WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HQB7_LEIBR

TriTrypDb:

LbrM.35.6290 , LBRM2903_350074300

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.475
CLV_NRD_NRD_1	329	331	PF00675	0.378
CLV_NRD_NRD_1	378	380	PF00675	0.674
CLV_NRD_NRD_1	404	406	PF00675	0.464
CLV_NRD_NRD_1	434	436	PF00675	0.376
CLV_NRD_NRD_1	553	555	PF00675	0.503
CLV_NRD_NRD_1	74	76	PF00675	0.836
CLV_PCSK_KEX2_1	239	241	PF00082	0.475
CLV_PCSK_KEX2_1	328	330	PF00082	0.332
CLV_PCSK_KEX2_1	404	406	PF00082	0.460
CLV_PCSK_KEX2_1	434	436	PF00082	0.537
CLV_PCSK_KEX2_1	553	555	PF00082	0.489
DEG_COP1_1	90	99	PF00400	0.509
DEG_SPOP_SBC_1	383	387	PF00917	0.506
DEG_SPOP_SBC_1	41	45	PF00917	0.557
DEG_SPOP_SBC_1	515	519	PF00917	0.525
DOC_CYCLIN_yCln2_LP_2	371	374	PF00134	0.469
DOC_MAPK_DCC_7	369	378	PF00069	0.542
DOC_MAPK_gen_1	239	248	PF00069	0.490
DOC_MAPK_gen_1	404	412	PF00069	0.401
DOC_MAPK_MEF2A_6	158	165	PF00069	0.535
DOC_MAPK_MEF2A_6	185	194	PF00069	0.344
DOC_MAPK_MEF2A_6	369	378	PF00069	0.497
DOC_MAPK_MEF2A_6	405	414	PF00069	0.324
DOC_MAPK_NFAT4_5	158	166	PF00069	0.551
DOC_PP2B_LxvP_1	370	373	PF13499	0.402
DOC_PP2B_LxvP_1	412	415	PF13499	0.486
DOC_PP4_FxxP_1	110	113	PF00568	0.591
DOC_USP7_MATH_1	14	18	PF00917	0.675
DOC_USP7_MATH_1	244	248	PF00917	0.573
DOC_USP7_MATH_1	252	256	PF00917	0.556
DOC_USP7_MATH_1	279	283	PF00917	0.428
DOC_USP7_MATH_1	31	35	PF00917	0.655
DOC_USP7_MATH_1	383	387	PF00917	0.582
DOC_USP7_MATH_1	39	43	PF00917	0.594
DOC_USP7_MATH_1	395	399	PF00917	0.543
DOC_USP7_MATH_1	508	512	PF00917	0.685
DOC_USP7_MATH_1	53	57	PF00917	0.712
DOC_USP7_MATH_1	542	546	PF00917	0.367
DOC_USP7_UBL2_3	72	76	PF12436	0.546
DOC_WW_Pin1_4	112	117	PF00397	0.616
DOC_WW_Pin1_4	125	130	PF00397	0.496
DOC_WW_Pin1_4	194	199	PF00397	0.609
DOC_WW_Pin1_4	277	282	PF00397	0.674
DOC_WW_Pin1_4	379	384	PF00397	0.659
DOC_WW_Pin1_4	391	396	PF00397	0.620
LIG_14-3-3_CanoR_1	185	194	PF00244	0.425
LIG_14-3-3_CanoR_1	256	260	PF00244	0.677
LIG_14-3-3_CanoR_1	379	383	PF00244	0.549
LIG_14-3-3_CanoR_1	404	412	PF00244	0.322
LIG_14-3-3_CanoR_1	434	440	PF00244	0.480
LIG_14-3-3_CanoR_1	553	557	PF00244	0.527
LIG_14-3-3_CanoR_1	86	92	PF00244	0.565
LIG_Actin_WH2_2	148	164	PF00022	0.566
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BRCT_BRCA1_1	471	475	PF00533	0.321
LIG_Clathr_ClatBox_1	192	196	PF01394	0.347
LIG_deltaCOP1_diTrp_1	213	221	PF00928	0.474
LIG_EVH1_1	110	114	PF00568	0.628
LIG_EVH1_1	412	416	PF00568	0.351
LIG_EVH1_1	540	544	PF00568	0.434
LIG_FHA_1	185	191	PF00498	0.426
LIG_FHA_1	30	36	PF00498	0.619
LIG_FHA_1	310	316	PF00498	0.366
LIG_FHA_1	387	393	PF00498	0.608
LIG_FHA_1	404	410	PF00498	0.410
LIG_FHA_1	419	425	PF00498	0.462
LIG_FHA_1	478	484	PF00498	0.553
LIG_FHA_1	496	502	PF00498	0.700
LIG_FHA_1	517	523	PF00498	0.542
LIG_FHA_1	91	97	PF00498	0.629
