Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellum targeting protein kharon1, putative

Species:

Leishmania braziliensis

UniProt:

A4HQA3_LEIBR

TriTrypDb:

LbrM.35.6150 , LBRM2903_350072800

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.572
CLV_NRD_NRD_1	144	146	PF00675	0.579
CLV_NRD_NRD_1	295	297	PF00675	0.567
CLV_NRD_NRD_1	403	405	PF00675	0.545
CLV_NRD_NRD_1	47	49	PF00675	0.664
CLV_PCSK_KEX2_1	115	117	PF00082	0.617
CLV_PCSK_KEX2_1	144	146	PF00082	0.660
CLV_PCSK_KEX2_1	225	227	PF00082	0.562
CLV_PCSK_KEX2_1	403	405	PF00082	0.545
CLV_PCSK_KEX2_1	433	435	PF00082	0.665
CLV_PCSK_KEX2_1	47	49	PF00082	0.664
CLV_PCSK_KEX2_1	476	478	PF00082	0.662
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.562
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.670
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.651
CLV_PCSK_PC7_1	399	405	PF00082	0.550
CLV_PCSK_SKI1_1	154	158	PF00082	0.562
CLV_PCSK_SKI1_1	226	230	PF00082	0.617
CLV_PCSK_SKI1_1	233	237	PF00082	0.607
CLV_PCSK_SKI1_1	447	451	PF00082	0.716
CLV_PCSK_SKI1_1	67	71	PF00082	0.577
DOC_ANK_TNKS_1	83	90	PF00023	0.483
DOC_CKS1_1	314	319	PF01111	0.602
DOC_MAPK_gen_1	506	514	PF00069	0.619
DOC_MAPK_MEF2A_6	33	42	PF00069	0.560
DOC_MAPK_NFAT4_5	33	41	PF00069	0.557
DOC_PP1_RVXF_1	445	451	PF00149	0.490
DOC_PP4_FxxP_1	63	66	PF00568	0.610
DOC_PP4_FxxP_1	70	73	PF00568	0.534
DOC_USP7_MATH_1	266	270	PF00917	0.472
DOC_USP7_MATH_1	372	376	PF00917	0.660
DOC_USP7_MATH_1	389	393	PF00917	0.553
DOC_USP7_MATH_1	414	418	PF00917	0.678
DOC_USP7_MATH_1	475	479	PF00917	0.525
DOC_USP7_MATH_1	59	63	PF00917	0.547
DOC_USP7_UBL2_3	225	229	PF12436	0.474
DOC_USP7_UBL2_3	261	265	PF12436	0.663
DOC_USP7_UBL2_3	447	451	PF12436	0.569
DOC_WW_Pin1_4	123	128	PF00397	0.503
DOC_WW_Pin1_4	161	166	PF00397	0.521
DOC_WW_Pin1_4	3	8	PF00397	0.637
DOC_WW_Pin1_4	313	318	PF00397	0.603
DOC_WW_Pin1_4	368	373	PF00397	0.548
DOC_WW_Pin1_4	385	390	PF00397	0.520
DOC_WW_Pin1_4	426	431	PF00397	0.639
DOC_WW_Pin1_4	62	67	PF00397	0.721
LIG_14-3-3_CanoR_1	151	157	PF00244	0.571
LIG_14-3-3_CanoR_1	195	199	PF00244	0.454
LIG_14-3-3_CanoR_1	390	398	PF00244	0.550
LIG_14-3-3_CanoR_1	509	515	PF00244	0.483
LIG_14-3-3_CanoR_1	60	66	PF00244	0.568
LIG_BRCT_BRCA1_1	92	96	PF00533	0.414
LIG_Clathr_ClatBox_1	35	39	PF01394	0.443
LIG_FHA_1	350	356	PF00498	0.601
LIG_FHA_1	509	515	PF00498	0.511
LIG_FHA_2	182	188	PF00498	0.575
LIG_FHA_2	277	283	PF00498	0.516
LIG_FHA_2	369	375	PF00498	0.597
LIG_FHA_2	9	15	PF00498	0.510
LIG_LIR_Apic_2	327	333	PF02991	0.616
LIG_LIR_Apic_2	62	66	PF02991	0.584
LIG_LIR_Apic_2	68	73	PF02991	0.558
LIG_LIR_Gen_1	249	258	PF02991	0.484
LIG_LIR_Nem_3	249	255	PF02991	0.486
LIG_LIR_Nem_3	503	507	PF02991	0.480
LIG_MYND_1	301	305	PF01753	0.513
LIG_PCNA_yPIPBox_3	451	462	PF02747	0.536
LIG_PDZ_Class_1	510	515	PF00595	0.482
LIG_Pex14_2	439	443	PF04695	0.495
LIG_SH2_CRK	130	134	PF00017	0.611
LIG_SH2_CRK	290	294	PF00017	0.450
LIG_SH2_CRK	357	361	PF00017	0.504
LIG_SH2_STAT3	139	142	PF00017	0.571
LIG_SH2_STAT5	102	105	PF00017	0.535
LIG_SH2_STAT5	207	210	PF00017	0.646
LIG_SH2_STAT5	276	279	PF00017	0.520
LIG_SH3_2	186	191	PF14604	0.590
LIG_SH3_2	301	306	PF14604	0.539
LIG_SH3_3	180	186	PF00018	0.706
LIG_SH3_3	210	216	PF00018	0.596
LIG_SH3_3	225	231	PF00018	0.486
