Mkiaa0324 protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mkiaa0324 protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HQ98_LEIBR

TriTrypDb:

LbrM.35.6100 , LBRM2903_350072400

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.586
CLV_NRD_NRD_1	12	14	PF00675	0.485
CLV_NRD_NRD_1	132	134	PF00675	0.524
CLV_NRD_NRD_1	142	144	PF00675	0.415
CLV_NRD_NRD_1	175	177	PF00675	0.530
CLV_NRD_NRD_1	183	185	PF00675	0.594
CLV_NRD_NRD_1	187	189	PF00675	0.571
CLV_NRD_NRD_1	193	195	PF00675	0.593
CLV_NRD_NRD_1	208	210	PF00675	0.637
CLV_NRD_NRD_1	236	238	PF00675	0.587
CLV_NRD_NRD_1	254	256	PF00675	0.630
CLV_NRD_NRD_1	294	296	PF00675	0.704
CLV_NRD_NRD_1	302	304	PF00675	0.613
CLV_NRD_NRD_1	313	315	PF00675	0.528
CLV_NRD_NRD_1	324	326	PF00675	0.638
CLV_NRD_NRD_1	332	334	PF00675	0.644
CLV_NRD_NRD_1	376	378	PF00675	0.609
CLV_NRD_NRD_1	401	403	PF00675	0.586
CLV_NRD_NRD_1	404	406	PF00675	0.629
CLV_NRD_NRD_1	412	414	PF00675	0.647
CLV_NRD_NRD_1	423	425	PF00675	0.464
CLV_NRD_NRD_1	43	45	PF00675	0.399
CLV_NRD_NRD_1	444	446	PF00675	0.380
CLV_NRD_NRD_1	66	68	PF00675	0.613
CLV_NRD_NRD_1	85	87	PF00675	0.540
CLV_NRD_NRD_1	93	95	PF00675	0.600
CLV_PCSK_FUR_1	108	112	PF00082	0.512
CLV_PCSK_FUR_1	330	334	PF00082	0.448
CLV_PCSK_KEX2_1	110	112	PF00082	0.732
CLV_PCSK_KEX2_1	12	14	PF00082	0.557
CLV_PCSK_KEX2_1	132	134	PF00082	0.524
CLV_PCSK_KEX2_1	144	146	PF00082	0.397
CLV_PCSK_KEX2_1	163	165	PF00082	0.449
CLV_PCSK_KEX2_1	180	182	PF00082	0.550
CLV_PCSK_KEX2_1	192	194	PF00082	0.651
CLV_PCSK_KEX2_1	204	206	PF00082	0.537
CLV_PCSK_KEX2_1	208	210	PF00082	0.563
CLV_PCSK_KEX2_1	228	230	PF00082	0.616
CLV_PCSK_KEX2_1	250	252	PF00082	0.767
CLV_PCSK_KEX2_1	254	256	PF00082	0.598
CLV_PCSK_KEX2_1	301	303	PF00082	0.630
CLV_PCSK_KEX2_1	313	315	PF00082	0.604
CLV_PCSK_KEX2_1	323	325	PF00082	0.626
CLV_PCSK_KEX2_1	332	334	PF00082	0.618
CLV_PCSK_KEX2_1	376	378	PF00082	0.609
CLV_PCSK_KEX2_1	387	389	PF00082	0.438
CLV_PCSK_KEX2_1	401	403	PF00082	0.560
CLV_PCSK_KEX2_1	411	413	PF00082	0.645
CLV_PCSK_KEX2_1	444	446	PF00082	0.380
CLV_PCSK_KEX2_1	484	486	PF00082	0.641
CLV_PCSK_KEX2_1	85	87	PF00082	0.525
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.732
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.520
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.449
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.550
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.606
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.564
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.633
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.664
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.623
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.761
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.482
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.617
CLV_PCSK_PC7_1	176	182	PF00082	0.524
CLV_PCSK_PC7_1	188	194	PF00082	0.594
CLV_PCSK_PC7_1	309	315	PF00082	0.506
CLV_PCSK_PC7_1	319	325	PF00082	0.535
CLV_PCSK_SKI1_1	118	122	PF00082	0.630
CLV_PCSK_SKI1_1	144	148	PF00082	0.533
CLV_PCSK_SKI1_1	189	193	PF00082	0.528
CLV_PCSK_SKI1_1	201	205	PF00082	0.605
