Nitroreductase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nitroreductase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ99_LEIBR

TriTrypDb:

LbrM.35.6110 , LBRM2903_350072500

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ99

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	8
GO:0006979	response to oxidative stress	3	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034599	cellular response to oxidative stress	4	8
GO:0042221	response to chemical	2	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0062197	cellular response to chemical stress	4	8
GO:0070887	cellular response to chemical stimulus	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	8
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.305
CLV_PCSK_KEX2_1	41	43	PF00082	0.296
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.413
CLV_PCSK_SKI1_1	190	194	PF00082	0.329
CLV_PCSK_SKI1_1	97	101	PF00082	0.331
DOC_MAPK_gen_1	77	85	PF00069	0.189
DOC_PP4_FxxP_1	193	196	PF00568	0.329
DOC_USP7_MATH_1	206	210	PF00917	0.329
DOC_USP7_MATH_1	216	220	PF00917	0.601
DOC_USP7_MATH_1	23	27	PF00917	0.623
DOC_USP7_UBL2_3	57	61	PF12436	0.230
DOC_USP7_UBL2_3	97	101	PF12436	0.270
LIG_14-3-3_CanoR_1	145	151	PF00244	0.189
LIG_14-3-3_CanoR_1	43	49	PF00244	0.307
LIG_14-3-3_CterR_2	229	233	PF00244	0.414
LIG_Actin_WH2_2	88	103	PF00022	0.270
LIG_BIR_III_2	215	219	PF00653	0.460
LIG_FHA_2	102	108	PF00498	0.329
LIG_FHA_2	189	195	PF00498	0.189
LIG_FHA_2	60	66	PF00498	0.293
LIG_LIR_Apic_2	191	196	PF02991	0.202
LIG_LIR_Gen_1	197	207	PF02991	0.346
LIG_LIR_Nem_3	142	146	PF02991	0.184
LIG_LIR_Nem_3	197	202	PF02991	0.329
LIG_SH2_SRC	130	133	PF00017	0.440
LIG_SH2_SRC	35	38	PF00017	0.436
LIG_SH2_STAP1	130	134	PF00017	0.250
LIG_SH2_STAP1	146	150	PF00017	0.430
LIG_SH2_STAT5	109	112	PF00017	0.237
LIG_SH2_STAT5	35	38	PF00017	0.436
LIG_SH3_3	215	221	PF00018	0.456
LIG_SH3_3	25	31	PF00018	0.464
LIG_SH3_4	30	37	PF00018	0.425
LIG_TRAF2_1	104	107	PF00917	0.329
LIG_WRC_WIRS_1	150	155	PF05994	0.346
MOD_CK1_1	149	155	PF00069	0.278
MOD_CK1_1	44	50	PF00069	0.189
MOD_CK1_1	5	11	PF00069	0.599
MOD_CK2_1	101	107	PF00069	0.279
MOD_CK2_1	52	58	PF00069	0.329
MOD_GlcNHglycan	131	135	PF01048	0.302
MOD_GlcNHglycan	157	160	PF01048	0.272
MOD_GlcNHglycan	166	169	PF01048	0.274
MOD_GlcNHglycan	23	26	PF01048	0.663
MOD_GlcNHglycan	31	34	PF01048	0.687
MOD_GSK3_1	151	158	PF00069	0.286
MOD_GSK3_1	37	44	PF00069	0.329
MOD_GSK3_1	48	55	PF00069	0.329
MOD_GSK3_1	59	66	PF00069	0.366
MOD_LATS_1	89	95	PF00433	0.189
MOD_N-GLC_2	117	119	PF02516	0.243
MOD_NEK2_1	151	156	PF00069	0.302
MOD_NEK2_1	4	9	PF00069	0.524
MOD_NEK2_1	48	53	PF00069	0.352
MOD_NEK2_2	206	211	PF00069	0.375
MOD_PIKK_1	151	157	PF00454	0.346
MOD_PK_1	41	47	PF00069	0.254
MOD_PKA_1	101	107	PF00069	0.347
MOD_PKA_1	41	47	PF00069	0.329
MOD_PKA_2	41	47	PF00069	0.288
MOD_Plk_1	48	54	PF00069	0.189
MOD_Plk_1	63	69	PF00069	0.153
MOD_Plk_2-3	107	113	PF00069	0.189
MOD_Plk_4	123	129	PF00069	0.270
MOD_Plk_4	146	152	PF00069	0.324
MOD_SUMO_rev_2	107	116	PF00179	0.329
MOD_SUMO_rev_2	209	219	PF00179	0.564
TRG_DiLeu_BaEn_1	197	202	PF01217	0.329
TRG_ENDOCYTIC_2	181	184	PF00928	0.270
TRG_NES_CRM1_1	183	198	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAF5	Leptomonas seymouri	65%	100%
A0A3Q8IWH0	Leishmania donovani	74%	100%
C9ZSG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AHY5	Leishmania infantum	74%	100%
E9AU17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
P37261	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4Q0H8	Leishmania major	74%	100%
Q96VH4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%