Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQC0_LEIBR

TriTrypDb:

LbrM.35.6320 , LBRM2903_350074600

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.556
CLV_NRD_NRD_1	134	136	PF00675	0.492
CLV_NRD_NRD_1	330	332	PF00675	0.616
CLV_NRD_NRD_1	376	378	PF00675	0.534
CLV_NRD_NRD_1	435	437	PF00675	0.579
CLV_NRD_NRD_1	441	443	PF00675	0.549
CLV_NRD_NRD_1	467	469	PF00675	0.644
CLV_NRD_NRD_1	494	496	PF00675	0.525
CLV_PCSK_FUR_1	257	261	PF00082	0.348
CLV_PCSK_KEX2_1	134	136	PF00082	0.495
CLV_PCSK_KEX2_1	259	261	PF00082	0.479
CLV_PCSK_KEX2_1	330	332	PF00082	0.616
CLV_PCSK_KEX2_1	376	378	PF00082	0.534
CLV_PCSK_KEX2_1	441	443	PF00082	0.636
CLV_PCSK_KEX2_1	467	469	PF00082	0.644
CLV_PCSK_KEX2_1	494	496	PF00082	0.525
CLV_PCSK_KEX2_1	553	555	PF00082	0.489
CLV_PCSK_KEX2_1	574	576	PF00082	0.490
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.486
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.489
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.490
CLV_PCSK_PC7_1	326	332	PF00082	0.479
CLV_PCSK_SKI1_1	234	238	PF00082	0.472
CLV_PCSK_SKI1_1	270	274	PF00082	0.452
CLV_PCSK_SKI1_1	307	311	PF00082	0.335
CLV_PCSK_SKI1_1	331	335	PF00082	0.495
CLV_PCSK_SKI1_1	377	381	PF00082	0.567
CLV_PCSK_SKI1_1	412	416	PF00082	0.631
CLV_PCSK_SKI1_1	550	554	PF00082	0.509
CLV_PCSK_SKI1_1	589	593	PF00082	0.540
DEG_APCC_DBOX_1	336	344	PF00400	0.375
DEG_APCC_DBOX_1	618	626	PF00400	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DEG_SPOP_SBC_1	398	402	PF00917	0.511
DEG_SPOP_SBC_1	459	463	PF00917	0.740
DEG_SPOP_SBC_1	483	487	PF00917	0.518
DOC_ANK_TNKS_1	5	12	PF00023	0.507
DOC_CKS1_1	73	78	PF01111	0.505
DOC_CYCLIN_RxL_1	406	417	PF00134	0.611
DOC_MAPK_gen_1	124	133	PF00069	0.427
DOC_MAPK_gen_1	249	258	PF00069	0.467
DOC_MAPK_gen_1	330	336	PF00069	0.495
DOC_MAPK_gen_1	441	448	PF00069	0.575
DOC_MAPK_gen_1	494	500	PF00069	0.491
DOC_MAPK_gen_1	565	573	PF00069	0.456
DOC_MAPK_MEF2A_6	565	573	PF00069	0.398
DOC_MAPK_RevD_3	363	377	PF00069	0.495
DOC_PP1_RVXF_1	556	563	PF00149	0.352
DOC_PP4_FxxP_1	469	472	PF00568	0.500
DOC_PP4_FxxP_1	57	60	PF00568	0.651
DOC_USP7_MATH_1	103	107	PF00917	0.805
DOC_USP7_MATH_1	13	17	PF00917	0.592
DOC_USP7_MATH_1	155	159	PF00917	0.348
DOC_USP7_MATH_1	29	33	PF00917	0.600
DOC_USP7_MATH_1	352	356	PF00917	0.488
DOC_USP7_MATH_1	428	432	PF00917	0.565
DOC_USP7_MATH_1	444	448	PF00917	0.587
DOC_USP7_MATH_1	458	462	PF00917	0.761
DOC_USP7_MATH_1	475	479	PF00917	0.521
DOC_USP7_MATH_1	482	486	PF00917	0.611
DOC_USP7_MATH_1	50	54	PF00917	0.513
DOC_USP7_MATH_1	511	515	PF00917	0.670
DOC_WW_Pin1_4	106	111	PF00397	0.655
DOC_WW_Pin1_4	381	386	PF00397	0.712
DOC_WW_Pin1_4	417	422	PF00397	0.615
DOC_WW_Pin1_4	424	429	PF00397	0.594
DOC_WW_Pin1_4	46	51	PF00397	0.654
DOC_WW_Pin1_4	468	473	PF00397	0.681
DOC_WW_Pin1_4	516	521	PF00397	0.621
DOC_WW_Pin1_4	72	77	PF00397	0.673
LIG_14-3-3_CanoR_1	211	218	PF00244	0.471
LIG_14-3-3_CanoR_1	275	283	PF00244	0.567
LIG_14-3-3_CanoR_1	412	421	PF00244	0.649
