DUF2263 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HQB0_LEIBR

TriTrypDb:

LbrM.35.6220 , LBRM2903_350073700

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQB0

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031047	RNA-mediated gene silencing	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060147	regulation of post-transcriptional gene silencing	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0060964	regulation of miRNA-mediated gene silencing	8	1
GO:0060966	regulation of gene silencing by RNA	6	1
GO:0065007	biological regulation	1	1
GO:1900368	regulation of post-transcriptional gene silencing by RNA	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.638
CLV_C14_Caspase3-7	51	55	PF00656	0.561
CLV_NRD_NRD_1	258	260	PF00675	0.612
CLV_NRD_NRD_1	480	482	PF00675	0.648
CLV_PCSK_KEX2_1	258	260	PF00082	0.612
CLV_PCSK_KEX2_1	480	482	PF00082	0.654
CLV_PCSK_SKI1_1	168	172	PF00082	0.549
CLV_PCSK_SKI1_1	226	230	PF00082	0.440
CLV_PCSK_SKI1_1	373	377	PF00082	0.458
CLV_PCSK_SKI1_1	429	433	PF00082	0.687
CLV_PCSK_SKI1_1	518	522	PF00082	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.600
DEG_SPOP_SBC_1	321	325	PF00917	0.682
DOC_CKS1_1	466	471	PF01111	0.768
DOC_MAPK_MEF2A_6	154	162	PF00069	0.478
DOC_PIKK_1	97	104	PF02985	0.767
DOC_PP2B_LxvP_1	92	95	PF13499	0.669
DOC_PP4_FxxP_1	334	337	PF00568	0.379
DOC_PP4_FxxP_1	65	68	PF00568	0.567
DOC_USP7_MATH_1	110	114	PF00917	0.710
DOC_USP7_MATH_1	116	120	PF00917	0.638
DOC_USP7_MATH_1	228	232	PF00917	0.501
DOC_USP7_MATH_1	254	258	PF00917	0.684
DOC_USP7_MATH_1	315	319	PF00917	0.592
DOC_USP7_MATH_1	321	325	PF00917	0.577
DOC_USP7_MATH_1	359	363	PF00917	0.520
DOC_USP7_MATH_1	77	81	PF00917	0.619
DOC_USP7_UBL2_3	238	242	PF12436	0.625
DOC_USP7_UBL2_3	251	255	PF12436	0.656
DOC_WW_Pin1_4	108	113	PF00397	0.720
DOC_WW_Pin1_4	141	146	PF00397	0.538
DOC_WW_Pin1_4	226	231	PF00397	0.526
DOC_WW_Pin1_4	326	331	PF00397	0.589
DOC_WW_Pin1_4	394	399	PF00397	0.619
DOC_WW_Pin1_4	465	470	PF00397	0.759
DOC_WW_Pin1_4	64	69	PF00397	0.592
LIG_14-3-3_CanoR_1	258	262	PF00244	0.604
LIG_14-3-3_CanoR_1	82	92	PF00244	0.604
LIG_BIR_III_2	109	113	PF00653	0.754
LIG_BRCT_BRCA1_1	11	15	PF00533	0.729
LIG_BRCT_BRCA1_1	361	365	PF00533	0.533
LIG_BRCT_BRCA1_1	52	56	PF00533	0.491
LIG_Clathr_ClatBox_1	159	163	PF01394	0.423
LIG_deltaCOP1_diTrp_1	284	290	PF00928	0.545
LIG_eIF4E_1	371	377	PF01652	0.543
LIG_FHA_1	180	186	PF00498	0.636
LIG_FHA_1	353	359	PF00498	0.530
LIG_FHA_1	466	472	PF00498	0.728
LIG_FHA_2	21	27	PF00498	0.536
LIG_FHA_2	227	233	PF00498	0.442
LIG_FHA_2	397	403	PF00498	0.562
LIG_FHA_2	422	428	PF00498	0.692
LIG_GBD_Chelix_1	513	521	PF00786	0.547
LIG_LIR_Apic_2	63	68	PF02991	0.592
LIG_LIR_Gen_1	284	293	PF02991	0.530
LIG_LIR_Gen_1	295	306	PF02991	0.367
LIG_LIR_Gen_1	310	316	PF02991	0.385
LIG_LIR_Gen_1	422	431	PF02991	0.694
LIG_LIR_Gen_1	44	52	PF02991	0.455
LIG_LIR_Nem_3	284	288	PF02991	0.557
LIG_LIR_Nem_3	289	293	PF02991	0.416
LIG_LIR_Nem_3	310	316	PF02991	0.412
LIG_LIR_Nem_3	422	426	PF02991	0.685
LIG_LIR_Nem_3	44	49	PF02991	0.437
LIG_LIR_Nem_3	483	489	PF02991	0.551
LIG_PDZ_Class_2	518	523	PF00595	0.597
LIG_Pex14_2	57	61	PF04695	0.490
LIG_REV1ctd_RIR_1	54	62	PF16727	0.557
LIG_SH2_CRK	311	315	PF00017	0.517
LIG_SH2_CRK	350	354	PF00017	0.558
LIG_SH2_CRK	46	50	PF00017	0.543
LIG_SH2_CRK	489	493	PF00017	0.538
LIG_SH2_NCK_1	410	414	PF00017	0.516
LIG_SH2_NCK_1	46	50	PF00017	0.543
LIG_SH2_NCK_1	511	515	PF00017	0.519
LIG_SH2_SRC	196	199	PF00017	0.490
LIG_SH2_STAP1	371	375	PF00017	0.435
