LeishMANIAdb
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Lipase_3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipase_3 domain-containing protein
Gene product:
Flagellum attachment zone protein 5
Species:
Leishmania braziliensis
UniProt:
A4HQB6_LEIBR
TriTrypDb:
LbrM.35.6280 , LBRM2903_350074200 *
Length:
636

Annotations

LeishMANIAdb annotations

Very tentatively might be a transmembrane chaperone for some unknown protein secretion process. Not unique to kinetoplastids, also found in fungi and other Eukaryotes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4HQB6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.707
CLV_NRD_NRD_1 221 223 PF00675 0.316
CLV_NRD_NRD_1 33 35 PF00675 0.334
CLV_NRD_NRD_1 379 381 PF00675 0.441
CLV_NRD_NRD_1 501 503 PF00675 0.476
CLV_NRD_NRD_1 53 55 PF00675 0.204
CLV_NRD_NRD_1 532 534 PF00675 0.530
CLV_NRD_NRD_1 537 539 PF00675 0.498
CLV_PCSK_KEX2_1 221 223 PF00082 0.316
CLV_PCSK_KEX2_1 379 381 PF00082 0.415
CLV_PCSK_KEX2_1 501 503 PF00082 0.509
CLV_PCSK_KEX2_1 532 534 PF00082 0.530
CLV_PCSK_KEX2_1 537 539 PF00082 0.498
CLV_PCSK_PC7_1 533 539 PF00082 0.449
CLV_PCSK_SKI1_1 27 31 PF00082 0.320
CLV_PCSK_SKI1_1 34 38 PF00082 0.331
CLV_PCSK_SKI1_1 411 415 PF00082 0.511
DEG_Nend_UBRbox_2 1 3 PF02207 0.584
DEG_SPOP_SBC_1 22 26 PF00917 0.455
DOC_CKS1_1 384 389 PF01111 0.631
DOC_CYCLIN_yCln2_LP_2 20 23 PF00134 0.475
DOC_MAPK_gen_1 332 342 PF00069 0.347
DOC_MAPK_MEF2A_6 297 304 PF00069 0.512
DOC_PP1_RVXF_1 25 32 PF00149 0.506
DOC_PP2B_LxvP_1 20 23 PF13499 0.498
DOC_PP2B_LxvP_1 466 469 PF13499 0.653
DOC_PP4_FxxP_1 175 178 PF00568 0.357
DOC_USP7_MATH_1 23 27 PF00917 0.555
DOC_USP7_MATH_1 426 430 PF00917 0.615
DOC_USP7_MATH_1 517 521 PF00917 0.690
DOC_WW_Pin1_4 160 165 PF00397 0.498
DOC_WW_Pin1_4 383 388 PF00397 0.642
DOC_WW_Pin1_4 483 488 PF00397 0.765
DOC_WW_Pin1_4 532 537 PF00397 0.751
LIG_14-3-3_CanoR_1 233 238 PF00244 0.483
LIG_14-3-3_CanoR_1 267 273 PF00244 0.355
LIG_14-3-3_CanoR_1 34 39 PF00244 0.548
LIG_14-3-3_CanoR_1 379 388 PF00244 0.546
LIG_14-3-3_CanoR_1 411 417 PF00244 0.608
LIG_14-3-3_CanoR_1 472 480 PF00244 0.733
LIG_14-3-3_CanoR_1 516 526 PF00244 0.639
LIG_14-3-3_CanoR_1 527 536 PF00244 0.641
LIG_14-3-3_CanoR_1 610 615 PF00244 0.727
LIG_Actin_WH2_2 270 288 PF00022 0.202
LIG_BIR_III_4 64 68 PF00653 0.562
LIG_BRCT_BRCA1_1 243 247 PF00533 0.215
LIG_BRCT_BRCA1_1 324 328 PF00533 0.292
