TRUD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pseudouridine synthase TruD, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ91_LEIBR

TriTrypDb:

LbrM.35.6030 , LBRM2903_350071700

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HQ91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ91

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006396	RNA processing	6	9
GO:0006399	tRNA metabolic process	7	9
GO:0008033	tRNA processing	8	9
GO:0034470	ncRNA processing	7	9
GO:0034660	ncRNA metabolic process	6	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.285
CLV_C14_Caspase3-7	626	630	PF00656	0.527
CLV_C14_Caspase3-7	66	70	PF00656	0.502
CLV_NRD_NRD_1	202	204	PF00675	0.289
CLV_NRD_NRD_1	207	209	PF00675	0.286
CLV_NRD_NRD_1	28	30	PF00675	0.449
CLV_NRD_NRD_1	474	476	PF00675	0.195
CLV_NRD_NRD_1	512	514	PF00675	0.411
CLV_PCSK_KEX2_1	100	102	PF00082	0.581
CLV_PCSK_KEX2_1	167	169	PF00082	0.561
CLV_PCSK_KEX2_1	202	204	PF00082	0.289
CLV_PCSK_KEX2_1	206	208	PF00082	0.287
CLV_PCSK_KEX2_1	256	258	PF00082	0.285
CLV_PCSK_KEX2_1	27	29	PF00082	0.408
CLV_PCSK_KEX2_1	474	476	PF00082	0.337
CLV_PCSK_KEX2_1	512	514	PF00082	0.422
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.579
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.561
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.285
CLV_PCSK_PC7_1	202	208	PF00082	0.289
CLV_PCSK_SKI1_1	160	164	PF00082	0.536
CLV_PCSK_SKI1_1	173	177	PF00082	0.462
CLV_PCSK_SKI1_1	257	261	PF00082	0.362
CLV_PCSK_SKI1_1	311	315	PF00082	0.408
CLV_PCSK_SKI1_1	364	368	PF00082	0.416
CLV_PCSK_SKI1_1	384	388	PF00082	0.266
CLV_PCSK_SKI1_1	424	428	PF00082	0.285
CLV_PCSK_SKI1_1	512	516	PF00082	0.388
CLV_PCSK_SKI1_1	566	570	PF00082	0.388
CLV_PCSK_SKI1_1	589	593	PF00082	0.241
DEG_APCC_DBOX_1	26	34	PF00400	0.429
DEG_APCC_DBOX_1	379	387	PF00400	0.408
DEG_APCC_DBOX_1	423	431	PF00400	0.285
DEG_APCC_DBOX_1	521	529	PF00400	0.401
DEG_APCC_KENBOX_2	224	228	PF00400	0.285
DEG_Nend_UBRbox_3	1	3	PF02207	0.581
DEG_SCF_FBW7_1	619	625	PF00400	0.597
DEG_SPOP_SBC_1	119	123	PF00917	0.594
DOC_CKS1_1	333	338	PF01111	0.300
DOC_CKS1_1	601	606	PF01111	0.488
DOC_CKS1_1	619	624	PF01111	0.576
DOC_MAPK_DCC_7	311	321	PF00069	0.195
DOC_MAPK_gen_1	254	261	PF00069	0.285
DOC_MAPK_gen_1	27	33	PF00069	0.444
DOC_MAPK_gen_1	378	387	PF00069	0.422
DOC_MAPK_HePTP_8	375	387	PF00069	0.335
