MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 4 gamma 4

Species:

Leishmania braziliensis

UniProt:

A4HQC5_LEIBR

TriTrypDb:

LbrM.35.6370 , LBRM2903_350075100

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003743	translation initiation factor activity	4	8
GO:0005488	binding	1	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	182	188	PF00089	0.276
CLV_NRD_NRD_1	216	218	PF00675	0.367
CLV_NRD_NRD_1	320	322	PF00675	0.359
CLV_NRD_NRD_1	502	504	PF00675	0.601
CLV_NRD_NRD_1	54	56	PF00675	0.688
CLV_NRD_NRD_1	576	578	PF00675	0.422
CLV_NRD_NRD_1	85	87	PF00675	0.406
CLV_PCSK_KEX2_1	192	194	PF00082	0.457
CLV_PCSK_KEX2_1	218	220	PF00082	0.367
CLV_PCSK_KEX2_1	278	280	PF00082	0.457
CLV_PCSK_KEX2_1	320	322	PF00082	0.374
CLV_PCSK_KEX2_1	54	56	PF00082	0.507
CLV_PCSK_KEX2_1	576	578	PF00082	0.409
CLV_PCSK_KEX2_1	85	87	PF00082	0.436
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.457
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.367
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.457
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.507
CLV_PCSK_PC7_1	50	56	PF00082	0.486
CLV_PCSK_SKI1_1	239	243	PF00082	0.406
CLV_PCSK_SKI1_1	258	262	PF00082	0.406
CLV_PCSK_SKI1_1	422	426	PF00082	0.645
CLV_PCSK_SKI1_1	44	48	PF00082	0.620
CLV_PCSK_SKI1_1	565	569	PF00082	0.532
CLV_PCSK_SKI1_1	576	580	PF00082	0.477
CLV_PCSK_SKI1_1	739	743	PF00082	0.489
DEG_MDM2_SWIB_1	28	35	PF02201	0.636
DEG_MDM2_SWIB_1	665	673	PF02201	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.683
DOC_ANK_TNKS_1	439	446	PF00023	0.866
DOC_CYCLIN_RxL_1	41	48	PF00134	0.616
DOC_MAPK_DCC_7	54	64	PF00069	0.662
DOC_MAPK_gen_1	12	22	PF00069	0.698
DOC_MAPK_gen_1	217	226	PF00069	0.567
DOC_MAPK_MEF2A_6	119	126	PF00069	0.606
DOC_MAPK_MEF2A_6	55	64	PF00069	0.662
DOC_MAPK_MEF2A_6	556	564	PF00069	0.409
DOC_MAPK_RevD_3	264	279	PF00069	0.606
DOC_MAPK_RevD_3	40	55	PF00069	0.449
DOC_MAPK_RevD_3	60	75	PF00069	0.615
DOC_PP1_RVXF_1	318	325	PF00149	0.569
DOC_PP2B_LxvP_1	650	653	PF13499	0.598
DOC_PP4_FxxP_1	474	477	PF00568	0.731
DOC_PP4_MxPP_1	468	471	PF00568	0.743
DOC_PP4_MxPP_1	486	489	PF00568	0.669
DOC_SPAK_OSR1_1	323	327	PF12202	0.606
DOC_USP7_MATH_1	170	174	PF00917	0.476
DOC_USP7_MATH_1	243	247	PF00917	0.606
DOC_USP7_MATH_1	308	312	PF00917	0.606
DOC_USP7_MATH_1	339	343	PF00917	0.815
DOC_USP7_MATH_1	418	422	PF00917	0.702
DOC_USP7_MATH_1	493	497	PF00917	0.811
DOC_USP7_UBL2_3	93	97	PF12436	0.606
DOC_WW_Pin1_4	105	110	PF00397	0.567
DOC_WW_Pin1_4	253	258	PF00397	0.658
DOC_WW_Pin1_4	507	512	PF00397	0.716
LIG_14-3-3_CanoR_1	233	242	PF00244	0.657
LIG_14-3-3_CanoR_1	307	316	PF00244	0.582
LIG_14-3-3_CanoR_1	409	414	PF00244	0.708
LIG_14-3-3_CanoR_1	595	600	PF00244	0.453
LIG_AP2alpha_1	197	201	PF02296	0.606
LIG_APCC_ABBAyCdc20_2	737	743	PF00400	0.678
LIG_BIR_III_4	721	725	PF00653	0.410
