Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania braziliensis

UniProt:

A4HQA6_LEIBR

TriTrypDb:

LbrM.35.6180 , LBRM2903_350073100

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1905360	GTPase complex	3	1
GO:1990131	Gtr1-Gtr2 GTPase complex	4	1

Expansion

Sequence features

A4HQA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA6

Function

Biological processes
Term	Name	Level	Count
GO:0001101	response to acid chemical	3	1
GO:0006950	response to stress	2	1
GO:0007154	cell communication	2	1
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1
GO:0009719	response to endogenous stimulus	2	1
GO:0009894	regulation of catabolic process	4	1
GO:0009966	regulation of signal transduction	4	1
GO:0009967	positive regulation of signal transduction	5	1
GO:0009987	cellular process	1	1
GO:0009991	response to extracellular stimulus	3	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010506	regulation of autophagy	6	1
GO:0010646	regulation of cell communication	4	1
GO:0010647	positive regulation of cell communication	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0023051	regulation of signaling	3	1
GO:0023056	positive regulation of signaling	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031667	response to nutrient levels	4	1
GO:0031668	cellular response to extracellular stimulus	3	1
GO:0031669	cellular response to nutrient levels	4	1
GO:0032006	regulation of TOR signaling	6	1
GO:0032008	positive regulation of TOR signaling	7	1
GO:0033554	cellular response to stress	3	1
GO:0042221	response to chemical	2	1
GO:0042594	response to starvation	3	1
GO:0043200	response to amino acid	4	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048584	positive regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0065007	biological regulation	1	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071229	cellular response to acid chemical	4	1
GO:0071230	cellular response to amino acid stimulus	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071417	cellular response to organonitrogen compound	4	1
GO:0071495	cellular response to endogenous stimulus	3	1
GO:0071496	cellular response to external stimulus	3	1
GO:1901698	response to nitrogen compound	3	1
GO:1901699	cellular response to nitrogen compound	4	1
GO:1901700	response to oxygen-containing compound	3	1
GO:1901701	cellular response to oxygen-containing compound	4	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902533	positive regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.273
CLV_NRD_NRD_1	16	18	PF00675	0.254
CLV_PCSK_KEX2_1	148	150	PF00082	0.273
CLV_PCSK_SKI1_1	10	14	PF00082	0.274
CLV_PCSK_SKI1_1	155	159	PF00082	0.314
CLV_PCSK_SKI1_1	188	192	PF00082	0.288
CLV_PCSK_SKI1_1	26	30	PF00082	0.238
CLV_PCSK_SKI1_1	354	358	PF00082	0.402
DOC_AGCK_PIF_2	59	64	PF00069	0.238
DOC_CYCLIN_yClb1_LxF_4	163	168	PF00134	0.331
DOC_MAPK_MEF2A_6	117	126	PF00069	0.315
DOC_PP1_RVXF_1	163	169	PF00149	0.253
DOC_PP1_RVXF_1	24	30	PF00149	0.238
DOC_PP2B_LxvP_1	6	9	PF13499	0.496
DOC_USP7_MATH_1	289	293	PF00917	0.637
DOC_USP7_MATH_1	34	38	PF00917	0.289
DOC_USP7_MATH_1	46	50	PF00917	0.234
DOC_WW_Pin1_4	276	281	PF00397	0.431
LIG_Actin_WH2_2	1	19	PF00022	0.272
LIG_AP2alpha_2	69	71	PF02296	0.272
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	212	216	PF00533	0.242
LIG_BRCT_BRCA1_1	52	56	PF00533	0.277
LIG_deltaCOP1_diTrp_1	60	64	PF00928	0.238
LIG_EH1_1	78	86	PF00400	0.272
LIG_eIF4E_1	79	85	PF01652	0.272
LIG_FHA_1	196	202	PF00498	0.242
LIG_FHA_1	234	240	PF00498	0.265
LIG_FHA_1	283	289	PF00498	0.576
