Putative rab-like GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rab-like GTPase activating protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQC7_LEIBR

TriTrypDb:

LbrM.35.6390 , LBRM2903_350075300

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HQC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC7

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.603
CLV_NRD_NRD_1	127	129	PF00675	0.482
CLV_NRD_NRD_1	160	162	PF00675	0.392
CLV_NRD_NRD_1	41	43	PF00675	0.721
CLV_PCSK_KEX2_1	101	103	PF00082	0.615
CLV_PCSK_KEX2_1	127	129	PF00082	0.483
CLV_PCSK_KEX2_1	160	162	PF00082	0.374
CLV_PCSK_KEX2_1	395	397	PF00082	0.422
CLV_PCSK_KEX2_1	41	43	PF00082	0.497
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.489
CLV_PCSK_SKI1_1	233	237	PF00082	0.313
CLV_PCSK_SKI1_1	281	285	PF00082	0.415
CLV_PCSK_SKI1_1	362	366	PF00082	0.379
CLV_PCSK_SKI1_1	402	406	PF00082	0.373
CLV_Separin_Metazoa	230	234	PF03568	0.169
CLV_Separin_Metazoa	399	403	PF03568	0.393
DEG_APCC_DBOX_1	361	369	PF00400	0.413
DOC_CYCLIN_RxL_1	369	382	PF00134	0.169
DOC_MAPK_gen_1	127	137	PF00069	0.358
DOC_MAPK_gen_1	369	378	PF00069	0.203
DOC_MAPK_MEF2A_6	358	367	PF00069	0.251
DOC_MAPK_MEF2A_6	402	409	PF00069	0.422
DOC_PP1_RVXF_1	166	173	PF00149	0.280
DOC_PP1_RVXF_1	404	410	PF00149	0.451
DOC_PP2B_LxvP_1	36	39	PF13499	0.475
DOC_USP7_MATH_1	196	200	PF00917	0.295
DOC_USP7_MATH_1	387	391	PF00917	0.407
DOC_USP7_MATH_1	86	90	PF00917	0.672
DOC_USP7_UBL2_3	406	410	PF12436	0.408
DOC_WW_Pin1_4	81	86	PF00397	0.733
LIG_14-3-3_CanoR_1	191	196	PF00244	0.476
LIG_14-3-3_CanoR_1	306	310	PF00244	0.169
LIG_14-3-3_CanoR_1	374	379	PF00244	0.473
LIG_Actin_WH2_2	3	21	PF00022	0.447
LIG_AP2alpha_1	107	111	PF02296	0.382
LIG_APCC_ABBA_1	9	14	PF00400	0.683
LIG_BRCT_BRCA1_1	287	291	PF00533	0.255
LIG_Clathr_ClatBox_1	367	371	PF01394	0.368
LIG_CtBP_PxDLS_1	85	89	PF00389	0.452
LIG_deltaCOP1_diTrp_1	266	273	PF00928	0.416
LIG_eIF4E_1	339	345	PF01652	0.393
LIG_FHA_1	214	220	PF00498	0.358
LIG_FHA_1	256	262	PF00498	0.335
LIG_FHA_1	29	35	PF00498	0.725
LIG_FHA_1	380	386	PF00498	0.434
LIG_FHA_2	114	120	PF00498	0.469
LIG_FHA_2	143	149	PF00498	0.329
LIG_FHA_2	378	384	PF00498	0.357
LIG_IRF3_LxIS_1	401	408	PF10401	0.226
LIG_LIR_Gen_1	104	115	PF02991	0.371
LIG_LIR_Gen_1	145	155	PF02991	0.422
LIG_LIR_Gen_1	188	197	PF02991	0.238
LIG_LIR_Gen_1	268	277	PF02991	0.337
LIG_LIR_Gen_1	346	353	PF02991	0.404
LIG_LIR_Nem_3	145	150	PF02991	0.355
LIG_LIR_Nem_3	188	192	PF02991	0.260
LIG_LIR_Nem_3	267	273	PF02991	0.301
LIG_LIR_Nem_3	288	294	PF02991	0.362
LIG_LIR_Nem_3	334	339	PF02991	0.329
LIG_LIR_Nem_3	346	352	PF02991	0.373
LIG_LIR_Nem_3	355	360	PF02991	0.316
LIG_PCNA_PIPBox_1	309	318	PF02747	0.413
LIG_Pex14_1	357	361	PF04695	0.293
LIG_Pex14_2	107	111	PF04695	0.362
LIG_Pex14_2	287	291	PF04695	0.386
LIG_Pex14_2	332	336	PF04695	0.301
LIG_SH2_CRK	132	136	PF00017	0.269
LIG_SH2_CRK	189	193	PF00017	0.275
LIG_SH2_GRB2like	239	242	PF00017	0.291
LIG_SH2_GRB2like	339	342	PF00017	0.393
LIG_SH2_SRC	325	328	PF00017	0.169
LIG_SH2_STAP1	327	331	PF00017	0.257
LIG_SH2_STAT3	421	424	PF00017	0.441
LIG_SH2_STAT5	136	139	PF00017	0.416
LIG_SH2_STAT5	158	161	PF00017	0.523
LIG_SH2_STAT5	248	251	PF00017	0.300
LIG_SH2_STAT5	325	328	PF00017	0.341
LIG_SH2_STAT5	339	342	PF00017	0.334
LIG_SH2_STAT5	413	416	PF00017	0.251