CLV_PCSK_SKI1_1	213	217	PF00082	0.690
CLV_PCSK_SKI1_1	237	241	PF00082	0.577
CLV_PCSK_SKI1_1	359	363	PF00082	0.470
CLV_PCSK_SKI1_1	470	474	PF00082	0.354
CLV_PCSK_SKI1_1	485	489	PF00082	0.453
CLV_Separin_Metazoa	129	133	PF03568	0.503
DEG_APCC_DBOX_1	387	395	PF00400	0.409
DEG_APCC_DBOX_1	423	431	PF00400	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.557
DOC_MAPK_gen_1	143	151	PF00069	0.516
DOC_MAPK_gen_1	163	171	PF00069	0.458
DOC_MAPK_gen_1	226	233	PF00069	0.545
DOC_MAPK_gen_1	234	244	PF00069	0.522
DOC_MAPK_gen_1	330	339	PF00069	0.485
DOC_MAPK_gen_1	424	432	PF00069	0.462
DOC_MAPK_MEF2A_6	163	171	PF00069	0.454
DOC_MAPK_MEF2A_6	258	267	PF00069	0.646
DOC_MAPK_MEF2A_6	28	36	PF00069	0.378
DOC_MAPK_MEF2A_6	330	339	PF00069	0.485
DOC_MAPK_RevD_3	32	45	PF00069	0.347
DOC_PP2B_LxvP_1	159	162	PF13499	0.613
DOC_PP4_FxxP_1	54	57	PF00568	0.439
DOC_USP7_MATH_1	15	19	PF00917	0.419
DOC_USP7_MATH_1	207	211	PF00917	0.755
DOC_USP7_MATH_1	273	277	PF00917	0.700
DOC_USP7_MATH_1	283	287	PF00917	0.602
DOC_USP7_MATH_1	89	93	PF00917	0.657
DOC_USP7_UBL2_3	185	189	PF12436	0.538
DOC_USP7_UBL2_3	192	196	PF12436	0.513
DOC_USP7_UBL2_3	484	488	PF12436	0.576
DOC_WW_Pin1_4	118	123	PF00397	0.525
DOC_WW_Pin1_4	259	264	PF00397	0.573
DOC_WW_Pin1_4	393	398	PF00397	0.438
DOC_WW_Pin1_4	415	420	PF00397	0.631
LIG_14-3-3_CanoR_1	157	162	PF00244	0.511
LIG_14-3-3_CanoR_1	208	214	PF00244	0.624
LIG_14-3-3_CanoR_1	237	244	PF00244	0.662
LIG_14-3-3_CanoR_1	303	309	PF00244	0.581
LIG_14-3-3_CanoR_1	411	417	PF00244	0.556
LIG_14-3-3_CanoR_1	44	48	PF00244	0.385
LIG_14-3-3_CanoR_1	53	57	PF00244	0.443
LIG_BRCT_BRCA1_1	216	220	PF00533	0.531
LIG_EH_1	445	449	PF12763	0.417
LIG_FHA_1	177	183	PF00498	0.466
LIG_FHA_1	344	350	PF00498	0.438
LIG_FHA_1	366	372	PF00498	0.394
LIG_FHA_1	380	386	PF00498	0.415
LIG_IBAR_NPY_1	334	336	PF08397	0.447
LIG_LIR_Apic_2	52	57	PF02991	0.371
LIG_LIR_Gen_1	121	131	PF02991	0.466
LIG_LIR_Gen_1	451	459	PF02991	0.402
LIG_LIR_Nem_3	121	126	PF02991	0.503
LIG_LIR_Nem_3	18	23	PF02991	0.513
LIG_LIR_Nem_3	451	455	PF02991	0.382
LIG_Pex14_2	16	20	PF04695	0.329
LIG_REV1ctd_RIR_1	17	25	PF16727	0.349
LIG_RPA_C_Fungi	290	302	PF08784	0.523
LIG_RPA_C_Insects	290	305	PF08784	0.497
LIG_RPA_C_Plants	314	325	PF08784	0.483
LIG_SH2_CRK	342	346	PF00017	0.334
LIG_SH2_CRK	452	456	PF00017	0.396
LIG_SH2_STAP1	452	456	PF00017	0.396
LIG_SH2_STAT5	336	339	PF00017	0.424
LIG_SH3_3	20	26	PF00018	0.501
LIG_SH3_3	347	353	PF00018	0.482
LIG_SH3_3	392	398	PF00018	0.559
LIG_SH3_3	411	417	PF00018	0.509
LIG_UBA3_1	429	433	PF00899	0.424
LIG_WRC_WIRS_1	16	21	PF05994	0.472
MOD_CDK_SPK_2	259	264	PF00069	0.565
MOD_CK1_1	224	230	PF00069	0.560
MOD_CK1_1	246	252	PF00069	0.546
MOD_CK1_1	294	300	PF00069	0.499
MOD_CK1_1	312	318	PF00069	0.429
MOD_CK1_1	393	399	PF00069	0.424
MOD_CK1_1	415	421	PF00069	0.518
MOD_CK1_1	52	58	PF00069	0.360
MOD_Cter_Amidation	83	86	PF01082	0.542
MOD_GlcNHglycan	159	162	PF01048	0.462
MOD_GlcNHglycan	201	204	PF01048	0.649
MOD_GlcNHglycan	223	226	PF01048	0.587
MOD_GlcNHglycan	275	278	PF01048	0.712
MOD_GlcNHglycan	326	329	PF01048	0.643
MOD_GlcNHglycan	485	488	PF01048	0.460
