Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein (LRRP), putative

Species:

Leishmania braziliensis

UniProt:

A4HQ95_LEIBR

TriTrypDb:

LbrM.35.6070 , LBRM2903_350072100

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4HQ95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.566
CLV_PCSK_FUR_1	31	35	PF00082	0.306
CLV_PCSK_KEX2_1	3	5	PF00082	0.470
CLV_PCSK_KEX2_1	33	35	PF00082	0.605
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.470
CLV_PCSK_SKI1_1	148	152	PF00082	0.655
CLV_PCSK_SKI1_1	98	102	PF00082	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.612
DOC_CDC14_PxL_1	115	123	PF14671	0.423
DOC_USP7_MATH_1	114	118	PF00917	0.498
DOC_USP7_MATH_1	138	142	PF00917	0.559
DOC_USP7_MATH_1	169	173	PF00917	0.594
DOC_USP7_MATH_1	212	216	PF00917	0.514
DOC_USP7_MATH_1	80	84	PF00917	0.429
LIG_14-3-3_CanoR_1	170	177	PF00244	0.463
LIG_14-3-3_CanoR_1	185	190	PF00244	0.617
LIG_Clathr_ClatBox_1	149	153	PF01394	0.617
LIG_EH1_1	84	92	PF00400	0.514
LIG_eIF4E_1	22	28	PF01652	0.305
LIG_FHA_1	192	198	PF00498	0.540
LIG_FHA_1	204	210	PF00498	0.627
LIG_FHA_1	222	228	PF00498	0.335
LIG_FHA_2	224	230	PF00498	0.645
LIG_FHA_2	9	15	PF00498	0.506
LIG_FHA_2	92	98	PF00498	0.344
LIG_HP1_1	114	118	PF01393	0.498
LIG_LIR_Gen_1	108	116	PF02991	0.419
LIG_LIR_Gen_1	215	223	PF02991	0.632
LIG_LIR_Nem_3	108	112	PF02991	0.431
LIG_LIR_Nem_3	215	219	PF02991	0.619
LIG_SH2_NCK_1	37	41	PF00017	0.267
LIG_SH2_SRC	22	25	PF00017	0.315
LIG_SH2_STAT3	163	166	PF00017	0.351
LIG_SH3_3	113	119	PF00018	0.505
LIG_SUMO_SIM_par_1	148	153	PF11976	0.526
LIG_SUMO_SIM_par_1	52	57	PF11976	0.475
LIG_WRC_WIRS_1	106	111	PF05994	0.296
LIG_WRC_WIRS_1	213	218	PF05994	0.614
MOD_CK1_1	108	114	PF00069	0.570
MOD_CK1_1	204	210	PF00069	0.567
MOD_CK1_1	215	221	PF00069	0.634
MOD_CK1_1	257	263	PF00069	0.628
MOD_CK1_1	62	68	PF00069	0.520
MOD_CK2_1	185	191	PF00069	0.607
MOD_CK2_1	204	210	PF00069	0.311
MOD_CK2_1	223	229	PF00069	0.603
MOD_CK2_1	257	263	PF00069	0.508
MOD_CK2_1	6	12	PF00069	0.430
MOD_CK2_1	62	68	PF00069	0.446
MOD_CK2_1	91	97	PF00069	0.327
MOD_GlcNHglycan	238	242	PF01048	0.367
MOD_GlcNHglycan	259	262	PF01048	0.510
MOD_GlcNHglycan	55	59	PF01048	0.394
MOD_GlcNHglycan	64	67	PF01048	0.424
MOD_GlcNHglycan	86	90	PF01048	0.435
MOD_GSK3_1	139	146	PF00069	0.690
MOD_GSK3_1	198	205	PF00069	0.510
MOD_GSK3_1	62	69	PF00069	0.576
MOD_LATS_1	183	189	PF00433	0.370
MOD_N-GLC_1	191	196	PF02516	0.524
MOD_NEK2_1	139	144	PF00069	0.581
MOD_NEK2_1	16	21	PF00069	0.487
MOD_NEK2_1	223	228	PF00069	0.642
MOD_NEK2_1	54	59	PF00069	0.302
MOD_NEK2_2	80	85	PF00069	0.367
MOD_PIKK_1	139	145	PF00454	0.419
MOD_PIKK_1	16	22	PF00454	0.559
MOD_PIKK_1	245	251	PF00454	0.446
MOD_PIKK_1	254	260	PF00454	0.487
MOD_PKA_1	245	251	PF00069	0.446
MOD_PKA_2	169	175	PF00069	0.506
MOD_Plk_1	6	12	PF00069	0.378
MOD_Plk_1	80	86	PF00069	0.450
MOD_Plk_4	204	210	PF00069	0.544
MOD_Plk_4	72	78	PF00069	0.461
MOD_SUMO_for_1	227	230	PF00179	0.370
MOD_SUMO_rev_2	257	267	PF00179	0.506
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.577
TRG_ENDOCYTIC_2	37	40	PF00928	0.507
TRG_ER_diArg_1	184	187	PF00400	0.594
TRG_ER_diArg_1	30	33	PF00400	0.523
TRG_ER_diLys_1	264	269	PF00400	0.504
TRG_NLS_MonoExtN_4	243	249	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGK7	Leptomonas seymouri	48%	100%
A0A3S7XBW4	Leishmania donovani	71%	100%
A4IDZ3	Leishmania infantum	71%	100%
D0A416	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AU13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	73%
Q4Q0I2	Leishmania major	70%	100%
V5BNS2	Trypanosoma cruzi	35%	100%