Putative rab-like GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

disgorgin, putative

Species:

Leishmania braziliensis

UniProt:

A4HQC6_LEIBR

TriTrypDb:

LbrM.35.6380 , LBRM2903_350075200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HQC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC6

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.581
CLV_C14_Caspase3-7	155	159	PF00656	0.570
CLV_C14_Caspase3-7	450	454	PF00656	0.456
CLV_NRD_NRD_1	108	110	PF00675	0.605
CLV_NRD_NRD_1	184	186	PF00675	0.452
CLV_NRD_NRD_1	193	195	PF00675	0.369
CLV_NRD_NRD_1	220	222	PF00675	0.381
CLV_NRD_NRD_1	462	464	PF00675	0.363
CLV_PCSK_KEX2_1	108	110	PF00082	0.615
CLV_PCSK_KEX2_1	184	186	PF00082	0.460
CLV_PCSK_KEX2_1	193	195	PF00082	0.375
CLV_PCSK_KEX2_1	376	378	PF00082	0.270
CLV_PCSK_KEX2_1	462	464	PF00082	0.385
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.270
CLV_PCSK_PC7_1	458	464	PF00082	0.320
CLV_PCSK_SKI1_1	194	198	PF00082	0.403
CLV_PCSK_SKI1_1	295	299	PF00082	0.289
CLV_PCSK_SKI1_1	346	350	PF00082	0.376
CLV_PCSK_SKI1_1	404	408	PF00082	0.258
CLV_PCSK_SKI1_1	419	423	PF00082	0.327
CLV_PCSK_SKI1_1	458	462	PF00082	0.345
CLV_Separin_Metazoa	459	463	PF03568	0.385
DEG_MDM2_SWIB_1	388	396	PF02201	0.372
DEG_MDM2_SWIB_1	414	421	PF02201	0.362
DEG_SCF_FBW7_1	81	88	PF00400	0.507
DOC_CKS1_1	134	139	PF01111	0.595
DOC_CKS1_1	63	68	PF01111	0.476
DOC_CYCLIN_RxL_1	400	411	PF00134	0.255
DOC_MAPK_gen_1	105	114	PF00069	0.450
DOC_MAPK_gen_1	373	383	PF00069	0.314
DOC_MAPK_gen_1	462	469	PF00069	0.328
DOC_PP1_RVXF_1	192	199	PF00149	0.355
DOC_PP1_RVXF_1	227	234	PF00149	0.240
DOC_PP1_RVXF_1	417	423	PF00149	0.279
DOC_PP1_RVXF_1	464	470	PF00149	0.437
DOC_USP7_MATH_1	447	451	PF00917	0.354
DOC_USP7_MATH_1	72	76	PF00917	0.641
DOC_USP7_UBL2_3	15	19	PF12436	0.485
DOC_USP7_UBL2_3	211	215	PF12436	0.388
DOC_USP7_UBL2_3	259	263	PF12436	0.372
DOC_WW_Pin1_4	133	138	PF00397	0.740
DOC_WW_Pin1_4	23	28	PF00397	0.653
DOC_WW_Pin1_4	40	45	PF00397	0.655
DOC_WW_Pin1_4	58	63	PF00397	0.536
DOC_WW_Pin1_4	81	86	PF00397	0.782
DOC_WW_Pin1_4	88	93	PF00397	0.665
LIG_14-3-3_CanoR_1	108	116	PF00244	0.513
LIG_14-3-3_CanoR_1	70	80	PF00244	0.573
LIG_14-3-3_CanoR_1	9	18	PF00244	0.503
LIG_BIR_III_4	138	142	PF00653	0.544
LIG_BRCT_BRCA1_1	389	393	PF00533	0.290
LIG_BRCT_BRCA1_1	42	46	PF00533	0.472
LIG_deltaCOP1_diTrp_1	195	205	PF00928	0.379
LIG_deltaCOP1_diTrp_1	416	422	PF00928	0.288
LIG_deltaCOP1_diTrp_1	479	487	PF00928	0.246
LIG_eIF4E_1	343	349	PF01652	0.356
LIG_eIF4E_1	361	367	PF01652	0.252
