C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A distinct subfamily of CDD/CDA-like deaminases, putative

Species:

Leishmania braziliensis

UniProt:

A4HQB2_LEIBR

TriTrypDb:

LbrM.35.6240 , LBRM2903_350073900

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	613	617	PF00656	0.544
CLV_C14_Caspase3-7	627	631	PF00656	0.573
CLV_NRD_NRD_1	450	452	PF00675	0.329
CLV_NRD_NRD_1	512	514	PF00675	0.418
CLV_NRD_NRD_1	601	603	PF00675	0.441
CLV_PCSK_KEX2_1	150	152	PF00082	0.485
CLV_PCSK_KEX2_1	512	514	PF00082	0.418
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.489
CLV_PCSK_SKI1_1	169	173	PF00082	0.320
CLV_PCSK_SKI1_1	232	236	PF00082	0.514
CLV_PCSK_SKI1_1	550	554	PF00082	0.329
CLV_PCSK_SKI1_1	581	585	PF00082	0.377
CLV_PCSK_SKI1_1	603	607	PF00082	0.436
DEG_APCC_DBOX_1	191	199	PF00400	0.529
DEG_COP1_1	83	94	PF00400	0.522
DEG_ODPH_VHL_1	66	79	PF01847	0.538
DEG_SCF_FBW7_1	272	277	PF00400	0.474
DEG_SCF_FBW7_1	522	528	PF00400	0.329
DOC_CDC14_PxL_1	195	203	PF14671	0.535
DOC_CKS1_1	500	505	PF01111	0.470
DOC_CKS1_1	522	527	PF01111	0.329
DOC_MAPK_DCC_7	194	203	PF00069	0.536
DOC_MAPK_gen_1	512	518	PF00069	0.418
DOC_MAPK_gen_1	602	609	PF00069	0.329
DOC_MAPK_MEF2A_6	194	203	PF00069	0.536
DOC_MAPK_MEF2A_6	289	296	PF00069	0.512
DOC_MAPK_MEF2A_6	366	375	PF00069	0.352
DOC_MAPK_MEF2A_6	602	609	PF00069	0.329
DOC_PP1_RVXF_1	181	187	PF00149	0.528
DOC_PP1_RVXF_1	600	607	PF00149	0.441
DOC_PP2B_LxvP_1	542	545	PF13499	0.512
DOC_PP2B_LxvP_1	607	610	PF13499	0.433
DOC_PP4_FxxP_1	98	101	PF00568	0.519
DOC_USP7_MATH_1	326	330	PF00917	0.498
DOC_USP7_MATH_1	356	360	PF00917	0.470
DOC_USP7_MATH_1	37	41	PF00917	0.592
DOC_USP7_MATH_1	446	450	PF00917	0.362
DOC_USP7_MATH_1	50	54	PF00917	0.658
DOC_USP7_MATH_1	525	529	PF00917	0.329
DOC_WW_Pin1_4	113	118	PF00397	0.733
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	264	269	PF00397	0.624
DOC_WW_Pin1_4	270	275	PF00397	0.627
DOC_WW_Pin1_4	499	504	PF00397	0.470
DOC_WW_Pin1_4	521	526	PF00397	0.329
DOC_WW_Pin1_4	597	602	PF00397	0.470
DOC_WW_Pin1_4	70	75	PF00397	0.638
DOC_WW_Pin1_4	90	95	PF00397	0.672
DOC_WW_Pin1_4	97	102	PF00397	0.730
LIG_14-3-3_CanoR_1	176	186	PF00244	0.529
LIG_14-3-3_CanoR_1	200	206	PF00244	0.528
LIG_14-3-3_CanoR_1	252	260	PF00244	0.471
LIG_14-3-3_CanoR_1	445	451	PF00244	0.336
LIG_14-3-3_CanoR_1	457	467	PF00244	0.299
LIG_14-3-3_CanoR_1	529	536	PF00244	0.345
LIG_APCC_ABBA_1	258	263	PF00400	0.402
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	10	14	PF00533	0.447
LIG_BRCT_BRCA1_1	122	126	PF00533	0.496
LIG_BRCT_BRCA1_1	616	620	PF00533	0.391
LIG_BRCT_BRCA1_1	94	98	PF00533	0.505
LIG_BRCT_BRCA1_2	10	16	PF00533	0.472
LIG_BRCT_BRCA1_2	616	622	PF00533	0.396
LIG_Dynein_DLC8_1	273	279	PF01221	0.458
LIG_FHA_1	277	283	PF00498	0.617
LIG_FHA_1	342	348	PF00498	0.476
LIG_FHA_1	433	439	PF00498	0.399
