Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ97_LEIBR

TriTrypDb:

LbrM.35.6090 , LBRM2903_350072300

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.573
CLV_NRD_NRD_1	274	276	PF00675	0.461
CLV_NRD_NRD_1	384	386	PF00675	0.709
CLV_NRD_NRD_1	388	390	PF00675	0.693
CLV_PCSK_KEX2_1	274	276	PF00082	0.484
CLV_PCSK_KEX2_1	386	388	PF00082	0.659
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.659
CLV_PCSK_SKI1_1	267	271	PF00082	0.485
CLV_PCSK_SKI1_1	305	309	PF00082	0.511
CLV_PCSK_SKI1_1	311	315	PF00082	0.543
DEG_APCC_DBOX_1	266	274	PF00400	0.529
DEG_Kelch_Keap1_1	232	237	PF01344	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DOC_CYCLIN_RxL_1	264	271	PF00134	0.467
DOC_MAPK_gen_1	314	323	PF00069	0.489
DOC_MAPK_MEF2A_6	316	325	PF00069	0.472
DOC_PP2B_LxvP_1	261	264	PF13499	0.531
DOC_PP2B_LxvP_1	345	348	PF13499	0.515
DOC_USP7_MATH_1	25	29	PF00917	0.572
DOC_USP7_MATH_1	44	48	PF00917	0.690
DOC_USP7_MATH_1	51	55	PF00917	0.602
DOC_USP7_MATH_2	133	139	PF00917	0.471
DOC_USP7_UBL2_3	386	390	PF12436	0.667
DOC_USP7_UBL2_3	432	436	PF12436	0.355
DOC_WW_Pin1_4	33	38	PF00397	0.651
DOC_WW_Pin1_4	47	52	PF00397	0.483
LIG_14-3-3_CanoR_1	146	155	PF00244	0.511
LIG_14-3-3_CanoR_1	258	264	PF00244	0.425
LIG_14-3-3_CanoR_1	296	304	PF00244	0.428
LIG_14-3-3_CanoR_1	316	322	PF00244	0.491
LIG_14-3-3_CanoR_1	92	96	PF00244	0.540
LIG_14-3-3_CterR_2	445	447	PF00244	0.433
LIG_BIR_III_4	222	226	PF00653	0.513
LIG_FHA_1	24	30	PF00498	0.567
LIG_FHA_2	238	244	PF00498	0.691
LIG_FHA_2	407	413	PF00498	0.490
LIG_FHA_2	72	78	PF00498	0.555
LIG_LIR_Gen_1	299	308	PF02991	0.458
LIG_LIR_Gen_1	317	325	PF02991	0.513
LIG_LIR_Gen_1	66	75	PF02991	0.519
LIG_LIR_Nem_3	188	193	PF02991	0.584
LIG_LIR_Nem_3	299	304	PF02991	0.445
LIG_LIR_Nem_3	317	322	PF02991	0.513
LIG_LIR_Nem_3	66	71	PF02991	0.501
LIG_LYPXL_SIV_4	300	308	PF13949	0.473
LIG_NRBOX	265	271	PF00104	0.531
LIG_NRBOX	340	346	PF00104	0.518
LIG_SH2_CRK	144	148	PF00017	0.308
LIG_SH2_CRK	17	21	PF00017	0.581
LIG_SH2_STAP1	193	197	PF00017	0.568
LIG_SH2_STAT5	148	151	PF00017	0.549
LIG_SH2_STAT5	193	196	PF00017	0.581
LIG_SH2_STAT5	2	5	PF00017	0.564
LIG_SH2_STAT5	68	71	PF00017	0.336
LIG_SH3_3	31	37	PF00018	0.588
LIG_SH3_3	361	367	PF00018	0.648
LIG_SUMO_SIM_par_1	198	205	PF11976	0.435
LIG_SUMO_SIM_par_1	2	8	PF11976	0.524
LIG_SUMO_SIM_par_1	405	412	PF11976	0.371
LIG_TRAF2_1	156	159	PF00917	0.555
LIG_TYR_ITIM	15	20	PF00017	0.569
MOD_CK1_1	125	131	PF00069	0.694
MOD_CK1_1	196	202	PF00069	0.576
MOD_CK1_1	23	29	PF00069	0.573
