Q3	Leptomonas seymouri	36%	100%
A0A0N1IMR9	Leptomonas seymouri	85%	100%
A0A0N1PB14	Leptomonas seymouri	35%	78%
A0A0S4ILD1	Bodo saltans	55%	94%
A0A0S4INC8	Bodo saltans	38%	88%
A0A0S4IS38	Bodo saltans	33%	100%
A0A0S4J2T4	Bodo saltans	33%	96%
A0A0S4J7U6	Bodo saltans	40%	100%
A0A0S4JFC8	Bodo saltans	33%	97%
A0A0S4JFY6	Bodo saltans	27%	100%
A0A0S4JTP8	Bodo saltans	30%	100%
A0A0S4KIF8	Bodo saltans	33%	83%
A0A1X0NEW2	Trypanosomatidae	40%	86%
A0A1X0NM23	Trypanosomatidae	64%	99%
A0A1X0NMM5	Trypanosomatidae	33%	100%
A0A1X0NTH2	Trypanosomatidae	36%	100%
A0A1X0NVB5	Trypanosomatidae	30%	89%
A0A1X0P3L8	Trypanosomatidae	27%	100%
A0A1X0P9X3	Trypanosomatidae	37%	91%
A0A3Q8IHK5	Leishmania donovani	36%	91%
A0A3Q8IPV4	Leishmania donovani	93%	100%
A0A3R7K2E4	Trypanosoma rangeli	29%	100%
A0A3R7KFP2	Trypanosoma rangeli	60%	77%
A0A3R7M547	Trypanosoma rangeli	37%	100%
A0A3R7NPA6	Trypanosoma rangeli	27%	89%
A0A3S7WPW7	Leishmania donovani	35%	88%
A0A3S7WXD9	Leishmania donovani	35%	100%
A0A422MQ47	Trypanosoma rangeli	35%	100%
A0A422N487	Trypanosoma rangeli	36%	100%
A0A422N5Z1	Trypanosoma rangeli	39%	87%
A0A422P0I1	Trypanosoma rangeli	37%	91%
A2WN93	Oryza sativa subsp. indica	33%	100%
A2WNH1	Oryza sativa subsp. indica	32%	100%
A2Y609	Oryza sativa subsp. indica	33%	100%
A3E3H0	Pfiesteria piscicida	34%	100%
A3E4D8	Prorocentrum minimum	34%	100%
A3E4F9	Karlodinium veneficum	34%	100%
A4H522	Leishmania braziliensis	35%	100%
A4H5R9	Leishmania braziliensis	33%	100%
A4HAV0	Leishmania braziliensis	37%	100%
A4HCI2	Leishmania braziliensis	34%	100%
A4HT95	Leishmania infantum	35%	88%
A4HU13	Leishmania infantum	33%	100%
A4I000	Leishmania infantum	35%	100%
A4IA04	Leishmania infantum	36%	91%
A4IE23	Leishmania infantum	92%	100%
A4UHC0	Alexandrium fundyense	34%	100%
A8CEP3	Saccharina japonica	32%	100%
A8I1Q0	Heterocapsa triquetra	34%	100%
B1PSN3	Leishmania donovani	33%	100%
C9ZML6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
C9ZSQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZUM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	84%
D0A3W9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D0A8H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A9T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
E9AL84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	88%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ATE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
E9AU46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AVX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B525	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
J9W034	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	39%	95%
O00897	Dictyostelium discoideum	24%	100%
O02367	Ciona intestinalis	32%	100%
O15182	Homo sapiens	35%	99%
O16305	Caenorhabditis elegans	32%	100%
O23184	Arabidopsis thaliana	35%	99%
O23320	Arabidopsis thaliana	28%	100%
O35648	Mus musculus	35%	99%
O60041	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
O74435	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	94%
O82018	Mougeotia scalaris	32%	100%
O82659	Arabidopsis thaliana	32%	98%
O94739	Pleurotus ostreatus	33%	100%
O96081	Halocynthia roretzi	32%	100%
O96102	Physarum polycephalum	33%	100%
O97341	Suberites domuncula	32%	100%
P02585	Homo sapiens	26%	100%
P02586	Oryctolagus cuniculus	26%	100%
P02587	Sus scrofa	26%	100%
P02588	Gallus gallus	27%	100%
P02589	Pelophylax lessonae	26%	100%