MOD_GlcNHglycan	54	57	PF01048	0.515
MOD_GlcNHglycan	86	89	PF01048	0.573
MOD_GSK3_1	131	138	PF00069	0.543
MOD_GSK3_1	176	183	PF00069	0.570
MOD_GSK3_1	233	240	PF00069	0.598
MOD_GSK3_1	304	311	PF00069	0.639
MOD_GSK3_1	386	393	PF00069	0.554
MOD_GSK3_1	428	435	PF00069	0.438
MOD_GSK3_1	462	469	PF00069	0.370
MOD_LATS_1	178	184	PF00433	0.467
MOD_NEK2_1	131	136	PF00069	0.474
MOD_NEK2_1	2	7	PF00069	0.529
MOD_NEK2_1	214	219	PF00069	0.536
MOD_NEK2_1	27	32	PF00069	0.532
MOD_NEK2_1	291	296	PF00069	0.557
MOD_NEK2_1	308	313	PF00069	0.452
MOD_NEK2_1	317	322	PF00069	0.480
MOD_NEK2_1	343	348	PF00069	0.423
MOD_NEK2_1	448	453	PF00069	0.382
MOD_NEK2_2	15	20	PF00069	0.467
MOD_NEK2_2	304	309	PF00069	0.488
MOD_PIKK_1	89	95	PF00454	0.522
MOD_PK_1	21	27	PF00069	0.342
MOD_PK_1	243	249	PF00069	0.578
MOD_PKA_1	176	182	PF00069	0.506
MOD_PKA_1	184	190	PF00069	0.697
MOD_PKA_1	192	198	PF00069	0.678
MOD_PKA_1	208	214	PF00069	0.543
MOD_PKA_1	237	243	PF00069	0.565
MOD_PKA_1	323	329	PF00069	0.571
MOD_PKA_1	412	418	PF00069	0.553
MOD_PKA_2	131	137	PF00069	0.571
MOD_PKA_2	180	186	PF00069	0.524
MOD_PKA_2	192	198	PF00069	0.588
MOD_PKA_2	207	213	PF00069	0.646
MOD_PKA_2	233	239	PF00069	0.602
MOD_PKA_2	291	297	PF00069	0.650
MOD_PKA_2	304	310	PF00069	0.552
MOD_PKA_2	312	318	PF00069	0.538
MOD_PKA_2	323	329	PF00069	0.500
MOD_PKA_2	343	349	PF00069	0.389
MOD_PKA_2	379	385	PF00069	0.490
MOD_PKA_2	412	418	PF00069	0.599
MOD_PKA_2	43	49	PF00069	0.386
MOD_PKA_2	466	472	PF00069	0.359
MOD_PKA_2	52	58	PF00069	0.482
MOD_PKA_2	77	83	PF00069	0.513
MOD_PKA_2	84	90	PF00069	0.581
MOD_PKA_2	97	103	PF00069	0.619
MOD_Plk_4	15	21	PF00069	0.475
MOD_Plk_4	390	396	PF00069	0.422
MOD_ProDKin_1	118	124	PF00069	0.516
MOD_ProDKin_1	259	265	PF00069	0.572
MOD_ProDKin_1	393	399	PF00069	0.446
MOD_ProDKin_1	415	421	PF00069	0.628
MOD_SUMO_rev_2	435	440	PF00179	0.362
MOD_SUMO_rev_2	479	486	PF00179	0.611
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.450
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.352
TRG_ENDOCYTIC_2	336	339	PF00928	0.457
TRG_ENDOCYTIC_2	340	343	PF00928	0.463
TRG_ENDOCYTIC_2	452	455	PF00928	0.389
TRG_ER_diArg_1	11	13	PF00400	0.467
TRG_ER_diArg_1	131	133	PF00400	0.522
TRG_ER_diArg_1	143	146	PF00400	0.399
TRG_ER_diArg_1	231	234	PF00400	0.576
TRG_ER_diArg_1	254	256	PF00400	0.650
TRG_ER_diArg_1	302	305	PF00400	0.645
TRG_ER_diArg_1	330	333	PF00400	0.657
TRG_ER_diArg_1	376	378	PF00400	0.609
TRG_ER_diArg_1	400	402	PF00400	0.487
TRG_ER_diArg_1	411	413	PF00400	0.525
TRG_ER_diArg_1	443	445	PF00400	0.368
TRG_NLS_Bipartite_1	132	147	PF00514	0.378
TRG_NLS_Bipartite_1	176	196	PF00514	0.572
TRG_NLS_Bipartite_1	305	327	PF00514	0.566
TRG_NLS_Bipartite_1	94	114	PF00514	0.488
TRG_NLS_MonoExtC_3	191	196	PF00514	0.469
TRG_NLS_MonoExtC_3	300	305	PF00514	0.646
TRG_NLS_MonoExtN_4	108	114	PF00514	0.741
TRG_NLS_MonoExtN_4	189	196	PF00514	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V1	Leptomonas seymouri	41%	100%
A0A3Q8IK24	Leishmania donovani	63%	100%
A4IDZ5	Leishmania infantum	63%	100%
E9AU16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q0H9	Leishmania major	63%	100%