Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hook complex protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQB8_LEIBR

TriTrypDb:

LbrM.35.6300 , LBRM2903_350074400

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	479	483	PF00656	0.533
CLV_C14_Caspase3-7	622	626	PF00656	0.654
CLV_C14_Caspase3-7	643	647	PF00656	0.538
CLV_NRD_NRD_1	377	379	PF00675	0.382
CLV_NRD_NRD_1	438	440	PF00675	0.702
CLV_NRD_NRD_1	633	635	PF00675	0.662
CLV_NRD_NRD_1	663	665	PF00675	0.636
CLV_PCSK_FUR_1	375	379	PF00082	0.335
CLV_PCSK_FUR_1	661	665	PF00082	0.548
CLV_PCSK_KEX2_1	334	336	PF00082	0.562
CLV_PCSK_KEX2_1	377	379	PF00082	0.397
CLV_PCSK_KEX2_1	438	440	PF00082	0.724
CLV_PCSK_KEX2_1	633	635	PF00082	0.662
CLV_PCSK_KEX2_1	661	663	PF00082	0.627
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.562
CLV_PCSK_SKI1_1	116	120	PF00082	0.546
CLV_PCSK_SKI1_1	127	131	PF00082	0.382
CLV_PCSK_SKI1_1	146	150	PF00082	0.257
CLV_PCSK_SKI1_1	197	201	PF00082	0.602
CLV_PCSK_SKI1_1	369	373	PF00082	0.446
CLV_PCSK_SKI1_1	416	420	PF00082	0.552
DEG_APCC_DBOX_1	194	202	PF00400	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.290
DEG_SCF_FBW7_1	651	658	PF00400	0.573
DEG_SPOP_SBC_1	263	267	PF00917	0.429
DOC_CDC14_PxL_1	488	496	PF14671	0.541
DOC_CKS1_1	652	657	PF01111	0.613
DOC_CYCLIN_RxL_1	143	150	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	490	493	PF00134	0.534
DOC_MAPK_gen_1	127	136	PF00069	0.335
DOC_MAPK_gen_1	438	445	PF00069	0.546
DOC_MAPK_MEF2A_6	369	376	PF00069	0.444
DOC_PP1_RVXF_1	144	150	PF00149	0.335
DOC_PP1_RVXF_1	323	329	PF00149	0.417
DOC_PP2B_LxvP_1	199	202	PF13499	0.563
DOC_PP2B_LxvP_1	490	493	PF13499	0.534
DOC_PP2B_LxvP_1	558	561	PF13499	0.494
DOC_PP4_FxxP_1	478	481	PF00568	0.538
DOC_USP7_MATH_1	163	167	PF00917	0.638
DOC_USP7_MATH_1	173	177	PF00917	0.594
DOC_USP7_MATH_1	319	323	PF00917	0.449
DOC_USP7_MATH_1	400	404	PF00917	0.706
DOC_USP7_MATH_1	49	53	PF00917	0.650
DOC_USP7_MATH_1	546	550	PF00917	0.752
DOC_USP7_MATH_1	599	603	PF00917	0.664
DOC_USP7_MATH_1	640	644	PF00917	0.720
DOC_USP7_MATH_1	645	649	PF00917	0.749
DOC_USP7_MATH_1	655	659	PF00917	0.599
DOC_USP7_MATH_1	671	675	PF00917	0.519
DOC_USP7_MATH_2	365	371	PF00917	0.393
DOC_WW_Pin1_4	178	183	PF00397	0.697
DOC_WW_Pin1_4	232	237	PF00397	0.565
DOC_WW_Pin1_4	293	298	PF00397	0.343
