Conserved oligomeric Golgi complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG (conserved oligomeric Golgi) complex component, COG2/Domain of unknown function (DUF3510), putative

Species:

Leishmania braziliensis

UniProt:

A4HQC3_LEIBR

TriTrypDb:

LbrM.35.6350 , LBRM2903_350074900

Length:

980

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	10
GO:0016020	membrane	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0017119	Golgi transport complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4HQC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	11
GO:0007030	Golgi organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.282
CLV_C14_Caspase3-7	393	397	PF00656	0.497
CLV_NRD_NRD_1	129	131	PF00675	0.347
CLV_NRD_NRD_1	804	806	PF00675	0.306
CLV_NRD_NRD_1	878	880	PF00675	0.279
CLV_NRD_NRD_1	962	964	PF00675	0.403
CLV_PCSK_KEX2_1	128	130	PF00082	0.407
CLV_PCSK_KEX2_1	482	484	PF00082	0.275
CLV_PCSK_KEX2_1	676	678	PF00082	0.681
CLV_PCSK_KEX2_1	877	879	PF00082	0.279
CLV_PCSK_KEX2_1	962	964	PF00082	0.403
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.275
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.526
CLV_PCSK_SKI1_1	30	34	PF00082	0.524
CLV_PCSK_SKI1_1	465	469	PF00082	0.481
CLV_PCSK_SKI1_1	482	486	PF00082	0.443
CLV_PCSK_SKI1_1	676	680	PF00082	0.561
CLV_PCSK_SKI1_1	709	713	PF00082	0.353
CLV_PCSK_SKI1_1	781	785	PF00082	0.292
CLV_PCSK_SKI1_1	932	936	PF00082	0.446
CLV_Separin_Metazoa	846	850	PF03568	0.292
DEG_APCC_DBOX_1	193	201	PF00400	0.410
DEG_APCC_DBOX_1	454	462	PF00400	0.372
DEG_APCC_DBOX_1	931	939	PF00400	0.443
DEG_SCF_FBW7_1	662	669	PF00400	0.448
DEG_SCF_FBW7_2	7	13	PF00400	0.510
DEG_SPOP_SBC_1	740	744	PF00917	0.504
DOC_CDC14_PxL_1	493	501	PF14671	0.432
DOC_CKS1_1	637	642	PF01111	0.350
DOC_CKS1_1	7	12	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.403
DOC_MAPK_DCC_7	289	298	PF00069	0.628
DOC_MAPK_gen_1	144	153	PF00069	0.355
DOC_MAPK_gen_1	482	488	PF00069	0.330
DOC_MAPK_gen_1	920	927	PF00069	0.279
DOC_MAPK_MEF2A_6	289	298	PF00069	0.392
DOC_MAPK_MEF2A_6	920	929	PF00069	0.286
DOC_MAPK_NFAT4_5	922	930	PF00069	0.304
DOC_PP1_RVXF_1	311	317	PF00149	0.390
DOC_PP2B_LxvP_1	943	946	PF13499	0.531
DOC_PP4_FxxP_1	953	956	PF00568	0.293
DOC_USP7_MATH_1	152	156	PF00917	0.369
DOC_USP7_MATH_1	25	29	PF00917	0.584
DOC_USP7_MATH_1	274	278	PF00917	0.673
DOC_USP7_MATH_1	297	301	PF00917	0.687
DOC_USP7_MATH_1	369	373	PF00917	0.430
DOC_USP7_MATH_1	397	401	PF00917	0.651
DOC_USP7_MATH_1	470	474	PF00917	0.390
DOC_USP7_MATH_1	594	598	PF00917	0.456
DOC_USP7_MATH_1	608	612	PF00917	0.464
DOC_USP7_MATH_1	666	670	PF00917	0.716