LIG_14-3-3_CanoR_1	436	440	PF00244	0.513
LIG_14-3-3_CanoR_1	494	500	PF00244	0.594
LIG_14-3-3_CanoR_1	619	625	PF00244	0.451
LIG_Actin_WH2_2	237	254	PF00022	0.332
LIG_BRCT_BRCA1_1	620	624	PF00533	0.590
LIG_Clathr_ClatBox_1	404	408	PF01394	0.629
LIG_FHA_1	18	24	PF00498	0.541
LIG_FHA_1	211	217	PF00498	0.488
LIG_FHA_1	218	224	PF00498	0.376
LIG_FHA_1	236	242	PF00498	0.408
LIG_FHA_1	399	405	PF00498	0.520
LIG_FHA_1	599	605	PF00498	0.431
LIG_FHA_1	612	618	PF00498	0.438
LIG_FHA_2	134	140	PF00498	0.487
LIG_FHA_2	147	153	PF00498	0.487
LIG_FHA_2	155	161	PF00498	0.518
LIG_FHA_2	165	171	PF00498	0.422
LIG_FHA_2	193	199	PF00498	0.485
LIG_FHA_2	260	266	PF00498	0.487
LIG_FHA_2	290	296	PF00498	0.394
LIG_FHA_2	484	490	PF00498	0.675
LIG_FHA_2	494	500	PF00498	0.622
LIG_FHA_2	508	514	PF00498	0.672
LIG_FHA_2	529	535	PF00498	0.707
LIG_LIR_Apic_2	56	60	PF02991	0.637
LIG_LIR_Gen_1	225	236	PF02991	0.511
LIG_LIR_Gen_1	359	370	PF02991	0.479
LIG_LIR_Nem_3	225	231	PF02991	0.450
LIG_LIR_Nem_3	247	251	PF02991	0.465
LIG_LIR_Nem_3	253	258	PF02991	0.500
LIG_LIR_Nem_3	359	365	PF02991	0.478
LIG_LIR_Nem_3	534	540	PF02991	0.711
LIG_PCNA_TLS_4	354	361	PF02747	0.406
LIG_PTAP_UEV_1	543	548	PF05743	0.575
LIG_SH2_PTP2	255	258	PF00017	0.338
LIG_SH2_STAP1	204	208	PF00017	0.499
LIG_SH2_STAP1	304	308	PF00017	0.430
LIG_SH2_STAT5	255	258	PF00017	0.338
LIG_SH3_1	541	547	PF00018	0.616
LIG_SH3_2	472	477	PF14604	0.494
LIG_SH3_3	469	475	PF00018	0.615
LIG_SH3_3	532	538	PF00018	0.584
LIG_SH3_3	541	547	PF00018	0.547
LIG_SH3_3	71	77	PF00018	0.526
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.673
LIG_TRAF2_1	136	139	PF00917	0.480
LIG_TRAF2_1	167	170	PF00917	0.494
LIG_TRAF2_1	195	198	PF00917	0.519
LIG_TRAF2_1	364	367	PF00917	0.452
LIG_TRAF2_1	510	513	PF00917	0.534
LIG_TRAF2_1	531	534	PF00917	0.532
LIG_WRC_WIRS_1	357	362	PF05994	0.467
MOD_CDK_SPxxK_3	381	388	PF00069	0.499
MOD_CDK_SPxxK_3	516	523	PF00069	0.534
MOD_CK1_1	106	112	PF00069	0.785
MOD_CK1_1	426	432	PF00069	0.540
MOD_CK1_1	461	467	PF00069	0.625
MOD_CK1_1	49	55	PF00069	0.550
MOD_CK1_1	542	548	PF00069	0.595
MOD_CK1_1	611	617	PF00069	0.639
MOD_CK1_1	618	624	PF00069	0.561
MOD_CK1_1	72	78	PF00069	0.612
MOD_CK1_1	90	96	PF00069	0.750
MOD_CK2_1	133	139	PF00069	0.488
MOD_CK2_1	154	160	PF00069	0.559
MOD_CK2_1	164	170	PF00069	0.451
MOD_CK2_1	192	198	PF00069	0.483
MOD_CK2_1	29	35	PF00069	0.576
MOD_CK2_1	352	358	PF00069	0.430
MOD_CK2_1	507	513	PF00069	0.510
MOD_CK2_1	528	534	PF00069	0.503
MOD_GlcNHglycan	105	108	PF01048	0.658
MOD_GlcNHglycan	156	160	PF01048	0.509
MOD_GlcNHglycan	27	30	PF01048	0.531
MOD_GlcNHglycan	344	347	PF01048	0.625
MOD_GlcNHglycan	464	467	PF01048	0.642
MOD_GlcNHglycan	486	489	PF01048	0.667
MOD_GlcNHglycan	501	504	PF01048	0.494
MOD_GlcNHglycan	544	547	PF01048	0.749
MOD_GSK3_1	13	20	PF00069	0.659
MOD_GSK3_1	160	167	PF00069	0.367
MOD_GSK3_1	21	28	PF00069	0.649
MOD_GSK3_1	235	242	PF00069	0.379
MOD_GSK3_1	307	314	PF00069	0.370
MOD_GSK3_1	352	359	PF00069	0.444
