Putative choline/ethanolamine phosphotransferase (CEPT)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQA8_LEIBR

TriTrypDb:

LbrM.35.6200 , LBRM2903_350073300

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HQA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9
GO:0009058	biosynthetic process	2	9
GO:0009987	cellular process	1	9
GO:0019637	organophosphate metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	9
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004142	diacylglycerol cholinephosphotransferase activity	6	4
GO:0004307	ethanolaminephosphotransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.431
CLV_NRD_NRD_1	119	121	PF00675	0.228
CLV_NRD_NRD_1	8	10	PF00675	0.440
CLV_PCSK_KEX2_1	119	121	PF00082	0.228
CLV_PCSK_KEX2_1	8	10	PF00082	0.413
CLV_PCSK_SKI1_1	245	249	PF00082	0.348
CLV_PCSK_SKI1_1	43	47	PF00082	0.340
DEG_APCC_DBOX_1	244	252	PF00400	0.299
DEG_APCC_DBOX_1	325	333	PF00400	0.347
DEG_APCC_DBOX_1	8	16	PF00400	0.588
DOC_AGCK_PIF_1	102	107	PF00069	0.166
DOC_CDC14_PxL_1	282	290	PF14671	0.220
DOC_CKS1_1	138	143	PF01111	0.247
DOC_CKS1_1	152	157	PF01111	0.247
DOC_CKS1_1	212	217	PF01111	0.280
DOC_MAPK_MEF2A_6	245	252	PF00069	0.349
DOC_MAPK_NFAT4_5	245	253	PF00069	0.220
DOC_PP1_RVXF_1	243	250	PF00149	0.330
DOC_PP1_RVXF_1	303	309	PF00149	0.186
DOC_PP1_RVXF_1	370	377	PF00149	0.234
DOC_PP4_FxxP_1	138	141	PF00568	0.262
DOC_USP7_MATH_1	233	237	PF00917	0.432
DOC_USP7_MATH_1	413	417	PF00917	0.610
DOC_WW_Pin1_4	122	127	PF00397	0.452
DOC_WW_Pin1_4	137	142	PF00397	0.175
DOC_WW_Pin1_4	151	156	PF00397	0.247
DOC_WW_Pin1_4	211	216	PF00397	0.361
DOC_WW_Pin1_4	276	281	PF00397	0.442
LIG_14-3-3_CanoR_1	326	330	PF00244	0.436
LIG_14-3-3_CanoR_1	331	335	PF00244	0.452
LIG_14-3-3_CanoR_1	8	13	PF00244	0.570
LIG_BRCT_BRCA1_1	245	249	PF00533	0.281
LIG_BRCT_BRCA1_1	297	301	PF00533	0.414
LIG_BRCT_BRCA1_1	34	38	PF00533	0.423
LIG_deltaCOP1_diTrp_1	157	167	PF00928	0.166
LIG_eIF4E_1	99	105	PF01652	0.247
LIG_FHA_1	138	144	PF00498	0.248
LIG_FHA_1	189	195	PF00498	0.476
LIG_FHA_1	212	218	PF00498	0.336
LIG_FHA_1	260	266	PF00498	0.357
LIG_FHA_1	277	283	PF00498	0.405
LIG_FHA_1	351	357	PF00498	0.218
LIG_FHA_1	67	73	PF00498	0.279
LIG_FHA_2	152	158	PF00498	0.299
LIG_FHA_2	270	276	PF00498	0.410
LIG_IRF3_LxIS_1	400	407	PF10401	0.536
LIG_LIR_Apic_2	136	141	PF02991	0.421
LIG_LIR_Apic_2	151	155	PF02991	0.262
LIG_LIR_Apic_2	16	22	PF02991	0.581
LIG_LIR_Apic_2	209	215	PF02991	0.257
LIG_LIR_Gen_1	140	150	PF02991	0.301
LIG_LIR_Gen_1	163	172	PF02991	0.301
