HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQA0_LEIBR

TriTrypDb:

LbrM.35.6120 , LBRM2903_350072600

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HQA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQA0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.634
CLV_NRD_NRD_1	150	152	PF00675	0.690
CLV_NRD_NRD_1	39	41	PF00675	0.470
CLV_PCSK_KEX2_1	199	201	PF00082	0.668
CLV_PCSK_KEX2_1	203	205	PF00082	0.628
CLV_PCSK_KEX2_1	39	41	PF00082	0.472
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.707
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.686
CLV_PCSK_SKI1_1	106	110	PF00082	0.508
CLV_PCSK_SKI1_1	200	204	PF00082	0.686
CLV_PCSK_SKI1_1	238	242	PF00082	0.589
CLV_PCSK_SKI1_1	260	264	PF00082	0.457
CLV_PCSK_SKI1_1	32	36	PF00082	0.617
CLV_PCSK_SKI1_1	45	49	PF00082	0.504
CLV_PCSK_SKI1_1	80	84	PF00082	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.601
DEG_SPOP_SBC_1	305	309	PF00917	0.740
DOC_ANK_TNKS_1	228	235	PF00023	0.583
DOC_CKS1_1	140	145	PF01111	0.648
DOC_CKS1_1	317	322	PF01111	0.715
DOC_CKS1_1	337	342	PF01111	0.429
DOC_MAPK_gen_1	104	113	PF00069	0.566
DOC_MAPK_gen_1	242	251	PF00069	0.449
DOC_MAPK_MEF2A_6	138	147	PF00069	0.647
DOC_PP2B_LxvP_1	333	336	PF13499	0.527
DOC_USP7_MATH_1	134	138	PF00917	0.500
DOC_USP7_MATH_1	188	192	PF00917	0.814
DOC_USP7_MATH_1	283	287	PF00917	0.801
DOC_USP7_MATH_1	305	309	PF00917	0.777
DOC_USP7_UBL2_3	165	169	PF12436	0.673
DOC_USP7_UBL2_3	173	177	PF12436	0.603
DOC_USP7_UBL2_3	199	203	PF12436	0.619
DOC_WW_Pin1_4	139	144	PF00397	0.698
DOC_WW_Pin1_4	153	158	PF00397	0.685
DOC_WW_Pin1_4	205	210	PF00397	0.573
DOC_WW_Pin1_4	271	276	PF00397	0.766
DOC_WW_Pin1_4	285	290	PF00397	0.745
DOC_WW_Pin1_4	308	313	PF00397	0.732
DOC_WW_Pin1_4	316	321	PF00397	0.780
DOC_WW_Pin1_4	336	341	PF00397	0.672
DOC_WW_Pin1_4	7	12	PF00397	0.433
DOC_WW_Pin1_4	99	104	PF00397	0.565
LIG_14-3-3_CanoR_1	236	241	PF00244	0.619
LIG_BRCT_BRCA1_1	341	345	PF00533	0.529
LIG_BRCT_BRCA1_1	43	47	PF00533	0.594
LIG_DCNL_PONY_1	1	4	PF03556	0.669
LIG_FHA_1	140	146	PF00498	0.715
LIG_FHA_2	239	245	PF00498	0.600
LIG_FHA_2	275	281	PF00498	0.792
LIG_FHA_2	33	39	PF00498	0.612
LIG_FHA_2	81	87	PF00498	0.445
LIG_LIR_Gen_1	208	218	PF02991	0.527
LIG_LIR_Gen_1	83	91	PF02991	0.448
LIG_LIR_Nem_3	208	213	PF02991	0.496
LIG_LIR_Nem_3	235	240	PF02991	0.582
LIG_LIR_Nem_3	44	50	PF02991	0.507
LIG_LIR_Nem_3	83	88	PF02991	0.435
LIG_PDZ_Class_2	340	345	PF00595	0.676
LIG_Rb_LxCxE_1	18	35	PF01857	0.530
LIG_REV1ctd_RIR_1	85	94	PF16727	0.337
LIG_SH2_STAP1	210	214	PF00017	0.514
LIG_SH2_STAT5	78	81	PF00017	0.618
LIG_SH3_1	151	157	PF00018	0.749
LIG_SH3_2	146	151	PF14604	0.769
LIG_SH3_3	137	143	PF00018	0.602
LIG_SH3_3	151	157	PF00018	0.600
LIG_SH3_3	191	197	PF00018	0.734