LIG_SH3_3	160	166	PF00018	0.353
LIG_SH3_3	5	11	PF00018	0.644
LIG_SUMO_SIM_par_1	374	383	PF11976	0.477
LIG_SUMO_SIM_par_1	384	390	PF11976	0.385
LIG_TRAF2_1	390	393	PF00917	0.370
LIG_UBA3_1	367	372	PF00899	0.250
LIG_UBA3_1	384	389	PF00899	0.430
MOD_CK1_1	377	383	PF00069	0.366
MOD_CK1_1	408	414	PF00069	0.235
MOD_CK1_1	65	71	PF00069	0.666
MOD_CK1_1	80	86	PF00069	0.551
MOD_CK1_1	89	95	PF00069	0.445
MOD_CK2_1	113	119	PF00069	0.433
MOD_CK2_1	377	383	PF00069	0.423
MOD_CK2_1	387	393	PF00069	0.364
MOD_CK2_1	81	87	PF00069	0.677
MOD_GlcNHglycan	132	135	PF01048	0.284
MOD_GlcNHglycan	21	24	PF01048	0.529
MOD_GlcNHglycan	224	227	PF01048	0.295
MOD_GlcNHglycan	67	70	PF01048	0.669
MOD_GlcNHglycan	87	91	PF01048	0.632
MOD_GSK3_1	19	26	PF00069	0.664
MOD_GSK3_1	387	394	PF00069	0.511
MOD_GSK3_1	48	55	PF00069	0.700
MOD_GSK3_1	58	65	PF00069	0.664
MOD_GSK3_1	77	84	PF00069	0.644
MOD_N-GLC_2	56	58	PF02516	0.457
MOD_NEK2_1	175	180	PF00069	0.315
MOD_NEK2_1	210	215	PF00069	0.319
MOD_NEK2_1	255	260	PF00069	0.337
MOD_NEK2_1	305	310	PF00069	0.169
MOD_NEK2_1	405	410	PF00069	0.439
MOD_NEK2_2	331	336	PF00069	0.310
MOD_PIKK_1	191	197	PF00454	0.364
MOD_PIKK_1	77	83	PF00454	0.666
MOD_PKA_1	101	107	PF00069	0.352
MOD_PKA_2	305	311	PF00069	0.313
MOD_PKA_2	95	101	PF00069	0.570
MOD_Plk_1	86	92	PF00069	0.604
MOD_Plk_2-3	48	54	PF00069	0.541
MOD_Plk_4	185	191	PF00069	0.236
MOD_Plk_4	255	261	PF00069	0.307
MOD_Plk_4	331	337	PF00069	0.315
MOD_ProDKin_1	81	87	PF00069	0.730
MOD_SUMO_for_1	368	371	PF00179	0.316
MOD_SUMO_rev_2	194	202	PF00179	0.284
MOD_SUMO_rev_2	390	397	PF00179	0.437
TRG_DiLeu_BaEn_1	371	376	PF01217	0.310
TRG_DiLeu_BaEn_1	381	386	PF01217	0.345
TRG_DiLeu_LyEn_5	371	376	PF01217	0.310
TRG_ENDOCYTIC_2	132	135	PF00928	0.284
TRG_ENDOCYTIC_2	189	192	PF00928	0.317
TRG_ENDOCYTIC_2	313	316	PF00928	0.287
TRG_ENDOCYTIC_2	339	342	PF00928	0.356
TRG_ER_diArg_1	100	102	PF00400	0.617
TRG_ER_diArg_1	190	193	PF00400	0.169
TRG_NES_CRM1_1	250	265	PF08389	0.335
TRG_NLS_MonoExtN_4	127	132	PF00514	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T4	Leptomonas seymouri	53%	99%
A0A0N1PDX9	Leptomonas seymouri	41%	77%
A0A0S4II34	Bodo saltans	35%	100%
A0A0S4ITU5	Bodo saltans	27%	100%
A0A1X0NLM2	Trypanosomatidae	43%	100%
A0A1X0NLQ9	Trypanosomatidae	42%	100%
A0A3Q8IEG1	Leishmania donovani	27%	81%
A0A3S7X3S6	Leishmania donovani	26%	100%
A0A3S7XBZ8	Leishmania donovani	72%	100%
A0A3S7XC15	Leishmania donovani	40%	86%
A0A422NJ84	Trypanosoma rangeli	41%	100%
A0A422NJE8	Trypanosoma rangeli	43%	100%
A4HIL7	Leishmania braziliensis	25%	100%
A4HQC6	Leishmania braziliensis	41%	87%
A4I4L7	Leishmania infantum	27%	81%
A4I5W2	Leishmania infantum	25%	100%
A4IE19	Leishmania infantum	40%	86%
A4IE20	Leishmania infantum	72%	100%
D0A3X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AE15	Leishmania major	26%	81%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	76%
E9AU43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B157	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P58802	Mus musculus	32%	85%
Q09844	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	90%
Q4Q0F2	Leishmania major	71%	99%
Q4Q0F3	Leishmania major	37%	100%
Q6GL87	Xenopus tropicalis	29%	100%
Q9BXI6	Homo sapiens	32%	84%
Q9VGL8	Drosophila melanogaster	30%	100%
V5BT66	Trypanosoma cruzi	38%	100%