DOC_USP7_MATH_1	725	729	PF00917	0.574
DOC_USP7_MATH_1	740	744	PF00917	0.713
DOC_USP7_MATH_1	763	767	PF00917	0.436
DOC_USP7_MATH_1	830	834	PF00917	0.414
DOC_USP7_MATH_1	893	897	PF00917	0.466
DOC_USP7_MATH_1	97	101	PF00917	0.447
DOC_USP7_UBL2_3	224	228	PF12436	0.355
DOC_WW_Pin1_4	199	204	PF00397	0.258
DOC_WW_Pin1_4	21	26	PF00397	0.734
DOC_WW_Pin1_4	382	387	PF00397	0.357
DOC_WW_Pin1_4	40	45	PF00397	0.750
DOC_WW_Pin1_4	400	405	PF00397	0.629
DOC_WW_Pin1_4	419	424	PF00397	0.584
DOC_WW_Pin1_4	49	54	PF00397	0.741
DOC_WW_Pin1_4	6	11	PF00397	0.660
DOC_WW_Pin1_4	636	641	PF00397	0.383
DOC_WW_Pin1_4	662	667	PF00397	0.561
DOC_WW_Pin1_4	685	690	PF00397	0.649
DOC_WW_Pin1_4	889	894	PF00397	0.424
LIG_14-3-3_CanoR_1	323	331	PF00244	0.488
LIG_14-3-3_CanoR_1	348	353	PF00244	0.446
LIG_14-3-3_CanoR_1	471	480	PF00244	0.397
LIG_14-3-3_CanoR_1	587	595	PF00244	0.457
LIG_14-3-3_CanoR_1	644	648	PF00244	0.418
LIG_14-3-3_CanoR_1	774	780	PF00244	0.454
LIG_14-3-3_CanoR_1	781	790	PF00244	0.369
LIG_14-3-3_CanoR_1	798	808	PF00244	0.312
LIG_14-3-3_CanoR_1	911	915	PF00244	0.385
LIG_Actin_WH2_2	629	646	PF00022	0.377
LIG_Actin_WH2_2	650	665	PF00022	0.284
LIG_Actin_WH2_2	780	797	PF00022	0.197
LIG_APCC_ABBA_1	336	341	PF00400	0.473
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	50	54	PF00653	0.582
LIG_BRCT_BRCA1_1	1	5	PF00533	0.497
LIG_BRCT_BRCA1_1	112	116	PF00533	0.330
LIG_BRCT_BRCA1_1	17	21	PF00533	0.519
LIG_BRCT_BRCA1_1	445	449	PF00533	0.384
LIG_BRCT_BRCA1_1	630	634	PF00533	0.412
LIG_FHA_1	179	185	PF00498	0.410
LIG_FHA_1	313	319	PF00498	0.555
LIG_FHA_1	475	481	PF00498	0.366
LIG_FHA_1	488	494	PF00498	0.378
LIG_FHA_1	508	514	PF00498	0.200
LIG_FHA_1	695	701	PF00498	0.490
LIG_FHA_1	711	717	PF00498	0.527
LIG_FHA_1	750	756	PF00498	0.512
LIG_FHA_1	782	788	PF00498	0.197
LIG_FHA_1	922	928	PF00498	0.279
LIG_FHA_2	665	671	PF00498	0.591
LIG_FHA_2	7	13	PF00498	0.510
LIG_FHA_2	749	755	PF00498	0.373
LIG_FHA_2	914	920	PF00498	0.279
LIG_FHA_2	947	953	PF00498	0.518
LIG_IRF3_LxIS_1	698	703	PF10401	0.356
LIG_LIR_Apic_2	813	818	PF02991	0.264
LIG_LIR_Apic_2	952	956	PF02991	0.301
LIG_LIR_Gen_1	113	122	PF02991	0.353
LIG_LIR_Gen_1	181	191	PF02991	0.279
LIG_LIR_Gen_1	2	11	PF02991	0.618
LIG_LIR_Gen_1	238	249	PF02991	0.293
LIG_LIR_Gen_1	434	442	PF02991	0.288
LIG_LIR_Gen_1	631	642	PF02991	0.429
LIG_LIR_Gen_1	955	964	PF02991	0.490
LIG_LIR_Nem_3	113	119	PF02991	0.444
LIG_LIR_Nem_3	162	166	PF02991	0.193
LIG_LIR_Nem_3	181	186	PF02991	0.279
LIG_LIR_Nem_3	2	8	PF02991	0.620
LIG_LIR_Nem_3	446	452	PF02991	0.420
LIG_LIR_Nem_3	490	495	PF02991	0.418
LIG_LIR_Nem_3	512	518	PF02991	0.426
LIG_LIR_Nem_3	631	637	PF02991	0.441