LIG_SH3_3	286	292	PF00018	0.744
LIG_SH3_3	334	340	PF00018	0.535
LIG_TRAF2_1	241	244	PF00917	0.645
LIG_TRAF2_1	312	315	PF00917	0.557
LIG_UBA3_1	55	59	PF00899	0.588
LIG_WRC_WIRS_1	284	289	PF05994	0.546
MOD_CDC14_SPxK_1	10	13	PF00782	0.412
MOD_CDK_SPK_2	99	104	PF00069	0.611
MOD_CDK_SPxK_1	7	13	PF00069	0.425
MOD_CDK_SPxxK_3	99	106	PF00069	0.553
MOD_CK1_1	156	162	PF00069	0.798
MOD_CK1_1	179	185	PF00069	0.739
MOD_CK1_1	205	211	PF00069	0.571
MOD_CK1_1	274	280	PF00069	0.756
MOD_CK1_1	308	314	PF00069	0.726
MOD_CK1_1	325	331	PF00069	0.725
MOD_CK2_1	113	119	PF00069	0.352
MOD_CK2_1	160	166	PF00069	0.547
MOD_CK2_1	238	244	PF00069	0.599
MOD_CK2_1	27	33	PF00069	0.553
MOD_CK2_1	274	280	PF00069	0.793
MOD_CK2_1	80	86	PF00069	0.450
MOD_CK2_1	99	105	PF00069	0.595
MOD_GlcNHglycan	158	161	PF01048	0.790
MOD_GlcNHglycan	162	165	PF01048	0.778
MOD_GlcNHglycan	204	207	PF01048	0.484
MOD_GlcNHglycan	325	328	PF01048	0.735
MOD_GSK3_1	134	141	PF00069	0.549
MOD_GSK3_1	156	163	PF00069	0.744
MOD_GSK3_1	267	274	PF00069	0.712
MOD_GSK3_1	304	311	PF00069	0.821
MOD_GSK3_1	325	332	PF00069	0.804
MOD_GSK3_1	335	342	PF00069	0.735
MOD_LATS_1	136	142	PF00433	0.451
MOD_N-GLC_1	27	32	PF02516	0.492
MOD_N-GLC_1	323	328	PF02516	0.794
MOD_NEK2_1	2	7	PF00069	0.554
MOD_NEK2_1	306	311	PF00069	0.553
MOD_PIKK_1	299	305	PF00454	0.804
MOD_PIKK_1	310	316	PF00454	0.622
MOD_PKA_1	138	144	PF00069	0.508
MOD_PKA_1	176	182	PF00069	0.743
MOD_PKA_2	2	8	PF00069	0.583
MOD_PKA_2	60	66	PF00069	0.467
MOD_PKB_1	236	244	PF00069	0.633
MOD_Plk_1	27	33	PF00069	0.499
MOD_Plk_4	208	214	PF00069	0.466
MOD_Plk_4	325	331	PF00069	0.546
MOD_Plk_4	339	345	PF00069	0.464
MOD_ProDKin_1	139	145	PF00069	0.702
MOD_ProDKin_1	153	159	PF00069	0.686
MOD_ProDKin_1	205	211	PF00069	0.568
MOD_ProDKin_1	271	277	PF00069	0.767
MOD_ProDKin_1	285	291	PF00069	0.744
MOD_ProDKin_1	308	314	PF00069	0.736
MOD_ProDKin_1	316	322	PF00069	0.783
MOD_ProDKin_1	336	342	PF00069	0.676
MOD_ProDKin_1	7	13	PF00069	0.425
MOD_ProDKin_1	99	105	PF00069	0.560
MOD_SUMO_for_1	262	265	PF00179	0.462
MOD_SUMO_rev_2	102	111	PF00179	0.570
MOD_SUMO_rev_2	162	170	PF00179	0.537
TRG_ENDOCYTIC_2	114	117	PF00928	0.538
TRG_ENDOCYTIC_2	210	213	PF00928	0.485
TRG_ENDOCYTIC_2	85	88	PF00928	0.436
TRG_ER_diArg_1	229	232	PF00400	0.589
TRG_NLS_Bipartite_1	138	155	PF00514	0.724
TRG_NLS_MonoExtN_4	149	155	PF00514	0.683
TRG_NLS_MonoExtN_4	165	172	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P908	Leptomonas seymouri	52%	97%
A0A1X0NMA4	Trypanosomatidae	32%	100%
A0A3Q8IGP8	Leishmania donovani	68%	99%
A4IDZ6	Leishmania infantum	68%	99%
D0A409	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AU18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q0H7	Leishmania major	70%	100%