LIG_LIR_Gen_1	246	257	PF02991	0.294
LIG_LIR_Gen_1	298	309	PF02991	0.373
LIG_LIR_Gen_1	339	350	PF02991	0.456
LIG_LIR_Gen_1	35	46	PF02991	0.495
LIG_LIR_Gen_1	382	392	PF02991	0.375
LIG_LIR_Gen_1	395	404	PF02991	0.464
LIG_LIR_Gen_1	96	107	PF02991	0.190
LIG_LIR_Nem_3	101	105	PF02991	0.381
LIG_LIR_Nem_3	106	110	PF02991	0.346
LIG_LIR_Nem_3	140	145	PF02991	0.350
LIG_LIR_Nem_3	157	162	PF02991	0.204
LIG_LIR_Nem_3	163	167	PF02991	0.314
LIG_LIR_Nem_3	168	173	PF02991	0.346
LIG_LIR_Nem_3	246	252	PF02991	0.256
LIG_LIR_Nem_3	298	304	PF02991	0.332
LIG_LIR_Nem_3	313	319	PF02991	0.323
LIG_LIR_Nem_3	339	345	PF02991	0.456
LIG_LIR_Nem_3	382	387	PF02991	0.349
LIG_LIR_Nem_3	395	400	PF02991	0.449
LIG_LIR_Nem_3	67	71	PF02991	0.390
LIG_LIR_Nem_3	94	98	PF02991	0.390
LIG_LYPXL_SIV_4	223	231	PF13949	0.223
LIG_PCNA_PIPBox_1	153	162	PF02747	0.264
LIG_PCNA_yPIPBox_3	146	158	PF02747	0.323
LIG_Pex14_1	160	164	PF04695	0.180
LIG_Pex14_1	95	99	PF04695	0.247
LIG_Pex14_2	138	142	PF04695	0.367
LIG_Pex14_2	170	174	PF04695	0.262
LIG_Rb_pABgroove_1	125	133	PF01858	0.410
LIG_SH2_CRK	152	156	PF00017	0.262
LIG_SH2_CRK	316	320	PF00017	0.358
LIG_SH2_GRB2like	186	189	PF00017	0.533
LIG_SH2_GRB2like	403	406	PF00017	0.480
LIG_SH2_GRB2like	49	52	PF00017	0.461
LIG_SH2_NCK_1	220	224	PF00017	0.379
LIG_SH2_PTP2	19	22	PF00017	0.556
LIG_SH2_SRC	186	189	PF00017	0.533
LIG_SH2_SRC	19	22	PF00017	0.556
LIG_SH2_SRC	403	406	PF00017	0.480
LIG_SH2_STAP1	220	224	PF00017	0.344
LIG_SH2_STAP1	99	103	PF00017	0.262
LIG_SH2_STAT3	44	47	PF00017	0.472
LIG_SH2_STAT5	186	189	PF00017	0.509
LIG_SH2_STAT5	19	22	PF00017	0.492
LIG_SH2_STAT5	24	27	PF00017	0.459
LIG_SH2_STAT5	403	406	PF00017	0.513
LIG_SH2_STAT5	44	47	PF00017	0.478
LIG_SH2_STAT5	83	86	PF00017	0.237
LIG_SH3_3	184	190	PF00018	0.593
LIG_SH3_3	219	225	PF00018	0.313
LIG_SH3_3	265	271	PF00018	0.504
LIG_SH3_3	303	309	PF00018	0.340
LIG_SUMO_SIM_anti_2	76	83	PF11976	0.167
LIG_SUMO_SIM_par_1	318	323	PF11976	0.276
LIG_UBA3_1	408	415	PF00899	0.536
LIG_WRC_WIRS_1	161	166	PF05994	0.166
LIG_WRC_WIRS_1	99	104	PF05994	0.430
LIG_WW_1	21	24	PF00397	0.511
MOD_CDK_SPxxK_3	151	158	PF00069	0.238
MOD_CK1_1	148	154	PF00069	0.374
MOD_CK1_1	163	169	PF00069	0.237
MOD_CK1_1	243	249	PF00069	0.320
MOD_CK1_1	276	282	PF00069	0.468
MOD_CK1_1	39	45	PF00069	0.484
MOD_CK1_1	395	401	PF00069	0.442
MOD_CK1_1	407	413	PF00069	0.489
MOD_CK2_1	151	157	PF00069	0.299
MOD_GlcNHglycan	203	206	PF01048	0.351
MOD_GlcNHglycan	235	238	PF01048	0.454
MOD_GlcNHglycan	394	397	PF01048	0.503
MOD_GlcNHglycan	76	79	PF01048	0.276
