Putative kinetoplast DNA-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast DNA-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQA9_LEIBR

TriTrypDb:

LbrM.35.6210 , LBRM2903_350073600

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.616
CLV_NRD_NRD_1	51	53	PF00675	0.398
CLV_NRD_NRD_1	64	66	PF00675	0.502
CLV_NRD_NRD_1	73	75	PF00675	0.461
CLV_NRD_NRD_1	82	84	PF00675	0.362
CLV_NRD_NRD_1	94	96	PF00675	0.397
CLV_PCSK_FUR_1	49	53	PF00082	0.286
CLV_PCSK_KEX2_1	34	36	PF00082	0.392
CLV_PCSK_KEX2_1	51	53	PF00082	0.421
CLV_PCSK_KEX2_1	56	58	PF00082	0.429
CLV_PCSK_KEX2_1	96	98	PF00082	0.379
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.392
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.480
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.379
CLV_PCSK_PC7_1	52	58	PF00082	0.429
CLV_PCSK_SKI1_1	117	121	PF00082	0.566
CLV_PCSK_SKI1_1	122	126	PF00082	0.583
CLV_PCSK_SKI1_1	142	146	PF00082	0.615
CLV_PCSK_SKI1_1	156	160	PF00082	0.522
CLV_PCSK_SKI1_1	65	69	PF00082	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.527
DOC_USP7_MATH_1	138	142	PF00917	0.692
DOC_USP7_UBL2_3	131	135	PF12436	0.576
DOC_USP7_UBL2_3	136	140	PF12436	0.521
DOC_USP7_UBL2_3	151	155	PF12436	0.662
DOC_USP7_UBL2_3	156	160	PF12436	0.629
DOC_USP7_UBL2_3	161	165	PF12436	0.582
DOC_USP7_UBL2_3	37	41	PF12436	0.443
DOC_WW_Pin1_4	9	14	PF00397	0.379
LIG_14-3-3_CanoR_1	74	82	PF00244	0.540
LIG_14-3-3_CanoR_1	95	105	PF00244	0.452
LIG_LIR_Gen_1	12	19	PF02991	0.358
LIG_LIR_Gen_1	76	86	PF02991	0.417
LIG_LIR_Nem_3	12	17	PF02991	0.348
LIG_LIR_Nem_3	40	46	PF02991	0.411
LIG_LIR_Nem_3	76	81	PF02991	0.429
LIG_SH2_CRK	86	90	PF00017	0.334
LIG_UBA3_1	38	44	PF00899	0.374
LIG_WW_3	71	75	PF00397	0.506
MOD_CK1_1	12	18	PF00069	0.352
MOD_CK1_1	99	105	PF00069	0.441
MOD_GlcNHglycan	128	131	PF01048	0.612
MOD_GlcNHglycan	98	101	PF01048	0.440
MOD_GSK3_1	156	163	PF00069	0.683
MOD_PIKK_1	99	105	PF00454	0.362
MOD_PKA_1	125	131	PF00069	0.514
MOD_PKA_1	160	166	PF00069	0.657
MOD_PKA_1	96	102	PF00069	0.442
MOD_PKA_2	73	79	PF00069	0.560
MOD_PKA_2	96	102	PF00069	0.442
MOD_Plk_1	44	50	PF00069	0.278
MOD_ProDKin_1	9	15	PF00069	0.377
TRG_DiLeu_BaEn_2	76	82	PF01217	0.479
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.486
TRG_ENDOCYTIC_2	43	46	PF00928	0.388
TRG_ENDOCYTIC_2	86	89	PF00928	0.373
TRG_ER_diArg_1	48	51	PF00400	0.516
TRG_ER_diArg_1	94	97	PF00400	0.400
TRG_NLS_Bipartite_1	51	69	PF00514	0.530
TRG_NLS_Bipartite_1	83	99	PF00514	0.252
TRG_NLS_MonoExtN_4	62	69	PF00514	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Y9	Leptomonas seymouri	68%	98%
A0A0N1IC67	Leptomonas seymouri	32%	100%
A0A0S4IRH7	Bodo saltans	33%	100%
A0A1X0NLS3	Trypanosomatidae	38%	100%
A0A1X0NNA1	Trypanosomatidae	56%	93%
A0A1X0NNA5	Trypanosomatidae	38%	100%
A0A1X0NND5	Trypanosomatidae	35%	100%
A0A3Q8ILR8	Leishmania donovani	35%	100%
A0A3Q8IPT9	Leishmania donovani	87%	100%
A0A3R7MMA3	Trypanosoma rangeli	33%	100%
A0A3R7NF04	Trypanosoma rangeli	56%	89%
A0A422NSG2	Trypanosoma rangeli	33%	100%
A4HQA1	Leishmania braziliensis	32%	100%
A4IDZ7	Leishmania infantum	35%	100%
A4IE05	Leishmania infantum	87%	100%
D0A3Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	79%
D0A408	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	89%
D0A410	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AU19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AU27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q07053	Crithidia fasciculata	35%	100%
Q4Q0G8	Leishmania major	88%	100%
Q4Q0H6	Leishmania major	35%	100%
V5BT80	Trypanosoma cruzi	58%	90%
V5DK57	Trypanosoma cruzi	33%	100%