LIG_BRCT_BRCA1_1 617 621 PF00533 0.612
LIG_eIF4E_1 15 21 PF01652 0.546
LIG_eIF4E_1 210 216 PF01652 0.351
LIG_eIF4E_1 42 48 PF01652 0.548
LIG_eIF4E_1 90 96 PF01652 0.357
LIG_FHA_1 130 136 PF00498 0.242
LIG_FHA_1 211 217 PF00498 0.348
LIG_FHA_1 297 303 PF00498 0.518
LIG_FHA_1 394 400 PF00498 0.649
LIG_FHA_1 425 431 PF00498 0.616
LIG_FHA_1 538 544 PF00498 0.661
LIG_FHA_1 84 90 PF00498 0.241
LIG_FHA_2 149 155 PF00498 0.559
LIG_FHA_2 449 455 PF00498 0.685
LIG_FHA_2 561 567 PF00498 0.655
LIG_FHA_2 572 578 PF00498 0.685
LIG_FHA_2 583 589 PF00498 0.701
LIG_LIR_Apic_2 214 220 PF02991 0.355
LIG_LIR_Apic_2 383 388 PF02991 0.559
LIG_LIR_Gen_1 117 128 PF02991 0.249
LIG_LIR_Gen_1 244 255 PF02991 0.215
LIG_LIR_Gen_1 271 281 PF02991 0.294
LIG_LIR_Gen_1 325 333 PF02991 0.313
LIG_LIR_Gen_1 352 362 PF02991 0.351
LIG_LIR_Gen_1 443 450 PF02991 0.672
LIG_LIR_Gen_1 555 565 PF02991 0.724
LIG_LIR_Gen_1 611 621 PF02991 0.715
LIG_LIR_Nem_3 117 123 PF02991 0.309
LIG_LIR_Nem_3 236 242 PF02991 0.244
LIG_LIR_Nem_3 271 276 PF02991 0.308
LIG_LIR_Nem_3 325 331 PF02991 0.266
LIG_LIR_Nem_3 352 358 PF02991 0.399
LIG_LIR_Nem_3 443 449 PF02991 0.674
LIG_LIR_Nem_3 542 547 PF02991 0.761
LIG_LIR_Nem_3 555 561 PF02991 0.712
LIG_LIR_Nem_3 611 617 PF02991 0.718
LIG_LIR_Nem_3 618 624 PF02991 0.708
LIG_LIR_Nem_3 63 69 PF02991 0.517
LIG_LIR_Nem_3 71 77 PF02991 0.522
LIG_MLH1_MIPbox_1 324 328 PF16413 0.292
LIG_NRBOX 13 19 PF00104 0.501
LIG_NRP_CendR_1 635 636 PF00754 0.515
LIG_Pex14_1 118 122 PF04695 0.267
LIG_Pex14_1 12 16 PF04695 0.542
LIG_Pex14_1 272 276 PF04695 0.292
LIG_Pex14_2 103 107 PF04695 0.215
LIG_Pex14_2 175 179 PF04695 0.357
LIG_Pex14_2 243 247 PF04695 0.351
LIG_REV1ctd_RIR_1 410 417 PF16727 0.607
LIG_SH2_CRK 350 354 PF00017 0.229
LIG_SH2_CRK 544 548 PF00017 0.638
LIG_SH2_CRK 58 62 PF00017 0.511
LIG_SH2_CRK 614 618 PF00017 0.717
LIG_SH2_CRK 66 70 PF00017 0.493
LIG_SH2_CRK 90 94 PF00017 0.351
LIG_SH2_GRB2like 580 583 PF00017 0.625
LIG_SH2_NCK_1 558 562 PF00017 0.722
LIG_SH2_NCK_1 575 579 PF00017 0.727
LIG_SH2_NCK_1 58 62 PF00017 0.544
LIG_SH2_NCK_1 614 618 PF00017 0.656
LIG_SH2_SRC 152 155 PF00017 0.612
LIG_SH2_SRC 575 578 PF00017 0.631
LIG_SH2_STAP1 211 215 PF00017 0.351
LIG_SH2_STAP1 350 354 PF00017 0.241
LIG_SH2_STAP1 446 450 PF00017 0.630
LIG_SH2_STAP1 580 584 PF00017 0.675
LIG_SH2_STAP1 90 94 PF00017 0.357
LIG_SH2_STAT3 586 589 PF00017 0.803