LIG_FHA_1	454	460	PF00498	0.328
LIG_FHA_1	49	55	PF00498	0.666
LIG_FHA_1	544	550	PF00498	0.329
LIG_FHA_1	578	584	PF00498	0.348
LIG_FHA_1	81	87	PF00498	0.711
LIG_FHA_2	313	319	PF00498	0.386
LIG_FHA_2	34	40	PF00498	0.460
LIG_FHA_2	377	383	PF00498	0.521
LIG_FHA_2	385	391	PF00498	0.456
LIG_FHA_2	463	469	PF00498	0.329
LIG_FHA_2	482	488	PF00498	0.329
LIG_IBAR_NPY_1	480	482	PF08397	0.237
LIG_LIR_Apic_2	95	101	PF02991	0.727
LIG_LIR_Gen_1	29	37	PF02991	0.407
LIG_LIR_Gen_1	340	348	PF02991	0.463
LIG_LIR_Gen_1	389	399	PF02991	0.517
LIG_LIR_Gen_1	414	422	PF02991	0.532
LIG_LIR_Nem_3	103	107	PF02991	0.524
LIG_LIR_Nem_3	123	129	PF02991	0.410
LIG_LIR_Nem_3	13	18	PF02991	0.405
LIG_LIR_Nem_3	144	148	PF02991	0.378
LIG_LIR_Nem_3	29	33	PF02991	0.403
LIG_LIR_Nem_3	340	345	PF02991	0.457
LIG_LIR_Nem_3	389	394	PF02991	0.487
LIG_LIR_Nem_3	414	420	PF02991	0.516
LIG_LIR_Nem_3	465	469	PF02991	0.441
LIG_LIR_Nem_3	617	623	PF02991	0.396
LIG_LIR_Nem_3	8	12	PF02991	0.460
LIG_MYND_1	64	68	PF01753	0.533
LIG_Pex14_1	338	342	PF04695	0.482
LIG_PTB_Apo_2	321	328	PF02174	0.484
LIG_PTB_Apo_2	561	568	PF02174	0.329
LIG_SH2_GRB2like	376	379	PF00017	0.316
LIG_SH2_PTP2	161	164	PF00017	0.585
LIG_SH2_PTP2	30	33	PF00017	0.384
LIG_SH2_STAP1	10	14	PF00017	0.460
LIG_SH2_STAP1	44	48	PF00017	0.451
LIG_SH2_STAT5	146	149	PF00017	0.445
LIG_SH2_STAT5	161	164	PF00017	0.449
LIG_SH2_STAT5	18	21	PF00017	0.411
LIG_SH2_STAT5	225	228	PF00017	0.442
LIG_SH2_STAT5	259	262	PF00017	0.487
LIG_SH2_STAT5	30	33	PF00017	0.390
LIG_SH2_STAT5	376	379	PF00017	0.438
LIG_SH3_1	452	458	PF00018	0.335
LIG_SH3_3	103	109	PF00018	0.693
LIG_SH3_3	150	156	PF00018	0.416
LIG_SH3_3	196	202	PF00018	0.547
LIG_SH3_3	368	374	PF00018	0.459
LIG_SH3_3	389	395	PF00018	0.350
LIG_SH3_3	452	458	PF00018	0.335
LIG_SH3_3	562	568	PF00018	0.329
LIG_SH3_3	602	608	PF00018	0.309
LIG_SH3_3	88	94	PF00018	0.716
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.536
LIG_SUMO_SIM_par_1	31	36	PF11976	0.383
LIG_TRAF2_1	484	487	PF00917	0.418
LIG_UBA3_1	419	424	PF00899	0.470
LIG_WRC_WIRS_1	463	468	PF05994	0.441
MOD_CDC14_SPxK_1	163	166	PF00782	0.605
MOD_CDK_SPK_2	160	165	PF00069	0.592
MOD_CDK_SPK_2	264	269	PF00069	0.651
MOD_CDK_SPK_2	270	275	PF00069	0.601
MOD_CDK_SPK_2	597	602	PF00069	0.470
MOD_CDK_SPxK_1	160	166	PF00069	0.592
MOD_CDK_SPxK_1	597	603	PF00069	0.470
MOD_CK1_1	100	106	PF00069	0.677
MOD_CK1_1	177	183	PF00069	0.363
MOD_CK1_1	280	286	PF00069	0.554
MOD_CK1_1	429	435	PF00069	0.295
MOD_CK1_1	462	468	PF00069	0.329
MOD_CK1_1	492	498	PF00069	0.347
MOD_CK1_1	523	529	PF00069	0.364
MOD_CK1_1	53	59	PF00069	0.649
MOD_CK1_1	84	90	PF00069	0.694
MOD_CK2_1	280	286	PF00069	0.494
MOD_CK2_1	294	300	PF00069	0.530
MOD_CK2_1	481	487	PF00069	0.470
MOD_CK2_1	492	498	PF00069	0.258
MOD_CK2_1	556	562	PF00069	0.237
MOD_GlcNHglycan	120	123	PF01048	0.679