LIG_LIR_Nem_3	84	90	PF02991	0.357
LIG_LIR_Nem_3	870	876	PF02991	0.299
LIG_LIR_Nem_3	955	961	PF02991	0.440
LIG_MYND_1	44	48	PF01753	0.521
LIG_MYND_1	505	509	PF01753	0.288
LIG_MYND_1	818	822	PF01753	0.378
LIG_NRBOX	261	267	PF00104	0.509
LIG_PCNA_PIPBox_1	622	631	PF02747	0.241
LIG_PCNA_yPIPBox_3	616	629	PF02747	0.235
LIG_PCNA_yPIPBox_3	841	849	PF02747	0.355
LIG_PDZ_Class_2	975	980	PF00595	0.637
LIG_Pex14_2	445	449	PF04695	0.460
LIG_Pex14_2	954	958	PF04695	0.498
LIG_PTAP_UEV_1	808	813	PF05743	0.239
LIG_SH2_CRK	137	141	PF00017	0.438
LIG_SH2_CRK	583	587	PF00017	0.363
LIG_SH2_CRK	651	655	PF00017	0.461
LIG_SH2_NCK_1	122	126	PF00017	0.301
LIG_SH2_NCK_1	252	256	PF00017	0.410
LIG_SH2_PTP2	815	818	PF00017	0.378
LIG_SH2_STAP1	163	167	PF00017	0.292
LIG_SH2_STAP1	252	256	PF00017	0.410
LIG_SH2_STAP1	546	550	PF00017	0.455
LIG_SH2_STAT3	619	622	PF00017	0.234
LIG_SH2_STAT5	166	169	PF00017	0.384
LIG_SH2_STAT5	245	248	PF00017	0.410
LIG_SH2_STAT5	365	368	PF00017	0.449
LIG_SH2_STAT5	619	622	PF00017	0.407
LIG_SH2_STAT5	815	818	PF00017	0.279
LIG_SH3_1	806	812	PF00018	0.250
LIG_SH3_3	34	40	PF00018	0.528
LIG_SH3_3	4	10	PF00018	0.508
LIG_SH3_3	417	423	PF00018	0.585
LIG_SH3_3	450	456	PF00018	0.479
LIG_SH3_3	491	497	PF00018	0.470
LIG_SH3_3	50	56	PF00018	0.631
LIG_SH3_3	529	535	PF00018	0.428
LIG_SH3_3	784	790	PF00018	0.197
LIG_SH3_3	806	812	PF00018	0.239
LIG_SH3_3	935	941	PF00018	0.534
LIG_SH3_3	970	976	PF00018	0.539
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.329
LIG_SUMO_SIM_anti_2	477	482	PF11976	0.385
LIG_SUMO_SIM_anti_2	547	555	PF11976	0.408
LIG_SUMO_SIM_anti_2	560	570	PF11976	0.429
LIG_SUMO_SIM_anti_2	696	704	PF11976	0.416
LIG_SUMO_SIM_par_1	547	555	PF11976	0.461
LIG_SUMO_SIM_par_1	696	704	PF11976	0.484
LIG_SUMO_SIM_par_1	941	947	PF11976	0.498
LIG_TRAF2_1	10	13	PF00917	0.505
LIG_TRAF2_1	24	27	PF00917	0.694
LIG_TRAF2_1	672	675	PF00917	0.514
LIG_TRAF2_1	895	898	PF00917	0.306
LIG_UBA3_1	338	343	PF00899	0.467
LIG_WRC_WIRS_1	708	713	PF05994	0.425
MOD_CDK_SPxxK_3	387	394	PF00069	0.427
MOD_CK1_1	100	106	PF00069	0.414
MOD_CK1_1	107	113	PF00069	0.413
MOD_CK1_1	115	121	PF00069	0.419
MOD_CK1_1	202	208	PF00069	0.480
MOD_CK1_1	219	225	PF00069	0.361
MOD_CK1_1	279	285	PF00069	0.647
MOD_CK1_1	287	293	PF00069	0.601
MOD_CK1_1	304	310	PF00069	0.495
MOD_CK1_1	317	323	PF00069	0.633
MOD_CK1_1	351	357	PF00069	0.543
MOD_CK1_1	382	388	PF00069	0.580
MOD_CK1_1	390	396	PF00069	0.592
MOD_CK1_1	399	405	PF00069	0.575
MOD_CK1_1	412	418	PF00069	0.691
MOD_CK1_1	597	603	PF00069	0.516
MOD_CK1_1	669	675	PF00069	0.699
MOD_CK1_1	684	690	PF00069	0.696
MOD_CK1_1	744	750	PF00069	0.655