LIG_FHA_1	102	108	PF00498	0.505
LIG_FHA_1	277	283	PF00498	0.333
LIG_FHA_1	284	290	PF00498	0.339
LIG_FHA_1	393	399	PF00498	0.262
LIG_FHA_1	469	475	PF00498	0.317
LIG_FHA_2	122	128	PF00498	0.716
LIG_GBD_Chelix_1	317	325	PF00786	0.255
LIG_LIR_Gen_1	195	203	PF02991	0.404
LIG_LIR_Gen_1	239	247	PF02991	0.342
LIG_LIR_Gen_1	249	260	PF02991	0.256
LIG_LIR_Gen_1	390	401	PF02991	0.279
LIG_LIR_Gen_1	438	448	PF02991	0.246
LIG_LIR_Gen_1	479	488	PF02991	0.461
LIG_LIR_Nem_3	165	170	PF02991	0.414
LIG_LIR_Nem_3	226	231	PF02991	0.395
LIG_LIR_Nem_3	239	243	PF02991	0.341
LIG_LIR_Nem_3	249	255	PF02991	0.273
LIG_LIR_Nem_3	328	334	PF02991	0.279
LIG_LIR_Nem_3	390	396	PF02991	0.304
LIG_LIR_Nem_3	415	421	PF02991	0.289
LIG_LIR_Nem_3	54	60	PF02991	0.459
LIG_MAD2	58	66	PF02301	0.471
LIG_OCRL_FandH_1	330	342	PF00620	0.279
LIG_PALB2_WD40_1	388	396	PF16756	0.238
LIG_PAM2_1	383	395	PF00658	0.301
LIG_Pex14_1	410	414	PF04695	0.324
LIG_Pex14_1	418	422	PF04695	0.288
LIG_Pex14_2	349	353	PF04695	0.336
LIG_Pex14_2	388	392	PF04695	0.287
LIG_Pex14_2	393	397	PF04695	0.271
LIG_Pex14_2	414	418	PF04695	0.374
LIG_PTB_Apo_2	337	344	PF02174	0.411
LIG_PTB_Phospho_1	337	343	PF10480	0.411
LIG_SH2_CRK	57	61	PF00017	0.461
LIG_SH2_PTP2	252	255	PF00017	0.256
LIG_SH2_STAT5	182	185	PF00017	0.450
LIG_SH2_STAT5	252	255	PF00017	0.256
LIG_SH2_STAT5	310	313	PF00017	0.285
LIG_SH3_3	348	354	PF00018	0.265
LIG_SH3_3	38	44	PF00018	0.610
LIG_SH3_3	56	62	PF00018	0.441
LIG_SH3_3	66	72	PF00018	0.485
LIG_SH3_3	74	80	PF00018	0.707
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.537
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.326
LIG_SUMO_SIM_par_1	435	440	PF11976	0.463
LIG_SUMO_SIM_par_1	442	450	PF11976	0.410
LIG_TRAF2_1	326	329	PF00917	0.277
LIG_TRAF2_1	34	37	PF00917	0.623
LIG_TRAF2_1	50	53	PF00917	0.707
LIG_UBA3_1	370	376	PF00899	0.321
LIG_UBA3_1	444	449	PF00899	0.406
LIG_WRC_WIRS_1	237	242	PF05994	0.402
MOD_CDC14_SPxK_1	61	64	PF00782	0.477
MOD_CDK_SPK_2	62	67	PF00069	0.475
MOD_CDK_SPK_2	88	93	PF00069	0.492
MOD_CDK_SPxK_1	58	64	PF00069	0.475
MOD_CK1_1	11	17	PF00069	0.690
MOD_CK1_1	20	26	PF00069	0.670
MOD_CK2_1	121	127	PF00069	0.724
MOD_CK2_1	31	37	PF00069	0.538
MOD_CK2_1	47	53	PF00069	0.428
MOD_DYRK1A_RPxSP_1	58	62	PF00069	0.506
MOD_GlcNHglycan	246	251	PF01048	0.165
MOD_GlcNHglycan	33	36	PF01048	0.534
MOD_GlcNHglycan	81	84	PF01048	0.535
MOD_GSK3_1	117	124	PF00069	0.687
MOD_GSK3_1	17	24	PF00069	0.682
MOD_GSK3_1	242	249	PF00069	0.268
MOD_GSK3_1	383	390	PF00069	0.268
