Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQB4_LEIBR

TriTrypDb:

LbrM.35.6260 , LBRM2903_350074000

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.538
CLV_C14_Caspase3-7	48	52	PF00656	0.486
CLV_C14_Caspase3-7	98	102	PF00656	0.499
CLV_PCSK_SKI1_1	148	152	PF00082	0.529
CLV_PCSK_SKI1_1	213	217	PF00082	0.478
CLV_PCSK_SKI1_1	234	238	PF00082	0.636
DEG_SCF_FBW7_1	330	336	PF00400	0.488
DOC_CKS1_1	247	252	PF01111	0.706
DOC_CKS1_1	330	335	PF01111	0.492
DOC_CYCLIN_RxL_1	231	241	PF00134	0.536
DOC_CYCLIN_yClb5_NLxxxL_5	203	211	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.516
DOC_PP1_RVXF_1	232	238	PF00149	0.536
DOC_PP2B_LxvP_1	254	257	PF13499	0.523
DOC_PP4_FxxP_1	237	240	PF00568	0.550
DOC_USP7_MATH_1	111	115	PF00917	0.497
DOC_USP7_MATH_1	248	252	PF00917	0.660
DOC_USP7_MATH_1	270	274	PF00917	0.580
DOC_USP7_MATH_1	314	318	PF00917	0.643
DOC_WW_Pin1_4	171	176	PF00397	0.599
DOC_WW_Pin1_4	246	251	PF00397	0.584
DOC_WW_Pin1_4	280	285	PF00397	0.556
DOC_WW_Pin1_4	297	302	PF00397	0.573
DOC_WW_Pin1_4	329	334	PF00397	0.499
DOC_WW_Pin1_4	46	51	PF00397	0.716
DOC_WW_Pin1_4	93	98	PF00397	0.509
LIG_14-3-3_CanoR_1	7	17	PF00244	0.661
LIG_14-3-3_CanoR_1	83	90	PF00244	0.567
LIG_AP2alpha_2	366	368	PF02296	0.458
LIG_BIR_III_2	229	233	PF00653	0.502
LIG_BIR_III_4	294	298	PF00653	0.535
LIG_FHA_1	140	146	PF00498	0.442
LIG_FHA_1	193	199	PF00498	0.594
LIG_FHA_1	202	208	PF00498	0.578
LIG_FHA_1	214	220	PF00498	0.434
LIG_FHA_1	27	33	PF00498	0.615
LIG_FHA_2	218	224	PF00498	0.585
LIG_FHA_2	256	262	PF00498	0.545
LIG_FHA_2	330	336	PF00498	0.488
LIG_FHA_2	77	83	PF00498	0.467
LIG_GBD_Chelix_1	207	215	PF00786	0.500
LIG_Integrin_RGD_1	244	246	PF01839	0.546
LIG_LIR_Gen_1	147	156	PF02991	0.427
LIG_LIR_Gen_1	220	230	PF02991	0.590
LIG_LIR_Gen_1	74	82	PF02991	0.379
LIG_LIR_Nem_3	147	152	PF02991	0.497
LIG_LIR_Nem_3	220	225	PF02991	0.626
LIG_LIR_Nem_3	366	371	PF02991	0.423
LIG_LIR_Nem_3	74	78	PF02991	0.369
LIG_Pex14_2	222	226	PF04695	0.597
LIG_Pex14_2	71	75	PF04695	0.547
LIG_SH2_CRK	149	153	PF00017	0.464
LIG_SH2_SRC	93	96	PF00017	0.481
LIG_SH2_STAP1	149	153	PF00017	0.550
LIG_SH2_STAP1	162	166	PF00017	0.506
LIG_SH2_STAP1	371	375	PF00017	0.579
LIG_SH2_STAP1	64	68	PF00017	0.433
LIG_SH2_STAT5	359	362	PF00017	0.470
LIG_SH3_3	237	243	PF00018	0.657
LIG_SH3_3	264	270	PF00018	0.534
LIG_SH3_3	315	321	PF00018	0.549
LIG_TRAF2_1	63	66	PF00917	0.516