LIG_FHA_2	260	266	PF00498	0.542
LIG_FHA_2	332	338	PF00498	0.475
LIG_FHA_2	385	391	PF00498	0.513
LIG_HCF-1_HBM_1	211	214	PF13415	0.383
LIG_Integrin_RGD_1	330	332	PF01839	0.344
LIG_LIR_Apic_2	107	113	PF02991	0.571
LIG_LIR_Apic_2	127	133	PF02991	0.567
LIG_LIR_Apic_2	567	573	PF02991	0.439
LIG_LIR_Apic_2	93	97	PF02991	0.668
LIG_LIR_Gen_1	213	224	PF02991	0.415
LIG_LIR_Gen_1	241	251	PF02991	0.499
LIG_LIR_Gen_1	420	427	PF02991	0.475
LIG_LIR_LC3C_4	406	411	PF02991	0.308
LIG_LIR_Nem_3	213	219	PF02991	0.444
LIG_LIR_Nem_3	241	246	PF02991	0.497
LIG_LIR_Nem_3	332	336	PF02991	0.433
LIG_LIR_Nem_3	366	371	PF02991	0.476
LIG_LIR_Nem_3	537	543	PF02991	0.643
LIG_LIR_Nem_3	555	561	PF02991	0.264
LIG_MYND_1	97	101	PF01753	0.499
LIG_MYND_2	373	377	PF01753	0.509
LIG_MYND_3	77	81	PF01753	0.582
LIG_NRP_CendR_1	580	583	PF00754	0.578
LIG_Pex14_1	216	220	PF04695	0.451
LIG_Pex14_2	423	427	PF04695	0.448
LIG_SH2_CRK	123	127	PF00017	0.691
LIG_SH2_CRK	130	134	PF00017	0.709
LIG_SH2_CRK	447	451	PF00017	0.458
LIG_SH2_NCK_1	130	134	PF00017	0.567
LIG_SH2_NCK_1	512	516	PF00017	0.529
LIG_SH2_STAT3	425	428	PF00017	0.317
LIG_SH2_STAT5	261	264	PF00017	0.425
LIG_SH2_STAT5	324	327	PF00017	0.454
LIG_SH2_STAT5	512	515	PF00017	0.614
LIG_SH2_STAT5	558	561	PF00017	0.376
LIG_SH3_3	108	114	PF00018	0.670
LIG_SH3_3	126	132	PF00018	0.701
LIG_SH3_3	135	141	PF00018	0.678
LIG_SH3_3	407	413	PF00018	0.449
LIG_SH3_3	533	539	PF00018	0.552
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.345
LIG_SUMO_SIM_anti_2	406	413	PF11976	0.476
LIG_SUMO_SIM_par_1	191	197	PF11976	0.355
LIG_TRAF2_1	208	211	PF00917	0.515
LIG_TRAF2_1	262	265	PF00917	0.514
LIG_TRAF2_1	399	402	PF00917	0.352
LIG_TRAF2_2	208	213	PF00917	0.396
LIG_TYR_ITIM	121	126	PF00017	0.518
LIG_UBA3_1	375	380	PF00899	0.429
LIG_ULM_U2AF65_1	239	244	PF00076	0.490
LIG_WW_2	140	143	PF00397	0.632
LIG_WW_2	541	544	PF00397	0.437
MOD_CK1_1	128	134	PF00069	0.494
MOD_CK1_1	22	28	PF00069	0.553
MOD_CK1_1	255	261	PF00069	0.728
MOD_CK1_1	30	36	PF00069	0.560
MOD_CK1_1	385	391	PF00069	0.555
MOD_CK1_1	40	46	PF00069	0.656
MOD_CK1_1	469	475	PF00069	0.356
MOD_CK1_1	48	54	PF00069	0.672
MOD_CK1_1	511	517	PF00069	0.529
MOD_CK1_1	520	526	PF00069	0.681
MOD_CK1_1	552	558	PF00069	0.445
MOD_CK1_1	56	62	PF00069	0.560
MOD_CK1_1	9	15	PF00069	0.620
MOD_CK1_1	90	96	PF00069	0.684
MOD_CK2_1	185	191	PF00069	0.457
MOD_CK2_1	219	225	PF00069	0.458
MOD_CK2_1	259	265	PF00069	0.523
MOD_CK2_1	384	390	PF00069	0.613
MOD_CK2_1	391	397	PF00069	0.540
MOD_CK2_1	493	499	PF00069	0.661
MOD_CK2_1	542	548	PF00069	0.384
MOD_CK2_1	56	62	PF00069	0.721
MOD_Cter_Amidation	237	240	PF01082	0.493
MOD_Cter_Amidation	563	566	PF01082	0.543
MOD_GlcNHglycan	11	14	PF01048	0.703
MOD_GlcNHglycan	145	148	PF01048	0.728
MOD_GlcNHglycan	29	32	PF01048	0.559
MOD_GlcNHglycan	37	40	PF01048	0.648