LIG_SH2_STAT3 592 595 PF00017 0.749
LIG_SH2_STAT5 115 118 PF00017 0.352
LIG_SH2_STAT5 16 19 PF00017 0.559
LIG_SH2_STAT5 174 177 PF00017 0.335
LIG_SH2_STAT5 196 199 PF00017 0.303
LIG_SH2_STAT5 273 276 PF00017 0.290
LIG_SH2_STAT5 291 294 PF00017 0.478
LIG_SH2_STAT5 298 301 PF00017 0.524
LIG_SH2_STAT5 327 330 PF00017 0.346
LIG_SH2_STAT5 46 49 PF00017 0.488
LIG_SH2_STAT5 558 561 PF00017 0.635
LIG_SH2_STAT5 56 59 PF00017 0.488
LIG_SH2_STAT5 584 587 PF00017 0.722
LIG_SH2_STAT5 592 595 PF00017 0.720
LIG_SH2_STAT5 599 602 PF00017 0.722
LIG_SH3_3 4 10 PF00018 0.510
LIG_SH3_3 73 79 PF00018 0.540
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.357
LIG_SUMO_SIM_par_1 132 138 PF11976 0.215
LIG_SUMO_SIM_par_1 320 325 PF11976 0.260
LIG_SUMO_SIM_par_1 85 91 PF11976 0.360
LIG_SUMO_SIM_par_1 92 97 PF11976 0.344
LIG_TRAF2_1 151 154 PF00917 0.598
LIG_TRAF2_1 375 378 PF00917 0.572
LIG_TRAF2_1 451 454 PF00917 0.729
LIG_TRAF2_1 553 556 PF00917 0.651
LIG_TRAF2_2 387 392 PF00917 0.566
LIG_TRFH_1 122 126 PF08558 0.215
LIG_TYR_ITIM 172 177 PF00017 0.351
LIG_TYR_ITIM 237 242 PF00017 0.311
LIG_TYR_ITIM 88 93 PF00017 0.351
LIG_UBA3_1 259 263 PF00899 0.234
LIG_WRC_WIRS_1 313 318 PF05994 0.351
MOD_CDK_SPK_2 532 537 PF00069 0.649
MOD_CDK_SPxK_1 532 538 PF00069 0.751
MOD_CK1_1 315 321 PF00069 0.351
MOD_CK1_1 383 389 PF00069 0.546
MOD_CK1_1 429 435 PF00069 0.705
MOD_CK1_1 500 506 PF00069 0.712
MOD_CK1_1 550 556 PF00069 0.674
MOD_CK1_1 612 618 PF00069 0.720
MOD_CK1_1 619 625 PF00069 0.640
MOD_CK1_1 626 632 PF00069 0.698
MOD_CK1_1 70 76 PF00069 0.469
MOD_CK2_1 148 154 PF00069 0.551
MOD_CK2_1 372 378 PF00069 0.574
MOD_CK2_1 438 444 PF00069 0.739
MOD_CK2_1 448 454 PF00069 0.717
MOD_CK2_1 550 556 PF00069 0.668
MOD_CK2_1 57 63 PF00069 0.537
MOD_GlcNHglycan 406 409 PF01048 0.505
MOD_GlcNHglycan 519 522 PF01048 0.510
MOD_GlcNHglycan 544 547 PF01048 0.489
MOD_GlcNHglycan 549 552 PF01048 0.506
MOD_GlcNHglycan 70 73 PF01048 0.315
MOD_GSK3_1 395 402 PF00069 0.695
MOD_GSK3_1 424 431 PF00069 0.706
MOD_GSK3_1 493 500 PF00069 0.723
MOD_GSK3_1 528 535 PF00069 0.784
MOD_GSK3_1 556 563 PF00069 0.735
MOD_GSK3_1 576 583 PF00069 0.596
MOD_GSK3_1 584 591 PF00069 0.652
MOD_GSK3_1 604 611 PF00069 0.722
MOD_GSK3_1 612 619 PF00069 0.699
MOD_GSK3_1 622 629 PF00069 0.621
MOD_LATS_1 608 614 PF00433 0.715
MOD_N-GLC_1 268 273 PF02516 0.524
MOD_N-GLC_1 438 443 PF02516 0.492
MOD_N-GLC_1 50 55 PF02516 0.345