LIG_SH2_STAP1	410	414	PF00017	0.516
LIG_SH2_STAP1	46	50	PF00017	0.491
LIG_SH2_STAT5	10	13	PF00017	0.737
LIG_SH2_STAT5	445	448	PF00017	0.432
LIG_SH2_STAT5	486	489	PF00017	0.560
LIG_SH2_STAT5	511	514	PF00017	0.497
LIG_SH3_1	392	398	PF00018	0.616
LIG_SH3_3	302	308	PF00018	0.428
LIG_SH3_3	324	330	PF00018	0.626
LIG_SH3_3	379	385	PF00018	0.498
LIG_SH3_3	392	398	PF00018	0.604
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.576
LIG_SUMO_SIM_anti_2	386	391	PF11976	0.455
LIG_SUMO_SIM_anti_2	448	453	PF11976	0.505
LIG_SUMO_SIM_par_1	266	271	PF11976	0.549
LIG_SUMO_SIM_par_1	386	391	PF11976	0.522
LIG_TRAF2_1	174	177	PF00917	0.607
LIG_TRAF2_1	425	428	PF00917	0.666
LIG_TRAF2_1	95	98	PF00917	0.750
LIG_TYR_ITIM	348	353	PF00017	0.543
LIG_UBA3_1	267	272	PF00899	0.545
MOD_CDK_SPxxK_3	141	148	PF00069	0.530
MOD_CK1_1	119	125	PF00069	0.670
MOD_CK1_1	144	150	PF00069	0.449
MOD_CK1_1	16	22	PF00069	0.637
MOD_CK1_1	257	263	PF00069	0.639
MOD_CK1_1	286	292	PF00069	0.530
MOD_CK1_1	322	328	PF00069	0.605
MOD_CK1_1	396	402	PF00069	0.583
MOD_CK1_1	465	471	PF00069	0.718
MOD_CK2_1	20	26	PF00069	0.566
MOD_CK2_1	421	427	PF00069	0.644
MOD_CK2_1	447	453	PF00069	0.464
MOD_GlcNHglycan	172	175	PF01048	0.589
MOD_GlcNHglycan	324	327	PF01048	0.624
MOD_GlcNHglycan	361	364	PF01048	0.536
MOD_GlcNHglycan	43	46	PF01048	0.497
MOD_GlcNHglycan	439	442	PF01048	0.544
MOD_GlcNHglycan	83	86	PF01048	0.548
MOD_GSK3_1	119	126	PF00069	0.648
MOD_GSK3_1	140	147	PF00069	0.547
MOD_GSK3_1	22	29	PF00069	0.499
MOD_GSK3_1	234	241	PF00069	0.595
MOD_GSK3_1	315	322	PF00069	0.624
MOD_GSK3_1	37	44	PF00069	0.290
MOD_GSK3_1	465	472	PF00069	0.655
MOD_GSK3_1	56	63	PF00069	0.448
MOD_GSK3_1	77	84	PF00069	0.525
MOD_GSK3_1	9	16	PF00069	0.654
MOD_N-GLC_1	286	291	PF02516	0.535
MOD_N-GLC_2	494	496	PF02516	0.590
MOD_NEK2_1	123	128	PF00069	0.749
MOD_NEK2_1	170	175	PF00069	0.527
MOD_NEK2_1	179	184	PF00069	0.590
MOD_NEK2_1	301	306	PF00069	0.587
MOD_NEK2_1	447	452	PF00069	0.497
MOD_NEK2_1	56	61	PF00069	0.467
MOD_NEK2_2	77	82	PF00069	0.624
MOD_OFUCOSY	151	157	PF10250	0.582
MOD_PIKK_1	236	242	PF00454	0.644
MOD_PIKK_1	462	468	PF00454	0.740
MOD_PIKK_1	56	62	PF00454	0.557
MOD_PK_1	383	389	PF00069	0.543
MOD_PKA_2	153	159	PF00069	0.557
MOD_PKA_2	257	263	PF00069	0.652
MOD_PKA_2	81	87	PF00069	0.604
MOD_Plk_1	119	125	PF00069	0.702
MOD_Plk_1	286	292	PF00069	0.530
MOD_Plk_1	301	307	PF00069	0.532
MOD_Plk_1	447	453	PF00069	0.503
MOD_Plk_4	26	32	PF00069	0.597
MOD_Plk_4	361	367	PF00069	0.412
MOD_Plk_4	38	44	PF00069	0.455
MOD_Plk_4	383	389	PF00069	0.498
MOD_Plk_4	396	402	PF00069	0.460
MOD_Plk_4	488	494	PF00069	0.540
MOD_ProDKin_1	108	114	PF00069	0.723
MOD_ProDKin_1	141	147	PF00069	0.528
MOD_ProDKin_1	226	232	PF00069	0.521
MOD_ProDKin_1	326	332	PF00069	0.582
MOD_ProDKin_1	394	400	PF00069	0.608
MOD_ProDKin_1	465	471	PF00069	0.764
MOD_ProDKin_1	64	70	PF00069	0.589
MOD_SUMO_rev_2	135	144	PF00179	0.682
TRG_DiLeu_BaEn_1	155	160	PF01217	0.546
TRG_DiLeu_BaEn_1	17	22	PF01217	0.699
TRG_DiLeu_BaEn_1	26	31	PF01217	0.413
TRG_DiLeu_BaEn_4	427	433	PF01217	0.694
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.532
TRG_ENDOCYTIC_2	298	301	PF00928	0.556
TRG_ENDOCYTIC_2	311	314	PF00928	0.287
TRG_ENDOCYTIC_2	350	353	PF00928	0.509
TRG_ENDOCYTIC_2	46	49	PF00928	0.482
TRG_ENDOCYTIC_2	489	492	PF00928	0.543
TRG_NES_CRM1_1	448	458	PF08389	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NNC5	Trypanosomatidae	28%	100%
A0A3R7RJN8	Trypanosoma rangeli	27%	100%
D0A3Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%