Putative glycerophosphoryl diester phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQB5_LEIBR

TriTrypDb:

LbrM.35.6270 , LBRM2903_350074100

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0006066	alcohol metabolic process	3	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006580	ethanolamine metabolic process	5	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009308	amine metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034308	primary alcohol metabolic process	4	1
GO:0042439	ethanolamine-containing compound metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0070291	N-acylethanolamine metabolic process	5	1
GO:1901160	primary amino compound metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.289
CLV_PCSK_KEX2_1	196	198	PF00082	0.440
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.440
CLV_PCSK_SKI1_1	14	18	PF00082	0.468
CLV_PCSK_SKI1_1	155	159	PF00082	0.395
CLV_PCSK_SKI1_1	251	255	PF00082	0.345
DEG_COP1_1	138	145	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DOC_MAPK_gen_1	153	160	PF00069	0.325
DOC_MAPK_gen_1	196	202	PF00069	0.278
DOC_MAPK_MEF2A_6	153	160	PF00069	0.298
DOC_MAPK_MEF2A_6	40	47	PF00069	0.339
DOC_MAPK_MEF2A_6	93	102	PF00069	0.263
DOC_PP4_FxxP_1	140	143	PF00568	0.289
DOC_PP4_FxxP_1	36	39	PF00568	0.382
DOC_USP7_MATH_1	210	214	PF00917	0.242
DOC_USP7_MATH_1	253	257	PF00917	0.415
DOC_USP7_MATH_1	75	79	PF00917	0.289
DOC_WW_Pin1_4	35	40	PF00397	0.489
DOC_WW_Pin1_4	46	51	PF00397	0.420
LIG_14-3-3_CanoR_1	197	201	PF00244	0.441
LIG_14-3-3_CanoR_1	44	48	PF00244	0.441
LIG_14-3-3_CanoR_1	93	101	PF00244	0.421
LIG_Actin_WH2_2	118	133	PF00022	0.370
LIG_Actin_WH2_2	30	46	PF00022	0.386
LIG_APCC_ABBA_1	100	105	PF00400	0.289
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.323
LIG_BRCT_BRCA1_1	204	208	PF00533	0.232
LIG_FHA_1	112	118	PF00498	0.249
LIG_FHA_1	175	181	PF00498	0.353
LIG_FHA_1	241	247	PF00498	0.289
LIG_FHA_2	119	125	PF00498	0.311
LIG_FHA_2	142	148	PF00498	0.302
LIG_FHA_2	216	222	PF00498	0.307
LIG_FHA_2	227	233	PF00498	0.235
LIG_Integrin_RGD_1	62	64	PF01839	0.289
LIG_Integrin_RGDW_4	62	65	PF00362	0.289
LIG_IRF3_LxIS_1	39	46	PF10401	0.356
LIG_KLC1_Yacidic_2	164	168	PF13176	0.325
LIG_LIR_Apic_2	138	143	PF02991	0.289
LIG_LIR_Apic_2	35	39	PF02991	0.389
LIG_LIR_Gen_1	188	198	PF02991	0.408
LIG_LIR_Gen_1	217	228	PF02991	0.307
LIG_LIR_Nem_3	168	174	PF02991	0.338
LIG_LIR_Nem_3	188	194	PF02991	0.219
LIG_LIR_Nem_3	205	211	PF02991	0.279
LIG_LIR_Nem_3	217	223	PF02991	0.370
LIG_LIR_Nem_3	283	289	PF02991	0.289
LIG_LIR_Nem_3	64	68	PF02991	0.289
LIG_LYPXL_S_1	170	174	PF13949	0.409
LIG_LYPXL_yS_3	171	174	PF13949	0.416
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.291