MOD_NEK2_1 268 273 PF00069 0.342
MOD_NEK2_1 296 301 PF00069 0.524
MOD_NEK2_1 322 327 PF00069 0.291
MOD_NEK2_1 360 365 PF00069 0.336
MOD_NEK2_1 412 417 PF00069 0.678
MOD_NEK2_1 57 62 PF00069 0.514
MOD_NEK2_1 68 73 PF00069 0.485
MOD_PIKK_1 180 186 PF00454 0.407
MOD_PIKK_1 380 386 PF00454 0.544
MOD_PK_1 233 239 PF00069 0.402
MOD_PKA_1 34 40 PF00069 0.548
MOD_PKA_1 501 507 PF00069 0.661
MOD_PKA_2 232 238 PF00069 0.488
MOD_PKA_2 500 506 PF00069 0.714
MOD_PKA_2 609 615 PF00069 0.713
MOD_Plk_1 268 274 PF00069 0.265
MOD_Plk_1 492 498 PF00069 0.636
MOD_Plk_1 559 565 PF00069 0.725
MOD_Plk_1 576 582 PF00069 0.724
MOD_Plk_1 587 593 PF00069 0.671
MOD_Plk_2-3 438 444 PF00069 0.703
MOD_Plk_2-3 448 454 PF00069 0.678
MOD_Plk_2-3 560 566 PF00069 0.630
MOD_Plk_2-3 588 594 PF00069 0.696
MOD_Plk_4 129 135 PF00069 0.337
MOD_Plk_4 211 217 PF00069 0.307
MOD_Plk_4 233 239 PF00069 0.402
MOD_Plk_4 268 274 PF00069 0.221
MOD_Plk_4 312 318 PF00069 0.303
MOD_Plk_4 360 366 PF00069 0.412
MOD_Plk_4 560 566 PF00069 0.721
MOD_Plk_4 588 594 PF00069 0.697
MOD_Plk_4 83 89 PF00069 0.311
MOD_ProDKin_1 160 166 PF00069 0.494
MOD_ProDKin_1 383 389 PF00069 0.646
MOD_ProDKin_1 483 489 PF00069 0.764
MOD_ProDKin_1 532 538 PF00069 0.751
TRG_DiLeu_BaEn_1 338 343 PF01217 0.339
TRG_DiLeu_BaEn_1 97 102 PF01217 0.351
TRG_DiLeu_BaEn_3 444 450 PF01217 0.632
TRG_DiLeu_LyEn_5 338 343 PF01217 0.289
TRG_ENDOCYTIC_2 15 18 PF00928 0.499
TRG_ENDOCYTIC_2 174 177 PF00928 0.292
TRG_ENDOCYTIC_2 199 202 PF00928 0.226
TRG_ENDOCYTIC_2 239 242 PF00928 0.289
TRG_ENDOCYTIC_2 273 276 PF00928 0.266
TRG_ENDOCYTIC_2 350 353 PF00928 0.342
TRG_ENDOCYTIC_2 446 449 PF00928 0.688
TRG_ENDOCYTIC_2 46 49 PF00928 0.488
TRG_ENDOCYTIC_2 544 547 PF00928 0.764
TRG_ENDOCYTIC_2 558 561 PF00928 0.712
TRG_ENDOCYTIC_2 58 61 PF00928 0.501
TRG_ENDOCYTIC_2 614 617 PF00928 0.718
TRG_ENDOCYTIC_2 66 69 PF00928 0.421
TRG_ENDOCYTIC_2 90 93 PF00928 0.351
TRG_ER_diArg_1 220 222 PF00400 0.515
TRG_ER_diArg_1 379 381 PF00400 0.617
TRG_ER_diArg_1 532 534 PF00400 0.673
TRG_ER_diArg_1 536 538 PF00400 0.675

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAE8 Leptomonas seymouri 58% 100%
A0A3S7XC04 Leishmania donovani 65% 100%
A4IE10 Leishmania infantum 65% 100%
E9AU32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
Q4Q0G3 Leishmania major 67% 100%
V5DK11 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS