Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania braziliensis

UniProt:

A4HQA5_LEIBR

TriTrypDb:

LbrM.35.6170 , LBRM2903_350073000

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HQA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.403
CLV_C14_Caspase3-7	753	757	PF00656	0.483
CLV_C14_Caspase3-7	99	103	PF00656	0.684
CLV_MEL_PAP_1	263	269	PF00089	0.577
CLV_NRD_NRD_1	323	325	PF00675	0.558
CLV_NRD_NRD_1	391	393	PF00675	0.437
CLV_NRD_NRD_1	434	436	PF00675	0.540
CLV_NRD_NRD_1	499	501	PF00675	0.526
CLV_NRD_NRD_1	762	764	PF00675	0.635
CLV_PCSK_FUR_1	320	324	PF00082	0.409
CLV_PCSK_FUR_1	432	436	PF00082	0.535
CLV_PCSK_FUR_1	497	501	PF00082	0.564
CLV_PCSK_KEX2_1	322	324	PF00082	0.571
CLV_PCSK_KEX2_1	391	393	PF00082	0.459
CLV_PCSK_KEX2_1	434	436	PF00082	0.540
CLV_PCSK_KEX2_1	499	501	PF00082	0.527
CLV_PCSK_KEX2_1	629	631	PF00082	0.670
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.670
CLV_PCSK_SKI1_1	161	165	PF00082	0.477
CLV_PCSK_SKI1_1	384	388	PF00082	0.397
CLV_PCSK_SKI1_1	435	439	PF00082	0.438
CLV_PCSK_SKI1_1	491	495	PF00082	0.568
CLV_PCSK_SKI1_1	499	503	PF00082	0.515
CLV_PCSK_SKI1_1	546	550	PF00082	0.607
CLV_PCSK_SKI1_1	569	573	PF00082	0.385
CLV_PCSK_SKI1_1	68	72	PF00082	0.627
CLV_PCSK_SKI1_1	740	744	PF00082	0.570
DEG_APCC_DBOX_1	182	190	PF00400	0.589
DEG_APCC_DBOX_1	434	442	PF00400	0.433
DEG_APCC_DBOX_1	498	506	PF00400	0.512
DEG_APCC_DBOX_1	568	576	PF00400	0.508
DEG_APCC_DBOX_1	739	747	PF00400	0.629
DEG_COP1_1	231	242	PF00400	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SPOP_SBC_1	189	193	PF00917	0.580
DEG_SPOP_SBC_1	610	614	PF00917	0.708
DOC_CYCLIN_RxL_1	381	390	PF00134	0.529
DOC_MAPK_DCC_7	740	748	PF00069	0.632
DOC_MAPK_gen_1	320	327	PF00069	0.498
DOC_MAPK_gen_1	391	399	PF00069	0.592
DOC_MAPK_gen_1	497	504	PF00069	0.525
DOC_MAPK_gen_1	664	672	PF00069	0.461
DOC_MAPK_gen_1	737	745	PF00069	0.626
DOC_MAPK_MEF2A_6	367	375	PF00069	0.728
DOC_MAPK_MEF2A_6	740	748	PF00069	0.607
DOC_PP1_RVXF_1	159	165	PF00149	0.516
DOC_PP4_FxxP_1	49	52	PF00568	0.620
DOC_PP4_FxxP_1	53	56	PF00568	0.637
DOC_PP4_FxxP_1	542	545	PF00568	0.497
DOC_PP4_FxxP_1	741	744	PF00568	0.589
DOC_USP7_MATH_1	293	297	PF00917	0.606
DOC_USP7_MATH_1	563	567	PF00917	0.372
DOC_USP7_MATH_1	581	585	PF00917	0.661
DOC_USP7_MATH_1	594	598	PF00917	0.640
DOC_USP7_MATH_1	625	629	PF00917	0.719
DOC_USP7_MATH_1	635	639	PF00917	0.728
DOC_USP7_MATH_1	725	729	PF00917	0.608
DOC_USP7_MATH_2	18	24	PF00917	0.458
DOC_WW_Pin1_4	248	253	PF00397	0.640
DOC_WW_Pin1_4	265	270	PF00397	0.694
DOC_WW_Pin1_4	460	465	PF00397	0.317
DOC_WW_Pin1_4	69	74	PF00397	0.596
DOC_WW_Pin1_4	715	720	PF00397	0.555
DOC_WW_Pin1_4	762	767	PF00397	0.646
DOC_WW_Pin1_4	9	14	PF00397	0.556
LIG_14-3-3_CanoR_1	165	173	PF00244	0.560
LIG_14-3-3_CanoR_1	515	524	PF00244	0.357
LIG_Actin_WH2_2	53	70	PF00022	0.638
LIG_AP2alpha_2	308	310	PF02296	0.721
LIG_BIR_III_4	649	653	PF00653	0.482
LIG_BRCT_BRCA1_1	394	398	PF00533	0.610
LIG_BRCT_BRCA1_1	560	564	PF00533	0.368
LIG_deltaCOP1_diTrp_1	705	714	PF00928	0.411
LIG_eIF4E_1	61	67	PF01652	0.666
LIG_eIF4E_1	717	723	PF01652	0.410
LIG_FHA_1	120	126	PF00498	0.708
LIG_FHA_1	133	139	PF00498	0.567
LIG_FHA_1	189	195	PF00498	0.384
LIG_FHA_1	292	298	PF00498	0.612
LIG_FHA_1	329	335	PF00498	0.566
LIG_FHA_1	344	350	PF00498	0.577
LIG_FHA_1	367	373	PF00498	0.661
LIG_FHA_1	394	400	PF00498	0.611
LIG_FHA_1	402	408	PF00498	0.535
LIG_FHA_1	473	479	PF00498	0.630
LIG_FHA_1	525	531	PF00498	0.418
LIG_FHA_1	583	589	PF00498	0.660
LIG_FHA_1	616	622	PF00498	0.616
LIG_FHA_2	270	276	PF00498	0.651
LIG_FHA_2	751	757	PF00498	0.596
LIG_LIR_Apic_2	47	52	PF02991	0.590
LIG_LIR_Apic_2	539	545	PF02991	0.492
LIG_LIR_Gen_1	110	119	PF02991	0.560
LIG_LIR_Gen_1	12	22	PF02991	0.691
LIG_LIR_Gen_1	133	142	PF02991	0.476
LIG_LIR_Gen_1	308	314	PF02991	0.672
LIG_LIR_Gen_1	39	50	PF02991	0.395
LIG_LIR_Gen_1	556	564	PF02991	0.398
LIG_LIR_Gen_1	771	782	PF02991	0.474
LIG_LIR_LC3C_4	618	623	PF02991	0.715
LIG_LIR_Nem_3	110	114	PF02991	0.559
LIG_LIR_Nem_3	12	17	PF02991	0.680
LIG_LIR_Nem_3	133	139	PF02991	0.477
LIG_LIR_Nem_3	157	163	PF02991	0.504
LIG_LIR_Nem_3	275	279	PF02991	0.553
LIG_LIR_Nem_3	308	313	PF02991	0.698
LIG_LIR_Nem_3	39	45	PF02991	0.384
LIG_LIR_Nem_3	420	424	PF02991	0.575
LIG_LIR_Nem_3	556	562	PF02991	0.421
LIG_LIR_Nem_3	675	681	PF02991	0.437
LIG_LIR_Nem_3	771	777	PF02991	0.490
LIG_LYPXL_S_1	677	681	PF13949	0.438
LIG_NRBOX	698	704	PF00104	0.344
LIG_PCNA_yPIPBox_3	400	409	PF02747	0.435
LIG_Pex14_1	310	314	PF04695	0.687
LIG_Pex14_1	421	425	PF04695	0.412
LIG_Pex14_2	160	164	PF04695	0.469
LIG_Pex14_2	49	53	PF04695	0.652
LIG_Pex14_2	741	745	PF04695	0.474
LIG_SH2_CRK	134	138	PF00017	0.466
LIG_SH2_CRK	139	143	PF00017	0.496
LIG_SH2_CRK	184	188	PF00017	0.592
LIG_SH2_CRK	425	429	PF00017	0.362
LIG_SH2_CRK	81	85	PF00017	0.471
LIG_SH2_NCK_1	111	115	PF00017	0.473
LIG_SH2_NCK_1	413	417	PF00017	0.705
LIG_SH2_NCK_1	425	429	PF00017	0.345
LIG_SH2_SRC	413	416	PF00017	0.716
LIG_SH2_SRC	61	64	PF00017	0.444
LIG_SH2_STAP1	111	115	PF00017	0.451
LIG_SH2_STAP1	134	138	PF00017	0.566
LIG_SH2_STAT5	134	137	PF00017	0.463