DOC_MAPK_MEF2A_6	378	387	PF00069	0.343
DOC_MAPK_NFAT4_5	380	388	PF00069	0.335
DOC_PP1_RVXF_1	244	251	PF00149	0.285
DOC_PP1_RVXF_1	397	404	PF00149	0.405
DOC_PP2B_LxvP_1	334	337	PF13499	0.195
DOC_PP2B_LxvP_1	530	533	PF13499	0.285
DOC_PP4_FxxP_1	647	650	PF00568	0.323
DOC_PP4_FxxP_1	662	665	PF00568	0.330
DOC_USP7_MATH_1	119	123	PF00917	0.672
DOC_USP7_MATH_1	158	162	PF00917	0.547
DOC_USP7_MATH_1	323	327	PF00917	0.437
DOC_USP7_MATH_1	455	459	PF00917	0.196
DOC_USP7_MATH_1	47	51	PF00917	0.352
DOC_USP7_MATH_1	623	627	PF00917	0.620
DOC_USP7_MATH_1	94	98	PF00917	0.744
DOC_WW_Pin1_4	319	324	PF00397	0.282
DOC_WW_Pin1_4	325	330	PF00397	0.269
DOC_WW_Pin1_4	332	337	PF00397	0.241
DOC_WW_Pin1_4	413	418	PF00397	0.441
DOC_WW_Pin1_4	499	504	PF00397	0.399
DOC_WW_Pin1_4	600	605	PF00397	0.498
DOC_WW_Pin1_4	618	623	PF00397	0.482
LIG_14-3-3_CanoR_1	210	216	PF00244	0.238
LIG_14-3-3_CanoR_1	257	262	PF00244	0.285
LIG_14-3-3_CanoR_1	384	394	PF00244	0.353
LIG_APCC_ABBA_1	221	226	PF00400	0.285
LIG_BIR_III_4	304	308	PF00653	0.362
LIG_BIR_III_4	37	41	PF00653	0.530
LIG_BRCT_BRCA1_1	278	282	PF00533	0.362
LIG_BRCT_BRCA1_1	94	98	PF00533	0.477
LIG_BRCT_BRCA1_2	94	100	PF00533	0.480
LIG_EH1_1	453	461	PF00400	0.285
LIG_FHA_1	129	135	PF00498	0.530
LIG_FHA_1	152	158	PF00498	0.456
LIG_FHA_1	360	366	PF00498	0.298
LIG_FHA_1	581	587	PF00498	0.419
LIG_FHA_1	601	607	PF00498	0.440
LIG_FHA_1	619	625	PF00498	0.376
LIG_FHA_1	654	660	PF00498	0.256
LIG_FHA_2	161	167	PF00498	0.564
LIG_FHA_2	267	273	PF00498	0.408
LIG_FHA_2	279	285	PF00498	0.408
LIG_FHA_2	292	298	PF00498	0.149
LIG_FHA_2	513	519	PF00498	0.300
LIG_FHA_2	54	60	PF00498	0.454
LIG_FHA_2	546	552	PF00498	0.408
LIG_HCF-1_HBM_1	668	671	PF13415	0.372
LIG_HP1_1	47	51	PF01393	0.259
LIG_LIR_Apic_2	600	604	PF02991	0.455
LIG_LIR_Apic_2	661	665	PF02991	0.395
LIG_LIR_Gen_1	458	469	PF02991	0.285
LIG_LIR_Gen_1	53	63	PF02991	0.351
LIG_LIR_Gen_1	550	559	PF02991	0.422
LIG_LIR_LC3C_4	641	645	PF02991	0.235
LIG_LIR_Nem_3	416	421	PF02991	0.278
LIG_LIR_Nem_3	458	464	PF02991	0.422
LIG_LIR_Nem_3	53	58	PF02991	0.356
LIG_LIR_Nem_3	550	555	PF02991	0.373
LIG_LIR_Nem_3	580	584	PF02991	0.408
LIG_MYND_1	332	336	PF01753	0.300
LIG_NRBOX	142	148	PF00104	0.316
LIG_NRBOX	382	388	PF00104	0.195
LIG_PCNA_PIPBox_1	397	406	PF02747	0.422
LIG_SH2_CRK	552	556	PF00017	0.408
LIG_SH2_CRK	581	585	PF00017	0.305
LIG_SH2_STAP1	34	38	PF00017	0.362