LIG_SH3_3	238	244	PF00018	0.629
LIG_SH3_3	298	304	PF00018	0.551
LIG_SH3_3	450	456	PF00018	0.520
LIG_SH3_3	70	76	PF00018	0.523
LIG_SH3_4	229	236	PF00018	0.468
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.470
LIG_TRAF2_1	318	321	PF00917	0.569
LIG_TRAF2_1	360	363	PF00917	0.681
LIG_TRAF2_2	360	365	PF00917	0.507
LIG_WW_3	214	218	PF00397	0.628
MOD_CDC14_SPxK_1	126	129	PF00782	0.500
MOD_CDK_SPK_2	368	373	PF00069	0.548
MOD_CDK_SPK_2	385	390	PF00069	0.513
MOD_CDK_SPK_2	62	67	PF00069	0.588
MOD_CDK_SPxK_1	123	129	PF00069	0.505
MOD_CDK_SPxK_1	313	319	PF00069	0.603
MOD_CDK_SPxK_1	426	432	PF00069	0.607
MOD_CDK_SPxxK_3	426	433	PF00069	0.607
MOD_CK1_1	397	403	PF00069	0.599
MOD_CK1_1	407	413	PF00069	0.602
MOD_CK1_1	508	514	PF00069	0.615
MOD_CK1_1	62	68	PF00069	0.437
MOD_CK2_1	181	187	PF00069	0.581
MOD_CK2_1	276	282	PF00069	0.524
MOD_CK2_1	368	374	PF00069	0.597
MOD_CK2_1	479	485	PF00069	0.669
MOD_CK2_1	62	68	PF00069	0.574
MOD_CK2_1	8	14	PF00069	0.517
MOD_Cter_Amidation	223	226	PF01082	0.567
MOD_GlcNHglycan	133	136	PF01048	0.692
MOD_GlcNHglycan	16	19	PF01048	0.543
MOD_GlcNHglycan	26	29	PF01048	0.621
MOD_GlcNHglycan	368	371	PF01048	0.641
MOD_GlcNHglycan	374	377	PF01048	0.623
MOD_GlcNHglycan	399	402	PF01048	0.622
MOD_GlcNHglycan	412	415	PF01048	0.556
MOD_GlcNHglycan	477	480	PF01048	0.524
MOD_GlcNHglycan	80	83	PF01048	0.697
MOD_GSK3_1	10	17	PF00069	0.528
MOD_GSK3_1	161	168	PF00069	0.628
MOD_GSK3_1	368	375	PF00069	0.640
MOD_GSK3_1	385	392	PF00069	0.692
MOD_GSK3_1	399	406	PF00069	0.601
MOD_GSK3_1	410	417	PF00069	0.574
MOD_GSK3_1	475	482	PF00069	0.616
MOD_N-GLC_1	123	128	PF02516	0.486
MOD_N-GLC_1	152	157	PF02516	0.611
MOD_N-GLC_1	161	166	PF02516	0.500
MOD_N-GLC_1	266	271	PF02516	0.486
MOD_N-GLC_2	179	181	PF02516	0.620
MOD_NEK2_1	488	493	PF00069	0.507
MOD_NEK2_2	146	151	PF00069	0.601
MOD_PK_1	129	135	PF00069	0.512
MOD_PKA_1	403	409	PF00069	0.543
MOD_PKA_2	194	200	PF00069	0.455
MOD_PKA_2	372	378	PF00069	0.617
MOD_PKA_2	389	395	PF00069	0.825
MOD_PKA_2	402	408	PF00069	0.606
MOD_PKA_2	410	416	PF00069	0.577
MOD_PKA_2	508	514	PF00069	0.707
MOD_PKA_2	59	65	PF00069	0.452
MOD_PKA_2	78	84	PF00069	0.620
MOD_PKA_2	90	96	PF00069	0.551
MOD_PKB_1	347	355	PF00069	0.462
MOD_Plk_1	152	158	PF00069	0.519
MOD_Plk_1	266	272	PF00069	0.488
MOD_Plk_4	251	257	PF00069	0.485
MOD_Plk_4	483	489	PF00069	0.516
MOD_ProDKin_1	123	129	PF00069	0.505
MOD_ProDKin_1	161	167	PF00069	0.521
MOD_ProDKin_1	3	9	PF00069	0.637
MOD_ProDKin_1	313	319	PF00069	0.603
MOD_ProDKin_1	368	374	PF00069	0.549
MOD_ProDKin_1	385	391	PF00069	0.520
MOD_ProDKin_1	426	432	PF00069	0.637
MOD_ProDKin_1	62	68	PF00069	0.713
MOD_SUMO_for_1	98	101	PF00179	0.406
MOD_SUMO_rev_2	363	368	PF00179	0.523
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.416
TRG_ENDOCYTIC_2	102	105	PF00928	0.526
TRG_ENDOCYTIC_2	130	133	PF00928	0.613
TRG_ENDOCYTIC_2	290	293	PF00928	0.457
TRG_ER_diArg_1	115	118	PF00400	0.579
TRG_NLS_MonoExtN_4	21	27	PF00514	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C6	Leptomonas seymouri	56%	100%
A0A3Q8IL75	Leishmania donovani	64%	97%
A4IDZ8	Leishmania infantum	64%	97%
E9AU20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
Q4Q0H5	Leishmania major	60%	100%
V5B3K7	Trypanosoma cruzi	27%	100%