MOD_GSK3_1	118	125	PF00069	0.458
MOD_GSK3_1	207	214	PF00069	0.282
MOD_GSK3_1	269	276	PF00069	0.585
MOD_GSK3_1	295	302	PF00069	0.244
MOD_GSK3_1	318	325	PF00069	0.251
MOD_GSK3_1	32	39	PF00069	0.513
MOD_N-GLC_1	145	150	PF02516	0.359
MOD_N-GLC_1	361	366	PF02516	0.427
MOD_N-GLC_1	404	409	PF02516	0.280
MOD_NEK2_1	145	150	PF00069	0.441
MOD_NEK2_1	162	167	PF00069	0.243
MOD_NEK2_1	201	206	PF00069	0.276
MOD_NEK2_1	288	293	PF00069	0.219
MOD_NEK2_1	312	317	PF00069	0.296
MOD_NEK2_1	318	323	PF00069	0.248
MOD_NEK2_1	374	379	PF00069	0.409
MOD_NEK2_1	392	397	PF00069	0.288
MOD_NEK2_1	404	409	PF00069	0.467
MOD_NEK2_2	93	98	PF00069	0.169
MOD_PIKK_1	395	401	PF00454	0.437
MOD_PKA_1	8	14	PF00069	0.591
MOD_PKA_2	118	124	PF00069	0.438
MOD_PKA_2	269	275	PF00069	0.549
MOD_PKA_2	325	331	PF00069	0.272
MOD_PKA_2	8	14	PF00069	0.582
MOD_Plk_1	145	151	PF00069	0.403
MOD_Plk_1	312	318	PF00069	0.214
MOD_Plk_1	36	42	PF00069	0.476
MOD_Plk_1	361	367	PF00069	0.345
MOD_Plk_1	404	410	PF00069	0.441
MOD_Plk_4	145	151	PF00069	0.375
MOD_Plk_4	207	213	PF00069	0.320
MOD_Plk_4	295	301	PF00069	0.337
MOD_Plk_4	330	336	PF00069	0.457
MOD_Plk_4	352	358	PF00069	0.330
MOD_Plk_4	379	385	PF00069	0.348
MOD_ProDKin_1	122	128	PF00069	0.452
MOD_ProDKin_1	137	143	PF00069	0.175
MOD_ProDKin_1	151	157	PF00069	0.247
MOD_ProDKin_1	211	217	PF00069	0.363
MOD_ProDKin_1	276	282	PF00069	0.442
MOD_SUMO_rev_2	111	118	PF00179	0.410
TRG_DiLeu_BaEn_1	157	162	PF01217	0.190
TRG_ENDOCYTIC_2	107	110	PF00928	0.162
TRG_ENDOCYTIC_2	316	319	PF00928	0.351
TRG_ENDOCYTIC_2	389	392	PF00928	0.272
TRG_ENDOCYTIC_2	403	406	PF00928	0.512
TRG_ENDOCYTIC_2	49	52	PF00928	0.487
TRG_ENDOCYTIC_2	83	86	PF00928	0.259
TRG_ENDOCYTIC_2	99	102	PF00928	0.277
TRG_ER_diLys_1	412	417	PF00400	0.621
TRG_NLS_MonoExtN_4	26	33	PF00514	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I260	Leptomonas seymouri	63%	100%
A0A0S4JA45	Bodo saltans	37%	95%
A0A1X0NLI0	Trypanosomatidae	51%	92%
A0A3Q8IRT0	Leishmania donovani	80%	100%
A0A3R7NAX1	Trypanosoma rangeli	47%	97%
A4IE03	Leishmania infantum	80%	100%
D0A400	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AU25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O82567	Arabidopsis thaliana	31%	100%
O82568	Arabidopsis thaliana	31%	100%
P17898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q17QM4	Bos taurus	27%	100%
Q4Q0H0	Leishmania major	81%	100%
Q550W1	Dictyostelium discoideum	29%	100%
Q55AQ3	Dictyostelium discoideum	28%	100%
Q7ZW02	Danio rerio	27%	100%
V5B3K4	Trypanosoma cruzi	49%	96%