MOD_CK1_1	766	772	PF00069	0.344
MOD_CK1_1	796	802	PF00069	0.279
MOD_CK1_1	810	816	PF00069	0.279
MOD_CK1_1	883	889	PF00069	0.292
MOD_CK1_1	944	950	PF00069	0.583
MOD_CK2_1	21	27	PF00069	0.763
MOD_CK2_1	525	531	PF00069	0.402
MOD_CK2_1	6	12	PF00069	0.510
MOD_CK2_1	669	675	PF00069	0.557
MOD_CK2_1	840	846	PF00069	0.255
MOD_CK2_1	892	898	PF00069	0.396
MOD_CK2_1	946	952	PF00069	0.526
MOD_GlcNHglycan	123	126	PF01048	0.352
MOD_GlcNHglycan	186	189	PF01048	0.282
MOD_GlcNHglycan	271	274	PF01048	0.639
MOD_GlcNHglycan	278	281	PF01048	0.765
MOD_GlcNHglycan	286	289	PF01048	0.648
MOD_GlcNHglycan	305	309	PF01048	0.456
MOD_GlcNHglycan	39	43	PF01048	0.644
MOD_GlcNHglycan	404	407	PF01048	0.586
MOD_GlcNHglycan	411	414	PF01048	0.538
MOD_GlcNHglycan	445	448	PF01048	0.329
MOD_GlcNHglycan	727	730	PF01048	0.552
MOD_GlcNHglycan	743	746	PF01048	0.783
MOD_GlcNHglycan	763	766	PF01048	0.476
MOD_GlcNHglycan	809	812	PF01048	0.300
MOD_GlcNHglycan	832	835	PF01048	0.463
MOD_GlcNHglycan	897	902	PF01048	0.461
MOD_GlcNHglycan	904	907	PF01048	0.236
MOD_GSK3_1	107	114	PF00069	0.306
MOD_GSK3_1	11	18	PF00069	0.764
MOD_GSK3_1	174	181	PF00069	0.424
MOD_GSK3_1	195	202	PF00069	0.324
MOD_GSK3_1	21	28	PF00069	0.593
MOD_GSK3_1	269	276	PF00069	0.614
MOD_GSK3_1	279	286	PF00069	0.707
MOD_GSK3_1	297	304	PF00069	0.441
MOD_GSK3_1	396	403	PF00069	0.693
MOD_GSK3_1	412	419	PF00069	0.612
MOD_GSK3_1	470	477	PF00069	0.376
MOD_GSK3_1	503	510	PF00069	0.293
MOD_GSK3_1	594	601	PF00069	0.321
MOD_GSK3_1	662	669	PF00069	0.695
MOD_GSK3_1	681	688	PF00069	0.749
MOD_GSK3_1	700	707	PF00069	0.362
MOD_GSK3_1	730	737	PF00069	0.607
MOD_GSK3_1	740	747	PF00069	0.688
MOD_GSK3_1	862	869	PF00069	0.279
MOD_GSK3_1	889	896	PF00069	0.386
MOD_GSK3_1	97	104	PF00069	0.351
MOD_LATS_1	346	352	PF00433	0.397
MOD_N-GLC_1	184	189	PF02516	0.374
MOD_N-GLC_1	3	8	PF02516	0.510
MOD_N-GLC_1	409	414	PF02516	0.634
MOD_N-GLC_1	835	840	PF02516	0.197
MOD_NEK2_1	381	386	PF00069	0.469
MOD_NEK2_1	488	493	PF00069	0.400
MOD_NEK2_1	518	523	PF00069	0.511
MOD_NEK2_1	628	633	PF00069	0.495
MOD_NEK2_1	643	648	PF00069	0.286
MOD_NEK2_1	738	743	PF00069	0.661
MOD_NEK2_1	835	840	PF00069	0.374
MOD_PIKK_1	154	160	PF00454	0.385
MOD_PIKK_1	219	225	PF00454	0.317
MOD_PIKK_1	465	471	PF00454	0.427
MOD_PIKK_1	766	772	PF00454	0.283
MOD_PIKK_1	883	889	PF00454	0.371
MOD_PK_1	289	295	PF00069	0.393
MOD_PKA_1	676	682	PF00069	0.532
MOD_PKA_2	322	328	PF00069	0.503
MOD_PKA_2	470	476	PF00069	0.406
MOD_PKA_2	565	571	PF00069	0.262
MOD_PKA_2	586	592	PF00069	0.458
MOD_PKA_2	643	649	PF00069	0.364
MOD_PKA_2	676	682	PF00069	0.679
MOD_PKA_2	749	755	PF00069	0.596
MOD_PKA_2	773	779	PF00069	0.480
