Haloacid dehalogenase-like hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,3-diketo-5-methylthio-1-phosphopentane phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQB3_LEIBR

TriTrypDb:

LbrM.35.6250 , LBRM2903_350073400

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB3

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	3
GO:0000097	sulfur amino acid biosynthetic process	5	3
GO:0006082	organic acid metabolic process	3	3
GO:0006520	amino acid metabolic process	3	3
GO:0006555	methionine metabolic process	5	3
GO:0006790	sulfur compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008652	amino acid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009066	aspartate family amino acid metabolic process	5	3
GO:0009067	aspartate family amino acid biosynthetic process	6	3
GO:0009086	methionine biosynthetic process	6	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019509	L-methionine salvage from methylthioadenosine	6	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0043094	cellular metabolic compound salvage	3	3
GO:0043102	amino acid salvage	4	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044272	sulfur compound biosynthetic process	4	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071265	L-methionine biosynthetic process	7	3
GO:0071267	L-methionine salvage	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3
GO:1901605	alpha-amino acid metabolic process	4	3
GO:1901607	alpha-amino acid biosynthetic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0043874	acireductone synthase activity	6	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.332
CLV_PCSK_KEX2_1	137	139	PF00082	0.451
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.451
CLV_PCSK_SKI1_1	230	234	PF00082	0.419
CLV_PCSK_SKI1_1	280	284	PF00082	0.468
CLV_PCSK_SKI1_1	295	299	PF00082	0.239
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DOC_CYCLIN_RxL_1	274	285	PF00134	0.428
DOC_MAPK_gen_1	55	62	PF00069	0.313
DOC_MAPK_MEF2A_6	274	283	PF00069	0.257
DOC_MAPK_MEF2A_6	55	62	PF00069	0.313
DOC_MAPK_NFAT4_5	55	63	PF00069	0.321
DOC_PP1_RVXF_1	293	299	PF00149	0.253
DOC_PP2B_LxvP_1	60	63	PF13499	0.326
DOC_USP7_MATH_1	309	313	PF00917	0.355
DOC_USP7_MATH_1	314	318	PF00917	0.353
DOC_USP7_MATH_1	69	73	PF00917	0.547
DOC_USP7_UBL2_3	270	274	PF12436	0.355
DOC_WW_Pin1_4	130	135	PF00397	0.669
DOC_WW_Pin1_4	246	251	PF00397	0.321
DOC_WW_Pin1_4	287	292	PF00397	0.293
DOC_WW_Pin1_4	43	48	PF00397	0.432
DOC_WW_Pin1_4	86	91	PF00397	0.342
LIG_14-3-3_CanoR_1	138	146	PF00244	0.363
LIG_14-3-3_CanoR_1	38	43	PF00244	0.370
LIG_14-3-3_CanoR_1	95	99	PF00244	0.317
LIG_BRCT_BRCA1_1	206	210	PF00533	0.417
LIG_Clathr_ClatBox_1	81	85	PF01394	0.412
LIG_CtBP_PxDLS_1	291	295	PF00389	0.284
LIG_deltaCOP1_diTrp_1	327	331	PF00928	0.351
LIG_EH_1	254	258	PF12763	0.333
LIG_eIF4E_1	261	267	PF01652	0.422
LIG_FHA_1	17	23	PF00498	0.384
LIG_FHA_1	234	240	PF00498	0.281
LIG_FHA_1	44	50	PF00498	0.509
LIG_FHA_1	76	82	PF00498	0.401
LIG_FHA_1	86	92	PF00498	0.275
LIG_FHA_2	165	171	PF00498	0.395
LIG_FHA_2	43	49	PF00498	0.375
LIG_LIR_Apic_2	259	264	PF02991	0.322
LIG_LIR_Gen_1	170	179	PF02991	0.446
LIG_LIR_Gen_1	25	35	PF02991	0.465
LIG_LIR_Gen_1	275	284	PF02991	0.340
LIG_LIR_Gen_1	327	335	PF02991	0.484
LIG_LIR_Gen_1	344	349	PF02991	0.222
LIG_LIR_Gen_1	48	58	PF02991	0.303
LIG_LIR_Nem_3	140	146	PF02991	0.322
LIG_LIR_Nem_3	170	174	PF02991	0.441
LIG_LIR_Nem_3	207	213	PF02991	0.431
LIG_LIR_Nem_3	249	254	PF02991	0.489
LIG_LIR_Nem_3	25	31	PF02991	0.389
LIG_LIR_Nem_3	259	265	PF02991	0.388
LIG_LIR_Nem_3	275	279	PF02991	0.239
LIG_LIR_Nem_3	327	331	PF02991	0.486
LIG_LIR_Nem_3	344	348	PF02991	0.290
LIG_LIR_Nem_3	48	53	PF02991	0.285
LIG_Pex14_1	196	200	PF04695	0.373
LIG_Pex14_2	171	175	PF04695	0.432
LIG_REV1ctd_RIR_1	214	222	PF16727	0.345
LIG_SH2_CRK	276	280	PF00017	0.334