MOD_GlcNHglycan	397	400	PF01048	0.565
MOD_GlcNHglycan	456	459	PF01048	0.391
MOD_GlcNHglycan	519	522	PF01048	0.764
MOD_GlcNHglycan	544	547	PF01048	0.382
MOD_GlcNHglycan	55	58	PF01048	0.753
MOD_GlcNHglycan	562	565	PF01048	0.493
MOD_GSK3_1	124	131	PF00069	0.525
MOD_GSK3_1	14	21	PF00069	0.632
MOD_GSK3_1	141	148	PF00069	0.559
MOD_GSK3_1	180	187	PF00069	0.475
MOD_GSK3_1	215	222	PF00069	0.590
MOD_GSK3_1	255	262	PF00069	0.590
MOD_GSK3_1	27	34	PF00069	0.568
MOD_GSK3_1	277	284	PF00069	0.482
MOD_GSK3_1	35	42	PF00069	0.573
MOD_GSK3_1	378	385	PF00069	0.546
MOD_GSK3_1	391	398	PF00069	0.504
MOD_GSK3_1	45	52	PF00069	0.557
MOD_GSK3_1	510	517	PF00069	0.802
MOD_GSK3_1	520	527	PF00069	0.697
MOD_GSK3_1	53	60	PF00069	0.612
MOD_GSK3_1	560	567	PF00069	0.483
MOD_GSK3_1	95	102	PF00069	0.711
MOD_N-GLC_1	27	32	PF02516	0.523
MOD_N-GLC_1	469	474	PF02516	0.440
MOD_N-GLC_1	483	488	PF02516	0.636
MOD_N-GLC_1	501	506	PF02516	0.613
MOD_N-GLC_1	508	513	PF02516	0.662
MOD_N-GLC_2	134	136	PF02516	0.516
MOD_NEK2_1	145	150	PF00069	0.639
MOD_NEK2_1	166	171	PF00069	0.411
MOD_NEK2_1	37	42	PF00069	0.560
MOD_NEK2_1	378	383	PF00069	0.555
MOD_NEK2_1	493	498	PF00069	0.498
MOD_NEK2_1	560	565	PF00069	0.526
MOD_NEK2_1	87	92	PF00069	0.653
MOD_NEK2_2	105	110	PF00069	0.524
MOD_PIKK_1	483	489	PF00454	0.525
MOD_PIKK_1	572	578	PF00454	0.542
MOD_PIKK_1	81	87	PF00454	0.502
MOD_PKA_1	565	571	PF00069	0.520
MOD_PKA_2	166	172	PF00069	0.460
MOD_PKA_2	184	190	PF00069	0.416
MOD_PKA_2	238	244	PF00069	0.434
MOD_PKA_2	255	261	PF00069	0.525
MOD_PKA_2	295	301	PF00069	0.338
MOD_PKA_2	378	384	PF00069	0.651
MOD_PKA_2	403	409	PF00069	0.364
MOD_PKA_2	552	558	PF00069	0.451
MOD_PKA_2	7	13	PF00069	0.544
MOD_PKA_2	87	93	PF00069	0.696
MOD_Plk_1	418	424	PF00069	0.342
MOD_Plk_1	469	475	PF00069	0.335
MOD_Plk_1	501	507	PF00069	0.518
MOD_Plk_1	508	514	PF00069	0.530
MOD_Plk_4	105	111	PF00069	0.645
MOD_Plk_4	215	221	PF00069	0.455
MOD_Plk_4	287	293	PF00069	0.511
MOD_Plk_4	295	301	PF00069	0.383
MOD_Plk_4	405	411	PF00069	0.474
MOD_ProDKin_1	112	118	PF00069	0.616
MOD_ProDKin_1	125	131	PF00069	0.495
MOD_ProDKin_1	194	200	PF00069	0.616
MOD_ProDKin_1	277	283	PF00069	0.678
MOD_ProDKin_1	379	385	PF00069	0.659
MOD_ProDKin_1	391	397	PF00069	0.607
TRG_DiLeu_BaEn_1	366	371	PF01217	0.439
TRG_DiLeu_LyEn_5	366	371	PF01217	0.455
TRG_ENDOCYTIC_2	123	126	PF00928	0.693
TRG_ENDOCYTIC_2	447	450	PF00928	0.433
TRG_ENDOCYTIC_2	558	561	PF00928	0.380
TRG_ER_diArg_1	328	330	PF00400	0.338
TRG_ER_diArg_1	433	435	PF00400	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC61	Leptomonas seymouri	53%	90%
A0A0S4IPB1	Bodo saltans	34%	100%
A0A3S7XBY9	Leishmania donovani	75%	94%
A4IE11	Leishmania infantum	77%	100%
E9AU33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	94%
Q4Q0G2	Leishmania major	76%	100%