MOD_GlcNHglycan	126	129	PF01048	0.712
MOD_GlcNHglycan	132	136	PF01048	0.632
MOD_GlcNHglycan	175	179	PF01048	0.450
MOD_GlcNHglycan	279	282	PF01048	0.567
MOD_GlcNHglycan	358	361	PF01048	0.329
MOD_GlcNHglycan	503	506	PF01048	0.484
MOD_GlcNHglycan	525	528	PF01048	0.329
MOD_GlcNHglycan	55	58	PF01048	0.736
MOD_GlcNHglycan	616	619	PF01048	0.526
MOD_GlcNHglycan	87	90	PF01048	0.723
MOD_GSK3_1	118	125	PF00069	0.579
MOD_GSK3_1	270	277	PF00069	0.607
MOD_GSK3_1	33	40	PF00069	0.425
MOD_GSK3_1	458	465	PF00069	0.329
MOD_GSK3_1	521	528	PF00069	0.409
MOD_GSK3_1	610	617	PF00069	0.530
MOD_GSK3_1	80	87	PF00069	0.659
MOD_N-GLC_1	384	389	PF02516	0.503
MOD_N-GLC_1	432	437	PF02516	0.441
MOD_N-GLC_2	470	472	PF02516	0.441
MOD_NEK2_1	120	125	PF00069	0.649
MOD_NEK2_1	343	348	PF00069	0.423
MOD_NEK2_1	384	389	PF00069	0.491
MOD_NEK2_1	441	446	PF00069	0.404
MOD_NEK2_1	596	601	PF00069	0.351
MOD_NEK2_1	85	90	PF00069	0.683
MOD_NEK2_2	141	146	PF00069	0.455
MOD_NEK2_2	5	10	PF00069	0.568
MOD_NEK2_2	589	594	PF00069	0.441
MOD_OFUCOSY	174	181	PF10250	0.543
MOD_OFUCOSY	251	257	PF10250	0.494
MOD_PIKK_1	274	280	PF00454	0.591
MOD_PIKK_1	294	300	PF00454	0.399
MOD_PKA_2	528	534	PF00069	0.345
MOD_PKA_2	577	583	PF00069	0.441
MOD_PKA_2	614	620	PF00069	0.384
MOD_PKB_1	192	200	PF00069	0.529
MOD_PKB_1	408	416	PF00069	0.576
MOD_Plk_1	262	268	PF00069	0.610
MOD_Plk_1	37	43	PF00069	0.514
MOD_Plk_1	432	438	PF00069	0.441
MOD_Plk_1	489	495	PF00069	0.372
MOD_Plk_1	589	595	PF00069	0.392
MOD_Plk_4	141	147	PF00069	0.446
MOD_Plk_4	26	32	PF00069	0.512
MOD_Plk_4	343	349	PF00069	0.529
MOD_Plk_4	38	44	PF00069	0.620
MOD_Plk_4	402	408	PF00069	0.490
MOD_Plk_4	426	432	PF00069	0.348
MOD_Plk_4	459	465	PF00069	0.313
MOD_Plk_4	5	11	PF00069	0.519
MOD_Plk_4	81	87	PF00069	0.659
MOD_ProDKin_1	113	119	PF00069	0.732
MOD_ProDKin_1	160	166	PF00069	0.547
MOD_ProDKin_1	264	270	PF00069	0.633
MOD_ProDKin_1	499	505	PF00069	0.470
MOD_ProDKin_1	521	527	PF00069	0.329
MOD_ProDKin_1	597	603	PF00069	0.470
MOD_ProDKin_1	70	76	PF00069	0.636
MOD_ProDKin_1	90	96	PF00069	0.667
MOD_ProDKin_1	97	103	PF00069	0.732
MOD_SUMO_for_1	422	425	PF00179	0.357
MOD_SUMO_rev_2	346	356	PF00179	0.519
TRG_AP2beta_CARGO_1	340	349	PF09066	0.490
TRG_DiLeu_BaEn_1	38	43	PF01217	0.407
TRG_ENDOCYTIC_2	18	21	PF00928	0.446
TRG_ENDOCYTIC_2	30	33	PF00928	0.328
TRG_ER_diArg_1	191	194	PF00400	0.538
TRG_ER_diArg_1	407	410	PF00400	0.407
TRG_ER_diArg_1	511	513	PF00400	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C3	Leptomonas seymouri	66%	99%
A0A1X0NLM5	Trypanosomatidae	39%	100%
A0A3Q8IWI0	Leishmania donovani	79%	100%
A0A3R7NP46	Trypanosoma rangeli	39%	100%
D0A3Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AU29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q0G6	Leishmania major	76%	99%
V5B3J9	Trypanosoma cruzi	38%	100%