P02591	Oryctolagus cuniculus	28%	100%
P02594	Electrophorus electricus	31%	100%
P02595	Patinopecten sp.	32%	100%
P02597	Gallus gallus	29%	100%
P02598	Tetrahymena pyriformis	32%	100%
P02599	Dictyostelium discoideum	32%	100%
P04352	Chlamydomonas reinhardtii	34%	100%
P04353	Spinacia oleracea	33%	100%
P04464	Triticum aestivum	33%	100%
P04630	Caenorhabditis elegans	29%	100%
P05419	Gallus gallus	32%	100%
P05434	Chlamydomonas reinhardtii	41%	98%
P05932	Arbacia punctulata	32%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P05936	Coturnix japonica	26%	100%
P06704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P06787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P07463	Paramecium tetraurelia	32%	100%
P09860	Gallus gallus	27%	100%
P0DH95	Arabidopsis thaliana	33%	100%
P0DH96	Arabidopsis thaliana	33%	100%
P0DH97	Arabidopsis thaliana	32%	100%
P0DH98	Arabidopsis thaliana	32%	100%
P0DP23	Homo sapiens	31%	100%
P0DP24	Homo sapiens	31%	100%
P0DP25	Homo sapiens	31%	100%
P0DP26	Mus musculus	31%	100%
P0DP27	Mus musculus	31%	100%
P0DP28	Mus musculus	31%	100%
P0DP29	Rattus norvegicus	31%	100%
P0DP30	Rattus norvegicus	31%	100%
P0DP31	Rattus norvegicus	31%	100%
P0DP33	Xenopus laevis	31%	100%
P0DP34	Xenopus laevis	31%	100%
P0DP35	Xenopus laevis	31%	100%
P10246	Meleagris gallopavo	27%	100%
P11118	Euglena gracilis	34%	100%
P11120	Pleurotus cornucopiae	32%	100%
P11121	Pyuridae sp.	32%	100%
P13868	Solanum tuberosum	30%	100%
P14533	Doryteuthis pealeii	29%	100%
P15094	Achlya klebsiana	31%	100%
P15159	Tachypleus tridentatus	28%	100%
P17928	Medicago sativa	33%	100%
P18061	Trypanosoma cruzi	33%	100%
P19123	Mus musculus	28%	100%
P20801	Mus musculus	26%	100%
P21251	Stichopus japonicus	31%	100%
P23286	Candida albicans	26%	100%
P24032	Gallus gallus	27%	96%
P24044	Plasmodium falciparum	33%	100%
P24844	Homo sapiens	28%	96%
P27161	Solanum lycopersicum	30%	100%
P27163	Petunia hybrida	30%	100%
P27164	Petunia hybrida	34%	90%
P27165	Phytophthora infestans	32%	100%
P27166	Stylonychia lemnae	33%	100%
P27482	Homo sapiens	32%	100%
P29269	Sus scrofa	28%	96%
P29289	Homarus americanus	28%	100%
P30187	Arabidopsis thaliana	29%	86%
P41040	Zea mays	32%	100%
P41041	Pneumocystis carinii	33%	100%
P41208	Homo sapiens	40%	96%
P41209	Mus musculus	41%	96%
P41210	Atriplex nummularia	34%	99%
P43645	Spermatozopsis similis	37%	100%
P43646	Tetraselmis striata	41%	100%
P48593	Drosophila melanogaster	28%	85%
P48976	Malus domestica	32%	100%
P49258	Drosophila melanogaster	31%	100%
P53440	Naegleria gruberi	34%	100%
P53441	Naegleria gruberi	36%	96%
P54213	Dunaliella salina	40%	98%
P59220	Arabidopsis thaliana	33%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	31%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
P61860	Colletotrichum trifolii	31%	100%
P61861	Colletotrichum gloeosporioides	31%	100%
P62144	Anas platyrhynchos	31%	100%
P62145	Aplysia californica	32%	100%
P62146	Arbacia punctulata	31%	100%
P62147	Branchiostoma floridae	32%	100%
P62148	Branchiostoma lanceolatum	32%	100%
P62149	Gallus gallus	31%	100%
P62150	Oryzias latipes	31%	100%
P62151	Tetronarce californica	31%	100%
P62152	Drosophila melanogaster	32%	100%
P62153	Halocynthia roretzi	32%	100%
P62154	Locusta migratoria	32%	100%
P62156	Oncorhynchus sp.	31%	100%
P62157	Bos taurus	31%	100%
P62160	Oryctolagus cuniculus	31%	100%
P62162	Hordeum vulgare	33%	100%
P62163	Glycine max	33%	100%
P62184	Renilla reniformis	32%	100%