LIG_TRFH_1	363	367	PF08558	0.522
LIG_WRC_WIRS_1	360	365	PF05994	0.459
LIG_WRC_WIRS_1	72	77	PF05994	0.391
LIG_WW_3	231	235	PF00397	0.520
MOD_CDK_SPxxK_3	280	287	PF00069	0.532
MOD_CDK_SPxxK_3	297	304	PF00069	0.493
MOD_CK1_1	174	180	PF00069	0.508
MOD_CK1_1	275	281	PF00069	0.766
MOD_CK1_1	306	312	PF00069	0.611
MOD_CK1_1	44	50	PF00069	0.669
MOD_CK1_1	8	14	PF00069	0.615
MOD_CK2_1	255	261	PF00069	0.549
MOD_CK2_1	299	305	PF00069	0.662
MOD_CK2_1	310	316	PF00069	0.599
MOD_CK2_1	329	335	PF00069	0.496
MOD_CK2_1	60	66	PF00069	0.500
MOD_GlcNHglycan	113	116	PF01048	0.450
MOD_GlcNHglycan	117	120	PF01048	0.412
MOD_GlcNHglycan	274	277	PF01048	0.693
MOD_GlcNHglycan	301	304	PF01048	0.528
MOD_GlcNHglycan	312	315	PF01048	0.488
MOD_GlcNHglycan	97	100	PF01048	0.495
MOD_GSK3_1	111	118	PF00069	0.499
MOD_GSK3_1	161	168	PF00069	0.631
MOD_GSK3_1	174	181	PF00069	0.475
MOD_GSK3_1	213	220	PF00069	0.531
MOD_GSK3_1	22	29	PF00069	0.562
MOD_GSK3_1	286	293	PF00069	0.776
MOD_GSK3_1	299	306	PF00069	0.569
MOD_GSK3_1	310	317	PF00069	0.599
MOD_GSK3_1	329	336	PF00069	0.492
MOD_GSK3_1	41	48	PF00069	0.664
MOD_GSK3_1	5	12	PF00069	0.557
MOD_GSK3_1	67	74	PF00069	0.474
MOD_NEK2_1	169	174	PF00069	0.589
MOD_NEK2_1	323	328	PF00069	0.593
MOD_NEK2_1	337	342	PF00069	0.472
MOD_NEK2_1	71	76	PF00069	0.429
MOD_NEK2_2	333	338	PF00069	0.475
MOD_PIKK_1	249	255	PF00454	0.541
MOD_PIKK_1	278	284	PF00454	0.692
MOD_PKA_2	139	145	PF00069	0.553
MOD_PKA_2	278	284	PF00069	0.535
MOD_PKA_2	286	292	PF00069	0.648
MOD_PKA_2	303	309	PF00069	0.492
MOD_PKA_2	337	343	PF00069	0.626
MOD_PKA_2	6	12	PF00069	0.590
MOD_PKA_2	82	88	PF00069	0.553
MOD_Plk_1	169	175	PF00069	0.514
MOD_Plk_1	333	339	PF00069	0.477
MOD_Plk_2-3	165	171	PF00069	0.508
MOD_Plk_2-3	351	357	PF00069	0.464
MOD_Plk_4	148	154	PF00069	0.431
MOD_Plk_4	67	73	PF00069	0.599
MOD_ProDKin_1	171	177	PF00069	0.598
MOD_ProDKin_1	246	252	PF00069	0.582
MOD_ProDKin_1	280	286	PF00069	0.556
MOD_ProDKin_1	297	303	PF00069	0.572
MOD_ProDKin_1	329	335	PF00069	0.496
MOD_ProDKin_1	46	52	PF00069	0.708
MOD_ProDKin_1	93	99	PF00069	0.511
MOD_SUMO_for_1	88	91	PF00179	0.594
TRG_ENDOCYTIC_2	149	152	PF00928	0.461
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P903	Leptomonas seymouri	34%	100%
A0A3Q8IGQ8	Leishmania donovani	52%	100%
A4IE08	Leishmania infantum	52%	100%
E9AU30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4Q0G5	Leishmania major	51%	99%