LIG_SH2_STAT5	206	209	PF00017	0.627
LIG_SH2_STAT5	312	315	PF00017	0.586
LIG_SH3_3	126	132	PF00018	0.531
LIG_SH3_3	216	222	PF00018	0.588
LIG_SH3_3	619	625	PF00018	0.693
LIG_SH3_3	629	635	PF00018	0.735
LIG_SH3_3	650	656	PF00018	0.687
LIG_SH3_3	7	13	PF00018	0.573
LIG_SH3_3	91	97	PF00018	0.369
LIG_SUMO_SIM_anti_2	457	463	PF11976	0.576
LIG_SUMO_SIM_anti_2	570	576	PF11976	0.551
LIG_SUMO_SIM_anti_2	87	95	PF11976	0.502
LIG_SUMO_SIM_par_1	185	193	PF11976	0.467
LIG_SUMO_SIM_par_1	371	377	PF11976	0.721
LIG_SUMO_SIM_par_1	384	390	PF11976	0.356
LIG_SUMO_SIM_par_1	457	463	PF11976	0.481
LIG_SUMO_SIM_par_1	526	532	PF11976	0.456
LIG_TRAF2_1	169	172	PF00917	0.646
LIG_TRAF2_1	18	21	PF00917	0.690
LIG_TRAF2_1	268	271	PF00917	0.744
LIG_TYR_ITIM	79	84	PF00017	0.528
LIG_UBA3_1	781	786	PF00899	0.593
LIG_WRC_WIRS_1	403	408	PF05994	0.537
MOD_CDC14_SPxK_1	718	721	PF00782	0.409
MOD_CDK_SPK_2	69	74	PF00069	0.596
MOD_CDK_SPxK_1	715	721	PF00069	0.414
MOD_CK1_1	118	124	PF00069	0.672
MOD_CK1_1	12	18	PF00069	0.607
MOD_CK1_1	225	231	PF00069	0.708
MOD_CK1_1	232	238	PF00069	0.630
MOD_CK1_1	251	257	PF00069	0.628
MOD_CK1_1	358	364	PF00069	0.662
MOD_CK1_1	374	380	PF00069	0.706
MOD_CK1_1	612	618	PF00069	0.680
MOD_CK1_1	673	679	PF00069	0.615
MOD_CK2_1	166	172	PF00069	0.568
MOD_CK2_1	225	231	PF00069	0.613
MOD_CK2_1	265	271	PF00069	0.695
MOD_CK2_1	387	393	PF00069	0.603
MOD_CK2_1	470	476	PF00069	0.636
MOD_CK2_1	483	489	PF00069	0.624
MOD_GlcNHglycan	102	105	PF01048	0.582
MOD_GlcNHglycan	122	125	PF01048	0.395
MOD_GlcNHglycan	172	176	PF01048	0.699
MOD_GlcNHglycan	224	227	PF01048	0.571
MOD_GlcNHglycan	228	231	PF01048	0.593
MOD_GlcNHglycan	26	29	PF01048	0.446
MOD_GlcNHglycan	331	334	PF01048	0.520
MOD_GlcNHglycan	519	522	PF01048	0.482
MOD_GlcNHglycan	696	699	PF01048	0.497
MOD_GSK3_1	115	122	PF00069	0.637
MOD_GSK3_1	20	27	PF00069	0.559
MOD_GSK3_1	222	229	PF00069	0.710
MOD_GSK3_1	248	255	PF00069	0.582
MOD_GSK3_1	265	272	PF00069	0.633
MOD_GSK3_1	312	319	PF00069	0.507
MOD_GSK3_1	353	360	PF00069	0.587
MOD_GSK3_1	470	477	PF00069	0.445
MOD_GSK3_1	554	561	PF00069	0.691
MOD_GSK3_1	611	618	PF00069	0.573
MOD_GSK3_1	96	103	PF00069	0.685
MOD_N-GLC_1	535	540	PF02516	0.537
MOD_N-GLC_1	733	738	PF02516	0.587
MOD_NEK2_1	119	124	PF00069	0.678
MOD_NEK2_1	190	195	PF00069	0.594
MOD_NEK2_1	200	205	PF00069	0.625
MOD_NEK2_1	256	261	PF00069	0.595
MOD_NEK2_1	348	353	PF00069	0.569
MOD_NEK2_1	365	370	PF00069	0.606
MOD_NEK2_1	386	391	PF00069	0.496
MOD_NEK2_1	516	521	PF00069	0.480
MOD_NEK2_1	582	587	PF00069	0.512