LIG_FHA_1	327	333	PF00498	0.342
LIG_FHA_2	335	341	PF00498	0.511
LIG_LIR_Apic_2	60	65	PF02991	0.238
LIG_LIR_Gen_1	177	186	PF02991	0.238
LIG_LIR_Gen_1	211	222	PF02991	0.238
LIG_LIR_Gen_1	53	64	PF02991	0.238
LIG_LIR_LC3C_4	183	186	PF02991	0.253
LIG_LIR_Nem_3	177	182	PF02991	0.238
LIG_LIR_Nem_3	211	217	PF02991	0.238
LIG_LIR_Nem_3	220	226	PF02991	0.238
LIG_LIR_Nem_3	53	59	PF02991	0.238
LIG_MAD2	26	34	PF02301	0.238
LIG_SH2_NCK_1	254	258	PF00017	0.336
LIG_SH2_PTP2	223	226	PF00017	0.381
LIG_SH2_SRC	174	177	PF00017	0.191
LIG_SH2_STAP1	174	178	PF00017	0.191
LIG_SH2_STAP1	296	300	PF00017	0.391
LIG_SH2_STAT5	196	199	PF00017	0.238
LIG_SH2_STAT5	214	217	PF00017	0.238
LIG_SH2_STAT5	223	226	PF00017	0.238
LIG_SH2_STAT5	254	257	PF00017	0.385
LIG_SH2_STAT5	320	323	PF00017	0.291
LIG_SH2_STAT5	93	96	PF00017	0.405
LIG_SH3_3	67	73	PF00018	0.168
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.301
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.302
LIG_TYR_ITIM	212	217	PF00017	0.238
LIG_UBA3_1	12	21	PF00899	0.224
LIG_UBA3_1	5	10	PF00899	0.409
MOD_CK1_1	19	25	PF00069	0.239
MOD_CK1_1	269	275	PF00069	0.539
MOD_CK1_1	298	304	PF00069	0.393
MOD_CK1_1	326	332	PF00069	0.442
MOD_CK1_1	74	80	PF00069	0.381
MOD_CK2_1	334	340	PF00069	0.498
MOD_GlcNHglycan	18	21	PF01048	0.260
MOD_GlcNHglycan	267	271	PF01048	0.601
MOD_GlcNHglycan	291	294	PF01048	0.563
MOD_GlcNHglycan	36	39	PF01048	0.398
MOD_GlcNHglycan	362	365	PF01048	0.580
MOD_GSK3_1	16	23	PF00069	0.238
MOD_GSK3_1	248	255	PF00069	0.316
MOD_GSK3_1	272	279	PF00069	0.678
MOD_GSK3_1	36	43	PF00069	0.313
MOD_GSK3_1	46	53	PF00069	0.167
MOD_N-GLC_1	168	173	PF02516	0.245
MOD_N-GLC_1	360	365	PF02516	0.498
MOD_N-GLC_1	74	79	PF02516	0.262
MOD_NEK2_1	108	113	PF00069	0.238
MOD_NEK2_1	142	147	PF00069	0.253
MOD_NEK2_1	16	21	PF00069	0.274
MOD_NEK2_1	168	173	PF00069	0.256
MOD_NEK2_1	203	208	PF00069	0.205
MOD_NEK2_1	215	220	PF00069	0.218
MOD_NEK2_1	334	339	PF00069	0.466
MOD_NEK2_1	360	365	PF00069	0.480
MOD_NEK2_1	40	45	PF00069	0.336
MOD_NEK2_2	174	179	PF00069	0.191
MOD_PKA_2	16	22	PF00069	0.253
MOD_PKB_1	229	237	PF00069	0.267
MOD_Plk_1	168	174	PF00069	0.238
MOD_Plk_1	210	216	PF00069	0.238
MOD_Plk_1	282	288	PF00069	0.444
MOD_Plk_1	46	52	PF00069	0.257
MOD_Plk_1	74	80	PF00069	0.294
MOD_Plk_2-3	132	138	PF00069	0.253
MOD_Plk_4	169	175	PF00069	0.238
MOD_Plk_4	210	216	PF00069	0.238
MOD_Plk_4	283	289	PF00069	0.655
MOD_Plk_4	326	332	PF00069	0.299
MOD_ProDKin_1	276	282	PF00069	0.431
MOD_SUMO_rev_2	151	157	PF00179	0.314
TRG_DiLeu_BaEn_1	153	158	PF01217	0.253
TRG_DiLeu_BaEn_1	340	345	PF01217	0.505
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.253
TRG_ENDOCYTIC_2	214	217	PF00928	0.238
TRG_ENDOCYTIC_2	223	226	PF00928	0.238
TRG_ER_diArg_1	105	108	PF00400	0.304
TRG_ER_diArg_1	148	150	PF00400	0.274
TRG_ER_diArg_1	229	232	PF00400	0.326
TRG_NES_CRM1_1	323	336	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFN5	Leptomonas seymouri	82%	99%
A0A0S4J6M9	Bodo saltans	51%	100%
A0A1X0NLK4	Trypanosomatidae	67%	100%
A0A3R7KR72	Trypanosoma rangeli	68%	100%
A0A3S7XBX6	Leishmania donovani	92%	100%
A4IE01	Leishmania infantum	92%	100%
D0A404	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AU23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O74544	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P53290	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q4Q0H2	Leishmania major	91%	100%
Q7TT45	Mus musculus	38%	81%
Q99K70	Mus musculus	37%	92%
Q9HB90	Homo sapiens	37%	91%
Q9NQL2	Homo sapiens	37%	91%
V5BM39	Trypanosoma cruzi	22%	100%
V5BT86	Trypanosoma cruzi	69%	100%