Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQC4_LEIBR

TriTrypDb:

LbrM.35.6360 , LBRM2903_350075000

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC4

PDB structure(s): 7aih_An , 7am2_An , 7ane_An

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.426
CLV_C14_Caspase3-7	249	253	PF00656	0.553
CLV_NRD_NRD_1	145	147	PF00675	0.460
CLV_NRD_NRD_1	160	162	PF00675	0.459
CLV_NRD_NRD_1	17	19	PF00675	0.596
CLV_NRD_NRD_1	215	217	PF00675	0.561
CLV_NRD_NRD_1	296	298	PF00675	0.525
CLV_NRD_NRD_1	311	313	PF00675	0.500
CLV_PCSK_KEX2_1	145	147	PF00082	0.460
CLV_PCSK_KEX2_1	160	162	PF00082	0.445
CLV_PCSK_KEX2_1	310	312	PF00082	0.531
CLV_PCSK_SKI1_1	14	18	PF00082	0.630
CLV_PCSK_SKI1_1	195	199	PF00082	0.356
CLV_PCSK_SKI1_1	297	301	PF00082	0.520
DEG_APCC_DBOX_1	194	202	PF00400	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_ANK_TNKS_1	56	63	PF00023	0.508
DOC_PP1_RVXF_1	143	150	PF00149	0.473
DOC_USP7_MATH_1	197	201	PF00917	0.418
DOC_USP7_MATH_1	226	230	PF00917	0.429
DOC_USP7_UBL2_3	10	14	PF12436	0.703
DOC_WW_Pin1_4	149	154	PF00397	0.395
DOC_WW_Pin1_4	93	98	PF00397	0.572
LIG_14-3-3_CanoR_1	282	288	PF00244	0.496
LIG_14-3-3_CanoR_1	67	76	PF00244	0.446
LIG_AP_GAE_1	106	112	PF02883	0.518
LIG_CSL_BTD_1	82	85	PF09270	0.491
LIG_deltaCOP1_diTrp_1	265	268	PF00928	0.431
LIG_FHA_1	128	134	PF00498	0.383
LIG_FHA_1	3	9	PF00498	0.677
LIG_FHA_2	135	141	PF00498	0.422
LIG_FHA_2	170	176	PF00498	0.422
LIG_FHA_2	189	195	PF00498	0.422
LIG_FHA_2	39	45	PF00498	0.582
LIG_LIR_Apic_2	91	95	PF02991	0.563
LIG_LIR_Gen_1	106	116	PF02991	0.438
LIG_LIR_Gen_1	257	264	PF02991	0.451
LIG_LIR_Nem_3	106	112	PF02991	0.448
LIG_LIR_Nem_3	183	189	PF02991	0.572
LIG_LIR_Nem_3	79	84	PF02991	0.519
LIG_LYPXL_yS_3	81	84	PF13949	0.532
LIG_PCNA_yPIPBox_3	118	128	PF02747	0.436
LIG_Pex14_1	105	109	PF04695	0.428
LIG_Pex14_1	77	81	PF04695	0.495
LIG_PTB_Apo_2	162	169	PF02174	0.555
LIG_SH2_PTP2	92	95	PF00017	0.582
LIG_SH2_SRC	92	95	PF00017	0.605
LIG_SH2_STAP1	72	76	PF00017	0.579
LIG_SH2_STAT5	124	127	PF00017	0.411
LIG_SH2_STAT5	54	57	PF00017	0.535
LIG_SH2_STAT5	92	95	PF00017	0.606
LIG_SH3_1	232	238	PF00018	0.613
LIG_SH3_3	232	238	PF00018	0.514
LIG_SH3_3	269	275	PF00018	0.471
LIG_SH3_3	79	85	PF00018	0.468
LIG_SH3_3	91	97	PF00018	0.494
LIG_TRAF2_1	117	120	PF00917	0.549
LIG_TRAF2_1	299	302	PF00917	0.373
LIG_TRFH_1	186	190	PF08558	0.394
MOD_CDK_SPK_2	93	98	PF00069	0.604
MOD_CK2_1	114	120	PF00069	0.478
MOD_CK2_1	169	175	PF00069	0.435
MOD_CMANNOS	74	77	PF00535	0.440
MOD_GlcNHglycan	305	308	PF01048	0.491
MOD_GlcNHglycan	69	72	PF01048	0.451
MOD_GSK3_1	226	233	PF00069	0.537
MOD_GSK3_1	323	330	PF00069	0.687
MOD_GSK3_1	63	70	PF00069	0.441
MOD_N-GLC_1	283	288	PF02516	0.473
MOD_NEK2_1	134	139	PF00069	0.407
MOD_NEK2_1	2	7	PF00069	0.589
MOD_NEK2_1	207	212	PF00069	0.468
MOD_PIKK_1	134	140	PF00454	0.414
MOD_PIKK_1	76	82	PF00454	0.450
MOD_PIKK_1	8	14	PF00454	0.637
MOD_PKA_2	66	72	PF00069	0.452
MOD_Plk_1	169	175	PF00069	0.417
MOD_Plk_1	283	289	PF00069	0.476
MOD_Plk_2-3	169	175	PF00069	0.417
MOD_Plk_2-3	274	280	PF00069	0.514
MOD_Plk_4	120	126	PF00069	0.542
MOD_ProDKin_1	149	155	PF00069	0.389
MOD_ProDKin_1	93	99	PF00069	0.567
TRG_ENDOCYTIC_2	27	30	PF00928	0.477
TRG_ENDOCYTIC_2	81	84	PF00928	0.532
TRG_ER_diArg_1	144	146	PF00400	0.448
TRG_ER_diArg_1	160	162	PF00400	0.423
TRG_ER_diArg_1	310	312	PF00400	0.586
TRG_NLS_MonoExtC_3	17	22	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P900	Leptomonas seymouri	82%	100%
A0A0S4KF76	Bodo saltans	59%	100%
A0A1X0P370	Trypanosomatidae	63%	94%
A0A3R7NW18	Trypanosoma rangeli	65%	98%
A0A3S7XC20	Leishmania donovani	90%	100%
A4IE17	Leishmania infantum	90%	100%
D0A8R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9AU40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0F5	Leishmania major	89%	100%
V5BRZ1	Trypanosoma cruzi	67%	98%