LIG_Pex14_2	32	36	PF04695	0.405
LIG_SH2_NCK_1	220	224	PF00017	0.307
LIG_SH2_STAP1	198	202	PF00017	0.430
LIG_SH2_STAP1	234	238	PF00017	0.289
LIG_SH2_STAT5	166	169	PF00017	0.335
LIG_SH2_STAT5	248	251	PF00017	0.289
LIG_SH2_STAT5	288	291	PF00017	0.289
LIG_SH2_STAT5	309	312	PF00017	0.365
LIG_SH2_STAT5	68	71	PF00017	0.289
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.289
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.260
LIG_SUMO_SIM_anti_2	94	102	PF11976	0.205
LIG_SUMO_SIM_par_1	171	177	PF11976	0.424
LIG_SUMO_SIM_par_1	210	219	PF11976	0.207
LIG_SUMO_SIM_par_1	85	90	PF11976	0.308
LIG_TRAF2_1	144	147	PF00917	0.289
LIG_TYR_ITSM	216	223	PF00017	0.370
LIG_UBA3_1	157	162	PF00899	0.422
LIG_UBA3_1	245	254	PF00899	0.262
MOD_CDK_SPK_2	35	40	PF00069	0.438
MOD_CK1_1	187	193	PF00069	0.360
MOD_CK1_1	3	9	PF00069	0.572
MOD_CK1_1	46	52	PF00069	0.407
MOD_CK2_1	118	124	PF00069	0.289
MOD_CK2_1	141	147	PF00069	0.302
MOD_CK2_1	215	221	PF00069	0.385
MOD_GlcNHglycan	2	5	PF01048	0.616
MOD_GlcNHglycan	255	258	PF01048	0.370
MOD_GSK3_1	103	110	PF00069	0.424
MOD_GSK3_1	180	187	PF00069	0.336
MOD_GSK3_1	210	217	PF00069	0.311
MOD_GSK3_1	261	268	PF00069	0.289
MOD_N-GLC_1	111	116	PF02516	0.270
MOD_N-GLC_1	135	140	PF02516	0.289
MOD_NEK2_1	107	112	PF00069	0.414
MOD_NEK2_1	12	17	PF00069	0.462
MOD_NEK2_1	174	179	PF00069	0.338
MOD_NEK2_1	2	7	PF00069	0.524
MOD_NEK2_1	202	207	PF00069	0.234
MOD_NEK2_1	252	257	PF00069	0.207
MOD_NEK2_1	43	48	PF00069	0.357
MOD_PK_1	196	202	PF00069	0.278
MOD_PKA_1	196	202	PF00069	0.441
MOD_PKA_2	108	114	PF00069	0.195
MOD_PKA_2	196	202	PF00069	0.441
MOD_PKA_2	43	49	PF00069	0.340
MOD_PKA_2	92	98	PF00069	0.421
MOD_Plk_1	103	109	PF00069	0.289
MOD_Plk_1	118	124	PF00069	0.289
MOD_Plk_1	138	144	PF00069	0.157
MOD_Plk_1	180	186	PF00069	0.325
MOD_Plk_1	187	193	PF00069	0.352
MOD_Plk_1	215	221	PF00069	0.370
MOD_Plk_1	24	30	PF00069	0.445
MOD_Plk_1	69	75	PF00069	0.289
MOD_Plk_2-3	216	222	PF00069	0.307
MOD_Plk_4	180	186	PF00069	0.325
MOD_Plk_4	202	208	PF00069	0.233
MOD_Plk_4	261	267	PF00069	0.289
MOD_ProDKin_1	35	41	PF00069	0.480
MOD_ProDKin_1	46	52	PF00069	0.418
MOD_SUMO_for_1	185	188	PF00179	0.411
TRG_DiLeu_BaEn_1	146	151	PF01217	0.289
TRG_DiLeu_BaEn_4	146	152	PF01217	0.289
TRG_DiLeu_LyEn_5	169	174	PF01217	0.412
TRG_ENDOCYTIC_2	171	174	PF00928	0.336
TRG_ENDOCYTIC_2	220	223	PF00928	0.370
TRG_NES_CRM1_1	132	146	PF08389	0.289
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U2	Leptomonas seymouri	75%	100%
A0A3Q8ILT6	Leishmania donovani	87%	100%
A4IE09	Leishmania infantum	87%	100%
E9AU31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0G4	Leishmania major	85%	100%
Q9C907	Arabidopsis thaliana	25%	80%