DOC_WW_Pin1_4	394	399	PF00397	0.658
DOC_WW_Pin1_4	41	46	PF00397	0.361
DOC_WW_Pin1_4	438	443	PF00397	0.664
DOC_WW_Pin1_4	445	450	PF00397	0.595
DOC_WW_Pin1_4	467	472	PF00397	0.616
DOC_WW_Pin1_4	47	52	PF00397	0.460
DOC_WW_Pin1_4	498	503	PF00397	0.629
DOC_WW_Pin1_4	526	531	PF00397	0.688
DOC_WW_Pin1_4	535	540	PF00397	0.656
DOC_WW_Pin1_4	611	616	PF00397	0.566
DOC_WW_Pin1_4	651	656	PF00397	0.546
LIG_14-3-3_CanoR_1	10	18	PF00244	0.307
LIG_14-3-3_CanoR_1	246	251	PF00244	0.545
LIG_14-3-3_CanoR_1	327	331	PF00244	0.364
LIG_14-3-3_CanoR_1	416	421	PF00244	0.549
LIG_14-3-3_CanoR_1	475	481	PF00244	0.706
LIG_14-3-3_CanoR_1	498	502	PF00244	0.651
LIG_14-3-3_CanoR_1	583	589	PF00244	0.621
LIG_14-3-3_CanoR_1	603	608	PF00244	0.491
LIG_14-3-3_CanoR_1	661	667	PF00244	0.751
LIG_APCC_ABBAyCdc20_2	304	310	PF00400	0.373
LIG_BIR_III_2	527	531	PF00653	0.544
LIG_BIR_III_4	138	142	PF00653	0.453
LIG_BIR_III_4	25	29	PF00653	0.450
LIG_BRCT_BRCA1_1	668	672	PF00533	0.528
LIG_DCNL_PONY_1	1	4	PF03556	0.380
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.556
LIG_deltaCOP1_diTrp_1	590	595	PF00928	0.597
LIG_EH_1	669	673	PF12763	0.528
LIG_FHA_1	10	16	PF00498	0.309
LIG_FHA_1	251	257	PF00498	0.418
LIG_FHA_1	263	269	PF00498	0.598
LIG_FHA_1	294	300	PF00498	0.440
LIG_FHA_1	321	327	PF00498	0.474
LIG_FHA_1	483	489	PF00498	0.625
LIG_FHA_1	546	552	PF00498	0.631
LIG_FHA_1	62	68	PF00498	0.381
LIG_FHA_1	95	101	PF00498	0.326
LIG_FHA_2	264	270	PF00498	0.510
LIG_FHA_2	403	409	PF00498	0.551
LIG_FHA_2	456	462	PF00498	0.636
LIG_FHA_2	52	58	PF00498	0.508
LIG_GBD_Chelix_1	143	151	PF00786	0.246
LIG_LIR_Apic_2	356	360	PF02991	0.439
LIG_LIR_Apic_2	388	393	PF02991	0.518
LIG_LIR_Gen_1	669	676	PF02991	0.529
LIG_LIR_Nem_3	16	21	PF02991	0.368
LIG_LIR_Nem_3	353	357	PF02991	0.615
LIG_LIR_Nem_3	5	9	PF02991	0.433
LIG_LIR_Nem_3	66	72	PF02991	0.348
LIG_LIR_Nem_3	669	675	PF02991	0.529
LIG_PDZ_Class_1	671	676	PF00595	0.529
LIG_Pex14_2	18	22	PF04695	0.410
LIG_Pex14_2	37	41	PF04695	0.394
LIG_Pex14_2	386	390	PF04695	0.506
LIG_SH2_CRK	357	361	PF00017	0.434
LIG_SH2_GRB2like	59	62	PF00017	0.396
LIG_SH2_NCK_1	105	109	PF00017	0.471
LIG_SH2_NCK_1	357	361	PF00017	0.434
LIG_SH2_SRC	357	360	PF00017	0.436
LIG_SH2_SRC	432	435	PF00017	0.550
LIG_SH2_SRC	59	62	PF00017	0.396
LIG_SH2_STAP1	132	136	PF00017	0.335