MOD_PKA_2	804	810	PF00069	0.410
MOD_PKA_2	859	865	PF00069	0.410
MOD_PKA_2	910	916	PF00069	0.308
MOD_Plk_1	107	113	PF00069	0.364
MOD_Plk_1	195	201	PF00069	0.428
MOD_Plk_1	229	235	PF00069	0.197
MOD_Plk_1	3	9	PF00069	0.510
MOD_Plk_1	369	375	PF00069	0.416
MOD_Plk_1	733	739	PF00069	0.468
MOD_Plk_1	835	841	PF00069	0.274
MOD_Plk_1	869	875	PF00069	0.304
MOD_Plk_2-3	915	921	PF00069	0.279
MOD_Plk_4	138	144	PF00069	0.340
MOD_Plk_4	195	201	PF00069	0.391
MOD_Plk_4	216	222	PF00069	0.474
MOD_Plk_4	289	295	PF00069	0.466
MOD_Plk_4	361	367	PF00069	0.588
MOD_Plk_4	369	375	PF00069	0.485
MOD_Plk_4	457	463	PF00069	0.280
MOD_Plk_4	488	494	PF00069	0.484
MOD_Plk_4	509	515	PF00069	0.375
MOD_Plk_4	518	524	PF00069	0.342
MOD_Plk_4	525	531	PF00069	0.249
MOD_Plk_4	629	635	PF00069	0.406
MOD_Plk_4	643	649	PF00069	0.361
MOD_Plk_4	694	700	PF00069	0.452
MOD_Plk_4	810	816	PF00069	0.279
MOD_Plk_4	859	865	PF00069	0.296
MOD_Plk_4	880	886	PF00069	0.330
MOD_ProDKin_1	199	205	PF00069	0.258
MOD_ProDKin_1	21	27	PF00069	0.734
MOD_ProDKin_1	382	388	PF00069	0.358
MOD_ProDKin_1	40	46	PF00069	0.754
MOD_ProDKin_1	400	406	PF00069	0.627
MOD_ProDKin_1	419	425	PF00069	0.571
MOD_ProDKin_1	49	55	PF00069	0.743
MOD_ProDKin_1	6	12	PF00069	0.660
MOD_ProDKin_1	636	642	PF00069	0.375
MOD_ProDKin_1	662	668	PF00069	0.573
MOD_ProDKin_1	685	691	PF00069	0.642
MOD_ProDKin_1	889	895	PF00069	0.424
MOD_SUMO_rev_2	669	678	PF00179	0.513
TRG_DiLeu_BaEn_1	333	338	PF01217	0.472
TRG_DiLeu_BaEn_1	696	701	PF01217	0.279
TRG_DiLeu_BaEn_4	560	566	PF01217	0.520
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.546
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.416
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.228
TRG_ENDOCYTIC_2	137	140	PF00928	0.438
TRG_ENDOCYTIC_2	252	255	PF00928	0.322
TRG_ENDOCYTIC_2	436	439	PF00928	0.359
TRG_ENDOCYTIC_2	546	549	PF00928	0.447
TRG_ENDOCYTIC_2	583	586	PF00928	0.324
TRG_ENDOCYTIC_2	651	654	PF00928	0.458
TRG_ER_diArg_1	128	130	PF00400	0.347
TRG_ER_diArg_1	876	879	PF00400	0.279
TRG_ER_diArg_1	961	963	PF00400	0.395
TRG_NES_CRM1_1	209	223	PF08389	0.292
TRG_NES_CRM1_1	258	271	PF08389	0.394
TRG_NES_CRM1_1	777	792	PF08389	0.197
TRG_NES_CRM1_1	846	861	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.197

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C0	Leptomonas seymouri	58%	100%
A0A1X0P3C4	Trypanosomatidae	31%	100%
A0A3Q8II01	Leishmania donovani	75%	100%
A0A3R7L6I8	Trypanosoma rangeli	33%	100%
A4IE16	Leishmania infantum	75%	100%
D0A8R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0F6	Leishmania major	75%	100%
V5DND8	Trypanosoma cruzi	32%	100%