MOD_CK1_1	230	236	PF00069	0.642
MOD_CK1_1	317	323	PF00069	0.436
MOD_CK1_1	350	356	PF00069	0.482
MOD_CK1_1	47	53	PF00069	0.614
MOD_CK2_1	153	159	PF00069	0.432
MOD_CK2_1	2	8	PF00069	0.555
MOD_CK2_1	237	243	PF00069	0.648
MOD_CK2_1	296	302	PF00069	0.561
MOD_CK2_1	326	332	PF00069	0.451
MOD_CK2_1	408	414	PF00069	0.498
MOD_GlcNHglycan	149	152	PF01048	0.611
MOD_GlcNHglycan	204	207	PF01048	0.532
MOD_GlcNHglycan	23	26	PF01048	0.719
MOD_GlcNHglycan	253	256	PF01048	0.444
MOD_GlcNHglycan	261	264	PF01048	0.461
MOD_GlcNHglycan	298	301	PF01048	0.557
MOD_GlcNHglycan	316	319	PF01048	0.268
MOD_GlcNHglycan	349	352	PF01048	0.383
MOD_GSK3_1	114	121	PF00069	0.648
MOD_GSK3_1	149	156	PF00069	0.573
MOD_GSK3_1	16	23	PF00069	0.668
MOD_GSK3_1	223	230	PF00069	0.650
MOD_GSK3_1	33	40	PF00069	0.576
MOD_GSK3_1	402	409	PF00069	0.643
MOD_GSK3_1	440	447	PF00069	0.411
MOD_GSK3_1	47	54	PF00069	0.672
MOD_NEK2_1	122	127	PF00069	0.734
MOD_NEK2_1	147	152	PF00069	0.509
MOD_NEK2_1	257	262	PF00069	0.436
MOD_NEK2_1	352	357	PF00069	0.540
MOD_NEK2_1	428	433	PF00069	0.522
MOD_NEK2_1	83	88	PF00069	0.503
MOD_PIKK_1	268	274	PF00454	0.558
MOD_PIKK_1	38	44	PF00454	0.510
MOD_PIKK_1	400	406	PF00454	0.680
MOD_PIKK_1	440	446	PF00454	0.372
MOD_PKA_1	170	176	PF00069	0.564
MOD_PKA_2	257	263	PF00069	0.428
MOD_PKA_2	91	97	PF00069	0.543
MOD_PKA_2	98	104	PF00069	0.659
MOD_Plk_1	326	332	PF00069	0.532
MOD_Plk_2-3	228	234	PF00069	0.718
MOD_Plk_2-3	412	418	PF00069	0.354
MOD_Plk_4	196	202	PF00069	0.503
MOD_Plk_4	2	8	PF00069	0.447
MOD_Plk_4	25	31	PF00069	0.597
MOD_Plk_4	352	358	PF00069	0.516
MOD_Plk_4	403	409	PF00069	0.550
MOD_ProDKin_1	33	39	PF00069	0.650
MOD_ProDKin_1	47	53	PF00069	0.472
TRG_DiLeu_BaEn_1	419	424	PF01217	0.599
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.537
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.584
TRG_ENDOCYTIC_2	144	147	PF00928	0.308
TRG_ENDOCYTIC_2	17	20	PF00928	0.579
TRG_ENDOCYTIC_2	301	304	PF00928	0.410
TRG_ENDOCYTIC_2	68	71	PF00928	0.429
TRG_ER_diArg_1	273	275	PF00400	0.468
TRG_NLS_MonoCore_2	384	389	PF00514	0.554
TRG_NLS_MonoExtC_3	384	389	PF00514	0.554
TRG_NLS_MonoExtN_4	385	391	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF3	Leptomonas seymouri	44%	84%
A0A1X0NLI7	Trypanosomatidae	26%	100%
A0A3Q8IPS4	Leishmania donovani	70%	100%
A0A3R7NLX1	Trypanosoma rangeli	28%	100%
D0A414	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHY4	Leishmania infantum	71%	100%
E9AU15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q0I0	Leishmania major	69%	100%