LIG_SH2_CRK	32	36	PF00017	0.300
LIG_SH2_NCK_1	32	36	PF00017	0.300
LIG_SH2_NCK_1	68	72	PF00017	0.535
LIG_SH2_SRC	68	71	PF00017	0.378
LIG_SH2_STAP1	28	32	PF00017	0.473
LIG_SH2_STAT5	261	264	PF00017	0.412
LIG_SH2_STAT5	341	344	PF00017	0.402
LIG_SH3_3	112	118	PF00018	0.348
LIG_SH3_3	60	66	PF00018	0.515
LIG_SH3_5	24	28	PF00018	0.316
LIG_SUMO_SIM_par_1	263	269	PF11976	0.463
LIG_TYR_ITIM	26	31	PF00017	0.420
LIG_WRC_WIRS_1	342	347	PF05994	0.354
MOD_CDK_SPxxK_3	130	137	PF00069	0.670
MOD_CK1_1	16	22	PF00069	0.355
MOD_CK1_1	184	190	PF00069	0.303
MOD_CK1_1	235	241	PF00069	0.352
MOD_CK1_1	304	310	PF00069	0.387
MOD_CK2_1	148	154	PF00069	0.288
MOD_CK2_1	164	170	PF00069	0.394
MOD_CK2_1	304	310	PF00069	0.389
MOD_CK2_1	69	75	PF00069	0.366
MOD_GlcNHglycan	150	153	PF01048	0.447
MOD_GlcNHglycan	305	309	PF01048	0.352
MOD_GlcNHglycan	310	314	PF01048	0.378
MOD_GSK3_1	105	112	PF00069	0.333
MOD_GSK3_1	144	151	PF00069	0.364
MOD_GSK3_1	180	187	PF00069	0.327
MOD_GSK3_1	297	304	PF00069	0.355
MOD_GSK3_1	38	45	PF00069	0.383
MOD_GSK3_1	71	78	PF00069	0.471
MOD_N-GLC_1	301	306	PF02516	0.508
MOD_NEK2_1	13	18	PF00069	0.361
MOD_NEK2_1	233	238	PF00069	0.472
MOD_NEK2_1	266	271	PF00069	0.369
MOD_NEK2_1	343	348	PF00069	0.343
MOD_PIKK_1	204	210	PF00454	0.319
MOD_PIKK_1	343	349	PF00454	0.324
MOD_PK_1	38	44	PF00069	0.342
MOD_PKA_1	137	143	PF00069	0.386
MOD_PKA_1	180	186	PF00069	0.412
MOD_PKA_2	137	143	PF00069	0.402
MOD_PKA_2	16	22	PF00069	0.461
MOD_PKA_2	361	367	PF00069	0.281
MOD_PKA_2	94	100	PF00069	0.309
MOD_Plk_1	13	19	PF00069	0.309
MOD_Plk_1	226	232	PF00069	0.362
MOD_Plk_2-3	327	333	PF00069	0.444
MOD_Plk_4	105	111	PF00069	0.237
MOD_Plk_4	272	278	PF00069	0.438
MOD_Plk_4	30	36	PF00069	0.302
MOD_Plk_4	315	321	PF00069	0.424
MOD_Plk_4	94	100	PF00069	0.302
MOD_ProDKin_1	130	136	PF00069	0.667
MOD_ProDKin_1	246	252	PF00069	0.324
MOD_ProDKin_1	287	293	PF00069	0.296
MOD_ProDKin_1	43	49	PF00069	0.421
MOD_ProDKin_1	86	92	PF00069	0.345
MOD_SUMO_rev_2	151	161	PF00179	0.317
MOD_SUMO_rev_2	198	205	PF00179	0.531
MOD_SUMO_rev_2	48	58	PF00179	0.303
TRG_ENDOCYTIC_2	251	254	PF00928	0.350
TRG_ENDOCYTIC_2	276	279	PF00928	0.333
TRG_ENDOCYTIC_2	28	31	PF00928	0.388
TRG_ENDOCYTIC_2	32	35	PF00928	0.382
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN0	Leptomonas seymouri	46%	96%
A0A0S4JWP4	Bodo saltans	33%	100%
A0A1X0NM36	Trypanosomatidae	25%	100%
A0A3Q8IJW9	Leishmania donovani	75%	100%
A0A3R7M5E0	Trypanosoma rangeli	31%	100%
A4IE04	Leishmania infantum	75%	100%
A6SRT0	Botryotinia fuckeliana (strain B05.10)	28%	100%
A7E3Z4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	29%	100%
A9RBS1	Physcomitrium patens	28%	74%
A9V2Y9	Monosiga brevicollis	31%	100%
B3M173	Drosophila ananassae	31%	100%
B3P2A7	Drosophila erecta	32%	100%
B4GFE6	Drosophila persimilis	29%	100%
B4I3X6	Drosophila sechellia	33%	100%
B4PV71	Drosophila yakuba	33%	100%
B4QW91	Drosophila simulans	33%	100%
B5X2D1	Salmo salar	29%	100%
B9N1F9	Populus trichocarpa	28%	72%
B9SQI7	Ricinus communis	27%	71%
B9WAM8	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	100%
C3XR70	Branchiostoma floridae	26%	100%
C4YJE1	Candida albicans (strain WO-1)	26%	100%
C9SUS0	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	28%	100%
E9AU26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q0VD27	Bos taurus	29%	100%
Q28C69	Xenopus tropicalis	29%	100%
Q296B0	Drosophila pseudoobscura pseudoobscura	29%	100%
Q4Q0G9	Leishmania major	74%	100%
Q5AM80	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	100%
Q5PPH0	Rattus norvegicus	31%	100%
Q6FLR5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
Q6GMI7	Danio rerio	28%	100%
Q7Q9C0	Anopheles gambiae	28%	100%
Q8BGB7	Mus musculus	31%	100%
Q9FN41	Arabidopsis thaliana	31%	74%
Q9UHY7	Homo sapiens	28%	100%
Q9VN95	Drosophila melanogaster	35%	100%
V5BJ24	Trypanosoma cruzi	28%	100%