MOD_GSK3_1	413	420	PF00069	0.555
MOD_GSK3_1	422	429	PF00069	0.522
MOD_GSK3_1	458	465	PF00069	0.697
MOD_GSK3_1	46	53	PF00069	0.619
MOD_GSK3_1	507	514	PF00069	0.705
MOD_GSK3_1	611	618	PF00069	0.556
MOD_GSK3_1	75	82	PF00069	0.580
MOD_GSK3_1	85	92	PF00069	0.550
MOD_N-GLC_1	29	34	PF02516	0.498
MOD_NEK2_1	133	138	PF00069	0.475
MOD_NEK2_1	186	191	PF00069	0.468
MOD_NEK2_1	251	256	PF00069	0.384
MOD_NEK2_1	273	278	PF00069	0.531
MOD_NEK2_1	309	314	PF00069	0.338
MOD_NEK2_1	423	428	PF00069	0.580
MOD_NEK2_1	539	544	PF00069	0.507
MOD_NEK2_1	55	60	PF00069	0.528
MOD_NEK2_1	593	598	PF00069	0.458
MOD_NEK2_1	87	92	PF00069	0.661
MOD_NEK2_2	21	26	PF00069	0.489
MOD_NEK2_2	444	449	PF00069	0.482
MOD_PIKK_1	139	145	PF00454	0.500
MOD_PIKK_1	235	241	PF00454	0.354
MOD_PIKK_1	275	281	PF00454	0.400
MOD_PIKK_1	311	317	PF00454	0.343
MOD_PIKK_1	475	481	PF00454	0.675
MOD_PIKK_1	584	590	PF00454	0.369
MOD_PKA_1	259	265	PF00069	0.480
MOD_PKA_2	133	139	PF00069	0.489
MOD_PKA_2	210	216	PF00069	0.393
MOD_PKA_2	251	257	PF00069	0.411
MOD_PKA_2	259	265	PF00069	0.460
MOD_PKA_2	387	393	PF00069	0.569
MOD_PKA_2	435	441	PF00069	0.635
MOD_PKA_2	493	499	PF00069	0.529
MOD_PKA_2	618	624	PF00069	0.552
MOD_Plk_1	21	27	PF00069	0.558
MOD_Plk_1	239	245	PF00069	0.564
MOD_Plk_1	29	35	PF00069	0.526
MOD_Plk_1	533	539	PF00069	0.485
MOD_Plk_1	55	61	PF00069	0.493
MOD_Plk_4	239	245	PF00069	0.376
MOD_Plk_4	251	257	PF00069	0.304
MOD_Plk_4	356	362	PF00069	0.432
MOD_Plk_4	400	406	PF00069	0.705
MOD_Plk_4	593	599	PF00069	0.640
MOD_Plk_4	620	626	PF00069	0.565
MOD_Plk_4	69	75	PF00069	0.610
MOD_ProDKin_1	106	112	PF00069	0.654
MOD_ProDKin_1	381	387	PF00069	0.716
MOD_ProDKin_1	417	423	PF00069	0.617
MOD_ProDKin_1	424	430	PF00069	0.592
MOD_ProDKin_1	46	52	PF00069	0.659
MOD_ProDKin_1	468	474	PF00069	0.680
MOD_ProDKin_1	516	522	PF00069	0.621
MOD_ProDKin_1	72	78	PF00069	0.674
MOD_SUMO_for_1	599	602	PF00179	0.416
MOD_SUMO_rev_2	242	251	PF00179	0.336
MOD_SUMO_rev_2	303	309	PF00179	0.487
MOD_SUMO_rev_2	429	439	PF00179	0.518
MOD_SUMO_rev_2	545	555	PF00179	0.536
MOD_SUMO_rev_2	608	617	PF00179	0.458
TRG_DiLeu_BaEn_1	375	380	PF01217	0.516
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.595
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.502
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.478
TRG_ENDOCYTIC_2	193	196	PF00928	0.377
TRG_ENDOCYTIC_2	248	251	PF00928	0.480
TRG_ENDOCYTIC_2	255	258	PF00928	0.480
TRG_ENDOCYTIC_2	362	365	PF00928	0.451
TRG_ER_diArg_1	123	126	PF00400	0.532
TRG_ER_diArg_1	133	135	PF00400	0.495
TRG_ER_diArg_1	440	442	PF00400	0.573
TRG_ER_diArg_1	467	469	PF00400	0.570
TRG_ER_diArg_1	493	495	PF00400	0.529
TRG_NLS_MonoExtC_3	573	579	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK1	Leptomonas seymouri	46%	98%
A0A3S7XC33	Leishmania donovani	57%	94%
A4IE14	Leishmania infantum	57%	94%
D0A3Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AU36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	94%
Q4Q0F9	Leishmania major	60%	94%