LIG_SH2_STAP1	409	413	PF00017	0.282
LIG_SH2_STAP1	552	556	PF00017	0.422
LIG_SH2_STAP1	654	658	PF00017	0.328
LIG_SH2_STAT5	354	357	PF00017	0.408
LIG_SH2_STAT5	419	422	PF00017	0.276
LIG_SH2_STAT5	437	440	PF00017	0.272
LIG_SH2_STAT5	452	455	PF00017	0.285
LIG_SH2_STAT5	55	58	PF00017	0.455
LIG_SH3_3	130	136	PF00018	0.578
LIG_SH3_3	326	332	PF00018	0.378
LIG_SH3_3	525	531	PF00018	0.305
LIG_Sin3_3	144	151	PF02671	0.307
LIG_SUMO_SIM_anti_2	641	646	PF11976	0.235
LIG_SUMO_SIM_par_1	29	37	PF11976	0.414
LIG_SUMO_SIM_par_1	317	322	PF11976	0.195
LIG_SUMO_SIM_par_1	47	53	PF11976	0.289
LIG_SUMO_SIM_par_1	71	76	PF11976	0.373
LIG_TRAF2_1	104	107	PF00917	0.557
LIG_TRAF2_1	294	297	PF00917	0.222
LIG_TRAF2_1	515	518	PF00917	0.257
LIG_TRFH_1	647	651	PF08558	0.334
LIG_UBA3_1	146	155	PF00899	0.428
MOD_CDK_SPxxK_3	600	607	PF00069	0.522
MOD_CK1_1	128	134	PF00069	0.428
MOD_CK1_1	36	42	PF00069	0.525
MOD_CK1_1	467	473	PF00069	0.444
MOD_CK1_1	50	56	PF00069	0.346
MOD_CK1_1	653	659	PF00069	0.345
MOD_CK1_1	79	85	PF00069	0.663
MOD_CK1_1	92	98	PF00069	0.686
MOD_CK2_1	126	132	PF00069	0.490
MOD_CK2_1	158	164	PF00069	0.549
MOD_CK2_1	266	272	PF00069	0.408
MOD_CK2_1	278	284	PF00069	0.410
MOD_CK2_1	291	297	PF00069	0.209
MOD_CK2_1	319	325	PF00069	0.414
MOD_CK2_1	512	518	PF00069	0.290
MOD_CK2_1	53	59	PF00069	0.455
MOD_CK2_1	629	635	PF00069	0.633
MOD_CK2_1	672	678	PF00069	0.639
MOD_Cter_Amidation	472	475	PF01082	0.195
MOD_GlcNHglycan	122	125	PF01048	0.615
MOD_GlcNHglycan	325	328	PF01048	0.402
MOD_GlcNHglycan	37	41	PF01048	0.535
MOD_GlcNHglycan	635	638	PF01048	0.442
MOD_GlcNHglycan	79	82	PF01048	0.658
MOD_GlcNHglycan	84	87	PF01048	0.628
MOD_GlcNHglycan	91	94	PF01048	0.718
MOD_GSK3_1	319	326	PF00069	0.236
MOD_GSK3_1	32	39	PF00069	0.554
MOD_GSK3_1	360	367	PF00069	0.291
MOD_GSK3_1	463	470	PF00069	0.409
MOD_GSK3_1	484	491	PF00069	0.221
MOD_GSK3_1	541	548	PF00069	0.429
MOD_GSK3_1	618	625	PF00069	0.524
MOD_GSK3_1	629	636	PF00069	0.443
MOD_GSK3_1	650	657	PF00069	0.463
MOD_LATS_1	240	246	PF00433	0.408
MOD_N-GLC_1	211	216	PF02516	0.416
MOD_N-GLC_1	672	677	PF02516	0.447
MOD_NEK2_1	179	184	PF00069	0.451
MOD_NEK2_1	241	246	PF00069	0.336
MOD_NEK2_1	360	365	PF00069	0.422
MOD_NEK2_1	385	390	PF00069	0.245
MOD_NEK2_1	464	469	PF00069	0.411
MOD_NEK2_1	484	489	PF00069	0.352
MOD_NEK2_1	577	582	PF00069	0.392
MOD_NEK2_1	77	82	PF00069	0.629