MOD_NEK2_1	589	594	PF00069	0.558
MOD_NEK2_1	749	754	PF00069	0.517
MOD_NEK2_2	554	559	PF00069	0.439
MOD_OFUCOSY	547	553	PF10250	0.470
MOD_OFUCOSY	724	729	PF10250	0.603
MOD_PIKK_1	166	172	PF00454	0.654
MOD_PIKK_1	374	380	PF00454	0.682
MOD_PKA_2	517	523	PF00069	0.588
MOD_PKA_2	749	755	PF00069	0.530
MOD_Plk_1	132	138	PF00069	0.561
MOD_Plk_1	392	398	PF00069	0.627
MOD_Plk_1	401	407	PF00069	0.420
MOD_Plk_1	483	489	PF00069	0.632
MOD_Plk_1	535	541	PF00069	0.581
MOD_Plk_1	673	679	PF00069	0.577
MOD_Plk_1	733	739	PF00069	0.516
MOD_Plk_2-3	474	480	PF00069	0.641
MOD_Plk_2-3	483	489	PF00069	0.497
MOD_Plk_4	132	138	PF00069	0.571
MOD_Plk_4	234	240	PF00069	0.615
MOD_Plk_4	393	399	PF00069	0.614
MOD_Plk_4	402	408	PF00069	0.510
MOD_Plk_4	554	560	PF00069	0.555
MOD_Plk_4	673	679	PF00069	0.599
MOD_ProDKin_1	248	254	PF00069	0.634
MOD_ProDKin_1	265	271	PF00069	0.695
MOD_ProDKin_1	460	466	PF00069	0.325
MOD_ProDKin_1	69	75	PF00069	0.593
MOD_ProDKin_1	715	721	PF00069	0.553
MOD_ProDKin_1	762	768	PF00069	0.640
MOD_ProDKin_1	9	15	PF00069	0.552
MOD_SUMO_for_1	408	411	PF00179	0.643
MOD_SUMO_for_1	481	484	PF00179	0.467
MOD_SUMO_rev_2	270	279	PF00179	0.664
MOD_SUMO_rev_2	532	539	PF00179	0.432
TRG_DiLeu_BaEn_2	401	407	PF01217	0.438
TRG_DiLeu_BaEn_3	88	94	PF01217	0.622
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.492
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.731
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.482
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.664
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.662
TRG_ENDOCYTIC_2	111	114	PF00928	0.537
TRG_ENDOCYTIC_2	134	137	PF00928	0.463
TRG_ENDOCYTIC_2	184	187	PF00928	0.562
TRG_ENDOCYTIC_2	197	200	PF00928	0.421
TRG_ENDOCYTIC_2	678	681	PF00928	0.424
TRG_ENDOCYTIC_2	774	777	PF00928	0.453
TRG_ENDOCYTIC_2	81	84	PF00928	0.472
TRG_ER_diArg_1	320	323	PF00400	0.549
TRG_ER_diArg_1	432	435	PF00400	0.420
TRG_ER_diArg_1	498	500	PF00400	0.536
TRG_ER_diArg_1	735	738	PF00400	0.535
TRG_NES_CRM1_1	34	48	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.358
TRG_PTS1	784	787	PF00515	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS3	Leptomonas seymouri	44%	96%
A0A0S4JAE8	Bodo saltans	27%	100%
A0A1X0NLN9	Trypanosomatidae	27%	100%
A0A3Q8IJ99	Leishmania donovani	67%	99%
A0A3R7K3C1	Trypanosoma rangeli	28%	100%
A4IE00	Leishmania infantum	67%	99%
D0A406	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AU22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q0H3	Leishmania major	67%	100%
V5BJ29	Trypanosoma cruzi	28%	100%