MOD_GSK3_1	58	65	PF00069	0.653
MOD_GSK3_1	81	88	PF00069	0.616
MOD_N-GLC_1	205	210	PF02516	0.474
MOD_N-GLC_2	148	150	PF02516	0.499
MOD_NEK2_1	1	6	PF00069	0.509
MOD_NEK2_1	107	112	PF00069	0.652
MOD_NEK2_1	236	241	PF00069	0.294
MOD_NEK2_1	273	278	PF00069	0.288
MOD_NEK2_1	283	288	PF00069	0.291
MOD_NEK2_1	31	36	PF00069	0.607
MOD_NEK2_1	387	392	PF00069	0.267
MOD_NEK2_2	392	397	PF00069	0.279
MOD_PIKK_1	107	113	PF00454	0.654
MOD_PIKK_1	121	127	PF00454	0.655
MOD_PIKK_1	320	326	PF00454	0.255
MOD_PIKK_1	387	393	PF00454	0.238
MOD_PKA_2	107	113	PF00069	0.547
MOD_PKA_2	141	147	PF00069	0.669
MOD_PKA_2	151	157	PF00069	0.615
MOD_PKA_2	372	378	PF00069	0.302
MOD_PKA_2	8	14	PF00069	0.475
MOD_Plk_1	327	333	PF00069	0.239
MOD_Plk_4	312	318	PF00069	0.295
MOD_Plk_4	327	333	PF00069	0.267
MOD_Plk_4	383	389	PF00069	0.298
MOD_Plk_4	392	398	PF00069	0.324
MOD_ProDKin_1	133	139	PF00069	0.740
MOD_ProDKin_1	23	29	PF00069	0.655
MOD_ProDKin_1	40	46	PF00069	0.657
MOD_ProDKin_1	58	64	PF00069	0.538
MOD_ProDKin_1	81	87	PF00069	0.781
MOD_ProDKin_1	88	94	PF00069	0.664
MOD_SUMO_for_1	429	432	PF00179	0.286
MOD_SUMO_rev_2	173	183	PF00179	0.534
MOD_SUMO_rev_2	450	457	PF00179	0.390
TRG_DiLeu_BaEn_1	432	437	PF01217	0.286
TRG_DiLeu_BaEn_2	482	488	PF01217	0.271
TRG_DiLeu_BaEn_4	432	438	PF01217	0.283
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.354
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.260
TRG_ENDOCYTIC_2	252	255	PF00928	0.298
TRG_ENDOCYTIC_2	57	60	PF00928	0.459
TRG_ER_diArg_1	107	109	PF00400	0.457
TRG_ER_diArg_1	183	185	PF00400	0.415
TRG_ER_diArg_1	192	194	PF00400	0.349
TRG_ER_diArg_1	461	463	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T4	Leptomonas seymouri	39%	100%
A0A0N1PDX9	Leptomonas seymouri	69%	89%
A0A0S4II34	Bodo saltans	53%	100%
A0A1X0NLQ9	Trypanosomatidae	64%	100%
A0A3S7XBZ8	Leishmania donovani	40%	100%
A0A3S7XC15	Leishmania donovani	79%	99%
A0A422NJE8	Trypanosoma rangeli	39%	100%
A4HQC7	Leishmania braziliensis	41%	100%
A4IE19	Leishmania infantum	79%	99%
A4IE20	Leishmania infantum	41%	100%
A6H7I8	Bos taurus	26%	71%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	88%
E9AU43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
M0R7T9	Rattus norvegicus	25%	71%
Q04322	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	68%
Q0IHY4	Xenopus tropicalis	27%	72%
Q4Q0F2	Leishmania major	38%	100%
Q4Q0F3	Leishmania major	79%	100%
Q9P2M4	Homo sapiens	26%	71%
Q9Y7J5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
V5BT66	Trypanosoma cruzi	62%	100%