MOD_NEK2_2	47	52	PF00069	0.354
MOD_PIKK_1	4	10	PF00454	0.541
MOD_PK_1	126	132	PF00069	0.346
MOD_PK_1	20	26	PF00069	0.498
MOD_PKA_1	206	212	PF00069	0.409
MOD_PKA_1	512	518	PF00069	0.408
MOD_PKA_2	206	212	PF00069	0.297
MOD_PKA_2	266	272	PF00069	0.375
MOD_PKA_2	467	473	PF00069	0.405
MOD_PKA_2	512	518	PF00069	0.349
MOD_PKB_1	206	214	PF00069	0.317
MOD_Plk_1	20	26	PF00069	0.448
MOD_Plk_1	267	273	PF00069	0.361
MOD_Plk_1	283	289	PF00069	0.260
MOD_Plk_1	484	490	PF00069	0.422
MOD_Plk_1	589	595	PF00069	0.317
MOD_Plk_1	672	678	PF00069	0.575
MOD_Plk_2-3	629	635	PF00069	0.478
MOD_Plk_4	190	196	PF00069	0.394
MOD_Plk_4	283	289	PF00069	0.195
MOD_Plk_4	455	461	PF00069	0.303
MOD_Plk_4	50	56	PF00069	0.368
MOD_Plk_4	629	635	PF00069	0.474
MOD_Plk_4	654	660	PF00069	0.372
MOD_Plk_4	94	100	PF00069	0.480
MOD_ProDKin_1	319	325	PF00069	0.282
MOD_ProDKin_1	332	338	PF00069	0.319
MOD_ProDKin_1	413	419	PF00069	0.441
MOD_ProDKin_1	499	505	PF00069	0.399
MOD_ProDKin_1	600	606	PF00069	0.493
MOD_ProDKin_1	618	624	PF00069	0.481
TRG_DiLeu_BaEn_1	381	386	PF01217	0.335
TRG_DiLeu_BaEn_1	478	483	PF01217	0.408
TRG_DiLeu_BaEn_4	295	301	PF01217	0.422
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.515
TRG_DiLeu_LyEn_5	381	386	PF01217	0.335
TRG_ENDOCYTIC_2	218	221	PF00928	0.362
TRG_ENDOCYTIC_2	55	58	PF00928	0.335
TRG_ENDOCYTIC_2	552	555	PF00928	0.350
TRG_ENDOCYTIC_2	581	584	PF00928	0.285
TRG_ER_diArg_1	206	208	PF00400	0.306
TRG_ER_diArg_1	27	29	PF00400	0.481
TRG_ER_diArg_1	511	513	PF00400	0.412
TRG_NLS_MonoCore_2	99	104	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P912	Leptomonas seymouri	59%	95%
A0A0S4K0L8	Bodo saltans	23%	67%
A0A1X0NMC1	Trypanosomatidae	43%	94%
A0A3Q8IJ87	Leishmania donovani	76%	100%
A0A422NSE9	Trypanosoma rangeli	43%	100%
A4IDY9	Leishmania infantum	76%	100%
D0A420	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AU09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
O74343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q08647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q08DI8	Bos taurus	28%	100%
Q17426	Caenorhabditis elegans	25%	100%
Q4Q0I6	Leishmania major	75%	100%
Q5V1E6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q91VU7	Mus musculus	28%	100%
Q96PZ0	Homo sapiens	28%	100%
Q9H0K6	Homo sapiens	27%	97%
Q9VSK9	Drosophila melanogaster	26%	93%
V5BT95	Trypanosoma cruzi	43%	92%