LIG_SH2_STAT3	308	311	PF00017	0.365
LIG_SH2_STAT5	124	127	PF00017	0.486
LIG_SH2_STAT5	227	230	PF00017	0.565
LIG_SH2_STAT5	291	294	PF00017	0.557
LIG_SH2_STAT5	452	455	PF00017	0.555
LIG_SH2_STAT5	567	570	PF00017	0.533
LIG_SH2_STAT5	59	62	PF00017	0.419
LIG_SH3_3	390	396	PF00018	0.703
LIG_SH3_3	415	421	PF00018	0.579
LIG_SH3_3	536	542	PF00018	0.581
LIG_SH3_3	646	652	PF00018	0.630
LIG_TRFH_1	340	344	PF08558	0.438
LIG_WRC_WIRS_1	34	39	PF05994	0.539
LIG_WRC_WIRS_1	95	100	PF05994	0.376
MOD_CDC14_SPxK_1	181	184	PF00782	0.723
MOD_CDC14_SPxK_1	235	238	PF00782	0.558
MOD_CDC14_SPxK_1	448	451	PF00782	0.552
MOD_CDK_SPK_2	41	46	PF00069	0.361
MOD_CDK_SPxK_1	178	184	PF00069	0.722
MOD_CDK_SPxK_1	232	238	PF00069	0.562
MOD_CDK_SPxK_1	438	444	PF00069	0.672
MOD_CDK_SPxK_1	445	451	PF00069	0.596
MOD_CDK_SPxK_1	498	504	PF00069	0.633
MOD_CDK_SPxK_1	535	541	PF00069	0.574
MOD_CDK_SPxxK_3	41	48	PF00069	0.382
MOD_CK1_1	103	109	PF00069	0.460
MOD_CK1_1	16	22	PF00069	0.323
MOD_CK1_1	231	237	PF00069	0.560
MOD_CK1_1	241	247	PF00069	0.650
MOD_CK1_1	394	400	PF00069	0.630
MOD_CK1_1	469	475	PF00069	0.572
MOD_CK1_1	50	56	PF00069	0.713
MOD_CK1_1	606	612	PF00069	0.705
MOD_CK1_1	616	622	PF00069	0.603
MOD_CK1_1	626	632	PF00069	0.490
MOD_CK1_1	665	671	PF00069	0.693
MOD_CK2_1	326	332	PF00069	0.417
MOD_CK2_1	455	461	PF00069	0.600
MOD_CK2_1	51	57	PF00069	0.513
MOD_CK2_1	584	590	PF00069	0.617
MOD_CMANNOS	592	595	PF00535	0.594
MOD_Cter_Amidation	332	335	PF01082	0.377
MOD_GlcNHglycan	105	108	PF01048	0.599
MOD_GlcNHglycan	14	18	PF01048	0.329
MOD_GlcNHglycan	203	206	PF01048	0.562
MOD_GlcNHglycan	369	372	PF01048	0.422
MOD_GlcNHglycan	382	386	PF01048	0.592
MOD_GlcNHglycan	511	514	PF01048	0.563
MOD_GlcNHglycan	517	520	PF01048	0.573
MOD_GlcNHglycan	615	618	PF01048	0.738
MOD_GSK3_1	163	170	PF00069	0.765
MOD_GSK3_1	223	230	PF00069	0.708
MOD_GSK3_1	246	253	PF00069	0.564
MOD_GSK3_1	287	294	PF00069	0.436
MOD_GSK3_1	33	40	PF00069	0.448
MOD_GSK3_1	359	366	PF00069	0.444
MOD_GSK3_1	381	388	PF00069	0.690
MOD_GSK3_1	394	401	PF00069	0.596
MOD_GSK3_1	408	415	PF00069	0.493
MOD_GSK3_1	416	423	PF00069	0.520
MOD_GSK3_1	466	473	PF00069	0.713
MOD_GSK3_1	47	54	PF00069	0.513
MOD_GSK3_1	476	483	PF00069	0.573
MOD_GSK3_1	511	518	PF00069	0.756
MOD_GSK3_1	599	606	PF00069	0.737
MOD_GSK3_1	619	626	PF00069	0.502
MOD_GSK3_1	651	658	PF00069	0.553
