Putative glycerophosphoryl diester phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQB5_LEIBR

TriTrypDb:

LbrM.35.6270 , LBRM2903_350074100

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HQB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB5

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006580	ethanolamine metabolic process	5	1
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	7
GO:0009308	amine metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.289
CLV_PCSK_KEX2_1	196	198	PF00082	0.440
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.440
CLV_PCSK_SKI1_1	14	18	PF00082	0.468
CLV_PCSK_SKI1_1	155	159	PF00082	0.395
CLV_PCSK_SKI1_1	251	255	PF00082	0.345
DEG_COP1_1	138	145	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DOC_MAPK_gen_1	153	160	PF00069	0.325
DOC_MAPK_gen_1	196	202	PF00069	0.278

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U2	Leptomonas seymouri	75%	100%
A0A3Q8ILT6	Leishmania donovani	87%	100%
A4IE09	Leishmania infantum	87%	100%
E9AU31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0G4	Leishmania major	85%	100%
Q9C907	Arabidopsis thaliana	25%	80%

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