Mechanosensitive ion channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mechanosensitive ion channel MscS, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ93_LEIBR

TriTrypDb:

LbrM.35.6050 , LBRM2903_350071900

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HQ93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ93

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0008381	mechanosensitive monoatomic ion channel activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	23	29	PF00089	0.294
CLV_PCSK_KEX2_1	2	4	PF00082	0.451
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.451
CLV_PCSK_SKI1_1	119	123	PF00082	0.259
CLV_PCSK_SKI1_1	2	6	PF00082	0.432
DEG_Nend_UBRbox_1	1	4	PF02207	0.450
DOC_MAPK_gen_1	118	124	PF00069	0.235
DOC_MAPK_gen_1	83	93	PF00069	0.338
DOC_MAPK_MEF2A_6	86	95	PF00069	0.393
DOC_PP2B_LxvP_1	122	125	PF13499	0.195
DOC_USP7_MATH_1	139	143	PF00917	0.495
DOC_USP7_MATH_1	146	150	PF00917	0.701
LIG_14-3-3_CanoR_1	26	32	PF00244	0.369
LIG_14-3-3_CanoR_1	3	9	PF00244	0.465
LIG_Actin_WH2_2	70	88	PF00022	0.289
LIG_FHA_1	10	16	PF00498	0.421
LIG_FHA_1	107	113	PF00498	0.323
LIG_FHA_1	41	47	PF00498	0.285
LIG_FHA_2	101	107	PF00498	0.417
LIG_LIR_Apic_2	135	139	PF02991	0.341
LIG_LIR_Gen_1	108	117	PF02991	0.274
LIG_LIR_Nem_3	108	114	PF02991	0.274
LIG_Pex14_1	107	111	PF04695	0.274
LIG_Pex14_2	69	73	PF04695	0.289
LIG_PTB_Apo_2	3	10	PF02174	0.342
LIG_PTB_Phospho_1	3	9	PF10480	0.423
LIG_SH2_PTP2	111	114	PF00017	0.350
LIG_SH2_STAT5	111	114	PF00017	0.276
MOD_CK1_1	132	138	PF00069	0.386
MOD_CK1_1	22	28	PF00069	0.409
MOD_CK2_1	4	10	PF00069	0.466
MOD_GlcNHglycan	100	103	PF01048	0.383
MOD_GlcNHglycan	141	144	PF01048	0.620
MOD_GlcNHglycan	148	151	PF01048	0.618
MOD_GlcNHglycan	158	162	PF01048	0.612
MOD_GlcNHglycan	27	30	PF01048	0.398
MOD_GlcNHglycan	79	82	PF01048	0.311
MOD_GSK3_1	36	43	PF00069	0.311
MOD_GSK3_1	73	80	PF00069	0.289
MOD_GSK3_1	9	16	PF00069	0.491
MOD_N-GLC_1	139	144	PF02516	0.591
MOD_NEK2_1	36	41	PF00069	0.202
MOD_NEK2_1	4	9	PF00069	0.459
MOD_NEK2_1	73	78	PF00069	0.299
MOD_PKA_2	25	31	PF00069	0.378
MOD_Plk_4	129	135	PF00069	0.287
MOD_Plk_4	4	10	PF00069	0.540
MOD_Plk_4	95	101	PF00069	0.350
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.334
TRG_ENDOCYTIC_2	111	114	PF00928	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C9	Leptomonas seymouri	70%	100%
A0A0S4JFG0	Bodo saltans	50%	78%
A0A1X0NLP4	Trypanosomatidae	68%	100%
A0A3S7XBY0	Leishmania donovani	83%	100%
A0A422NSI6	Trypanosoma rangeli	63%	100%
A4IDZ1	Leishmania infantum	83%	100%
D0A418	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AU11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0I4	Leishmania major	82%	100%
V5B3P8	Trypanosoma cruzi	71%	100%