Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQB1_LEIBR

TriTrypDb:

LbrM.35.6230 , LBRM2903_350073800

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0019905	syntaxin binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.588
CLV_NRD_NRD_1	235	237	PF00675	0.577
CLV_NRD_NRD_1	290	292	PF00675	0.508
CLV_NRD_NRD_1	40	42	PF00675	0.614
CLV_NRD_NRD_1	81	83	PF00675	0.543
CLV_NRD_NRD_1	91	93	PF00675	0.551
CLV_PCSK_KEX2_1	141	143	PF00082	0.528
CLV_PCSK_KEX2_1	234	236	PF00082	0.572
CLV_PCSK_KEX2_1	40	42	PF00082	0.473
CLV_PCSK_KEX2_1	90	92	PF00082	0.600
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.528
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.600
CLV_PCSK_SKI1_1	114	118	PF00082	0.519
CLV_PCSK_SKI1_1	203	207	PF00082	0.374
CLV_PCSK_SKI1_1	221	225	PF00082	0.575
CLV_PCSK_SKI1_1	235	239	PF00082	0.501
CLV_PCSK_SKI1_1	49	53	PF00082	0.566
CLV_PCSK_SKI1_1	7	11	PF00082	0.430
CLV_PCSK_SKI1_1	72	76	PF00082	0.635
DOC_CKS1_1	275	280	PF01111	0.461
DOC_CYCLIN_RxL_1	14	24	PF00134	0.580
DOC_MAPK_gen_1	14	22	PF00069	0.607
DOC_SPAK_OSR1_1	194	198	PF12202	0.583
DOC_USP7_MATH_1	225	229	PF00917	0.576
DOC_USP7_MATH_1	237	241	PF00917	0.442
DOC_USP7_UBL2_3	203	207	PF12436	0.484
DOC_USP7_UBL2_3	246	250	PF12436	0.483
DOC_WW_Pin1_4	274	279	PF00397	0.446
LIG_14-3-3_CanoR_1	159	167	PF00244	0.399
LIG_14-3-3_CanoR_1	194	198	PF00244	0.527
LIG_14-3-3_CanoR_1	262	271	PF00244	0.472
LIG_14-3-3_CanoR_1	7	15	PF00244	0.397
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_FHA_1	158	164	PF00498	0.586
LIG_FHA_1	169	175	PF00498	0.495
LIG_FHA_1	217	223	PF00498	0.608
LIG_FHA_1	270	276	PF00498	0.581
LIG_FHA_1	8	14	PF00498	0.623
LIG_FHA_2	167	173	PF00498	0.603
LIG_FHA_2	212	218	PF00498	0.593
LIG_FHA_2	264	270	PF00498	0.620
LIG_FHA_2	275	281	PF00498	0.554
LIG_LIR_Gen_1	133	140	PF02991	0.488
LIG_LIR_Gen_1	245	254	PF02991	0.367
LIG_LIR_Nem_3	133	138	PF02991	0.520
LIG_LIR_Nem_3	245	251	PF02991	0.374
LIG_LIR_Nem_3	68	74	PF02991	0.605
LIG_Pex14_2	191	195	PF04695	0.597
LIG_SH2_CRK	71	75	PF00017	0.602
LIG_SH2_NCK_1	209	213	PF00017	0.587
LIG_SH2_SRC	124	127	PF00017	0.600
LIG_SH3_2	287	292	PF14604	0.502
LIG_SH3_3	281	287	PF00018	0.652
LIG_TRAF2_1	55	58	PF00917	0.583
MOD_CK1_1	2	8	PF00069	0.637
MOD_CK1_1	211	217	PF00069	0.536
MOD_CK2_1	127	133	PF00069	0.581
MOD_CK2_1	166	172	PF00069	0.602
MOD_CK2_1	237	243	PF00069	0.484
MOD_CK2_1	263	269	PF00069	0.598
MOD_CK2_1	274	280	PF00069	0.598
MOD_CK2_1	52	58	PF00069	0.546
MOD_GlcNHglycan	125	130	PF01048	0.591
MOD_GlcNHglycan	210	213	PF01048	0.498
MOD_GlcNHglycan	280	284	PF01048	0.724
MOD_GSK3_1	193	200	PF00069	0.552
MOD_GSK3_1	263	270	PF00069	0.633
MOD_GSK3_1	52	59	PF00069	0.529
MOD_N-GLC_2	156	158	PF02516	0.358
MOD_PIKK_1	197	203	PF00454	0.553
MOD_PIKK_1	7	13	PF00454	0.398
MOD_PK_1	52	58	PF00069	0.554
MOD_PKA_1	235	241	PF00069	0.384
MOD_PKA_2	158	164	PF00069	0.529
MOD_PKA_2	193	199	PF00069	0.503
MOD_PKA_2	217	223	PF00069	0.574
MOD_PKA_2	235	241	PF00069	0.339
MOD_PKB_1	234	242	PF00069	0.600
MOD_Plk_1	279	285	PF00069	0.511
MOD_ProDKin_1	274	280	PF00069	0.455
MOD_SUMO_for_1	140	143	PF00179	0.388
MOD_SUMO_for_1	186	189	PF00179	0.502
MOD_SUMO_for_1	33	36	PF00179	0.599
MOD_SUMO_rev_2	182	186	PF00179	0.486
MOD_SUMO_rev_2	28	33	PF00179	0.594
TRG_AP2beta_CARGO_1	133	142	PF09066	0.593
TRG_DiLeu_BaEn_1	170	175	PF01217	0.500
TRG_ENDOCYTIC_2	71	74	PF00928	0.604
TRG_ER_diArg_1	13	16	PF00400	0.545
TRG_ER_diArg_1	234	236	PF00400	0.587
TRG_ER_diArg_1	39	41	PF00400	0.404
TRG_ER_diArg_1	91	93	PF00400	0.356
TRG_NLS_MonoExtC_3	89	95	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB0	Leptomonas seymouri	59%	100%
A0A1X0NMA0	Trypanosomatidae	33%	100%
A0A3Q8IK37	Leishmania donovani	76%	100%
A0A3R7KFM9	Trypanosoma rangeli	34%	100%
A4IE06	Leishmania infantum	76%	100%
D0A3Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q0G7	Leishmania major	75%	100%
V5BNM8	Trypanosoma cruzi	35%	100%