MOD_GSK3_1	662	669	PF00069	0.598
MOD_GSK3_1	9	16	PF00069	0.471
MOD_LATS_1	611	617	PF00433	0.565
MOD_N-GLC_1	455	460	PF02516	0.631
MOD_N-GLC_1	496	501	PF02516	0.663
MOD_NEK2_1	147	152	PF00069	0.335
MOD_NEK2_1	168	173	PF00069	0.548
MOD_NEK2_1	326	331	PF00069	0.416
MOD_NEK2_1	37	42	PF00069	0.397
MOD_NEK2_1	455	460	PF00069	0.707
MOD_NEK2_2	655	660	PF00069	0.515
MOD_PIKK_1	100	106	PF00454	0.411
MOD_PIKK_1	228	234	PF00454	0.685
MOD_PIKK_1	241	247	PF00454	0.600
MOD_PIKK_1	391	397	PF00454	0.576
MOD_PIKK_1	416	422	PF00454	0.547
MOD_PIKK_1	511	517	PF00454	0.532
MOD_PK_1	246	252	PF00069	0.482
MOD_PK_1	264	270	PF00069	0.597
MOD_PK_1	603	609	PF00069	0.698
MOD_PKA_1	662	668	PF00069	0.663
MOD_PKA_2	100	106	PF00069	0.411
MOD_PKA_2	241	247	PF00069	0.759
MOD_PKA_2	326	332	PF00069	0.362
MOD_PKA_2	412	418	PF00069	0.544
MOD_PKA_2	497	503	PF00069	0.656
MOD_PKA_2	638	644	PF00069	0.671
MOD_PKA_2	662	668	PF00069	0.743
MOD_PKA_2	9	15	PF00069	0.303
MOD_PKB_1	601	609	PF00069	0.662
MOD_Plk_1	13	19	PF00069	0.314
MOD_Plk_1	645	651	PF00069	0.620
MOD_Plk_1	655	661	PF00069	0.608
MOD_Plk_4	223	229	PF00069	0.698
MOD_Plk_4	246	252	PF00069	0.462
MOD_Plk_4	584	590	PF00069	0.617
MOD_Plk_4	626	632	PF00069	0.764
MOD_Plk_4	645	651	PF00069	0.480
MOD_Plk_4	655	661	PF00069	0.608
MOD_ProDKin_1	178	184	PF00069	0.700
MOD_ProDKin_1	232	238	PF00069	0.567
MOD_ProDKin_1	293	299	PF00069	0.350
MOD_ProDKin_1	394	400	PF00069	0.658
MOD_ProDKin_1	41	47	PF00069	0.371
MOD_ProDKin_1	438	444	PF00069	0.665
MOD_ProDKin_1	445	451	PF00069	0.598
MOD_ProDKin_1	467	473	PF00069	0.613
MOD_ProDKin_1	498	504	PF00069	0.633
MOD_ProDKin_1	526	532	PF00069	0.692
MOD_ProDKin_1	535	541	PF00069	0.654
MOD_ProDKin_1	611	617	PF00069	0.565
MOD_ProDKin_1	651	657	PF00069	0.545
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.664
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.482
TRG_ENDOCYTIC_2	452	455	PF00928	0.785
TRG_ER_diArg_1	374	377	PF00400	0.331
TRG_ER_diArg_1	540	543	PF00400	0.752
TRG_ER_diArg_1	660	663	PF00400	0.601
TRG_NES_CRM1_1	90	104	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS1	Leptomonas seymouri	46%	96%
A0A3S7XBZ6	Leishmania donovani	61%	100%
A4IE12	Leishmania infantum	62%	100%
E9AU34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q0G1	Leishmania major	63%	97%