LIG_BRCT_BRCA1_1	584	588	PF00533	0.589
LIG_CtBP_PxDLS_1	427	431	PF00389	0.766
LIG_deltaCOP1_diTrp_1	331	337	PF00928	0.606
LIG_deltaCOP1_diTrp_1	660	665	PF00928	0.493
LIG_deltaCOP1_diTrp_1	667	676	PF00928	0.445
LIG_EH1_1	323	331	PF00400	0.606
LIG_EVH1_2	470	474	PF00568	0.792
LIG_EVH1_2	477	481	PF00568	0.809
LIG_FHA_1	160	166	PF00498	0.624
LIG_FHA_1	245	251	PF00498	0.584
LIG_FHA_1	370	376	PF00498	0.645
LIG_FHA_1	46	52	PF00498	0.671
LIG_FHA_1	600	606	PF00498	0.525
LIG_FHA_1	668	674	PF00498	0.520
LIG_FHA_2	172	178	PF00498	0.476
LIG_FHA_2	19	25	PF00498	0.614
LIG_FHA_2	260	266	PF00498	0.606
LIG_FHA_2	568	574	PF00498	0.593
LIG_Integrin_isoDGR_2	183	185	PF01839	0.457
LIG_Integrin_RGD_1	433	435	PF01839	0.904
LIG_LIR_Apic_2	466	470	PF02991	0.652
LIG_LIR_Gen_1	136	146	PF02991	0.606
LIG_LIR_Gen_1	30	40	PF02991	0.636
LIG_LIR_Gen_1	454	463	PF02991	0.749
LIG_LIR_Gen_1	627	636	PF02991	0.543
LIG_LIR_Gen_1	662	673	PF02991	0.454
LIG_LIR_Gen_1	96	107	PF02991	0.567
LIG_LIR_Nem_3	132	138	PF02991	0.567
LIG_LIR_Nem_3	30	35	PF02991	0.638
LIG_LIR_Nem_3	303	309	PF02991	0.567
LIG_LIR_Nem_3	454	458	PF02991	0.700
LIG_LIR_Nem_3	611	616	PF02991	0.638
LIG_LIR_Nem_3	627	632	PF02991	0.413
LIG_LIR_Nem_3	648	654	PF02991	0.527
LIG_LIR_Nem_3	662	668	PF02991	0.417
LIG_LIR_Nem_3	736	741	PF02991	0.565
LIG_LIR_Nem_3	96	102	PF02991	0.567
LIG_PCNA_yPIPBox_3	39	50	PF02747	0.619
LIG_PDZ_Class_3	748	753	PF00595	0.719
LIG_Pex14_1	661	665	PF04695	0.494
LIG_Pex14_2	197	201	PF04695	0.606
LIG_Pex14_2	28	32	PF04695	0.628
LIG_Pex14_2	665	669	PF04695	0.476
LIG_PTB_Apo_2	220	227	PF02174	0.567
LIG_SH2_CRK	139	143	PF00017	0.575
LIG_SH2_CRK	467	471	PF00017	0.652
LIG_SH2_PTP2	561	564	PF00017	0.348
LIG_SH2_PTP2	651	654	PF00017	0.614
LIG_SH2_SRC	561	564	PF00017	0.435
LIG_SH2_SRC	646	649	PF00017	0.528
LIG_SH2_SRC	719	722	PF00017	0.390
LIG_SH2_STAP1	149	153	PF00017	0.606
LIG_SH2_STAP1	597	601	PF00017	0.511
LIG_SH2_STAP1	617	621	PF00017	0.272
LIG_SH2_STAT5	526	529	PF00017	0.508
LIG_SH2_STAT5	561	564	PF00017	0.377
LIG_SH2_STAT5	646	649	PF00017	0.528
LIG_SH2_STAT5	651	654	PF00017	0.614
LIG_SH2_STAT5	719	722	PF00017	0.642
LIG_SH3_1	467	473	PF00018	0.714
LIG_SH3_3	109	115	PF00018	0.577
LIG_SH3_3	199	205	PF00018	0.606
LIG_SH3_3	372	378	PF00018	0.639
LIG_SH3_3	467	473	PF00018	0.796
LIG_SH3_3	474	480	PF00018	0.796
LIG_SH3_3	484	490	PF00018	0.769
LIG_SH3_3	675	681	PF00018	0.482
LIG_Sin3_3	99	106	PF02671	0.657
LIG_SUMO_SIM_anti_2	686	692	PF11976	0.377
LIG_SUMO_SIM_par_1	240	247	PF11976	0.606
LIG_TRAF2_1	571	574	PF00917	0.504
LIG_UBA3_1	272	278	PF00899	0.572
LIG_UBA3_1	505	513	PF00899	0.642
LIG_UBA3_1	690	698	PF00899	0.557
MOD_CDC14_SPxK_1	510	513	PF00782	0.473
MOD_CDK_SPK_2	253	258	PF00069	0.657
MOD_CDK_SPxK_1	507	513	PF00069	0.647
MOD_CK1_1	171	177	PF00069	0.476
MOD_CK1_1	348	354	PF00069	0.862