P62199	Petunia hybrida	33%	100%
P62200	Daucus carota	33%	100%
P62201	Lilium longiflorum	33%	100%
P62202	Bryonia dioica	33%	100%
P62203	Plasmodium falciparum (isolate 3D7)	33%	100%
P63315	Bos taurus	27%	100%
P63316	Homo sapiens	28%	100%
P63317	Sus scrofa	27%	100%
P69097	Trypanosoma brucei brucei	32%	100%
P69098	Trypanosoma brucei gambiense	32%	100%
P84339	Agaricus bisporus	32%	100%
P93087	Capsicum annuum	32%	100%
P93171	Helianthus annuus	32%	100%
Q03509	Arabidopsis thaliana	33%	100%
Q06827	Scherffelia dubia	41%	98%
Q0IQB6	Oryza sativa subsp. japonica	28%	90%
Q0IUU4	Oryza sativa subsp. japonica	28%	90%
Q0JNL7	Oryza sativa subsp. japonica	32%	100%
Q0JNS6	Oryza sativa subsp. japonica	33%	100%
Q12798	Homo sapiens	41%	96%
Q24956	Giardia intestinalis	35%	94%
Q27177	Paramecium tetraurelia	31%	91%
Q27178	Paramecium tetraurelia	31%	90%
Q27179	Paramecium tetraurelia	31%	91%
Q2R1Z5	Oryza sativa subsp. japonica	27%	97%
Q2TBN3	Bos taurus	40%	96%
Q32LE3	Bos taurus	40%	96%
Q338P8	Oryza sativa subsp. japonica	34%	86%
Q39752	Fagus sylvatica	34%	100%
Q3SEK0	Paramecium tetraurelia	29%	95%
Q3SEK2	Paramecium tetraurelia	32%	90%
Q40302	Macrocystis pyrifera	32%	100%
Q40642	Oryza sativa subsp. indica	30%	88%
Q41420	Solanum tuberosum	33%	100%
Q4Q0E9	Leishmania major	92%	100%
Q4Q2W1	Leishmania major	37%	100%
Q4QBK6	Leishmania major	35%	100%
Q4QHT2	Leishmania major	33%	100%
Q4QIM0	Leishmania major	37%	100%
Q54IY3	Dictyostelium discoideum	26%	100%
Q568G4	Danio rerio	29%	99%
Q5RAD2	Pongo abelii	31%	100%
Q5RBA4	Pongo abelii	28%	96%
Q5U206	Rattus norvegicus	30%	100%
Q5ZD81	Oryza sativa subsp. japonica	30%	66%
Q64122	Rattus norvegicus	28%	96%
Q682T9	Arabidopsis thaliana	32%	100%
Q6AXQ2	Rattus norvegicus	29%	100%
Q6F332	Oryza sativa subsp. japonica	33%	100%
Q6IT78	Ctenopharyngodon idella	31%	100%
Q6L5F4	Oryza sativa subsp. japonica	29%	95%
Q6PI52	Danio rerio	31%	100%
Q6R520	Oreochromis mossambicus	31%	100%
Q6YNX6	Ovis aries	31%	100%
Q71UH5	Globisporangium splendens	32%	100%
Q71UH6	Perca flavescens	31%	100%
Q7DMN9	Solanum tuberosum	32%	100%
Q7DMP0	Solanum tuberosum	32%	100%
Q7F0J0	Oryza sativa subsp. japonica	34%	98%
Q7T3T2	Epinephelus akaara	30%	100%
Q7Y052	Euphorbia characias	33%	100%
Q7Z2B8	Dictyostelium discoideum	23%	100%
Q84MN0	Oryza sativa subsp. japonica	31%	100%
Q84VG0	Oryza sativa subsp. japonica	31%	100%
Q8K4K1	Mus musculus	44%	98%
Q8S1Y9	Oryza sativa subsp. japonica	30%	88%
Q8STF0	Strongylocentrotus intermedius	32%	100%
Q8VZ50	Arabidopsis thaliana	26%	100%
Q8X187	Paxillus involutus	32%	100%
Q94726	Paramecium tetraurelia	31%	91%
Q948R0	Oryza sativa subsp. japonica	25%	99%
Q94AZ4	Arabidopsis thaliana	29%	100%
Q95NI4	Halichondria okadai	32%	100%
Q95NR9	Metridium senile	32%	100%
Q96GE6	Homo sapiens	26%	84%
Q9BLG0	Todarodes pacificus	23%	100%
Q9BUY7	Homo sapiens	26%	100%
Q9CQ19	Mus musculus	28%	96%
Q9D6P8	Mus musculus	30%	100%
Q9GRJ1	Lumbricus rubellus	32%	100%
Q9HFY6	Blastocladiella emersonii	34%	100%
Q9LIK5	Arabidopsis thaliana	30%	95%
Q9LNE7	Arabidopsis thaliana	28%	100%
Q9M7R0	Olea europaea	27%	96%
Q9NZT1	Homo sapiens	30%	100%
Q9R1K9	Mus musculus	40%	96%
Q9S744	Arabidopsis thaliana	27%	100%
Q9U6D3	Myxine glutinosa	30%	100%
Q9UB37	Branchiostoma lanceolatum	31%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	100%
Q9XZP2	Branchiostoma floridae	32%	100%
V5BNS7	Trypanosoma cruzi	60%	99%
V5DQ66	Trypanosoma cruzi	40%	87%