MOD_CK1_1	355	361	PF00069	0.813
MOD_CK1_1	369	375	PF00069	0.710
MOD_CK1_1	376	382	PF00069	0.636
MOD_CK1_1	496	502	PF00069	0.633
MOD_CK1_1	582	588	PF00069	0.547
MOD_CK1_1	634	640	PF00069	0.447
MOD_CK1_1	671	677	PF00069	0.559
MOD_CK2_1	171	177	PF00069	0.476
MOD_CK2_1	356	362	PF00069	0.792
MOD_CK2_1	567	573	PF00069	0.576
MOD_Cter_Amidation	276	279	PF01082	0.406
MOD_GlcNHglycan	135	138	PF01048	0.406
MOD_GlcNHglycan	347	350	PF01048	0.795
MOD_GlcNHglycan	375	378	PF01048	0.887
MOD_GlcNHglycan	491	494	PF01048	0.785
MOD_GlcNHglycan	584	587	PF01048	0.561
MOD_GSK3_1	155	162	PF00069	0.476
MOD_GSK3_1	344	351	PF00069	0.848
MOD_GSK3_1	352	359	PF00069	0.790
MOD_GSK3_1	369	376	PF00069	0.884
MOD_GSK3_1	418	425	PF00069	0.866
MOD_GSK3_1	489	496	PF00069	0.733
MOD_GSK3_1	565	572	PF00069	0.518
MOD_GSK3_1	591	598	PF00069	0.501
MOD_GSK3_1	667	674	PF00069	0.374
MOD_N-GLC_1	309	314	PF02516	0.457
MOD_N-GLC_1	355	360	PF02516	0.824
MOD_N-GLC_1	369	374	PF02516	0.769
MOD_N-GLC_1	38	43	PF02516	0.621
MOD_N-GLC_1	731	736	PF02516	0.573
MOD_NEK2_1	168	173	PF00069	0.476
MOD_NEK2_1	197	202	PF00069	0.657
MOD_NEK2_1	28	33	PF00069	0.635
MOD_NEK2_1	309	314	PF00069	0.608
MOD_NEK2_1	579	584	PF00069	0.497
MOD_NEK2_1	640	645	PF00069	0.520
MOD_NEK2_1	712	717	PF00069	0.631
MOD_PIKK_1	456	462	PF00454	0.690
MOD_PIKK_1	493	499	PF00454	0.768
MOD_PIKK_1	712	718	PF00454	0.638
MOD_PK_1	409	415	PF00069	0.628
MOD_PKA_1	565	571	PF00069	0.568
MOD_PKA_2	28	34	PF00069	0.582
MOD_PKA_2	316	322	PF00069	0.559
MOD_PKA_2	366	372	PF00069	0.835
MOD_Plk_1	309	315	PF00069	0.657
MOD_Plk_1	38	44	PF00069	0.624
MOD_Plk_1	456	462	PF00069	0.758
MOD_Plk_2-3	569	575	PF00069	0.605
MOD_Plk_4	197	203	PF00069	0.657
MOD_Plk_4	301	307	PF00069	0.606
MOD_Plk_4	631	637	PF00069	0.533
MOD_Plk_4	668	674	PF00069	0.530
MOD_ProDKin_1	105	111	PF00069	0.567
MOD_ProDKin_1	253	259	PF00069	0.658
MOD_ProDKin_1	507	513	PF00069	0.726
MOD_SUMO_rev_2	429	439	PF00179	0.708
MOD_SUMO_rev_2	496	506	PF00179	0.615
TRG_DiLeu_BaEn_1	164	169	PF01217	0.657
TRG_DiLeu_BaEn_1	501	506	PF01217	0.649
TRG_DiLeu_BaEn_1	58	63	PF01217	0.687
TRG_DiLeu_BaEn_4	177	183	PF01217	0.476
TRG_ENDOCYTIC_2	139	142	PF00928	0.567
TRG_ENDOCYTIC_2	455	458	PF00928	0.663
TRG_ENDOCYTIC_2	561	564	PF00928	0.348
TRG_ENDOCYTIC_2	617	620	PF00928	0.482
TRG_ENDOCYTIC_2	651	654	PF00928	0.614
TRG_ENDOCYTIC_2	738	741	PF00928	0.600
TRG_ER_diArg_1	216	219	PF00400	0.567
TRG_ER_diArg_1	320	323	PF00400	0.574
TRG_ER_diArg_1	576	578	PF00400	0.409
TRG_ER_diArg_1	69	72	PF00400	0.672
TRG_ER_diArg_1	84	86	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL6	Leptomonas seymouri	66%	100%
A0A3Q8IJA9	Leishmania donovani	83%	99%
A4IE18	Leishmania infantum	83%	99%
D0A8R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AU41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q0F4	Leishmania major	82%	100%